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Information on EC 2.5.1.104 - N1-aminopropylagmatine synthase

for references in articles please use BRENDA:EC2.5.1.104

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IUBMB Comments

The enzyme is involved in the biosynthesis of spermidine from agmatine in some archaea and bacteria. The enzyme from the Gram-negative bacterium Thermus thermophilus accepts agmatine, spermidine and norspermidine with similar catalytic efficiency. The enzymes from the archaea Pyrococcus furiosus and Thermococcus kodakarensis prefer agmatine, but can utilize cadaverine, putrescine and propane-1,3-diamine with much lower catalytic efficiency. cf. EC 2.5.1.16, spermidine synthase, and EC 2.5.1.23, sym-norspermidine synthase.

The expected taxonomic range for this enzyme is: Bacteria, Archaea

Synonyms
acapt, pf0127, taapt, triamine/agmatine aminopropyltransferase, agmatine/cadaverine aminopropyl transferase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl 3-(methylsulfanyl)propylamine + agmatine = S-methyl-5'-thioadenosine + N1-(3-aminopropyl)agmatine
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
MetaCyc
spermidine biosynthesis III
Highest Expressing Human Cell Lines
Cell Line Links Gene Links