This enzyme, found in the bacterium Lactobacillus plantarum, is involved in the biosynthesis of a nickel-pincer cofactor. It carboxylates the pyridinium ring of deamido-NAD+ and cleaves the phosphoanhydride bond to release AMP and generate pyridinium-3,5-biscarboxylic acid mononucleotide (P2CMN).
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The enzyme appears in viruses and cellular organisms
This enzyme, found in the bacterium Lactobacillus plantarum, is involved in the biosynthesis of a nickel-pincer cofactor. It carboxylates the pyridinium ring of deamido-NAD+ and cleaves the phosphoanhydride bond to release AMP and generate pyridinium-3,5-biscarboxylic acid mononucleotide (P2CMN).
LarB can hydrolyze deamido-NAD+ directly or it first forms an adduct with deamido-NAD+ that releases AMP and reacts with CO2 to generate pyridinium-3,5-biscarboxylic acid mononucleotide
LarB can hydrolyze deamido-NAD+ directly or it first forms an adduct with deamido-NAD+ that releases AMP and reacts with CO2 to generate pyridinium-3,5-biscarboxylic acid mononucleotide
LarB is involved in synthesis of a (SCS)Ni(II) pincer complex derived from nicotinic acid. LarB carboxylates the pyridinium ring of nicotinic acid adenine dinucleotide and cleaves the phosphoanhydride bond to release AMP. The resulting biscarboxylic acid intermediate is transformed into a bisthiocarboxylic acid species by two singleturnover reactions in which sacrificial desulfurization of LarE converts its conserved Cys176 into dehydroalanine
LarB is involved in synthesis of a (SCS)Ni(II) pincer complex derived from nicotinic acid. LarB carboxylates the pyridinium ring of nicotinic acid adenine dinucleotide and cleaves the phosphoanhydride bond to release AMP. The resulting biscarboxylic acid intermediate is transformed into a bisthiocarboxylic acid species by two singleturnover reactions in which sacrificial desulfurization of LarE converts its conserved Cys176 into dehydroalanine
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2.5.1.143 pyridinium-3,5-biscarboxylic acid mononucleotide synthase
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