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Disease on EC 2.5.1.16 - spermidine synthase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Brain Neoplasms
Effects of dicyclohexylamine sulfate, a spermidine synthase inhibitor, in 9L rat brain tumor cells.
Breast Neoplasms
Targeting polyamine biosynthetic pathway through RNAi causes the abrogation of MCF 7 breast cancer cell line.
Carcinoma
Antitumor effect of dicyclohexylammonium sulfate, a potent inhibitor of spermidine, synthase.
Carcinoma, Hepatocellular
Dicyclohexylamine effects on HTC cell polyamine content and ornithine decarboxylase activity.
Inhibition of spermidine synthase gene expression by transforming growth factor-beta 1 in hepatoma cells.
Specific depletion of spermidine and spermine in HTC cells treated with inhibitors of aminopropyltransferases.
Chagas Disease
An NMR Biochemical Assay for Fragment-Based Drug Discovery: Evaluation of an Inhibitor Activity on Spermidine Synthase of Trypanosoma cruzi.
In silico, in vitro, X-ray crystallography, and integrated strategies for discovering spermidine synthase inhibitors for Chagas disease.
Polyamine biosynthetic enzymes as drug targets in parasitic protozoa.
Cysts
Arabidopsis spermidine synthase is targeted by an effector protein of the cyst nematode Heterodera schachtii.
Dehydration
Genome-wide identification of genes involved in polyamine biosynthesis and the role of exogenous polyamines in Malus hupehensis Rehd. under alkaline stress.
Hypersensitivity
Engineering a spermidine biosynthetic pathway in Clostridium thermocellum results in increased resistance to furans and increased ethanol production.
Infections
Arginase Is Essential for Survival of Leishmania donovani Promastigotes but Not Intracellular Amastigotes.
Spermidine synthase is required for virulence of Leishmania donovani.
Transcriptomic Analysis of Resistant and Susceptible Responses in a New Model Root-Knot Nematode Infection System Using Solanum torvum and Meloidogyne arenaria.
Leishmaniasis
A leishmaniasis study: Structure-based screening and molecular dynamics mechanistic analysis for discovering potent inhibitors of spermidine synthase.
Polyamine biosynthetic enzymes as drug targets in parasitic protozoa.
Spermidine synthase is required for virulence of Leishmania donovani.
Targeting polyamine metabolism for finding new drugs against leishmaniasis: a review.
Leukemia
2-Mercaptoethylamine, a competitive inhibitor of spermidine synthase in mammalian cells.
Antitumor effect of dicyclohexylammonium sulfate, a potent inhibitor of spermidine synthase against P388 leukemia.
Synthesis of N-chlorosulfonyl dicyclohexylamine as a potent inhibitor for spermidine synthase and its effects on human leukemia Molt4B cells.
Leukemia, Lymphoid
Inhibition by polyamines of methylthiopropylamine-induced ornithine decarboxylase in human lymphoid leukemia Molt 4B cells.
Methylthiopropylamine, a potent inhibitor of spermidine synthase and its antiproliferative effect on human lymphoid leukemia Molt 4B cells.
Lymphoma, B-Cell
Cancer chemoprevention locks onto a new polyamine metabolic target.
Chemoprevention of B-cell lymphomas by inhibition of the Myc target spermidine synthase.
Malaria
Binding and Inhibition of Spermidine Synthase from Plasmodium falciparum and Implications for In Vitro Inhibitor Testing.
Identification of Plasmodium falciparum spermidine synthase active site binders through structure-based virtual screening.
Polyamine biosynthetic enzymes as drug targets in parasitic protozoa.
Structural and mechanistic insights into the action of Plasmodium falciparum spermidine synthase.
The spermidine synthase of the malaria parasite Plasmodium falciparum: molecular and biochemical characterisation of the polyamine synthesis enzyme.
Nematode Infections
Arabidopsis spermidine synthase is targeted by an effector protein of the cyst nematode Heterodera schachtii.
Neoplasms
Binding and Inhibition of Spermidine Synthase from Plasmodium falciparum and Implications for In Vitro Inhibitor Testing.
Chain-fluorinated polyamines as tumor markers--IV. Comparison of 2-fluoroputrescine and 2,2-difluoroputrescine as substrates of spermidine synthase in vitro and in vivo.
Chemoprevention of B-cell lymphomas by inhibition of the Myc target spermidine synthase.
Osteoporosis
Modeling Snyder-Robinson Syndrome in multipotent stromal cells reveals impaired mitochondrial function as a potential cause for deficient osteogenesis.
Potassium Deficiency
Polyamine Metabolism in Scots Pine Embryogenic Cells under Potassium Deficiency.
Trypanosomiasis, African
Polyamine biosynthetic enzymes as drug targets in parasitic protozoa.