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Information on EC 2.4.99.17 - S-adenosylmethionine:tRNA ribosyltransferase-isomerase

for references in articles please use BRENDA:EC2.4.99.17

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IUBMB Comments

The reaction is a combined transfer and isomerization of the ribose moiety of S-adenosyl-L-methionine to the modified guanosine base in the wobble position in tRNAs specific for Tyr, His, Asp or Asn. It is part of the queuosine biosynthesis pathway.

The expected taxonomic range for this enzyme is: Bacteria, Archaea
Reaction Schemes
+
7-aminomethyl-7-carbaguanosine34 in tRNA
=
+
+
epoxyqueuosine34 in tRNA

Synonyms
s-adenosylmethionine:trna ribosyltransferase-isomerase, quea enzyme, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + 7-aminomethyl-7-carbaguanosine34 in tRNA = L-methionine + adenine + epoxyqueuosine34 in tRNA
show the reaction diagram
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -
Highest Expressing Human Cell Lines
Cell Line Links Gene Links