BRENDA Home
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
adenosylmethionine cyclotransferase,
morePlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
adenosylmethioninase
-
-
-
-
cyclotransferase, adenosylmethionine
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
S-adenosyl-L-methionine = S-methyl-5'-thioadenosine + 2-aminobutan-4-olide
S-adenosyl-L-methionine = S-methyl-5'-thioadenosine + 2-aminobutan-4-olide
mechanism
-
S-adenosyl-L-methionine = S-methyl-5'-thioadenosine + 2-aminobutan-4-olide
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
nucleophilic substitution
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
S-adenosyl-L-methionine alkyltransferase (cyclizing)
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
S-adenosyl-L-methionine
5'-methylthioadenosine + 2-aminobutan-4-olide
S-adenosyl-L-methionine
5'-methylthioadenosine + alpha-amino-gamma-butyrolactone
S-adenosylethionine
?
-
-
-
-
?
S-adenosyl-L-methionine
5'-methylthioadenosine + 2-aminobutan-4-olide
-
-
-
?
S-adenosyl-L-methionine
5'-methylthioadenosine + 2-aminobutan-4-olide
-
-
-
?
S-adenosyl-L-methionine
5'-methylthioadenosine + 2-aminobutan-4-olide
-
-
-
ir
S-adenosyl-L-methionine
5'-methylthioadenosine + 2-aminobutan-4-olide
-
-
-
?
S-adenosyl-L-methionine
5'-methylthioadenosine + alpha-amino-gamma-butyrolactone
-
-
-
?
S-adenosyl-L-methionine
5'-methylthioadenosine + alpha-amino-gamma-butyrolactone
-
-
-
ir
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
S-adenosyl-L-methionine
5'-methylthioadenosine + alpha-amino-gamma-butyrolactone
S-adenosyl-L-methionine
5'-methylthioadenosine + alpha-amino-gamma-butyrolactone
-
-
-
?
S-adenosyl-L-methionine
5'-methylthioadenosine + alpha-amino-gamma-butyrolactone
-
-
-
ir
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
additional information
-
no cofactor is required
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
5'-O-Methyladenosine
-
weak inhibition
adenine
-
weak inhibition
adenosine
-
weak inhibition
Allo-S-Adenosyl-L-methionine
-
4 mM inhibits more than 50%
dimethyladenosylsulfonium
-
weak inhibition
ethylthioadenosine
-
4 mM inhibits more than 50%
L-methionine
-
weak inhibition
methionine methylsulfonium
-
weak inhibition
methylthioadenosine
-
4 mM inhibits more than 50%
Methylthioinosine
-
weak inhibition
S-adenosyl-L-homocysteine
SH-binding reagents
-
-
-
additional information
-
no effect: Mg2+, EDTA
-
S-adenosyl-L-ethionine
-
racemic mixture, 0.2 mM, 50% inhibition
S-adenosyl-L-ethionine
-
4 mM inhibits more than 50%
S-adenosyl-L-homocysteine
-
-
S-adenosyl-L-homocysteine
-
4 mM inhibits 25-50%
S-adenosyl-L-homocysteine
-
-
S-Ribosylmethionine
-
-
S-Ribosylmethionine
-
weak inhibition
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.05 - 1
S-adenosyl-L-methionine
0.05
S-adenosyl-L-methionine
-
-
1
S-adenosyl-L-methionine
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.05
S-adenosyl-L-homocysteine
-
competitive inhibitor to S-adenosylmethionine
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.099
-
porcine liver homogenate supernatant
0.117
-
ammonium sulfate-treated, pH 5 enzyme preparation
28.3
-
E. coli infected with bacteriophage UV-T3
3.07
-
E. coli infected with bacteriophage T3
additional information
-
synthesized enzyme tested according to the method of Gefter et al.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
6 - 9
-
about 60% of activity maximum at pH 6 and 9
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
-
brenda
Sprague-Dawley rat
-
-
brenda
-
-
-
brenda
pig
-
-
brenda
infected with bacteriophage T3
-
-
brenda
infected with bacteriophage T3 and UV-T3
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
cells
brenda
-
-
brenda
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
not stable to repeated freezing and thawing
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-10°C, enzyme from E. coli infected with bacteriophage UV-T3 is stable for 2 weeks
-
0°C or -10°C, enzyme from E. coli infected with bacteriophage T3 loses all of its activity within 3 days
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
method that includes chromatography on DEAE-cellulose
-
partial purification by a method that includes precipitation with acetone, differential heat inactivation and precipitation by ammonium sulfate
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Mudd, S.H.
Enzymatic cleavage of S-adenosylmethionine
J. Biol. Chem.
234
87-92
1959
Saccharomyces cerevisiae
brenda
Mudd, S.H.
The mechanism of the enzymatic cleavage of S-adenosylmethionine to alpha-amino-gamma-butyrolactone
J. Biol. Chem.
234
1784-1786
1959
Saccharomyces cerevisiae
brenda
Gefter, M.L.
T3 and UV-T3-induced S-adenosylmethionine cleavage enzyme (Escherichia coli)
Methods Enzymol.
17 B
406-411
1971
Escherichia coli
-
brenda
Swiatek, K.R.; Simon, L.N.; Chao, K.L.
Nicotinamide methyltransferase and S-adenosylmethionine: 5-methylthioadenosine hydrolase. Control of transfer ribonucleic acid methylation
Biochemistry
12
4670-4674
1973
Homo sapiens, Rattus norvegicus, Sus scrofa
brenda
Gazarian, K.G.; Gening, L.V.; Gazarian, T.G.
L-Homoserine: a novel excreted metabolic marker of hepatitis B abnormally produced in liver from methionine
Med. Hypotheses
58
279-283
2002
Escherichia coli
brenda
Select items on the left to see more content.
html completed
2.5.1.4 adenosylmethionine cyclotransferase
top
