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Information on EC 2.4.99.12 - lipid IVA 3-deoxy-D-manno-octulosonic acid transferase

for references in articles please use BRENDA:EC2.4.99.12

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IUBMB Comments

The enzyme from Escherichia coli is bifunctional and transfers two 3-deoxy-D-manno-oct-2-ulosonate residues to lipid IVA (cf. EC 2.4.99.13 [(Kdo)-lipid IVA 3-deoxy-D-manno-octulosonic acid transferase]) . The monofunctional enzymes from Bordetella pertusis, Aquifex aeolicus and Haemophilus influenzae catalyse the transfer of a single 3-deoxy-D-manno-oct-2-ulosonate residue from CMP-3-deoxy-D-manno-oct-2-ulosonate to lipid IVA [2-4]. The enzymes from Chlamydia transfer three or more 3-deoxy-D-manno-oct-2-ulosonate residues and generate genus-specific epitopes .

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

Synonyms
kdo transferase, 3-deoxy-d-manno-oct-2-ulosonic acid transferase, monofunctional kdo transferase, multi-functional kdo-transferase, 3-deoxy-d-manno-octulosonic acid transferase, mono-functional kdo transferase, 3-deoxy-manno-octulosonic acid transferase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
lipid IVA + CMP-beta-Kdo = alpha-Kdo-(2->6)-lipid IVA + CMP
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
Kdo transfer to lipid IVA (Brucella), Kdo transfer to lipid IVA (E. coli), Kdo transfer to lipid IVA (generic), Kdo transfer to lipid IVA (H. pylori), Kdo transfer to lipid IVA (Haemophilus), Kdo transfer to lipid IVA (P. gingivalis), Kdo transfer to lipid IVA (P. putida), Kdo transfer to lipid IVA (Vibrio cholerae serogroup O1 El Tor)
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