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Information on EC 2.5.1.116 - homogentisate geranylgeranyltransferase and Organism(s) Synechocystis sp. and UniProt Accession P73726

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EC Tree
IUBMB Comments
Requires Mg2+ for activity. Involved in the biosynthesis of the vitamin E, tocotrienols. While the enzyme from the bacterium Synechocystis PCC 6803 has higher activity with phytyl diphosphate (EC 2.5.1.115, homogentisate phytyltransferase), the enzymes from barley, rice and wheat have only a low activity with that substrate .
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Synechocystis sp.
UNIPROT: P73726
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The taxonomic range for the selected organisms is: Synechocystis sp.
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
homogentisate geranylgeranyltransferase, homogentisic acid geranylgeranyl transferase, more
SYSTEMATIC NAME
IUBMB Comments
geranylgeranyl diphosphate:homogentisate geranylgeranyltransferase
Requires Mg2+ for activity. Involved in the biosynthesis of the vitamin E, tocotrienols. While the enzyme from the bacterium Synechocystis PCC 6803 has higher activity with phytyl diphosphate (EC 2.5.1.115, homogentisate phytyltransferase), the enzymes from barley, rice and wheat have only a low activity with that substrate [2].
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
geranylgeranyl diphosphate + homogentisate
diphosphate + 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2
show the reaction diagram
about 18% of the activity with phythyl diphosphate
-
-
?
phytyl diphosphate + homogentisate
diphosphate + 2-methyl-6-phytylbenzene-1,4-diol + CO2
show the reaction diagram
preferred substrate
-
-
?
additional information
?
-
no substrate: solanesyl diphosphate
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
SLR1736 gene disruption does not lead to significant differences in cellular plastoquinone, phylloquinone, and chlorophyll levels, but causes absence of tocopherols without affecting plastoquinone-9 levels
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Collakova, E.; DellaPenna, D.
Isolation and functional analysis of homogentisate phytyltransferase from Synechocystis sp. PCC 6803 and Arabidopsis
Plant Physiol.
127
1113-1124
2001
Synechocystis sp. (P73726)
Manually annotated by BRENDA team