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Information on EC 2.4.99.27 - O-antigen polymerase Wzy

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IUBMB Comments

The Wzy-type polymerase polymerizes O antigen repeat unit oligosaccharides that are anchored to the periplasmic face of the inner membrane, forming an O antigen polysaccharide that is still anchored to the membrane. A Wzz chain length regulator (sometimes referred to as an O-antigen co-polymerase) normally interacts with Wzy to confer a distinctive modal chain length distribution. The resultant polysaccharide is transferred from the membrane anchor to the lipid A-core oligosaccharide by EC 2.4.99.26, O-antigen ligase, forming a complete lipopolysaccharide structure. There is an enormous diversity of O antigen polymerases with different specificities, reflecting the variability in the structure and composition of O-antigens.

The enzyme appears in viruses and cellular organisms
Reaction Schemes
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n
lipid-linked O-antigen repeat units
=
a lipid-linked O antigen
+
(n-1)
polyisoprenyl diphosphate
n
lipid-linked O-antigen repeat units
=
a lipid-linked O antigen
+
(n-1)
polyisoprenyl diphosphate

Synonyms
CPS polymerase, ExoJ, lipid linked oligosaccharide polymerase, MXAN_3026, O antigen polymerase, O polymerase, O polysaccharide polymerase, O-Ag polymerase, O-polymerase, O-polysaccharide polymerase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
n lipid-linked O-antigen repeat units = a lipid-linked O antigen + (n-1) polyisoprenyl diphosphate
show the reaction diagram
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