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Information on EC 2.5.1.18 - glutathione transferase and Organism(s) Dermatophagoides pteronyssinus and UniProt Accession P46419

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IUBMB Comments
A group of enzymes of broad specificity. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. Also catalyses the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange.
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This record set is specific for:
Dermatophagoides pteronyssinus
UNIPROT: P46419
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The taxonomic range for the selected organisms is: Dermatophagoides pteronyssinus
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Reaction Schemes
hide
RX
+
glutathione
=
HX
+
R-S-glutathione
+
=
+
Synonyms
gst, glutathione s-transferase, gstm1, gstp1, gstt1, glutathione-s-transferase, glutathione transferase, gsta1, gst pi, gstm3, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
glutathione S-transferase
-
allergen Der p 2
-
-
allergen Der p 8
-
-
glutathione S-alkyl transferase
-
-
-
-
glutathione S-aralkyltransferase
-
-
-
-
glutathione S-aryltransferase
-
-
-
-
glutathione S-transferase
glutathione S-transferase X
-
-
-
-
GSH S-transferase
-
-
-
-
GSHTase-P
-
-
-
-
S-(hydroxyalkyl)glutathione lyase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
aryl group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
RX:glutathione R-transferase
A group of enzymes of broad specificity. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. Also catalyses the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange.
CAS REGISTRY NUMBER
COMMENTARY hide
50812-37-8
-
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.3
-
isozyme Der p 2
8.5
-
isozyme Der p 8
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
mu class GST; housedust mite, mu class GST isozyme
SwissProt
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
GSTM1_DERPT
219
0
25590
Swiss-Prot
other Location (Reliability: 3)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
25705
-
x * 25705, isozyme Der p 8, sequence calcualtion
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
-
x * 25705, isozyme Der p 8, sequence calcualtion
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
E46Q/E106K/I149V/N!60Y/H167R/R184K
-
naturally occuring polymorphisms, nucleotide difference between isozymes Der p 8 and Der p 2, overview
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant Der p 8 from Pichia pastoris by glutathione affinity chromatography, native enzyme Der p 2 by glutathione affinity chromatography
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
DNA and amino acid sequence determination and analysis, phylogenetic analysis
Der p 8, DNA and amino acid sequence determination and analysis, expression of Der p 8 in Pichia pastoris srain GS115
-
orf Dp7002H05, DNA and amino acid sequence determination and analysis, phylogenetic analysis
orf Dp7018E11, DNA and amino acid sequence determination and analysis, phylogenetic analysis
orf Dp7019C10, DNA and amino acid sequence determination and analysis, phylogenetic analysis
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Dougall, A.; Holt, D.C.; Fischer, K.; Currie, B.J.; Kemp, D.J.; Walton, S.F.
Identification and characterization of Sarcoptes scabiei and Dermatophagoides pteronyssinus glutathione S-transferases: implication as a potential major allergen in crusted scabies
Am. J. Trop. Med. Hyg.
73
977-984
2005
Dermatophagoides pteronyssinus (P46419), Dermatophagoides pteronyssinus (Q2YFE3), Dermatophagoides pteronyssinus (Q2YFE4), Dermatophagoides pteronyssinus (Q2YFE5), Dermatophagoides pteronyssinus, Sarcoptes scabiei (Q2YFE6), Sarcoptes scabiei (Q2YFE7), Sarcoptes scabiei (Q2YFE8), Sarcoptes scabiei (Q2YFE9), Sarcoptes scabiei (Q5ISV1), Sarcoptes scabiei (Q8I9R9), Sarcoptes scabiei
Manually annotated by BRENDA team
Huang, C.H.; Liew, L.M.; Mah, K.W.; Kuo, I.C.; Lee, B.W.; Chua, K.Y.
Characterization of glutathione S-transferase from dust mite, Der p 8 and its immunoglobulin E cross-reactivity with cockroach glutathione S-transferase
Clin. Exp. Allergy
36
369-376
2006
Dermatophagoides pteronyssinus, Periplaneta americana
Manually annotated by BRENDA team