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S-adenosyl 3-(methylthio)propylamine + agmatine
5'-S-methyl-5'-thioadenosine + N1-aminopropylagamatine
Substrates: the enzyme is involved in polyamine biosynthesis
Products: -
?
S-adenosyl 3-(methylthio)propylamine + agmatine
5'-S-methyl-5'-thioadenosine + N1-aminopropylagmatine
S-adenosyl 3-(methylthio)propylamine + agmatine
S-methyl-5'-thioadenosine + N1-aminopropylagmatine
Substrates: -
Products: -
?
S-adenosyl 3-(methylthio)propylamine + cadaverine
5'-S-methyl-5'-thioadenosine + N-(3-aminopropyl)cadaverine
S-adenosyl 3-(methylthio)propylamine + homospermidine
S-methyl-5'-thioadenosine + ?
Substrates: low activity
Products: -
?
S-adenosyl 3-(methylthio)propylamine + N,N'-bis(3-aminopropyl)-1,3-propanediamine
S-methyl-5'-thioadenosine + ?
Substrates: i.e. thermine. Low activity
Products: -
?
S-adenosyl 3-(methylthio)propylamine + norspermidine
S-methyl-5'-thioadenosine + N,N'-bis(3-aminopropyl)-1,3-propanediamine
Substrates: -
Products: i.e. thermine
?
S-adenosyl 3-(methylthio)propylamine + propane-1,3-diamine
5'-S-methyl-5'-thioadenosine + bis(3-aminopropyl)amine
Substrates: 2.9% of the activity compared to cadaverine
Products: -
?
S-adenosyl 3-(methylthio)propylamine + putrescine
5'-S-methyl-5'-thioadenosine + spermidine
S-adenosyl 3-(methylthio)propylamine + spermidine
5'-S-methyl-5'-thioadenosine + spermine
Substrates: 0.8% of the activity compared to cadaverine
Products: -
?
S-adenosyl 3-(methylthio)propylamine + spermidine
S-methyl-5'-thioadenosine + spermine
Substrates: -
Products: no formation of thermospermine (i.e. 1,12-diamino-4,8-diazadodecane)
?
S-adenosyl 3-(methylthio)propylamine + tris(3-aminopropyl)amine
S-methyl-5'-thioadenosine + N4-aminopropylthermine
Substrates: i.e. mitsubishine. Low activity. No formation of tetrakis(3-aminopropyl)ammonium
Products: -
?
additional information
?
-
S-adenosyl 3-(methylthio)propylamine + agmatine
5'-S-methyl-5'-thioadenosine + N1-aminopropylagmatine
Substrates: agmatine is the physiological substrate in the constitutive synthesis of spermidine, while cadaverine acts as an aminopropyl acceptor under stress conditions when an active and rapid synthesis of N-(3-aminopropyl)cadaverine could be required
Products: -
?
S-adenosyl 3-(methylthio)propylamine + agmatine
5'-S-methyl-5'-thioadenosine + N1-aminopropylagmatine
Substrates: 4.9% of the activity compared to cadaverine
Products: -
?
S-adenosyl 3-(methylthio)propylamine + agmatine
5'-S-methyl-5'-thioadenosine + N1-aminopropylagmatine
Substrates: -
Products: -
?
S-adenosyl 3-(methylthio)propylamine + agmatine
5'-S-methyl-5'-thioadenosine + N1-aminopropylagmatine
Substrates: -
Products: -
?
S-adenosyl 3-(methylthio)propylamine + agmatine
5'-S-methyl-5'-thioadenosine + N1-aminopropylagmatine
Substrates: the enzyme is involved in polyamine biosynthesis
Products: -
?
S-adenosyl 3-(methylthio)propylamine + cadaverine
5'-S-methyl-5'-thioadenosine + N-(3-aminopropyl)cadaverine
Substrates: -
Products: -
?
S-adenosyl 3-(methylthio)propylamine + cadaverine
5'-S-methyl-5'-thioadenosine + N-(3-aminopropyl)cadaverine
Substrates: agmatine is the physiological substrate in the constitutive synthesis of spermidine, while cadaverine acts as an aminopropyl acceptor under stress conditions when an active and rapid synthesis of N-(3-aminopropyl)cadaverine could be required
Products: -
?
S-adenosyl 3-(methylthio)propylamine + cadaverine
5'-S-methyl-5'-thioadenosine + N-(3-aminopropyl)cadaverine
Substrates: -
Products: -
?
S-adenosyl 3-(methylthio)propylamine + putrescine
5'-S-methyl-5'-thioadenosine + spermidine
Substrates: 8.7% of the activity compared to cadaverine
Products: -
?
S-adenosyl 3-(methylthio)propylamine + putrescine
5'-S-methyl-5'-thioadenosine + spermidine
Substrates: -
Products: -
?
additional information
?
-
Substrates: only faint activities (less than 10% of spermidine) are detected for diaminopropane [NH2(CH2)3NH2], putrescine, spermine, and caldopentamine
Products: -
?
additional information
?
-
-
Substrates: only faint activities (less than 10% of spermidine) are detected for diaminopropane [NH2(CH2)3NH2], putrescine, spermine, and caldopentamine
Products: -
?
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S-adenosyl 3-(methylthio)propylamine + agmatine
5'-S-methyl-5'-thioadenosine + N1-aminopropylagamatine
Substrates: the enzyme is involved in polyamine biosynthesis
Products: -
?
S-adenosyl 3-(methylthio)propylamine + agmatine
5'-S-methyl-5'-thioadenosine + N1-aminopropylagmatine
S-adenosyl 3-(methylthio)propylamine + cadaverine
5'-S-methyl-5'-thioadenosine + N-(3-aminopropyl)cadaverine
Substrates: agmatine is the physiological substrate in the constitutive synthesis of spermidine, while cadaverine acts as an aminopropyl acceptor under stress conditions when an active and rapid synthesis of N-(3-aminopropyl)cadaverine could be required
Products: -
?
S-adenosyl 3-(methylthio)propylamine + agmatine
5'-S-methyl-5'-thioadenosine + N1-aminopropylagmatine
Substrates: agmatine is the physiological substrate in the constitutive synthesis of spermidine, while cadaverine acts as an aminopropyl acceptor under stress conditions when an active and rapid synthesis of N-(3-aminopropyl)cadaverine could be required
Products: -
?
S-adenosyl 3-(methylthio)propylamine + agmatine
5'-S-methyl-5'-thioadenosine + N1-aminopropylagmatine
Substrates: the enzyme is involved in polyamine biosynthesis
Products: -
?
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Cacciapuoti, G.; Porcelli, M.; Moretti, M.A.; Sorrentino, F.; Concilio, L.; Zappia, V.; Liu, Z.J.; Tempel, W.; Schubot, F.; Rose, J.P.; Wang, B.C.; Brereton, P.S.; Jenney, F.E.; Adams, M.W.
The first agmatine/cadaverine aminopropyl transferase: biochemical and structural characterization of an enzyme involved in polyamine biosynthesis in the hyperthermophilic archaeon Pyrococcus furiosus
J. Bacteriol.
189
6057-6067
2007
Pyrococcus furiosus (Q8U4G1), Pyrococcus furiosus
brenda
Morimoto, N.; Fukuda, W.; Nakajima, N.; Masuda, T.; Terui, Y.; Kanai, T.; Oshima, T.; Imanaka, T.; Fujiwara, S.
Dual biosynthesis pathway for longer-chain polyamines in the hyperthermophilic archaeon Thermococcus kodakarensis
J. Bacteriol.
192
4991-5001
2010
Thermococcus kodakarensis (Q5JFG9)
brenda
Ohnuma, M.; Terui, Y.; Tamakoshi, M.; Mitome, H.; Niitsu, M.; Samejima, K.; Kawashima, E.; Oshima, T.
N1-aminopropylagmatine, a new polyamine produced as a key intermediate in polyamine biosynthesis of an extreme thermophile, Thermus thermophilus
J. Biol. Chem.
280
30073-30082
2005
Thermus thermophilus (Q5SK28)
brenda
Ohnuma, M.; Ganbe, T.; Terui, Y.; Niitsu, M.; Sato, T.; Tanaka, N.; Tamakoshi, M.; Samejima, K.; Kumasaka, T.; Oshima, T.
Crystal structures and enzymatic properties of a triamine/agmatine aminopropyltransferase from Thermus thermophilus
J. Mol. Biol.
408
971-986
2011
Thermus thermophilus (Q5SK28), Thermus thermophilus
brenda