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Information on EC 2.4.99.6 - N-acetyllactosaminide alpha-2,3-sialyltransferase

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IUBMB Comments
The enzyme recognizes the sequence beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl (known as type 2 histo-blood group precursor disaccharide) in non-reducing termini of glycan moieties in glycoproteins and glycolipids. The enzyme from chicken brain was shown to act on neolactotetraosylceramide, producing ganglioside LM1 .
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The enzyme appears in viruses and cellular organisms
Synonyms
alpha2,3(N) sialyltransferase, alpha2,3(N)ST, alpha2,3(O) sialyltransferase, alpha2,3(O)ST, alpha2-->3 sialyltransferase, CMP-NeuAc:Gal beta 1-4GlcNAc-R alpha(2-3)-sialyltransferase, cytidine monophosphoacetylneuraminate-beta-galactosyl(1-->4)acetylglucosaminide alpha2-->3-sialyltransferase, cytidine monophosphoacetylneuraminate-neolactotetraosylceramide sialyltransferase, Gal beta-1,3(4) GlcNAc alpha-2,3 sialyltransferase, Galbeta(1->4)GlcNAc-R alpha(2->3)sialyltransferase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
CMP-N-acetyl-beta-neuraminate + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R = CMP + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R
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acts on beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl termini on glycoprotein
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CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide
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