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Disease on EC 2.4.99.8 - alpha-N-acetylneuraminate alpha-2,8-sialyltransferase and Organism(s) Homo sapiens and UniProt Accession Q92185

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acquired Immunodeficiency Syndrome
Differential effect of disease-associated ST8SIA2 haplotype on cerebral white matter diffusion properties in schizophrenia and healthy controls.
Adenocarcinoma
Effects of intronic single nucleotide polymorphisms (iSNPs) of a polysialyltransferase, ST8SIA2 gene found in psychiatric disorders on its gene products.
Adenocarcinoma of Lung
Curcumin Downregulates Human GM3 Synthase (hST3Gal V) Gene Expression with Autophagy Induction in Human Colon Carcinoma HCT116 Cells.
Adenocarcinoma, Follicular
miR-146a and miR-146b promote proliferation, migration and invasion of follicular thyroid carcinoma via inhibition of ST8SIA4.
alpha-n-acetylneuraminate alpha-2,8-sialyltransferase deficiency
Altered developmental neuroplasticity due to polysialyltransferase ST8SiaII deficiency in mice leads to schizophrenia-like phenotype.
Amygdala GluN2B-NMDAR dysfunction is critical in abnormal aggression of neurodevelopmental origin induced by St8sia2 deficiency.
Effect of expression alteration in flanking genes on phenotypes of St8sia2-deficient mice.
Impact of the polysialyltransferases ST8SiaII and ST8SiaIV on polysialic acid synthesis during postnatal mouse brain development.
Level and localization of polysialic acid is critical for early peripheral nerve regeneration.
Polysialic acid affects pathophysiological consequences of status epilepticus.
Schizophrenia-like phenotype of polysialyltransferase ST8SIA2-deficient mice.
St8sia2 deficiency plus juvenile cannabis exposure in mice synergistically affect higher cognition in adulthood.
ST8SIA2 promotes oligodendrocyte differentiation and the integrity of myelin and axons.
Alzheimer Disease
Brain gangliosides of a transgenic mouse model of Alzheimer's disease with deficiency in GD3-synthase: expression of elevated levels of a cholinergic-specific ganglioside, GT1a?.
Astrocytoma
Expression profiling of glycosyltransferases and related enzymes using in situ hybridization.
Sialyltransferase levels and ganglioside expression in melanoma and other cultured human cancer cells.
Ataxia
Bacterial infections in Guillain-Barré and Fisher syndromes.
Campylobacter sialyltransferase gene polymorphism directs clinical features of Guillain-Barré syndrome.
[Campylobacter genes responsible for the development and determinant of clinical features of Guillain-Barré syndrome]
Atherosclerosis
Disialoganglioside (GD3) synthase gene expression suppresses vascular smooth muscle cell responses via the inhibition of ERK1/2 phosphorylation, cell cycle progression, and matrix metalloproteinase-9 expression.
Reactive oxygen species mediates disialoganglioside GD3-induced inhibition of ERK1/2 and matrix metalloproteinase-9 expression in vascular smooth muscle cells.
Autoimmune Diseases
Cutting Edge: ST8Sia6-Generated ?-2,8-Disialic Acids Mitigate Hyperglycemia in Multiple Low-Dose Streptozotocin-Induced Diabetes.
Basal Ganglia Diseases
Functional roles of ST8SIA3-mediated sialylation of striatal dopamine D2 and adenosine A2A receptors.
Brain Ischemia
Ganglioside GD3 is up-regulated in microglia and regulates phagocytosis following global cerebral ischemia.
Breast Neoplasms
Accumulation of Unusual Gangliosides GQ3 and GP3 in Breast Cancer Cells Expressing the GD3 Synthase.
Comprehensive Transcriptomic Analysis Identifies ST8SIA1 as a Survival-Related Sialyltransferase Gene in Breast Cancer.
Disialyl GD2 ganglioside suppresses ICAM-1-mediated invasiveness in human breast cancer MDA-MB231 cells.
Estradiol represses the G(D3) synthase gene ST8SIA1 expression in human breast cancer cells by preventing NF?B binding to ST8SIA1 promoter.
Functional roles of sialylation in breast cancer progression through miR-26a/26b targeting ST8SIA4.
GD2 and GD3 synthase: novel drug targets for cancer therapy.
GD3 Synthase Expression Enhances Proliferation and Tumor Growth of MDA-MB-231 Breast Cancer Cells through c-Met Activation.
GD3 synthase regulates epithelial-mesenchymal transition and metastasis in breast cancer.
Gene expression of ceramide kinase, galactosyl ceramide synthase and ganglioside GD3 synthase is associated with prognosis in breast cancer.
IKK inhibition by BMS-345541 suppresses breast tumorigenesis and metastases by targeting GD2+ cancer stem cells.
Interaction of glycosphingolipids GD3 and GD2 with growth factor receptors maintains breast cancer stem cell phenotype.
lncRNA MALAT1/miR?26a/26b/ST8SIA4 axis mediates cell invasion and migration in breast cancer cell lines.
ST8SIA1 inhibition sensitizes triple negative breast cancer to chemotherapy via suppressing Wnt/?-catenin and FAK/Akt/mTOR.
The ganglioside GD2 induces the constitutive activation of c-Met in MDA-MB-231 breast cancer cells expressing the GD3 synthase.
TNF differentially regulates ganglioside biosynthesis and expression in breast cancer cell lines.
Brucellosis
Comparison of a Brucella Enzyme Immunoassay and the Standard Agglutination with 2-Mercaptoethanol Test in the Diagnosis and Monitoring of Brucellosis in Mexican Patients.
Campylobacter Infections
Epidemiological association of Campylobacter jejuni groups with pathogenicity-associated genetic markers.
Carcinogenesis
Ganglioside GD3 synthase (GD3S), a novel cancer drug target.
IKK inhibition by BMS-345541 suppresses breast tumorigenesis and metastases by targeting GD2+ cancer stem cells.
Long noncoding RNA HOTAIR promotes renal cell carcinoma malignancy through alpha-2, 8-sialyltransferase 4 by sponging microRNA-124.
ST8SIA1 Regulates Tumor Growth and Metastasis in TNBC by Activating the FAK-AKT-mTOR Signaling Pathway.
ST8Sia6 Promotes Tumor Growth in Mice by Inhibiting Immune Responses.
Carcinoma
Apoptosis of human breast carcinoma cells in the presence of cis-platin and L-/D-PPMP: IV. Modulation of replication complexes and glycolipid: Glycosyltransferases.
Characterization of Distinct Populations of Carcinoma-Associated Fibroblasts from Non-Small Cell Lung Carcinoma Reveals a Role for ST8SIA2 in Cancer Cell Invasion.
Expression of polysialic acid in primary laryngeal squamous cell carcinoma.
Glycolipid sialyltransferases are enhanced during neural differentiation of mouse embryonic carcinoma cells, P19.
Glycosphingolipid expression in solid tumours and transformed cell lines.
Transcriptional Activation of Human GD3 Synthase (hST8Sia I) Gene in Curcumin-Induced Autophagy in A549 Human Lung Carcinoma Cells.
Upregulation of miR-181c inhibits chemoresistance by targeting ST8SIA4 in chronic myelocytic leukemia.
Carcinoma, Non-Small-Cell Lung
Characterization of Distinct Populations of Carcinoma-Associated Fibroblasts from Non-Small Cell Lung Carcinoma Reveals a Role for ST8SIA2 in Cancer Cell Invasion.
Expression of polysialic acid and STX, a human polysialyltransferase, is correlated with tumor progression in non-small cell lung cancer.
Prognostic significance of polysialic acid expression in resected non-small cell lung cancer.
Cholangiocarcinoma
miR-144-5p and miR-451a Inhibit the Growth of Cholangiocarcinoma Cells Through Decreasing the Expression of ST8SIA4.
Colonic Neoplasms
Evaluation of SAT-1, SAT-2 and GalNAcT-1 mRNA in colon cancer by real-time PCR.
ST8Sia6 Promotes Tumor Growth in Mice by Inhibiting Immune Responses.
The ceramide moiety of disialoganglioside (GD3) is essential for GD3 recognition by the sialic acid-binding lectin SIGLEC7 on the cell surface.
Colorectal Neoplasms
Decreased expression of alpha2,8 sialyltransferase and increased expression of beta1,4 N-acetylgalactosaminyltransferase in gastrointestinal cancers.
MicroRNA-33a and let-7e inhibit human colorectal cancer progression by targeting ST8SIA1.
Demyelinating Diseases
Polysialylation at Early Stages of Oligodendrocyte Differentiation Promotes Myelin Repair.
Remyelination after cuprizone induced demyelination is accelerated in mice deficient in the polysialic acid synthesizing enzyme St8siaIV.
ST8SIA2 promotes oligodendrocyte differentiation and the integrity of myelin and axons.
Encephalitis
Bickerstaff's brainstem encephalitis after an outbreak of Campylobacter jejuni enteritis.
Enteritis
Prevalence of potentially neuropathic Campylobacter jejuni strains on commercial broiler chicken products.
Epilepsy
Characterization of a 520?kb deletion on chromosome 15q26.1 including ST8SIA2 in a patient with behavioral disturbance, autism spectrum disorder, and epilepsy.
Characterization of a 520?kb deletion on chromosome 15q26.1 including ST8SIA2 in a patient with behavioral disturbance, autism spectrum disorder, and epilepsy: additional information.
Foot-and-Mouth Disease
A first molecular epidemiological study of SAT-2 type foot-and-mouth disease viruses in West Africa.
An investigation into the source and spread of foot and mouth disease virus from a wildlife conservancy in Zimbabwe.
Characterization of Foot and Mouth Disease Virus Serotype SAT-2 in Swamp Water Buffaloes (Bubalus bubalis) under the Egyptian Smallholder Production System.
Experimental infection of giraffe (Giraffa camelopardalis) with SAT-1 and SAT-2 foot-and-mouth disease virus.
Genetic relationships between southern African SAT-2 isolates of foot-and-mouth-disease virus.
Molecular characterization of SAT-2 foot-and-mouth disease virus isolates obtained from cattle during a four-month period in 2001 in Limpopo Province, South Africa.
Natural transmission of foot-and-mouth disease virus between African buffalo (Syncerus caffer) and impala (Aepyceros melampus) in the Kruger National Park, South Africa.
Persistent infection of African buffalo (Syncerus caffer) with SAT-type foot-and-mouth disease viruses: rate of fixation of mutations, antigenic change and interspecies transmission.
Study of the genetic heterogeneity of SAT-2 foot-and-mouth disease virus in sub-Saharan Africa with specific focus on East Africa.
Gastrointestinal Neoplasms
Decreased expression of alpha2,8 sialyltransferase and increased expression of beta1,4 N-acetylgalactosaminyltransferase in gastrointestinal cancers.
Glioblastoma
Accumulation of Unusual Gangliosides GQ3 and GP3 in Breast Cancer Cells Expressing the GD3 Synthase.
Glycolipid GD3 and GD3 synthase are key drivers for glioblastoma stem cells and tumorigenicity.
Isolation and functional analysis of the human glioblastoma-specific promoter region of the human GD3 synthase (hST8Sia I) gene.
Molecular mechanisms involved in transcriptional activation of the human Sia-alpha2,3-Gal-beta1,4-GlcNAc-R:alpha2,8-sialyltransferase (hST8Sia III) gene induced by KCl in human glioblastoma cells.
Transcriptional regulation of the human Sia-alpha2,3-Gal-beta1,4-GlcNAc-R:alpha2,8-sialyltransferase (hST8Sia III) by retinoic acid in human glioblastoma tumor cell line.
Glioma
Enhancement of malignant properties of human glioma cells by ganglioside GD3/GD2.
Increased tumorigenicity and invasiveness of C6 rat glioma cells transfected with the human alpha-2,8 sialyltransferase cDNA.
Lack of GD3 synthase (St8sia1) attenuates malignant properties of gliomas in genetically engineered mouse model.
Molecular mechanisms of GD3-induced apoptosis in U-1242 MG glioma cells.
The Effect of Polysialic Acid Expression on Glioma Cell Nano-mechanics.
Graves Ophthalmopathy
Identification and Functional Characterization of ST3GAL5 and ST8SIA1 Variants in Patients with Thyroid-Associated Ophthalmopathy.
Guillain-Barre Syndrome
Campylobacter jejuni cst-II polymorphisms and association with development of Guillain-Barré syndrome.
Heart Failure
Characterization of Foot and Mouth Disease Virus Serotype SAT-2 in Swamp Water Buffaloes (Bubalus bubalis) under the Egyptian Smallholder Production System.
Hyperalgesia
GD3 synthase gene knockout mice exhibit thermal hyperalgesia and mechanical allodynia but decreased response to formalin-induced prolonged noxious stimulation.
Glycosphingolipid Biosynthesis Pathway in the Spinal Cord and Dorsal Root Ganglia During Inflammatory Pain: Early and Late Changes in Expression Patterns of Glycosyltransferase Genes.
Hyperglycemia
Cutting Edge: ST8Sia6-Generated ?-2,8-Disialic Acids Mitigate Hyperglycemia in Multiple Low-Dose Streptozotocin-Induced Diabetes.
Infections
Experimental infection of giraffe (Giraffa camelopardalis) with SAT-1 and SAT-2 foot-and-mouth disease virus.
Prevalence of heat-stable II enterotoxigenic Escherichia coli in pigs, water, and people at farms in Thailand as determined by DNA hybridization.
The possible role that buffalo played in the recent outbreaks of foot-and-mouth disease in South Africa.
Influenza, Human
Influence of N-glycosylation and N-glycan trimming on the activity and intracellular traffic of GD3 synthase.
Intestinal Neoplasms
Evaluation of SAT-1, SAT-2 and GalNAcT-1 mRNA in colon cancer by real-time PCR.
Leukemia
Disialoganglioside GD3 synthase expression recruits membrane transglutaminase 2 during erythroid differentiation of the human chronic myelogenous leukemia K562 cells.
High expression of ganglioside alpha-2,8-sialyltransferase (GD3 synthase) gene in adult T-cell leukemia cells unrelated to the gene expression of human T-lymphotropic virus type I.
Regulation of glycolipid synthesis in HL-60 cells by antisense oligodeoxynucleotides to glycosyltransferase sequences: effect on cellular differentiation.
Upregulation of miR-181c inhibits chemoresistance by targeting ST8SIA4 in chronic myelocytic leukemia.
Leukemia, Erythroblastic, Acute
Purification and partial characterization of an alpha-2,8-sialyltransferase from human erythroleukemia K562 cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Disialoganglioside GD3 synthase expression recruits membrane transglutaminase 2 during erythroid differentiation of the human chronic myelogenous leukemia K562 cells.
Upregulation of miR-181c inhibits chemoresistance by targeting ST8SIA4 in chronic myelocytic leukemia.
Leukemia-Lymphoma, Adult T-Cell
High expression of ganglioside alpha-2,8-sialyltransferase (GD3 synthase) gene in adult T-cell leukemia cells unrelated to the gene expression of human T-lymphotropic virus type I.
Lumpy Skin Disease
High selectivity detection of FMDV- SAT-2 using a newly-developed electrochemical nanosensors.
Lung Neoplasms
Effects of the regulation of polysialyltransferase ST8SiaII on the invasiveness and metastasis of small cell lung cancer cells.
Expression of polysialic acid and STX, a human polysialyltransferase, is correlated with tumor progression in non-small cell lung cancer.
Fundamental study of small interfering RNAs for ganglioside GD3 synthase gene as a therapeutic target of lung cancers.
miRNA-mRNA Interaction Network in Non-small Cell Lung Cancer.
miRNA-mRNA interaction network in non-small-cell lung cancer.
Modification of ?2,6-sialylation mediates the invasiveness and tumorigenicity of non-small cell lung cancer cells in vitro and in vivo via Notch1/Hes1/MMPs pathway.
Prognostic significance of polysialic acid expression in resected non-small cell lung cancer.
Medulloblastoma
Microarray analysis detects novel Pax3 downstream target genes.
Melanoma
A cancer-unique glycan: de-N-acetyl polysialic acid (dPSA) linked to cell surface nucleolin depends on re-expression of the fetal polysialyltransferase ST8SIA2 gene.
Acceptor substrate specificity of a cloned GD3 synthase that catalyzes the biosynthesis of both GD3 and GD1c/GT1a/GQ1b.
Accumulation of Unusual Gangliosides GQ3 and GP3 in Breast Cancer Cells Expressing the GD3 Synthase.
Down-regulation of GD3 ganglioside and its O-acetylated derivative by stable transfection with antisense vector against GD3-synthase gene expression in hamster melanoma cells: effects on cellular growth, melanogenesis, and dendricity.
Expression cloning of a GM3-specific alpha-2,8-sialyltransferase (GD3 synthase).
Expression of the human CMP-NeuAc:GM3 alpha2,8-sialyltransferase (GD3 synthase) gene through the NF-kappaB activation in human melanoma SK-MEL-2 cells.
Isolation and functional analysis of the melanoma specific promoter region of human GD3 synthase gene.
Sialyltransferase levels and ganglioside expression in melanoma and other cultured human cancer cells.
TNF?-signal and cAMP-mediated signals oppositely regulate melanoma- associated ganglioside GD3 synthase gene in human melanocytes.
Triptolide downregulates human GD3 synthase (hST8Sia I) gene expression in SK-MEL-2 human melanoma cells.
Upregulation of cell surface GD3 ganglioside phenotype is associated with human melanoma brain metastasis.
UVB-irradiated keratinocytes induce melanoma-associated ganglioside GD3 synthase gene in melanocytes via secretion of tumor necrosis factor ? and interleukin 6.
Meningococcal Infections
Capsule phase variation in Neisseria meningitidis serogroup B by slipped-strand mispairing in the polysialyltransferase gene (siaD): correlation with bacterial invasion and the outbreak of meningococcal disease.
Mouth Diseases
An investigation into the source and spread of foot and mouth disease virus from a wildlife conservancy in Zimbabwe.
Characterization of Foot and Mouth Disease Virus Serotype SAT-2 in Swamp Water Buffaloes (Bubalus bubalis) under the Egyptian Smallholder Production System.
Multiple Sclerosis
Variants in ST8SIA1 do not play a major role in susceptibility to multiple sclerosis in Canadian families.
Variants of ST8SIA1 are associated with risk of developing multiple sclerosis.
Neoplasm Metastasis
Effects of the regulation of polysialyltransferase ST8SiaII on the invasiveness and metastasis of small cell lung cancer cells.
GD2 and GD3 synthase: novel drug targets for cancer therapy.
GD3 synthase regulates epithelial-mesenchymal transition and metastasis in breast cancer.
Long noncoding RNA HOTAIR promotes renal cell carcinoma malignancy through alpha-2, 8-sialyltransferase 4 by sponging microRNA-124.
Reduced cell migration, tumor growth and experimental metastasis of rat F-11 cells whose expression of GD3-synthase is suppressed.
ST8SIA1 Regulates Tumor Growth and Metastasis in TNBC by Activating the FAK-AKT-mTOR Signaling Pathway.
The Cooperative Effect between Polybasic Region (PBR) and Polysialyltransferase Domain (PSTD) within Tumor-Target Polysialyltranseferase ST8Sia II.
Upregulation of cell surface GD3 ganglioside phenotype is associated with human melanoma brain metastasis.
Variations in gene expression patterns correlated with phenotype of F-11 tumor cells whose expression of GD3-synthase is suppressed.
Neoplasms
A cancer-unique glycan: de-N-acetyl polysialic acid (dPSA) linked to cell surface nucleolin depends on re-expression of the fetal polysialyltransferase ST8SIA2 gene.
Accumulation of Unusual Gangliosides GQ3 and GP3 in Breast Cancer Cells Expressing the GD3 Synthase.
Alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 can support immune responses toward tumors overexpressing ganglioside D3 in mice.
An efficient assay for identification and quantitative evaluation of potential polysialyltransferase inhibitors.
Characterization of Distinct Populations of Carcinoma-Associated Fibroblasts from Non-Small Cell Lung Carcinoma Reveals a Role for ST8SIA2 in Cancer Cell Invasion.
Combining gene expression signature with clinical features for survival stratification of gastric cancer.
Control of NCAM polysialylation by the differential expression of polysialyltransferases ST8SiaII and ST8SiaIV.
Decreased expression of alpha2,8 sialyltransferase and increased expression of beta1,4 N-acetylgalactosaminyltransferase in gastrointestinal cancers.
Differential enhancing effects of alpha2,8-sialyltransferase on the cell proliferation and mobility.
Evaluation of SAT-1, SAT-2 and GalNAcT-1 mRNA in colon cancer by real-time PCR.
Exploring and Exploiting Acceptor Preferences of the Human Polysialyltransferases as a Basis for an Inhibitor Screen.
Expression of polysialic acid and STX, a human polysialyltransferase, is correlated with tumor progression in non-small cell lung cancer.
Expression of polysialic acid in primary laryngeal squamous cell carcinoma.
Expression of the mouse WNK1 gene in correlation with ganglioside GD3 and functional analysis of the mouse WNK1 promoter.
Functional activation of SRC family kinase yes is essential for the enhanced malignant properties of human melanoma cells expressing ganglioside GD3.
Functional roles of sialylation in breast cancer progression through miR-26a/26b targeting ST8SIA4.
Ganglioside GD3 synthase (GD3S), a novel cancer drug target.
GD2 and GD3 synthase: novel drug targets for cancer therapy.
GD3 Synthase Expression Enhances Proliferation and Tumor Growth of MDA-MB-231 Breast Cancer Cells through c-Met Activation.
GD3 synthase overexpression sensitizes hepatocarcinoma cells to hypoxia and reduces tumor growth by suppressing the cSrc/NF-kappaB survival pathway.
GD3 synthase regulates epithelial-mesenchymal transition and metastasis in breast cancer.
Gene expression of ceramide kinase, galactosyl ceramide synthase and ganglioside GD3 synthase is associated with prognosis in breast cancer.
Genome-scale detection of hypermethylated CpG islands in circulating cell-free DNA of hepatocellular carcinoma patients.
Glycolipid composition in bladder tumor: a crucial role of GM3 ganglioside in tumor invasion.
Glycolipids Recognized by A2B5 Antibody Promote Proliferation, Migration, and Clonogenicity in Glioblastoma Cells.
Glycosphingolipid expression in solid tumours and transformed cell lines.
Intrabodies against the Polysialyltransferases ST8SiaII and ST8SiaIV inhibit Polysialylation of NCAM in rhabdomyosarcoma tumor cells.
Knockdown of lncRNA MIR4435?2HG and ST8SIA1 expression inhibits the proliferation, invasion and migration of prostate cancer cells in vitro and in vivo by blocking the activation of the FAK/AKT/??catenin signaling pathway.
Long noncoding RNA HOTAIR promotes renal cell carcinoma malignancy through alpha-2, 8-sialyltransferase 4 by sponging microRNA-124.
Loss of Forkhead Box O3 Facilitates Inflammatory Colon Cancer: Transcriptome Profiling of the Immune Landscape and Novel Targets.
Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer.
MicroRNA-33a and let-7e inhibit human colorectal cancer progression by targeting ST8SIA1.
miR-144-5p and miR-451a Inhibit the Growth of Cholangiocarcinoma Cells Through Decreasing the Expression of ST8SIA4.
miR-146a and miR-146b promote proliferation, migration and invasion of follicular thyroid carcinoma via inhibition of ST8SIA4.
Novel Nine-Exon AR Transcripts (Exon 1/Exon 1b/Exons 2-8) in Normal and Cancerous Breast and Prostate Cells.
Pharmacological Inhibition of polysialyltransferase ST8SiaII Modulates Tumour Cell Migration.
Polysialic acid sustains cancer cell survival and migratory capacity in a hypoxic environment.
Polysialylation of NCAM.
Polysialylation of the neural cell adhesion molecule: interfering with polysialylation and migration in neuroblastoma cells.
Polysialyltransferase: a new target in metastatic cancer.
Prognostic significance of polysialic acid expression in resected non-small cell lung cancer.
Reduced cell migration, tumor growth and experimental metastasis of rat F-11 cells whose expression of GD3-synthase is suppressed.
ST8SIA1 inhibits the proliferation, migration and invasion of bladder cancer cells by blocking the JAK/STAT signaling pathway.
ST8SIA1 Regulates Tumor Growth and Metastasis in TNBC by Activating the FAK-AKT-mTOR Signaling Pathway.
ST8Sia6 Promotes Tumor Growth in Mice by Inhibiting Immune Responses.
Suppression of ganglioside GD3 expression in a rat F-11 tumor cell line reduces tumor growth, angiogenesis, and vascular endothelial growth factor production.
The Cooperative Effect between Polybasic Region (PBR) and Polysialyltransferase Domain (PSTD) within Tumor-Target Polysialyltranseferase ST8Sia II.
TNF differentially regulates ganglioside biosynthesis and expression in breast cancer cell lines.
Transcriptional regulation of the human Sia-alpha2,3-Gal-beta1,4-GlcNAc-R:alpha2,8-sialyltransferase (hST8Sia III) by retinoic acid in human glioblastoma tumor cell line.
UVB-irradiated keratinocytes induce melanoma-associated ganglioside GD3 synthase gene in melanocytes via secretion of tumor necrosis factor ? and interleukin 6.
Valproic acid modulates NCAM polysialylation and polysialyltransferase mRNA expression in human tumor cells.
Variations in gene expression patterns correlated with phenotype of F-11 tumor cells whose expression of GD3-synthase is suppressed.
Nephrosis
Decrease of glomerular disialogangliosides in puromycin nephrosis of the rat.
Neuroblastoma
A cancer-unique glycan: de-N-acetyl polysialic acid (dPSA) linked to cell surface nucleolin depends on re-expression of the fetal polysialyltransferase ST8SIA2 gene.
Accumulation of Unusual Gangliosides GQ3 and GP3 in Breast Cancer Cells Expressing the GD3 Synthase.
Changes in the ganglioside composition of human neuroblastoma cells under different growth conditions.
Cordycepin-mediated transcriptional regulation of human GD3 synthase (hST8Sia I) in human neuroblastoma SK-N-BE(2)-C cells.
Differential regulation of polysialyltransferase expression during hippocampus development: Implications for neuronal survival.
Effect of N-glycosylation on turnover and subcellular distribution of N-acetylgalactosaminyltransferase I and sialyltransferase II in neuroblastoma cells.
Effects of intronic single nucleotide polymorphisms (iSNPs) of a polysialyltransferase, ST8SIA2 gene found in psychiatric disorders on its gene products.
Expression of the neural cell adhesion molecule and polysialic acid in human neuroblastoma cell lines.
Gangliosides link the acidic sphingomyelinase-mediated induction of ceramide to 12-lipoxygenase-dependent apoptosis of neuroblastoma in response to fenretinide.
Genes modulated by expression of GD3 synthase in Chinese hamster ovary cells. Evidence that the Tis21 gene is involved in the induction of GD3 9-O-acetylation.
Glycosylation pathways in the biosynthesis of gangliosides in melanoma and neuroblastoma cells: relative glycosyltransferase levels determine ganglioside patterns.
Isolation of 10 differentially expressed cDNAs in differentiated Neuro2a cells induced through controlled expression of the GD3 synthase gene.
Polysialic acid engineering: synthesis of polysialylated neoglycosphingolipids by using the polysialyltransferase from neuroinvasive Escherichia coli K1.
Purification of an alpha-2,8-sialyltransferase, a potential initiating enzyme for the biosynthesis of polysialic acid in human neuroblastoma cells.
Regulated expression system for GD3 synthase cDNA and induction of differentiation in Neuro2a cells.
Relationship of glycosyltransferases and mRNA levels to ganglioside expression in neuroblastoma and melanoma cells.
Retinoic acid-induced changes in polysialyltransferase mRNA expression and NCAM polysialylation in human neuroblastoma cells.
Sialidase NEU4 hydrolyzes polysialic acids of neural cell adhesion molecules and negatively regulates neurite formation by hippocampal neurons.
Sialyltransferase levels and ganglioside expression in melanoma and other cultured human cancer cells.
Two polysialic acid synthases, mouse ST8Sia II and IV, synthesize different degrees of polysialic acids on different substrate glycoproteins in mouse neuroblastoma Neuro2a cells.
Unique genomic structure and expression of the mouse alpha 2,8-sialyltransferase (ST8Sia III) gene.
Upregulation of Human ST8Sia VI (?2,8-Sialyltransferase) Gene Expression by Physcion in SK-N-BE(2)-C Human Neuroblastoma Cells.
Valproic Acid Induces Transcriptional Activation of Human GD3 Synthase (hST8Sia I) by in SK-N-BE(2)-C Human Neuroblastoma Cells.
Valproic acid induces transcriptional activation of human GD3 synthase (hST8Sia I) in SK-N-BE(2)-C human neuroblastoma cells.
Neurologic Manifestations
Campylobacter gene polymorphism as a determinant of clinical features of Guillain-Barré syndrome.
Ophthalmoplegia
Bacterial infections in Guillain-Barré and Fisher syndromes.
Campylobacter sialyltransferase gene polymorphism directs clinical features of Guillain-Barré syndrome.
[Campylobacter genes responsible for the development and determinant of clinical features of Guillain-Barré syndrome]
Osteosarcoma
Enhancement of malignant properties of human osteosarcoma cells with disialyl gangliosides GD2/GD3.
Pancreatic Neoplasms
Disialoganglioside GD3-synthase over expression inhibits survival and angiogenesis of pancreatic cancer cells through cell cycle arrest at S-phase and disruption of integrin-?1-mediated anchorage.
Paralysis
Relationship of bacterial strains to clinical syndromes of Campylobacter-associated neuropathies.
Periodontitis
BACH1 Binding Links the Genetic Risk for Severe Periodontitis with ST8SIA1.
Pheochromocytoma
GD3 synthase gene expression in PC12 cells results in the continuous activation of TrkA and ERK1/2 and enhanced proliferation.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
High expression of ganglioside alpha-2,8-sialyltransferase (GD3 synthase) gene in adult T-cell leukemia cells unrelated to the gene expression of human T-lymphotropic virus type I.
Prion Diseases
Ganglioside Synthase Knockout Reduces Prion Disease Incubation Time in Mouse Models.
Prostatic Neoplasms
Knockdown of lncRNA MIR4435?2HG and ST8SIA1 expression inhibits the proliferation, invasion and migration of prostate cancer cells in vitro and in vivo by blocking the activation of the FAK/AKT/??catenin signaling pathway.
Novel Nine-Exon AR Transcripts (Exon 1/Exon 1b/Exons 2-8) in Normal and Cancerous Breast and Prostate Cells.
Rhabdomyosarcoma
Intrabodies against the Polysialyltransferases ST8SiaII and ST8SiaIV inhibit Polysialylation of NCAM in rhabdomyosarcoma tumor cells.
Sarcoma
Glycosphingolipid expression in solid tumours and transformed cell lines.
Scrapie
Ganglioside Synthase Knockout Reduces Prion Disease Incubation Time in Mouse Models.
Seizures
Differential expression of mRNAs for sialyltransferase isoenzymes induced in the hippocampus of mouse following kindled seizures.
Small Cell Lung Carcinoma
Effects of the regulation of polysialyltransferase ST8SiaII on the invasiveness and metastasis of small cell lung cancer cells.
Spinal Cord Injuries
Engineering polysialic acid on Schwann cells using polysialyltransferase gene transfer or purified enzyme exposure for spinal cord injury transplantation.
Squamous Cell Carcinoma of Head and Neck
Expression of polysialic acid in primary laryngeal squamous cell carcinoma.
Status Epilepticus
Polysialic acid affects pathophysiological consequences of status epilepticus.
Stomach Neoplasms
Decreased expression of alpha2,8 sialyltransferase and increased expression of beta1,4 N-acetylgalactosaminyltransferase in gastrointestinal cancers.
Thyroid Neoplasms
miR-146a and miR-146b promote proliferation, migration and invasion of follicular thyroid carcinoma via inhibition of ST8SIA4.
Triple Negative Breast Neoplasms
Comprehensive Transcriptomic Analysis Identifies ST8SIA1 as a Survival-Related Sialyltransferase Gene in Breast Cancer.
ST8SIA1 inhibition sensitizes triple negative breast cancer to chemotherapy via suppressing Wnt/?-catenin and FAK/Akt/mTOR.
Tuberculosis
Brucella melitensis and Mycobacterium tuberculosis depict overlapping gene expression patterns induced in infected THP-1 macrophages.
Urinary Bladder Neoplasms
ST8SIA1 inhibits the proliferation, migration and invasion of bladder cancer cells by blocking the JAK/STAT signaling pathway.