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BRENDA support

Information on EC 2.5.1.147 - 5-amino-6-(D-ribitylamino)uracil-L-tyrosine 4-hydroxyphenyl transferase

for references in articles please use BRENDA:EC2.5.1.147

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IUBMB Comments

The enzyme is involved in the production of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO), the precursor of the redox cofactor coenzyme F420, which is found in methanogens and in various actinobacteria. FO is also produced by some cyanobacteria and eukaryotes. The enzyme, which forms a complex with EC 4.3.1.32, 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, is a radical SAM enzyme that uses the 5′-deoxyadenosyl radical to initiate the reaction.

The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota

Synonyms
fo synthase, msmeg_5126, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine = 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + 2-iminoacetate + L-methionine + 5'-deoxyadenosine
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
MetaCyc
3PG-factor 420 biosynthesis, factor 420 biosynthesis I (archaea), factor 420 biosynthesis II (mycobacteria)
Highest Expressing Human Cell Lines
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