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Information on EC 2.5.1.29 - geranylgeranyl diphosphate synthase and Organism(s) Hevea brasiliensis and UniProt Accession Q94ID7

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EC Tree
IUBMB Comments
Some forms of this enzyme will also use geranyl diphosphate and dimethylallyl diphosphate as donors; it will not use larger prenyl diphosphates as efficient donors.
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This record set is specific for:
Hevea brasiliensis
UNIPROT: Q94ID7
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Word Map
The taxonomic range for the selected organisms is: Hevea brasiliensis
The enzyme appears in selected viruses and cellular organisms
Synonyms
geranylgeranyl diphosphate synthase, ggpp synthase, ggdps, ggps1, ggpps1, cotb1, tgfpps, geranylgeranyl diphosphate synthase 1, geranylgeranyl pyrophosphate synthetase, ggppase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
farnesyltransferase
-
-
-
-
geranylgeranyl diphosphate synthase
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-
-
-
geranylgeranyl pyrophosphate synthase
-
-
-
-
geranylgeranyl pyrophosphate synthetase
-
-
-
-
geranylgeranyl-PP synthetase
-
-
-
-
synthetase, geranylgeranyl pyrophosphate
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
alkenyl group transfer
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -, -, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
(2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase
Some forms of this enzyme will also use geranyl diphosphate and dimethylallyl diphosphate as donors; it will not use larger prenyl diphosphates as efficient donors.
CAS REGISTRY NUMBER
COMMENTARY hide
9032-58-0
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(E,E)-farnesyl diphosphate + isopentenyl diphosphate
geranylgeranyl diphosphate + diphosphate
show the reaction diagram
-
-
?
dimethylallyl diphosphate + 3 isopentenyl diphosphate
geranylgeranyl diphosphate + 3 diphosphate
show the reaction diagram
-
-
?
geranyl diphosphate + 2 isopentenyl diphosphate
geranylgeranyl diphosphate + 2 diphosphate
show the reaction diagram
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(E,E)-farnesyl diphosphate + isopentenyl diphosphate
geranylgeranyl diphosphate + diphosphate
show the reaction diagram
-
-
-
?
dimethylallyl diphosphate + 3 isopentenyl diphosphate
geranylgeranyl diphosphate + 3 diphosphate
show the reaction diagram
-
-
-
?
geranyl diphosphate + 2 isopentenyl diphosphate
geranylgeranyl diphosphate + 2 diphosphate
show the reaction diagram
-
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0115
dimethylallyl diphosphate
-
0.00678
farnesyl diphosphate
-
0.00234
geranyl diphosphate
-
0.024
isopentenyl diphosphate
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.123
recombinant enzyme
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
8 - 9
recombinant enzyme
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
low expression level
Manually annotated by BRENDA team
low expression level
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
GGPPS_HEVBR
370
0
40096
Swiss-Prot
Chloroplast (Reliability: 3)
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant his-tagged enzyme, Ni2+-column
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Takaya, A.; Zhang, Y.W.; Asawatreratanakul, K.; Wititsuwannakul, D.; Wititsuwannakul, R.; Takahashi, S.; Koyama, T.
Cloning, expression and characterization of a functional cDNA clone encoding geranylgeranyl diphosphate synthase of Hevea brasiliensis
Biochim. Biophys. Acta
1625
214-220
2003
Hevea brasiliensis (Q94ID7), Hevea brasiliensis
Manually annotated by BRENDA team