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IUBMB Comments The enzyme from the fungus Aspergillus fumigatus also shows some activity with fumitremorgin C. Involved in the biosynthetic pathways of several indole alkaloids such as fumitremorgins and verruculogen.
The expected taxonomic range for this enzyme is: Aspergillus subgen. Fumigati
Synonyms
ftmH , FtmPT2,
ftmPTS ,
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dimethylallyl diphosphate + 12alpha,13alpha-dihydroxyfumitremorgin C = diphosphate + fumitremorgin B
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dimethylallyl-diphosphate:12alpha,13alpha-dihydroxyfumitremorgin C dimethylallyl-N-1-transferase
The enzyme from the fungus Aspergillus fumigatus also shows some activity with fumitremorgin C. Involved in the biosynthetic pathways of several indole alkaloids such as fumitremorgins and verruculogen.
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dimethylallyl diphosphate + 12alpha,13alpha-dihydroxyfumitremorgin C
diphosphate + fumitremorgin B
dimethylallyl diphosphate + fumitremorgin C
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relative activity of 10% compared to 12,13-dihydroxyfumitremorgin C
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additional information
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dimethylallyl diphosphate + 12alpha,13alpha-dihydroxyfumitremorgin C
diphosphate + fumitremorgin B
the enzyme is involved in the biosynthetic pathways of several indole alkaloids such as fumitremorgins and verruculogen
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dimethylallyl diphosphate + 12alpha,13alpha-dihydroxyfumitremorgin C
diphosphate + fumitremorgin B
the enzyme is specific for dimethylallyl diphosphate as prenyl donor, no activity with geranyl diphosphate. Relatively high specificity towards the aromatic substrate, it is extremely regiospecific
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additional information
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no activity with brevianamide F, tryprostatin A or B
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additional information
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no activity with brevianamide F, tryprostatin A or B
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dimethylallyl diphosphate + 12alpha,13alpha-dihydroxyfumitremorgin C
diphosphate + fumitremorgin B
the enzyme is involved in the biosynthetic pathways of several indole alkaloids such as fumitremorgins and verruculogen
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additional information
product formation is independent of the presence of metal ions. Even in the presence of EDTA no loss of enzyme activity is not detected
additional information
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product formation is independent of the presence of metal ions. Even in the presence of EDTA no loss of enzyme activity is not detected
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0.096
12alpha,13alpha-dihydroxyfumitremorgin C
37°C, pH not specified in the publication
0.186
dimethylallyl diphosphate
37°C, pH not specified in the publication
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0.03
12alpha,13alpha-dihydroxyfumitremorgin C
37°C, pH not specified in the publication
0.03
dimethylallyl diphosphate
37°C, pH not specified in the publication
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brenda
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UniProt
brenda
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FTMH_ASPFM
427
0
48584
Swiss-Prot
other Location (Reliability: 2 )
FTMH_ASPFU
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
427
0
48530
Swiss-Prot
other Location (Reliability: 2 )
FTMH_NEOFI
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)
393
0
44505
Swiss-Prot
other Location (Reliability: 2 )
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50100
2 * 50100, SDS-PAGE
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homodimer
2 * 50100, SDS-PAGE
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expressed in Escherichia coli and Saccharomyces cerevisiae
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expression in Saccharomyces cerevisiae
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Steffan, N.; Grundmann, A.; Yin, W.B.; Kremer, A.; Li, S.M.
Indole prenyltransferases from fungi: a new enzyme group with high potential for the production of prenylated indole derivatives
Curr. Med. Chem.
16
218-231
2009
Aspergillus fumigatus
brenda
Grundmann, A.; Kuznetsova, T.; Afiyatullov, S.Sh.; Li, S.M.
FtmPT2, an N-prenyltransferase from Aspergillus fumigatus, catalyses the last step in the biosynthesis of fumitremorgin B
ChemBioChem
9
2059-2063
2008
Aspergillus fumigatus (B9WZX7), Aspergillus fumigatus
brenda
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Enzyme Nomenclature
2.5.1.110 12alpha,13alpha-dihydroxyfumitremorgin C prenyltransferase
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