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Information on EC 2.5.1.29 - geranylgeranyl diphosphate synthase and Organism(s) Catharanthus roseus and UniProt Accession Q42698

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EC Tree
IUBMB Comments
Some forms of this enzyme will also use geranyl diphosphate and dimethylallyl diphosphate as donors; it will not use larger prenyl diphosphates as efficient donors.
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This record set is specific for:
Catharanthus roseus
UNIPROT: Q42698
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Word Map
The taxonomic range for the selected organisms is: Catharanthus roseus
The enzyme appears in selected viruses and cellular organisms
Synonyms
geranylgeranyl diphosphate synthase, ggpp synthase, ggdps, ggps1, ggpps1, cotb1, tgfpps, geranylgeranyl diphosphate synthase 1, geranylgeranyl pyrophosphate synthetase, ggppase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
farnesyltransferase
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-
-
-
geranylgeranyl diphosphate synthase
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-
-
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geranylgeranyl pyrophosphate synthase
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-
-
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geranylgeranyl pyrophosphate synthetase
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-
-
-
geranylgeranyl-PP synthetase
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-
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synthetase, geranylgeranyl pyrophosphate
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
alkenyl group transfer
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-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -, -, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
(2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase
Some forms of this enzyme will also use geranyl diphosphate and dimethylallyl diphosphate as donors; it will not use larger prenyl diphosphates as efficient donors.
CAS REGISTRY NUMBER
COMMENTARY hide
9032-58-0
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate
diphosphate + geranylgeranyl diphosphate
show the reaction diagram
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate
diphosphate + geranylgeranyl diphosphate
show the reaction diagram
-
-
-
?
additional information
?
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
the type II GGPS carries an N-terminal transit peptide allowing plastid import and stroma/stromules localization of the protein
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
the enzyme from Catharanthus roseus is a plant type II GGPS belonging to the short-chain prenyltransferase subfamily
metabolism
the enzyme geranylgeranyl diphosphate synthase from Catharanthus roseus catalyses the formation of geranylgeranyl diphosphate from isopentenyl diphosphate and dimethylallyl diphosphate via three successive condensation reactions, exhibiting the activities of EC 2.5.1.1, EC 2.5.1.10, and EC 2.5.1.29
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
GGPPS_CATRO
357
0
38787
Swiss-Prot
Mitochondrion (Reliability: 3)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
41600
x * 41600, about, sequence calculation
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 41600, about, sequence calculation
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
DNA and amino acid sequence determination and analysis, expression in Escherichia coli strain BL21(DE3), functional complementation of the carotenogenic crt gene cluster in Escherichia coli, YFP-tagged GGPPS expression in Catharanthus roseus cell culture
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Thabet, I.; Gregory Guirimand, G.; Guihur, A.; Lanoue, A.; Courdavault, V.; Papon, N.; Bouzid, S.; Giglioli-Guivarch, N.; Simkin, A.; Clastre, M.
Characterization and subcellular localization of geranylgeranyl diphosphate synthase from Catharanthus roseus
Mol. Biol. Rep.
39
3235-3243
2012
Catharanthus roseus (Q42698), Catharanthus roseus
Manually annotated by BRENDA team