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Information on EC 2.5.1.105 - 7,8-dihydropterin-6-yl-methyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase and Organism(s) Methanocaldococcus jannaschii and UniProt Accession Q57749

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IUBMB Comments
The enzyme, which has been studied in the archaeon Methanocaldococcus jannaschii, is involved in the biosynthesis of tetrahydromethanopterin.
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Methanocaldococcus jannaschii
UNIPROT: Q57749
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The taxonomic range for the selected organisms is: Methanocaldococcus jannaschii
The expected taxonomic range for this enzyme is: Bacteria, Archaea
Synonyms
dihydropteroate synthase, MJ0301, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dihydropteroate synthase
ambiguous
SYSTEMATIC NAME
IUBMB Comments
(7,8-dihydropterin-6-yl)methyl diphosphate:4-(beta-D-ribofuranosyl)aniline 5'-phosphate 6-hydroxymethyl-7,8-dihydropterintransferase
The enzyme, which has been studied in the archaeon Methanocaldococcus jannaschii, is involved in the biosynthesis of tetrahydromethanopterin.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-(beta-D-ribofuranosyl)aniline 5'-phosphate
N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate + diphosphate
show the reaction diagram
6-hydroxymethyl-7,8-dihydropterin diphosphate + 1-(4-aminophenyl)-1-deoxy-D-ribitol
7,8-dihydropterin-6-methyl-1-(4-aminophenyl)-1-deoxy-D-ribitol + diphosphate
show the reaction diagram
about 25% of the activity compared to 4-(beta-D-ribofuranosyl)aminobenzene-5'-phosphate
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-
?
additional information
?
-
no activity with 4-(beta-D-ribofuranosyl)-aminobenzene
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-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-(beta-D-ribofuranosyl)aniline 5'-phosphate
N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate + diphosphate
show the reaction diagram
the enzyme is involved in the biosynthesis of methanopterin
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-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
33076
x * 33076, calculated from sequence
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 33076, calculated from sequence
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Xu, H.; Aurora, R.; Rose, G.D.; White, R.H.
Identifying two ancient enzymes in Archaea using predicted secondary structure alignment
Nat. Struct. Biol.
6
750-754
1999
Methanocaldococcus jannaschii (Q57749)
Manually annotated by BRENDA team