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Disease on EC 2.4.99.3 - alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
(n-acetylneuraminyl)-galactosylglucosylceramide n-acetylgalactosaminyltransferase deficiency
ST3GAL5-Related Disorders: A Deficiency in Ganglioside Metabolism and a Genetic Cause of Intellectual Disability and Choreoathetosis.
Acquired Immunodeficiency Syndrome
[Developments in the serological diagnosis of malignant diseases]
Adenocarcinoma
Alterations of CMP-NeuAc:asialofetuin sialyltransferase activities in human colorectal adenocarcinoma.
Association of cytosolic sialidase Neu2 with plasma membrane enhances Fas-mediated apoptosis by impairing PI3K-Akt/mTOR-mediated pathway in pancreatic cancer cells.
Enhancement of metastatic ability by ectopic expression of ST6GalNAcI on a gastric cancer cell line in a mouse model.
Enzyme activities in human breast tumor cells and sera.
Plasma sialyl transferase total and isoenzyme activity in the diagnosis of cancer of the colon.
Role of sialyltransferases involved in the biosynthesis of Lewis antigens in human pancreatic tumour cells.
ST6Gal-I sialyltransferase promotes chemoresistance in pancreatic ductal adenocarcinoma by abrogating gemcitabine-mediated DNA damage.
alpha 1-Antitrypsin Deficiency
The serum sialyltransferase activity in alpha 1-antitrypsin deficiency.
alpha-n-acetylgalactosaminide alpha-2,6-sialyltransferase deficiency
Cytidine-5'-monophosphate-N-acetylneuraminic acid. Asialoglycoprotein sialic acid transferase activity in liver and serum of patients with juvenile hepatic cirrhosis and alpha-1-antitrypsin deficiency.
Demonstration of sialyltransferase deficiency in the serum of a patient with alpha-1-antitrypsin deficiency and hepatic cirrhosis.
Genetically altered mice with different sialyltransferase deficiencies show tissue-specific alterations in sialylation and sialic acid 9-O-acetylation.
Letter:serum sialyltransferase deficiency in alpha-1-antitrypsin deficiency.
ST6Gal-I restrains CD22-dependent antigen receptor endocytosis and Shp-1 recruitment in normal and pathogenic immune signaling.
The serum sialyltransferase activity in alpha 1-antitrypsin deficiency.
Alzheimer Disease
A decrease in neural sialyltransferase activity in Alzheimer's disease.
A decrease in serum sialyltransferase levels in Alzheimer's disease.
The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.
Arthritis, Rheumatoid
Branch-specific sialylation of IgG-Fc glycans by ST6Gal-I.
Sialyltransferase and Neuraminidase Levels/Ratios and Sialic Acid Levels in Peripheral Blood B Cells Correlate with Measures of Disease Activity in Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis: A Pilot Study.
Astrocytoma
Sialyltransferase levels and ganglioside expression in melanoma and other cultured human cancer cells.
Atherosclerosis
Plasma sialyltransferase activity in healthy subjects and atherosclerotic patients.
Sialyltransferase activity and atherosclerosis.
Sialyltransferase activity of human plasma and aortic intima is enhanced in atherosclerosis.
ST6GAL1 negatively regulates monocyte transendothelial migration and atherosclerosis development.
Autoimmune Diseases
ST6Gal-I restrains CD22-dependent antigen receptor endocytosis and Shp-1 recruitment in normal and pathogenic immune signaling.
Bacteremia
Enhanced bacteremia in human factor H transgenic rats infected by Neisseria meningitidis.
Bernard-Soulier Syndrome
Glycoprotein-sialyltransferase activity of normal human, thrombasthenic and Bernard-Soulier platelets.
beta-d-galactosyl-(1->3)-n-acetyl-beta-d-galactosaminide alpha-2,3-sialyltransferase deficiency
Genetically altered mice with different sialyltransferase deficiencies show tissue-specific alterations in sialylation and sialic acid 9-O-acetylation.
beta-galactoside alpha-(2,6)-sialyltransferase deficiency
Sweet role of platelet endothelial cell adhesion molecule in understanding angiogenesis.
Blast Crisis
Sialyltransferase activity as a marker for the differentiation of lymphocytes. Increase in sialyltransferase activity of blasts from acute lymphoblastic leukaemia cases by 12-o-tetradecanoylphorbol-13-acetate (TPA).
Brachial Plexus Neuritis
Mutation analysis of a putative sialyltransferase gene, the SFRS2 splicing factor gene and the c-myb ET-locus in two families with hereditary neuralgic amyotrophy (HNA).
Brain Neoplasms
Alterations in serum sialyltransferase activities in patients with brain tumors.
The expression of CMP-NeuAc: Gal beta 1,4GlcNAc alpha 2,6 sialyltransferase [EC 2.4.99.1] and glycoproteins bearing alpha 2,6-linked sialic acids in human brain tumours.
The expression of Gal beta 1,4GlcNAc alpha 2,6 sialyltransferase and alpha 2,6-linked sialoglycoconjugates in human brain tumors.
Breast Neoplasms
A transfected sialyltransferase that is elevated in breast cancer and localizes to the medial/trans-Golgi apparatus inhibits the development of core-2-based O-glycans.
alpha 2-6-Linked sialic acids on N-glycans modulate carcinoma differentiation in vivo.
Alterations in serum glycosyltransferases and 5'-nucleotidase in breast cancer patients.
An alpha2,3 sialyltransferase (ST3Gal I) is elevated in primary breast carcinomas.
An In Vivo Functional Screen Identifies ST6GalNAc2 Sialyltransferase as a Breast Cancer Metastasis Suppressor.
Breast cancer cells expressing cancer-associated sialyl-Tn antigen have less capacity to develop osteolytic lesions in a mouse model of skeletal colonization.
Breast cancer markers: comparison between sialyltransferase and human mammary epithelial antigens (HME-Ags) for the detection of human breast tumors grafted in nude mice.
Clinical usefulness of alterations in sialic acid, sialyl transferase and sialoproteins in breast cancer.
Comprehensive Transcriptomic Analysis Identifies ST8SIA1 as a Survival-Related Sialyltransferase Gene in Breast Cancer.
Consequences of the expression of sialylated antigens in breast cancer.
Cyclooxygenase-2 enzyme induces the expression of the ?-2,3-sialyltransferase-3 (ST3Gal-I) in breast cancer.
Cyclooxygenase-2 induces the expression of the alpha 2,3 sialyltransferase-3 (ST3Gal-I) in breast cancer.
Expression of sialyl-Tn antigen in breast cancer cells transfected with the human CMP-Neu5Ac: GalNAc alpha2,6-sialyltransferase (ST6GalNac I) cDNA.
Functional roles of sialylation in breast cancer progression through miR-26a/26b targeting ST8SIA4.
Gene expression of fucosyl- and sialyl-transferases which synthesize sialyl Lewisx, the carbohydrate ligands for E-selectin, in human breast cancer.
Identification and functional characterization of a human GalNAc [alpha]2,6-sialyltransferase with altered expression in breast cancer.
Immunohistochemical expression of blood group substances and related carbohydrate antigens in breast carcinoma.
Multiplex reverse transcription polymerase chain reaction assessment of sialyltransferase expression in human breast cancer.
Multiplex RT-PCR method for the analysis of the expression of human sialyltransferases: application to breast cancer cells.
Over-expression of ST3Gal-I promotes mammary tumorigenesis.
Plasma sialyltransferase in patients with breast cancer.
Post-operative serum sialyltransferase levels and prognosis in breast cancer.
Prognostic utility of glycosyltransferase expression in breast cancer.
Prognostic value of tumoral sialyltransferase expression and circulating E-selectin concentrations in node-negative breast cancer patients.
Proteinases and sialyltransferase in human breast tumors.
Recombinant MUC1 probe authentically reflects cell-specific O-glycosylation profiles of endogenous breast cancer mucin. High density and prevalent core 2-based glycosylation.
Regulation of sialyltransferase expression by estradiol and 4-OH-tamoxifen in the human breast cancer cell MCF-7.
Serum and tumor sialyltransferase activities in women with breast cancer.
Serum sialyltransferase and 5'-nucleotidase as reliable biomarkers in women with breast cancer.
Sialyltransferase Inhibitors Suppress Breast Cancer Metastasis.
Some biochemical properties of human breast tumor sialyltransferase.
ST6Gal-I overexpression facilitates prostate cancer progression via the PI3K/Akt/GSK-3?/?-catenin signaling pathway.
ST6GalNAc I expression in MDA-MB-231 breast cancer cells greatly modifies their O-glycosylation pattern and enhances their tumourigenicity.
Stable expression of sialyl-Tn antigen in T47-D cells induces a decrease of cell adhesion and an increase of cell migration.
Sticking to Sugars at the Metastatic Site: Sialyltransferase ST6GalNAc2 Acts as a Breast Cancer Metastasis Suppressor.
Studies on sialyltransferase isoenzymes in plasma of patients with breast cancer.
The pattern of glycosyl- and sulfotransferase activities in cancer cell lines: a predictor of individual cancer-associated distinct carbohydrate structures for the structural identification of signature glycans.
The ST6GalNAc-I sialyltransferase localizes throughout the Golgi and Is responsible for the synthesis of the tumor-associated sialyl-Tn O-glycan in human breast cancer.
Carcinogenesis
?2,6-Sialylation mediates hepatocellular carcinoma growth in vitro and in vivo by targeting the Wnt/?-catenin pathway.
alpha 2-6-Linked sialic acids on N-glycans modulate carcinoma differentiation in vivo.
Clinical relevance of sialyltransferases ST6GAL-I and ST3GAL-III in gastric cancer.
Clinical significance of ST3Gal IV expression in human renal cell carcinoma.
Development of Monoclonal Antibodies against CMP-N-Acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (ST3Gal-I) Recombinant Protein Expressed in E. coli.
Elevation of alpha2-->6 sialyltransferase and alpha1-->2 fucosyltransferase activities in human choriocarcinoma.
Glycosyltransferase expression in human colonic tissue examined by oligonucleotide arrays.
ST6Gal-I Protein Expression Is Upregulated in Human Epithelial Tumors and Correlates with Stem Cell Markers in Normal Tissues and Colon Cancer Cell Lines.
The Tumor-Associated Glycosyltransferase ST6Gal-I Regulates Stem Cell Transcription Factors and Confers a Cancer Stem Cell Phenotype.
Carcinoma
Adrenal carcinoma tumor progression and penultimate cell surface oligosaccharides.
Alterations in plasma sialyltransferase associated with successful chemotherapy of a disseminated tumor. Case report.
Altered mRNA expression of glycosyltransferases in human colorectal carcinomas and liver metastases.
Altered mRNA expression of glycosyltransferases in human gastric carcinomas.
Altered mRNA expression of sialyltransferase in squamous cell carcinomas of the cervix.
Carcinoembryonic antigen carrying SLeX as a new biomarker of more aggressive gastric carcinomas.
CDX2 homeoprotein is involved in the regulation of ST6GalNAc-I gene in intestinal metaplasia.
Cell surface alpha 2,6 sialylation affects adhesion of breast carcinoma cells.
Colon carcinoma glycoproteins carrying alpha 2,6-linked sialic acid reactive with Sambucus nigra agglutinin are not constitutively expressed in normal human colon mucosa and are distinct from sialyl-Tn antigen.
Different sialyltransferase activities in human colorectal carcinoma cells from surgical specimens detected by specific glycoprotein and glycolipid acceptors.
Expression of alpha 2,6-sialylated sugar chains in normal and neoplastic colon tissues. Detection by digoxigenin-conjugated Sambucus nigra agglutinin.
Expression of sialyl-Tn epitopes on beta1 integrin alters epithelial cell phenotype, proliferation and haptotaxis.
Expression of sialyltransferase family members in cervix squamous cell carcinoma correlates with lymph node metastasis.
Glycomic analysis of gastric carcinoma cells discloses glycans as modulators of RON receptor tyrosine kinase activation in cancer.
Molecular cloning of a developmentally regulated N-acetylgalactosamine alpha2,6-sialyltransferase specific for sialylated glycoconjugates.
Monoclonal antibodies raised against NeuAc alpha 2-6neolactotetraosylceramide detect carcinoma-associated gangliosides.
Reversibility of retinoid effect on sialyltransferase activity, sialic acid content and invasive ability of human lung carcinoma cells.
Sialylation of beta1 integrins blocks cell adhesion to galectin-3 and protects cells against galectin-3-induced apoptosis.
Sialylation of the Fas death receptor by ST6Gal-I provides protection against Fas-mediated apoptosis in colon carcinoma cells.
Sialyltransferase family members and cervix squamous cell carcinoma.
Sialyltransferase levels and ganglioside expression in melanoma and other cultured human cancer cells.
ST6Gal-I expression in ovarian cancer cells promotes an invasive phenotype by altering integrin glycosylation and function.
ST6Gal-I predicts postoperative clinical outcome for patients with localized clear-cell renal cell carcinoma.
ST6Gal-I Protein Expression Is Upregulated in Human Epithelial Tumors and Correlates with Stem Cell Markers in Normal Tissues and Colon Cancer Cell Lines.
ST6GalNAc-I controls expression of sialyl-Tn antigen in gastrointestinal tissues.
The expression of soluble and cell-bound alpha 2,6 sialyltransferase in human colonic carcinoma CaCo-2 cells correlates with the degree of enterocytic differentiation.
The Tumor-Associated Glycosyltransferase ST6Gal-I Regulates Stem Cell Transcription Factors and Confers a Cancer Stem Cell Phenotype.
[Combinatorial effects of ST6Gal I siRNA and antisense oligonucleotide-mediated gene silence on metastasis ability of cervical carcinoma cells]
[Significance of alpha 2,6-specific sialyltransferase ST6N and alpha 2,3-specific sialyltransferase ST3N in stomach carcinoma]
Carcinoma, Bronchogenic
Serum sialyltransferase and fucosyltransferase activities in patients with bronchial carcinoma.
Carcinoma, Hepatocellular
?2,6-Sialylation mediates hepatocellular carcinoma growth in vitro and in vivo by targeting the Wnt/?-catenin pathway.
Activity and characterization of sialyltransferase from serum of normal rats, of rats bearing Zajdela ascitic hepatoma, in normal host liver and in Zajdela hepatoma cells.
Biosynthesis and intracellular transport of alpha-2,6-sialyltransferase in rat hepatoma cells.
Characterization of galactosyltransferase released from human hepatoma cells.
Characterization of glycosyltransferases in the Golgi complex from rat ascites hepatoma AH-130 cells: a comparison with those from normal liver.
Characterization of sialyltransferases from serum of normal and hepatoma Mc-29 bearing chickens.
Codistribution of galactosyl- and sialyltransferase: reorganization of trans Golgi apparatus elements in hepatocytes in intact liver and cell culture.
Comparative study of the levels of sialyltransferases responsible for the formation of sugar chains in glycoproteins and gangliosides in rat liver and hepatomas.
Distribution of glycosyltransferases among Golgi apparatus subfractions from liver and hepatomas of the rat.
Enhanced expression of ganglioside GD3 in human and rat hepatocellular carcinoma cells and NIH 3T3 cells transfected with human tumor DNAs.
Gangliosides of liver tumors induced by N-2 fluorenylacetamide III. Galactosyl and sialyl transferases in single carcinomas and nodules.
Glycosyltransferases and glycosidases in Morris hepatomas.
Hepatitis B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human telomerase gene.
Increase in serum sialyltransferase in tumor-bearing rats: the origin and nature of the increased enzyme.
Modification of sialylation mediates the invasive properties and chemosensitivity of human hepatocellular carcinoma.
Modification of Sialylation Mediates the Invasive Properties and Chemosensitivity of Human Hepatocellular Carcinoma.
Multiple forms of chicken liver and hepatoma Mc-29 microsomal and plasma-membrane sialyl and fucosyltransferases.
Partial characterization of microsomal sialyltransferase from chicken liver and hepatoma Mc-29: I. Effect of nucleotides and metal ions.
Partial characterization of microsomal sialyltransferase from chicken liver and hepatoma Mc-29: II. Measurement of enzyme activities utilizing microsomal glycoproteins as exogenous acceptors.
Purification and characterization of beta-galactoside (alpha 2 leads to 6)sialyltransferase from rat liver and hepatomas.
Regulation of beta-galactoside alpha 2,6-sialyltransferase gene expression by dexamethasone.
Sialyltransferase ST3GAL6 mediates the effect of microRNA-26a on cell growth, migration, and invasion in hepatocellular carcinoma through the protein kinase B/mammalian target of rapamycin pathway.
ST6Gal-I modulates docetaxel sensitivity in human hepatocarcinoma cells via the p38 MAPK/caspase pathway.
ST6Gal-I overexpression facilitates prostate cancer progression via the PI3K/Akt/GSK-3?/?-catenin signaling pathway.
Stimulation of release of Gal beta 1-4GlcNAc alpha 2-6 sialyltransferase from the FAZA hepatoma cell line by dexamethasone and phorbol ester.
The biochemical consequences of alpha2,6(N) sialyltransferase induction by dexamethasone on sialoglycoprotein expression in the rat H411e hepatoma cell line.
The clinical and physiological implications of hepatoma B12-binding proteins.
The specific release of sialytransferase activity by human hepatoma cell lines.
Carcinoma, Non-Small-Cell Lung
Modification of ?2,6-sialylation mediates the invasiveness and tumorigenicity of non-small cell lung cancer cells in vitro and in vivo via Notch1/Hes1/MMPs pathway.
Carcinoma, Papillary
Immunohistochemical study of type-1 blood antigen expressions in thyroid tumors: the significance for papillary carcinomas.
Carcinoma, Renal Cell
ST6Gal-I predicts postoperative clinical outcome for patients with localized clear-cell renal cell carcinoma.
Carcinoma, Squamous Cell
Altered mRNA expression of sialyltransferase in squamous cell carcinomas of the cervix.
Effect of retinoic acid and phorbol-12-myristate-13-acetate on glycosyltransferase activities in normal and transformed cells.
Expression of sialyltransferase family members in cervix squamous cell carcinoma correlates with lymph node metastasis.
Sialyltransferase family members and cervix squamous cell carcinoma.
Cardiomyopathies
Excitation-contraction coupling in normal and myopathic hamster hearts III: functional deficiencies in interstitial glycoproteins.
Orotic acid prevents changes in cardiac sarcolemmal glycoproteins and contractility associated with muscular dystrophy in hamsters.
Cataract
Kidney sialidase and sialyltransferase activities in spontaneously and experimentally diabetic rats. Influence of insulin and sorbinil treatments.
Choriocarcinoma
Elevation of alpha2-->6 sialyltransferase and alpha1-->2 fucosyltransferase activities in human choriocarcinoma.
Colonic Neoplasms
Correlation analysis between tumor-associated antigen sialyl-Tn expression and ST6GalNAc I activity in human colon adenocarcinoma.
Enhanced CMP-NeuAc:Gal beta 1,4GlcNAc-R alpha 2,6 sialyltransferase activity of human colon cancer xenografts in athymic nude mice and of xenograft-derived cell lines.
Human colon cancer cell lines permanently expressing alpha 2,6-sialylated sugar chains by transfection with rat beta-galactoside alpha 2,6 sialyltransferase cDNA.
Hypersialylation of beta1 integrins, observed in colon adenocarcinoma, may contribute to cancer progression by up-regulating cell motility.
Impact of sialyltransferase ST6GAL1 overexpression on different colon cancer cell types.
Inhibition of experimental pulmonary metastasis of mouse colon adenocarcinoma 26 sublines by a sialic acid:nucleoside conjugate having sialyltransferase inhibiting activity.
n-butyrate reduces the expression of beta-galactoside alpha 2,6-sialyltransferase in Hep G2 cells.
Possible mechanism of inhibition of experimental pulmonary metastasis of mouse colon adenocarcinoma 26 sublines by a sialic acid: nucleoside conjugate.
Sialylation of epidermal growth factor receptor regulates receptor activity and chemosensitivity to gefitinib in colon cancer cells.
ST6Gal-I expression in ovarian cancer cells promotes an invasive phenotype by altering integrin glycosylation and function.
ST6Gal-I Protein Expression Is Upregulated in Human Epithelial Tumors and Correlates with Stem Cell Markers in Normal Tissues and Colon Cancer Cell Lines.
Suppression of a sialyltransferase by antisense DNA reduces invasiveness of human colon cancer cells in vitro.
Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides.
The pattern of glycosyl- and sulfotransferase activities in cancer cell lines: a predictor of individual cancer-associated distinct carbohydrate structures for the structural identification of signature glycans.
Tumor cell migration and invasion are regulated by expression of variant integrin glycoforms.
[Structures, synthesis and functions of sialyl Le(a)/sialyl Le(x) antigens]
Colorectal Neoplasms
Alpha 2,6 sialylation of N-acetyllactosaminic sequences in human colorectal cancer cell lines. Relationship with non-adherent growth.
Alterations of CMP-NeuAc:asialofetuin sialyltransferase activities in human colorectal adenocarcinoma.
Altered mRNA expression of specific molecular species of fucosyl- and sialyl-transferases in human colorectal cancer tissues.
Correlation analysis between tumor-associated antigen sialyl-Tn expression and ST6GalNAc I activity in human colon adenocarcinoma.
Different sialyltransferase activities in human colorectal carcinoma cells from surgical specimens detected by specific glycoprotein and glycolipid acceptors.
Elevation of ST6Gal I activity in malignant and transitional tissue in human colorectal cancer.
Hypersialylation of beta1 integrins, observed in colon adenocarcinoma, may contribute to cancer progression by up-regulating cell motility.
Increased CMP-NeuAc:Gal beta 1,4GlcNAc-R alpha 2,6 sialyltransferase activity in human colorectal cancer tissues.
Overexpression of sialyltransferase CMP-sialic acid:Galbeta1,3GalNAc-R alpha6-Sialyltransferase is related to poor patient survival in human colorectal carcinomas.
Purification and characterization of a CMP-sialic:LcOse4Cer sialyltransferase from human colorectal carcinoma cell membranes.
Sialylation of epidermal growth factor receptor regulates receptor activity and chemosensitivity to gefitinib in colon cancer cells.
Sialyltransferase activity and hepatic tumor growth in a nude mouse model of colorectal cancer metastases.
The glycosyltransferase ST6Gal-I is enriched in cancer stem-like cells in colorectal carcinoma and contributes to their chemo-resistance.
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Sialylation regulates brain structure and function.
Coronary Disease
Mutation in ST6GALNAC5 identified in family with coronary artery disease.
Cystic Fibrosis
Comparison of the polypeptide composition of cystic fibrosis plasma with normal plasma by high resolution electrophoresis.
Cystic fibrosis liver sialyltransferase.
Cystic fibrosis transmembrane conductance regulator and H+ permeability in regulation of Golgi pH.
Demyelinating Diseases
Ectopic expression of polysialylated neural cell adhesion molecule in adult macaque Schwann cells promotes their migration and remyelination potential in the central nervous system.
Dermatitis, Contact
Polysialic acid, a glycan with highly restricted expression, is found on human and murine leukocytes and modulates immune responses.
Down Syndrome
A decrease in serum sialyltransferase levels in Alzheimer's disease.
Epilepsy
Sialyltransferase ST3Gal IV deletion protects against temporal lobe epilepsy.
Epilepsy, Temporal Lobe
Sialyltransferase ST3Gal IV deletion protects against temporal lobe epilepsy.
Esophageal Neoplasms
Identification of the expression profile of apoptotic esophageal cancer cells by adenoviral-fragile histidine triad treatment.
Fibroadenoma
Proteinases and sialyltransferase in human breast tumors.
Glioblastoma
ST3GAL1-Associated Transcriptomic Program in Glioblastoma Tumor Growth, Invasion, and Prognosis.
Glioma
Alterations in serum sialyltransferase activities in patients with brain tumors.
Effect of desipramine on a glycoprotein sialyltransferase activity in C6 cultured glioma cells.
Effect of retinoic acid on two glycosyltransferase activities in C6 cultured glioma cells.
Focused microarray analysis of glyco-gene expression in human glioblastomas.
Increased tumorigenicity and invasiveness of C6 rat glioma cells transfected with the human alpha-2,8 sialyltransferase cDNA.
Study of O-glycan sialylation in C6 cultured glioma cells: evidence for post-translational regulation of a beta-galactoside alpha 2,3 sialyltransferase activity by N-glycosylation.
Study of O-glycan sialylation in C6 cultured glioma cells: regulation of a beta-galactoside alpha 2,3 sialyltransferase activity by Ca2+/calmodulin antagonists and phosphatase inhibitors.
Study of O-sialylation of glycoproteins in C6 glioma cells treated with retinoic acid.
Goiter, Endemic
Hyposialylated thyroglobulin in a patient with congenital goiter and hypothyroidism.
Gonorrhea
The Lst Sialyltransferase of Neisseria gonorrhoeae Can Transfer Keto-Deoxyoctanoate as the Terminal Sugar of Lipooligosaccharide: a Glyco-Achilles Heel That Provides a New Strategy for Vaccines to Prevent Gonorrhea.
Graves Disease
Thyroid sialyltransferase mRNA level and activity are increased in Graves' disease.
Guillain-Barre Syndrome
Bacterial infections in Guillain-Barré and Fisher syndromes.
Campylobacter sialyltransferase gene polymorphism directs clinical features of Guillain-Barré syndrome.
Miller-Fisher syndrome associated with Campylobacter jejuni bearing lipopolysaccharide molecules that mimic human ganglioside GD3.
[Campylobacter genes responsible for the development and determinant of clinical features of Guillain-Barré syndrome]
Heart Failure
Aberrant sialylation causes dilated cardiomyopathy and stress-induced heart failure.
Hepatitis B
[Regulation of Gal beta 1,3GalNAc alpha 2,3-sialyltransferase (ST3GalI) by hepatitis B virus MHBst/HBx transactivator]
Hepatoblastoma
n-Butyrate mediation of ganglioside expression of human and murine cancer cells demonstrates relative cell specificity.
Hypertension, Pulmonary
Multiplex reverse transcription polymerase chain reaction assessment of sialyltransferase expression in peripheral blood mononuclear cells in systemic sclerosis.
Infections
?2,6-linked sialic acid serves as a high-affinity receptor for cancer oncolytic virotherapy with Newcastle disease virus.
An N-linked glycoprotein with alpha(2,3)-linked sialic acid is a receptor for BK virus.
Differential infection of receptor-modified host cells by receptor-specific influenza viruses.
Elevated glycosyltransferase activities in infected or traumatized hosts: nonspecific response to inflammation.
Legless pathogens: how bacterial physiology provides the key to understanding pathogenicity.
Myxoma virus encodes an alpha2,3-sialyltransferase that enhances virulence.
Non-culture diagnosis and serogroup determination of meningococcal B and C infection by a sialyltransferase (siaD) PCR ELISA.
Sensitivity to human serum of gammaretroviruses produced from pig endothelial cells transduced with glycosyltransferase genes.
Sialylation of lipooligosaccharides is dispensable for the virulence of Haemophilus ducreyi in humans.
Infertility
[Sialyltransferase activity in the spermatic membrane and its relation to human fertility and sterility]
Infertility, Male
Seminal plasma biochemistry II: seminal plasma and spermatozoal cytidine monophosphate-sialic acid synthetase and sialyltransferase activities.
Influenza in Birds
Inhibition of H5N1 highly pathogenic influenza virus by suppressing a specific sialyltransferase.
Influenza, Human
Characterization of sialyltransferases from serum of normal and hepatoma Mc-29 bearing chickens.
Inhibition of H5N1 highly pathogenic influenza virus by suppressing a specific sialyltransferase.
Overexpression of ?-2,6 sialyltransferase stimulates propagation of human influenza viruses in Vero cells.
The expression of essential components for human influenza virus internalisation in Vero and MDCK cells.
The hemagglutinins of the human influenza viruses A and B recognize different receptor microdomains.
The signal anchor and stem regions of the beta-galactoside alpha 2,6-sialyltransferase may each act to localize the enzyme to the Golgi apparatus.
Transfer of synthetic sialic acid analogues to N- and O-linked glycoprotein glycans using four different mammalian sialyltransferases.
Insulin Resistance
Mice lacking sialyltransferase ST3Gal-II develop late-onset obesity and insulin resistance.
Keratosis, Seborrheic
[Glycohistochemical analysis of seborrheic keratosis in eyelids]
Kidney Neoplasms
Identification and expression of a sialyltransferase responsible for the synthesis of disialylgalactosylgloboside in normal and malignant kidney cells: downregulation of ST6GalNAc VI in renal cancers.
Leukemia
Glycosyltransferase activities in leukemic cells from patients and human leukemic cell lines.
Role of clathrin-coated vesicles in glycoprotein transport from the cell surface to the Golgi complex.
Sensitivity to human serum of gammaretroviruses produced from pig endothelial cells transduced with glycosyltransferase genes.
Sialyltransferase activity in leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
Some properties of sialyltransferase in plasma and lymphocytes of patients with chronic lymphocytic leukemia.
Leukemia, Lymphoid
12-0-Tetradecanoylphorbol 13-acetate (TPA)-induced enzymatic change of human non-T, non-B lymphoid leukemia cell lines.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Increased activity of a specific sialyltransferase in chronic myelogenous leukemia.
Presence of cytidine 5'-monophospho-N-acetylneuraminic acid:Gal beta 1-3GalNAc-R alpha(2-3)-sialyltransferase in normal human leukocytes and increased activity of this enzyme in granulocytes from chronic myelogenous leukemia patients.
Sialyltransferase activity as a marker for the differentiation of lymphocytes. Increase in sialyltransferase activity of blasts from acute lymphoblastic leukaemia cases by 12-o-tetradecanoylphorbol-13-acetate (TPA).
Liver Cirrhosis
Cytidine-5'-monophosphate-N-acetylneuraminic acid. Asialoglycoprotein sialic acid transferase activity in liver and serum of patients with juvenile hepatic cirrhosis and alpha-1-antitrypsin deficiency.
Demonstration of sialyltransferase deficiency in the serum of a patient with alpha-1-antitrypsin deficiency and hepatic cirrhosis.
Liver Diseases
Cytidine-5'-monophosphate-N-acetylneuraminic acid. Asialoglycoprotein sialic acid transferase activity in liver and serum of patients with juvenile hepatic cirrhosis and alpha-1-antitrypsin deficiency.
[Analysis of serum sialyltransferase activities, with special reference to the fluctuations in liver diseases]
Liver Neoplasms
The pattern of glycosyl- and sulfotransferase activities in cancer cell lines: a predictor of individual cancer-associated distinct carbohydrate structures for the structural identification of signature glycans.
Lung Diseases
Serum sialyltransferase and fucosyltransferase activities in patients with bronchial carcinoma.
Lung Neoplasms
A novel sialyltransferase inhibitor AL10 suppresses invasion and metastasis of lung cancer cells by inhibiting integrin-mediated signaling.
Comparative study of the levels of sialyltransferases responsible for the formation of sugar chains in glycoproteins and gangliosides in rat liver and hepatomas.
Correlation between plasma carcinoembryonic antigen (CEA) and sialyltransferase as tumor marker.
Effect of sialylation on EGFR phosphorylation and resistance to tyrosine kinase inhibition.
Modification of ?2,6-sialylation mediates the invasiveness and tumorigenicity of non-small cell lung cancer cells in vitro and in vivo via Notch1/Hes1/MMPs pathway.
Multiplexed surrogate analysis of glycotransferase activity in whole biospecimens.
ST6GalNAc-I promotes lung cancer metastasis by altering MUC5AC sialylation.
Lupus Erythematosus, Systemic
Sialyltransferase and Neuraminidase Levels/Ratios and Sialic Acid Levels in Peripheral Blood B Cells Correlate with Measures of Disease Activity in Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis: A Pilot Study.
ST6Gal-I restrains CD22-dependent antigen receptor endocytosis and Shp-1 recruitment in normal and pathogenic immune signaling.
Lymphatic Metastasis
Expression of sialyltransferase family members in cervix squamous cell carcinoma correlates with lymph node metastasis.
Proteinases and sialyltransferase in human breast tumors.
Lymphoma
Glycosylation in lymphoma: Biology and glycotherapy.
Role of sialyltransferase in hypercupraemia of non-Hodgkin's lymphoma.
[Serum sialyltransferase activity: a possible aid in the staging and course control of malignant lymphomas]
Lymphoma, Non-Hodgkin
Role of sialyltransferase in hypercupraemia of non-Hodgkin's lymphoma.
Melanoma
A correlation between cell surface sialyltransferase, sialic acid, and glycosidase activities and the implantability of B16 murine melanoma.
Adrenal carcinoma tumor progression and penultimate cell surface oligosaccharides.
Alterations of cell surface carbohydrates and inhibition of metastatic property of murine melanomas by alpha 1,3 galactosyltransferase gene transfection.
Cell surface sialylation and tumor metastasis. Metastatic potential of B16 melanoma variants correlates with their relative numbers of specific penultimate oligosaccharide structures.
Characterization of two glycolipid: alpha 2-3sialyltransferases, SAT-3 (CMP-NeuAc:nLcOse4Cer alpha 2-3sialyltransferase) and SAT-4 (CMP-NeuAc:GgOse4Cer alpha 2-3sialyltransferase), from human colon carcinoma (Colo 205) cell line.
Correlation of retinoic acid-enhanced sialyltransferase activity and glycosylation of specific cell surface sialoglycoproteins with growth inhibition in a murine melanoma cell system.
Deficiency of ganglioside biosynthesis in metastatic human melanoma cells: relevance of CMP-NeuAc:LacCer alpha 2-3 sialyltransferase (GM3 synthase).
Down-regulation of GD3 ganglioside and its O-acetylated derivative by stable transfection with antisense vector against GD3-synthase gene expression in hamster melanoma cells: effects on cellular growth, melanogenesis, and dendricity.
Enhancement of sialyltransferase in two melanoma cell lines that are growth-inhibited by retinoic acid results in increased sialylation of different cell-surface glycoproteins.
Expression of fucosyltransferases contributes to melanoma invasive phenotype.
Growth inhibition of murine melanoma cells by antibodies to a cell surface glycoprotein implicated in retinoic acid action.
Melanoma Cell Galectin-1 Ligands Functionally Correlate with Malignant Potential.
Neobiosynthesis of glycosphingolipids by plasma membrane-associated glycosyltransferases.
Serum sialic acid and sialyltransferase as monitors of tumor burden in malignant melanoma patients.
Serum sialyltransferase and liver catalase activity in cachectic nude mice bearing a human malignant melanoma.
Sialyltransferase levels and ganglioside expression in melanoma and other cultured human cancer cells.
Sialyltransferase levels and sialic acid concentrations in sera of patients with malignant melanomas.
ST3GAL1 is a target of the SOX2-GLI1 transcriptional complex and promotes melanoma metastasis through AXL.
Stimulation of sialyltransferase activity of melanoma cells by retinoic acid.
[Clinical significant of sialic acid concentrations in the serum of melanoma patients]
[Sialyltransferase in human malignant melanoma]
Meningitis
Site-specific immobilization of enzymes on magnetic nanoparticles and their use in organic synthesis.
Meningococcal Infections
siaD PCR ELISA for confirmation and identification of serogroup Y and W135 meningococcal infections.
Miller Fisher Syndrome
Guillain-Barré syndrome and anti-ganglioside antibodies: a clinician-scientist's journey.
Monoclonal Gammopathy of Undetermined Significance
Sialyltransferase activity and sialic acid levels in multiple myeloma and monoclonal gammopathy.
Mouth Neoplasms
"Aberrant sialylation plays a significant role in oral squamous cell carcinoma progression".
Role of aberrant glycosylation enzymes in oral cancer progression.
Multiple Myeloma
Serum sialyltransferase and fucosyltransferase activities in patients with multiple myeloma.
Sialyltransferase activity and sialic acid levels in multiple myeloma and monoclonal gammopathy.
Sialyltransferase activity in plasma cells of multiple myeloma.
Sialyltransferase inhibition leads to inhibition of tumor cell interactions with E-selectin, VCAM1, and MADCAM1, and improves survival in a human multiple myeloma mouse model.
The sialyltransferase ST3GAL6 influences homing and survival in multiple myeloma.
Myasthenia Gravis
Possible relationship between poly(ADP-ribose)synthetase and formation of antibody against acetylcholine receptors in patients with myasthenia gravis.
Myotonic Dystrophy
Sialyltransferase activity in erythrocyte membranes and serum in patients with myotonic dystrophy.
Myxoma
Myxoma virus encodes an alpha2,3-sialyltransferase that enhances virulence.
Post-translational modification of the myxoma-virus anti-inflammatory serpin SERP-1 by a virally encoded sialyltransferase.
n-acetyllactosaminide alpha-2,3-sialyltransferase deficiency
Sialyltransferase ST3Gal-IV operates as a dominant modifier of hemostasis by concealing asialoglycoprotein receptor ligands.
Neoplasm Metastasis
?2,6-Sialylation mediates hepatocellular carcinoma growth in vitro and in vivo by targeting the Wnt/?-catenin pathway.
A novel sialyltransferase inhibitor AL10 suppresses invasion and metastasis of lung cancer cells by inhibiting integrin-mediated signaling.
A novel sialyltransferase inhibitor suppresses FAK/paxillin signaling and cancer angiogenesis and metastasis pathways.
Alterations in serum sialyltransferase activities in patients with brain tumors.
An In Vivo Functional Screen Identifies ST6GalNAc2 Sialyltransferase as a Breast Cancer Metastasis Suppressor.
Enzyme patterns in cancer.
Expression of sialyltransferase family members in cervix squamous cell carcinoma correlates with lymph node metastasis.
Glycosylation in lymphoma: Biology and glycotherapy.
Glycosyltransferase expression in human colonic tissue examined by oligonucleotide arrays.
Hypersialylation of beta1 integrins, observed in colon adenocarcinoma, may contribute to cancer progression by up-regulating cell motility.
Inhibition of experimental pulmonary metastasis of mouse colon adenocarcinoma 26 sublines by a sialic acid:nucleoside conjugate having sialyltransferase inhibiting activity.
Insights into the role of sialylation in cancer progression and metastasis.
Knockdown of ST6Gal-I increases cisplatin sensitivity in cervical cancer cells.
Modification of ?2,6-sialylation mediates the invasiveness and tumorigenicity of non-small cell lung cancer cells in vitro and in vivo via Notch1/Hes1/MMPs pathway.
Overexpression of sialyltransferase CMP-sialic acid:Galbeta1,3GalNAc-R alpha6-Sialyltransferase is related to poor patient survival in human colorectal carcinomas.
Plasma sialyl transferase total and isoenzyme activity in the diagnosis of cancer of the colon.
Possible mechanism of inhibition of experimental pulmonary metastasis of mouse colon adenocarcinoma 26 sublines by a sialic acid: nucleoside conjugate.
Proteinases and sialyltransferase in human breast tumors.
RNAi-mediated gene silencing of ST6GalNAc I suppresses the metastatic potential in gastric cancer cells.
Sialylation of the Fas death receptor by ST6Gal-I provides protection against Fas-mediated apoptosis in colon carcinoma cells.
Sialyltransferase activity and hepatic tumor growth in a nude mouse model of colorectal cancer metastases.
Sialyltransferase Inhibitors Suppress Breast Cancer Metastasis.
Silencing of ST6GalNAc I suppresses the proliferation, migration and invasion of hepatocarcinoma cells through PI3K/AKT/NF-?B pathway.
Soyasaponin I, a potent and specific sialyltransferase inhibitor.
ST6Gal-I expression in ovarian cancer cells promotes an invasive phenotype by altering integrin glycosylation and function.
ST6Gal-I predicts postoperative clinical outcome for patients with localized clear-cell renal cell carcinoma.
ST6Gal-I sialyltransferase confers cisplatin resistance in ovarian tumor cells.
ST6GalNAc-I promotes lung cancer metastasis by altering MUC5AC sialylation.
Sticking to Sugars at the Metastatic Site: Sialyltransferase ST6GalNAc2 Acts as a Breast Cancer Metastasis Suppressor.
The expression of Gal beta 1,4GlcNAc alpha 2,6 sialyltransferase and alpha 2,6-linked sialoglycoconjugates in human brain tumors.
Neoplasms
?2,3-sialyltransferase ST3Gal IV promotes migration and metastasis in pancreatic adenocarcinoma cells and tends to be highly expressed in pancreatic adenocarcinoma tissues.
?2,6-linked sialic acid serves as a high-affinity receptor for cancer oncolytic virotherapy with Newcastle disease virus.
?2,6-Sialylation mediates hepatocellular carcinoma growth in vitro and in vivo by targeting the Wnt/?-catenin pathway.
?2,6-Sialylation promotes immune escape in hepatocarcinoma cells by regulating T cell functions and CD147/MMP signaling.
A correlation between cell surface sialyltransferase, sialic acid, and glycosidase activities and the implantability of B16 murine melanoma.
A novel sialyltransferase inhibitor suppresses FAK/paxillin signaling and cancer angiogenesis and metastasis pathways.
Activity and characterization of sialyltransferase from serum of normal rats, of rats bearing Zajdela ascitic hepatoma, in normal host liver and in Zajdela hepatoma cells.
Advancement of Sialyltransferase Inhibitors: Therapeutic Challenges and Opportunities.
alpha 2-6-Linked sialic acids on N-glycans modulate carcinoma differentiation in vivo.
alpha2,3-sialyltransferase ST3Gal III modulates pancreatic cancer cell motility and adhesion in vitro and enhances its metastatic potential in vivo.
Alteration of ganglioside composition by stable transfection with antisense vectors against GD3-synthase gene expression.
Alterations in glycosyltransferase activity in human colon cancer.
Alterations in plasma sialyltransferase associated with successful chemotherapy of a disseminated tumor. Case report.
Alterations in plasma sialyltransferase levels in patients with neoplastic disease.
Alterations in serum sialyltransferase activities in patients with brain tumors.
Altered mRNA expression of glycosyltransferases in human colorectal carcinomas and liver metastases.
Altered mRNA expressions of sialyltransferases in human gastric cancer tissues.
Biochemical evidence for the role of alkyl-lysophospholipids on liver sialyltransferase.
Breast cancer markers: comparison between sialyltransferase and human mammary epithelial antigens (HME-Ags) for the detection of human breast tumors grafted in nude mice.
CDw75 antigen expression in breast lesions.
Characterization of Cancer Associated Mucin Type O-Glycans Using the Exchange Sialylation Properties of Mammalian Sialyltransferase ST3Gal-II.
Characterization of sialyltransferases from serum of normal and hepatoma Mc-29 bearing chickens.
Characterization of sialytransferase in noncancerous and neoplastic human liver tissue.
Clinical relevance of sialyltransferases ST6GAL-I and ST3GAL-III in gastric cancer.
Clinical usefulness of alterations in sialic acid, sialyl transferase and sialoproteins in breast cancer.
CMP-NeuAc:(NeuAc alpha 2-->8)n (colominic acid) sialyltransferase activity in rat brain and in tumour cells that express polysialic acid on neural cell adhesion molecules.
Comparative study of the levels of sialyltransferases responsible for the formation of sugar chains in glycoproteins and gangliosides in rat liver and hepatomas.
Computer-aided design of human sialyltransferase inhibitors of hST8Sia III.
Concomitant elevations in serum sialytransferase activity and sialic acid content in rats with metastasizing mammary tumors.
Correlation between plasma carcinoembryonic antigen (CEA) and sialyltransferase as tumor marker.
Correlation of serum, tumor, and liver serum glycoprotein: N-acetylneuraminic acid transferase activity with growth of the R3230AC mammary tumor in rats and relationship of the serum activity to tumor burden.
Defective thyroglobulin synthesis in an experimental rat thyroid tumor. Lack of membrane-bound sialyltransferase activity.
Demonstration of endogenous sialyltransferase on the surface of ehrlich tumour ascites cells.
Depletion of ST6GALNACIII retards A549 non-small cell lung cancer cell proliferation by downregulating transferrin receptor protein 1 expression.
Development of Monoclonal Antibodies against CMP-N-Acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (ST3Gal-I) Recombinant Protein Expressed in E. coli.
Differences in the isoelectric focusing patterns of gamma-glutamyl transpeptidase from normal and cancerous rat mammary tissue.
Different enzyme activities of sialyltransferases in gynecological cancer cell lines.
Different sialyltransferase activities in human colorectal carcinoma cells from surgical specimens detected by specific glycoprotein and glycolipid acceptors.
Differentially expressed genes in metastatic advanced Egyptian bladder cancer.
Disialyl GD2 ganglioside suppresses ICAM-1-mediated invasiveness in human breast cancer MDA-MB231 cells.
Effect of retinoic acid and phorbol-12-myristate-13-acetate on glycosyltransferase activities in normal and transformed cells.
Elevated plasma sialyltransferase in the cancer patient.
Elevation of ratio of urinary N-acetylneuraminlactose to free sialic acid in some advanced cancer patients.
Elucidation of sialyltransferase as a tumour marker.
Embryonic precancerous and cancerous human antigens recognized by monoclonal antibodies.
Enhanced activity of CMP-neuAc:Gal beta 1-4GlcNAc:alpha 2,6-sialyltransferase in metastasizing human colorectal tumor tissue and serum of tumor patients.
Enhancement of metastatic ability by ectopic expression of ST6GalNAcI on a gastric cancer cell line in a mouse model.
Enzyme activities in human breast tumor cells and sera.
Evaluation of serum sialic acid, sialyltransferase and sialoproteins in oral cavity cancer.
Expression of fucosyltransferases contributes to melanoma invasive phenotype.
Focused microarray analysis of glyco-gene expression in human glioblastomas.
Glycoproteomic identification of potential glycoprotein biomarkers in ovarian cancer proximal fluids.
Glycosyltransferase levels in tumors metastatic to liver and in uninvolved liver tissue.
Glycosyltransferase ST6Gal-I promotes the epithelial to mesenchymal transition in pancreatic cancer cells.
Hypoxia induces adhesion molecules on cancer cells: A missing link between Warburg effect and induction of selectin-ligand carbohydrates.
Identification and functional characterization of a human GalNAc [alpha]2,6-sialyltransferase with altered expression in breast cancer.
Immunohistochemical expression of blood group substances and related carbohydrate antigens in breast carcinoma.
Immunohistochemical study of type-1 blood antigen expressions in thyroid tumors: the significance for papillary carcinomas.
Increase in serum sialyltransferase in tumor-bearing rats: the origin and nature of the increased enzyme.
Increased alpha2,6 sialylation of N-glycans in a transgenic mouse model of hepatocellular carcinoma.
Increased CMP-NeuAc:Gal beta 1,4GlcNAc-R alpha 2,6 sialyltransferase activity in human colorectal cancer tissues.
Inhibition of experimental pulmonary metastasis of mouse colon adenocarcinoma 26 sublines by a sialic acid:nucleoside conjugate having sialyltransferase inhibiting activity.
Knockdown of ST6Gal-I increases cisplatin sensitivity in cervical cancer cells.
Loss of disialyl Lewis(a), the ligand for lymphocyte inhibitory receptor sialic acid-binding immunoglobulin-like lectin-7 (Siglec-7) associated with increased sialyl Lewis(a) expression on human colon cancers.
Mechanisms underlying aberrant glycosylation of MUC1 mucin in breast cancer cells.
Modification of sialylation mediates the invasive properties and chemosensitivity of human hepatocellular carcinoma.
Modification of Sialylation Mediates the Invasive Properties and Chemosensitivity of Human Hepatocellular Carcinoma.
Modulation of glycosyltransferase ST6Gal-I in gastric cancer-derived organoids disrupts homeostatic epithelial cell turnover.
O-glycan sialylation alters galectin-3 subcellular localization and decreases chemotherapy sensitivity in gastric cancer.
Over-expression of ST3Gal-I promotes mammary tumorigenesis.
Overexpression of ?2,3sialyl T-antigen in breast cancer determined by miniaturized glycosyltransferase assays and confirmed using tissue microarray immunohistochemical analysis.
Plasma sialyltransferase as a tumor marker.
Polysialic acid, a glycan with highly restricted expression, is found on human and murine leukocytes and modulates immune responses.
Possible mechanism of inhibition of experimental pulmonary metastasis of mouse colon adenocarcinoma 26 sublines by a sialic acid: nucleoside conjugate.
Prognostic significance of ST6GalNAc-1 expression in patients with non-metastatic clear cell renal cell carcinoma.
Promoter Polymorphisms of ST3GAL4 and ST6GAL1 Genes and Associations with Risk of Premalignant and Malignant Lesions of the Cervix.
Proteinases and sialyltransferase in human breast tumors.
Regulation of ST6GAL1 sialyltransferase expression in cancer cells.
Representational difference analysis in a lupus-prone mouse strain results in the identification of an unstable region of the genome on chromosome 11.
Ricin and lentil lectin-affinity chromatography reveals oligosaccharide heterogeneity of thyrotropin secreted by 12 human pituitary tumors.
RNAi-mediated gene silencing of ST6GalNAc I suppresses the metastatic potential in gastric cancer cells.
Role of sialyltransferase in hypercupraemia of non-Hodgkin's lymphoma.
Role of the human ST6GalNAc-I and ST6GalNAc-II in the synthesis of the cancer-associated sialyl-Tn antigen.
Serum and tumor sialyltransferase activities in women with breast cancer.
Serum sialic acid and sialyltransferase as monitors of tumor burden in malignant melanoma patients.
Serum sialyltransferase and 5'-nucleotidase as reliable biomarkers in women with breast cancer.
Serum sialyltransferase and fucosyltransferase activities in patients with multiple myeloma.
Serum sialyltransferase and liver catalase activity in cachectic nude mice bearing a human malignant melanoma.
Serum sialyltransferase levels as a parameter in the diagnosis and follow-up of gastrointestinal tumors.
Sialic Acid and Sialyltransferase Activity in Serum and Tissues of Dogs With Mammary Tumors.
Sialic acid metabolism in rats undergoing chemically-induced mammary gland carcinogenesis in specific dietary states.
Sialyl-tn in cancer: (how) did we miss the target?
Sialylation of beta1 integrins blocks cell adhesion to galectin-3 and protects cells against galectin-3-induced apoptosis.
Sialylation of EGFR by the ST6Gal-I sialyltransferase promotes EGFR activation and resistance to gefitinib-mediated cell death.
Sialylation of epidermal growth factor receptor regulates receptor activity and chemosensitivity to gefitinib in colon cancer cells.
Sialylation of FGFR1 by ST6Gal?I overexpression contributes to ovarian cancer cell migration and chemoresistance.
Sialylation of the Fas death receptor by ST6Gal-I provides protection against Fas-mediated apoptosis in colon carcinoma cells.
Sialyltransferase activity and hepatic tumor growth in a nude mouse model of colorectal cancer metastases.
Sialyltransferase activity in plasma cells of multiple myeloma.
Sialyltransferase activity in tumor tissues.
Sialyltransferase and nucleoside diphosphatase as markers for tumor monitoring.
Sialyltransferase inhibition and recent advances.
Sialyltransferase inhibition leads to inhibition of tumor cell interactions with E-selectin, VCAM1, and MADCAM1, and improves survival in a human multiple myeloma mouse model.
Sialyltransferase Inhibitors Suppress Breast Cancer Metastasis.
Sialyltransferase levels and ganglioside expression in melanoma and other cultured human cancer cells.
Sialyltransferase levels and sialic acid concentrations in sera of patients with malignant melanomas.
Sialyltransferase of the 13762 rat mammary ascites tumor cells.
Sialyltransferase ST3GAL1 promotes cell migration, invasion, and TGF-?1-induced EMT and confers paclitaxel resistance in ovarian cancer.
Sialyltransferase, sialic acid and sialoglycoconjugates in metastatic tumor and human liver tissue.
Siglec1-expressing subcapsular sinus macrophages provide soil for melanoma lymph node metastasis.
Silencing of ST6GalNAc I suppresses the proliferation, migration and invasion of hepatocarcinoma cells through PI3K/AKT/NF-?B pathway.
Some biochemical properties of human breast tumor sialyltransferase.
Sox2 promotes expression of the ST6Gal-I glycosyltransferase in ovarian cancer cells.
Soyasaponin I, a potent and specific sialyltransferase inhibitor.
Soyasaponin-I-modified invasive behavior of cancer by changing cell surface sialic acids.
ST3GAL1-Associated Transcriptomic Program in Glioblastoma Tumor Growth, Invasion, and Prognosis.
ST3Gal3 confers paclitaxel?mediated chemoresistance in ovarian cancer cells by attenuating caspase?8/3 signaling.
ST6Gal-I expression in ovarian cancer cells promotes an invasive phenotype by altering integrin glycosylation and function.
ST6Gal-I modulates docetaxel sensitivity in human hepatocarcinoma cells via the p38 MAPK/caspase pathway.
ST6Gal-I overexpression facilitates prostate cancer progression via the PI3K/Akt/GSK-3?/?-catenin signaling pathway.
ST6Gal-I predicts postoperative clinical outcome for patients with localized clear-cell renal cell carcinoma.
ST6Gal-I Protein Expression Is Upregulated in Human Epithelial Tumors and Correlates with Stem Cell Markers in Normal Tissues and Colon Cancer Cell Lines.
ST6Gal-I sialyltransferase confers cisplatin resistance in ovarian tumor cells.
ST6Gal-I sialyltransferase promotes tumor necrosis factor (TNF)-mediated cancer cell survival via sialylation of the TNF receptor 1 (TNFR1) death receptor.
ST6GAL1: A key player in cancer.
Sticking to Sugars at the Metastatic Site: Sialyltransferase ST6GalNAc2 Acts as a Breast Cancer Metastasis Suppressor.
Stimulation of sialyltransferase activity of melanoma cells by retinoic acid.
The control of sialyltransferase activity in tumor-cell lines derived from different tissues in multifactorial.
The glycosyltransferase ST6Gal-I is enriched in cancer stem-like cells in colorectal carcinoma and contributes to their chemo-resistance.
The Glycosyltransferase ST6Gal-I Protects Tumor Cells against Serum Growth Factor Withdrawal by Enhancing Survival Signaling and Proliferative Potential.
The ST6Gal-I sialyltransferase protects tumor cells against hypoxia by enhancing HIF-1? signaling.
The Tumor-Associated Glycosyltransferase ST6Gal-I Regulates Stem Cell Transcription Factors and Confers a Cancer Stem Cell Phenotype.
TNF up-regulates ST3GAL4 and sialyl-Lewisx expression in lung epithelial cells through an intronic ATF2-responsive element.
Triple-negative and HER2-overexpressing breast cancer cell sialylation impacts tumor microenvironment T-lymphocyte subset recruitment: a possible mechanism of tumor escape.
Tumor cell migration and invasion are regulated by expression of variant integrin glycoforms.
[Clinical significant of sialic acid concentrations in the serum of melanoma patients]
[Developments in the serological diagnosis of malignant diseases]
[Elevated serum-sialyltransferase activity in human malignant diseases: a new diagnostic tool? (author's transl)]
[Glycohistochemical analysis of apoptotic bodies in eyelid tumor]
Neurilemmoma
Alterations in serum sialyltransferase activities in patients with brain tumors.
Neuroblastoma
Alteration of ganglioside composition by stable transfection with antisense vectors against GD3-synthase gene expression.
Effect of membrane lipids on the lactosylceramide molecular species specificity of CMP-N-acetylneuraminate:lactosylceramide sialyltransferase.
Overexpression of alpha2,3 sialyltransferase in neuroblastoma cells results in an upset in the glycosylation process.
Overexpression of the alpha2,6 (N) sialyltransferase enzyme in human and rat neural cell lines is associated with increased expression of the polysialic acid epitope.
Retinoic acid induction of sialyltransferase activity in neuroblastoma cells of differing sialylation potentials.
Sialyltransferase levels and ganglioside expression in melanoma and other cultured human cancer cells.
Sialyltransferase STX (ST8SiaII): a novel molecular marker of metastatic neuroblastoma.
The generation and characterization of a rat neural cell line overexpressing the alpha2,6(N) sialyltransferase.
Obesity
Mice lacking sialyltransferase ST3Gal-II develop late-onset obesity and insulin resistance.
Oligospermia
Seminal plasma biochemistry II: seminal plasma and spermatozoal cytidine monophosphate-sialic acid synthetase and sialyltransferase activities.
Osteosarcoma
Knockdown of ST6Gal-I inhibits the growth and invasion of osteosarcoma MG-63 cells.
Otitis Media
Host-derived sialic acid is incorporated into Haemophilus influenzae lipopolysaccharide and is a major virulence factor in experimental otitis media.
Ovarian Neoplasms
A glycosphingolipid/caveolin-1 signaling complex inhibits motility of human ovarian carcinoma cells.
Altered mRNA expressions of sialyltransferases in ovarian cancers.
Prognostic role of the sialyltransferase ST6GAL1 in ovarian cancer.
Sialylation of EGFR by the ST6Gal-I sialyltransferase promotes EGFR activation and resistance to gefitinib-mediated cell death.
Sialyltransferase and nucleoside diphosphatase as markers for tumor monitoring.
Sialyltransferase ST3GAL1 promotes cell migration, invasion, and TGF-?1-induced EMT and confers paclitaxel resistance in ovarian cancer.
Sox2 promotes expression of the ST6Gal-I glycosyltransferase in ovarian cancer cells.
ST6Gal-I expression in ovarian cancer cells promotes an invasive phenotype by altering integrin glycosylation and function.
ST6Gal-I overexpression facilitates prostate cancer progression via the PI3K/Akt/GSK-3?/?-catenin signaling pathway.
ST6Gal-I sialyltransferase promotes tumor necrosis factor (TNF)-mediated cancer cell survival via sialylation of the TNF receptor 1 (TNFR1) death receptor.
The pattern of glycosyl- and sulfotransferase activities in cancer cell lines: a predictor of individual cancer-associated distinct carbohydrate structures for the structural identification of signature glycans.
The Tumor-Associated Glycosyltransferase ST6Gal-I Regulates Stem Cell Transcription Factors and Confers a Cancer Stem Cell Phenotype.
Pancreatic Neoplasms
Glycosyltransferase ST6Gal-I promotes the epithelial to mesenchymal transition in pancreatic cancer cells.
Sialylation of EGFR by the ST6Gal-I sialyltransferase promotes EGFR activation and resistance to gefitinib-mediated cell death.
The Glycosyltransferase ST6Gal-I Protects Tumor Cells against Serum Growth Factor Withdrawal by Enhancing Survival Signaling and Proliferative Potential.
The ST6Gal-I sialyltransferase protects tumor cells against hypoxia by enhancing HIF-1? signaling.
Paraproteinemias
Sialyltransferase activity and sialic acid levels in multiple myeloma and monoclonal gammopathy.
Pneumococcal Infections
Elevated glycosyltransferase activities in infected or traumatized hosts: nonspecific response to inflammation.
Pneumonia
Recombinant Sialyltransferase Infusion Mitigates Infection-Driven Acute Lung Inflammation.
Sialyltransferase ST3Gal-III regulates Siglec-F ligand formation and eosinophilic lung inflammation in mice.
Polycythemia Vera
[Glycoprotein sialylation and NEU1 and ST6GAL1 expressions in erythremia].
Precancerous Conditions
Role of aberrant glycosylation enzymes in oral cancer progression.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Elevated mRNA level of hST6Gal I and hST3Gal V positively correlates with the high risk of pediatric acute leukemia.
Sialyltransferase activity in leukemia.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
The regulatory ZFAS1/miR-150/ST6GAL1 crosstalk modulates sialylation of EGFR via PI3K/Akt pathway in T-cell acute lymphoblastic leukemia.
Prostatic Neoplasms
Computer-aided design of human sialyltransferase inhibitors of hST8Sia III.
ST6Gal-I overexpression facilitates prostate cancer progression via the PI3K/Akt/GSK-3?/?-catenin signaling pathway.
Pterygium
Alteration of sialyl Lewis epitope expression in pterygium.
Retinitis Pigmentosa
[Sialyltransferase and galactosyltransferase of lymphocyte in retinitis pigmentosa]
Rhabdomyosarcoma
Monosialoganglioside biosynthesis by subcellular membranes of rhabdomyosarcoma cell lines differing in metastatic potential.
Scleroderma, Systemic
Investigation of sialic acids and sialyltransferase activity in blood of patients with systemic scleroderma.
Multiplex reverse transcription polymerase chain reaction assessment of sialyltransferase expression in peripheral blood mononuclear cells in systemic sclerosis.
Seizures
Differential expression of mRNAs for sialyltransferase isoenzymes induced in the hippocampus of mouse following kindled seizures.
Sialyltransferase ST3Gal IV deletion protects against temporal lobe epilepsy.
Sinusitis
Reduced sialylation of glycoproteins in nasal glands of patients with chronic sinusitis.
Stomach Diseases
Characterization of ?2,3- and ?2,6-sialyltransferases from Helicobacter acinonychis.
Stomach Neoplasms
Clinical relevance of sialyltransferases ST6GAL-I and ST3GAL-III in gastric cancer.
Diagnostic utility of glycosyltransferase mRNA expression in gastric cancer.
Enhancement of metastatic ability by ectopic expression of ST6GalNAcI on a gastric cancer cell line in a mouse model.
Modulation of glycosyltransferase ST6Gal-I in gastric cancer-derived organoids disrupts homeostatic epithelial cell turnover.
RNAi-mediated gene silencing of ST6GalNAc I suppresses the metastatic potential in gastric cancer cells.
[Significance of alpha 2,6-specific sialyltransferase ST6N and alpha 2,3-specific sialyltransferase ST3N in stomach carcinoma]
Teratocarcinoma
Inhibition of ganglioside sialyltransferase activity and stimulation of neutral glycolipid exocytosis by heparin.
Thrombasthenia
Glycoprotein-sialyltransferase activity of normal human, thrombasthenic and Bernard-Soulier platelets.
Thrombocytopenia
Role of sialic acid for platelet life span: exposure of beta-galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor-expressing liver macrophages and hepatocytes.
Sialyltransferase ST3Gal-IV operates as a dominant modifier of hemostasis by concealing asialoglycoprotein receptor ligands.
Trichinellosis
Increased sialylation as a phenomenon in accommodation of the parasitic nematode Trichinella spiralis (Owen, 1835) in skeletal muscle fibres.
Urinary Bladder Neoplasms
Development of Monoclonal Antibodies against CMP-N-Acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (ST3Gal-I) Recombinant Protein Expressed in E. coli.
Expression of sialyl-Tn sugar antigen in bladder cancer cells affects response to Bacillus Calmette Guérin (BCG) and to oxidative damage.
Oxidative damage and response to Bacillus Calmette-Guérin in bladder cancer cells expressing sialyltransferase ST3GAL1.
Sialyl Tn-expressing bladder cancer cells induce a tolerogenic phenotype in innate and adaptive immune cells.
ST3Gal.I sialyltransferase relevance in bladder cancer tissues and cell lines.
Uterine Cervical Neoplasms
Knockdown of ST6Gal-I increases cisplatin sensitivity in cervical cancer cells.
ST3Gal IV Mediates the Growth and Proliferation of Cervical Cancer Cells In Vitro and In Vivo Via the Notch/p21/CDKs Pathway.
Virus Diseases
Enzyme distributions in subcellular fractions of BHK cells infected with Semliki forest virus: evidence for a major fraction of sphingomyelin synthase in the trans-golgi network.
Inhibition of H5N1 highly pathogenic influenza virus by suppressing a specific sialyltransferase.