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Information on EC 2.5.1.118 - beta-(isoxazolin-5-on-2-yl)-L-alanine synthase

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IUBMB Comments
The enzyme from the plants Lathyrus odoratus (sweet pea) and L. sativus (grass pea) also forms 3-(5-oxoisoxazolin-4-yl)-L-alanine in vitro (cf. EC 2.5.1.119). However, only 3-(5-oxoisoxazolin-2-yl)-L-alanine is formed in vivo. 3-(5-oxoisoxazolin-2-yl)-L-alanine is the biosynthetic precursor of the neurotoxin N3-oxalyl-L-2,3-diaminopropanoic acid, the cause of lathyrism. Closely related and possibly identical to EC 2.5.1.47, cysteine synthase, and EC 2.5.1.51, beta-pyrazolylalanine synthase.
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The expected taxonomic range for this enzyme is: Lathyrus
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
O-acetyl-L-serine + isoxazolin-5-one = 3-(5-oxoisoxazolin-2-yl)-L-alanine + acetate
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