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Information on EC 2.5.1.148 - lycopaoctaene synthase

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IUBMB Comments
The enzyme, characterized from the green microalga Botryococcus braunii race L, in involved in biosynthesis of (14E,18E)-lycopadiene. In vitro, the enzyme can accept (2E,6E)-farnesyl diphosphate and phytyl diphosphate as substrates, and is also able to catalyse the condensation of two different substrate molecules, forming chimeric products. However, the use of these alternative substrates is not significant in vivo.
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
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Synonyms
LOS, lycopaoctaene synthase, squalene synthase-like enzyme, SSL, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 geranylgeranyl diphosphate + NADPH + H+ = lycopaoctaene + 2 diphosphate + NADP+
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overall reaction
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2 geranylgeranyl diphosphate = diphosphate + prephytoene diphosphate
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(1a)
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prephytoene diphosphate + NADPH + H+ = lycopaoctaene + diphosphate + NADP+
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(1b)
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