We're sorry, but BRENDA doesn't work properly without JavaScript. Please make sure you have JavaScript enabled in your browser settings.
Information on EC 2.5.1.110 - 12alpha,13alpha-dihydroxyfumitremorgin C prenyltransferase for references in articles please use BRENDA:EC2.5.1.110
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments The enzyme from the fungus Aspergillus fumigatus also shows some activity with fumitremorgin C. Involved in the biosynthetic pathways of several indole alkaloids such as fumitremorgins and verruculogen.
The expected taxonomic range for this enzyme is: Fumigati
Synonyms
ftmH , FtmPT2,
ftmPTS ,
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
dimethylallyl diphosphate + 12alpha,13alpha-dihydroxyfumitremorgin C = diphosphate + fumitremorgin B
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
dimethylallyl-diphosphate:12alpha,13alpha-dihydroxyfumitremorgin C dimethylallyl-N-1-transferase
The enzyme from the fungus Aspergillus fumigatus also shows some activity with fumitremorgin C. Involved in the biosynthetic pathways of several indole alkaloids such as fumitremorgins and verruculogen.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
dimethylallyl diphosphate + 12alpha,13alpha-dihydroxyfumitremorgin C
diphosphate + fumitremorgin B
dimethylallyl diphosphate + fumitremorgin C
?
relative activity of 10% compared to 12,13-dihydroxyfumitremorgin C
-
-
?
additional information
?
-
no activity with brevianamide F, tryprostatin A or B
-
-
-
dimethylallyl diphosphate + 12alpha,13alpha-dihydroxyfumitremorgin C
diphosphate + fumitremorgin B
the enzyme is involved in the biosynthetic pathways of several indole alkaloids such as fumitremorgins and verruculogen
-
-
?
dimethylallyl diphosphate + 12alpha,13alpha-dihydroxyfumitremorgin C
diphosphate + fumitremorgin B
the enzyme is specific for dimethylallyl diphosphate as prenyl donor, no activity with geranyl diphosphate. Relatively high specificity towards the aromatic substrate, it is extremely regiospecific
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
dimethylallyl diphosphate + 12alpha,13alpha-dihydroxyfumitremorgin C
diphosphate + fumitremorgin B
the enzyme is involved in the biosynthetic pathways of several indole alkaloids such as fumitremorgins and verruculogen
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
additional information
product formation is independent of the presence of metal ions. Even in the presence of EDTA no loss of enzyme activity is not detected
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.096
12alpha,13alpha-dihydroxyfumitremorgin C
37°C, pH not specified in the publication
0.186
dimethylallyl diphosphate
37°C, pH not specified in the publication
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.03
12alpha,13alpha-dihydroxyfumitremorgin C
37°C, pH not specified in the publication
0.03
dimethylallyl diphosphate
37°C, pH not specified in the publication
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
-
brenda
-
UniProt
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
FTMH_ASPFM
427
0
48584
Swiss-Prot
FTMH_ASPFU
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
427
0
48530
Swiss-Prot
FTMH_NEOFI
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)
393
0
44505
Swiss-Prot
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
50100
2 * 50100, SDS-PAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
homodimer
2 * 50100, SDS-PAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
expressed in Escherichia coli and Saccharomyces cerevisiae
-
expression in Saccharomyces cerevisiae
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Steffan, N.; Grundmann, A.; Yin, W.B.; Kremer, A.; Li, S.M.
Indole prenyltransferases from fungi: a new enzyme group with high potential for the production of prenylated indole derivatives
Curr. Med. Chem.
16
218-231
2009
Aspergillus fumigatus
brenda
Grundmann, A.; Kuznetsova, T.; Afiyatullov, S.Sh.; Li, S.M.
FtmPT2, an N-prenyltransferase from Aspergillus fumigatus, catalyses the last step in the biosynthesis of fumitremorgin B
ChemBioChem
9
2059-2063
2008
Aspergillus fumigatus, Aspergillus fumigatus (B9WZX7)
brenda
Select items on the left to see more content.
html completed
HOME
login
history
all enzymes
BRENDA home
History
Enzyme Nomenclature
2.5.1.110 12alpha,13alpha-dihydroxyfumitremorgin C prenyltransferase
top
Information
