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Information on EC 2.5.1.127 - caldopentamine synthase

for references in articles please use BRENDA:EC2.5.1.127

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IUBMB Comments

The enzyme, characterized from the thermophilic archaeon Hyperthermus butylicus, can also synthesize norspermine from norspermidine and thermospermine from spermidine (with lower activity). The long-chain polyamines stabilize double-stranded DNA at high temperatures. In contrast to EC 2.5.1.23, sym-norspermidine synthase and EC 2.5.1.126, norspermine synthase, this enzyme shows no activity with propane-1,3-diamine.

The expected taxonomic range for this enzyme is: Hyperthermus butylicus

Synonyms
HbSpe II, long-chain polyamine synthase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl 3-(methylsulfanyl)propylamine + norspermine = S-methyl-5'-thioadenosine + caldopentamine
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
MetaCyc
long-chain polyamine biosynthesis
Highest Expressing Human Cell Lines
Cell Line Links Gene Links