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Disease on EC 2.4.99.1 - beta-galactoside alpha-(2,6)-sialyltransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
Clinical correlations of alpha2,6-sialyltransferase expression in colorectal cancer patients.
Sox2 promotes expression of the ST6Gal-I glycosyltransferase in ovarian cancer cells.
Alzheimer Disease
Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase.
Disrupted glycosylation of lipids and proteins is a cause of neurodegeneration.
The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.
Arthritis, Rheumatoid
Branch-specific sialylation of IgG-Fc glycans by ST6Gal-I.
Estrogen induces St6gal1 expression and increases IgG sialylation in mice and patients with rheumatoid arthritis: a potential explanation for the increased risk of rheumatoid arthritis in postmenopausal women.
Asthma
Sialylation of MUC4? N-glycans by ST6GAL1 orchestrates human airway epithelial cell differentiation associated with Type-2 inflammation.
Astrocytoma
Association of ST6GAL1 and CYP19A1 polymorphisms in the 3'-UTR with astrocytoma risk and prognosis in a Chinese Han population.
Atherosclerosis
ST6GAL1 negatively regulates monocyte transendothelial migration and atherosclerosis development.
beta-galactoside alpha-(2,6)-sialyltransferase deficiency
Altered eosinophil profile in mice with ST6Gal-1 deficiency: an additional role for ST6Gal-1 generated by the P1 promoter in regulating allergic inflammation.
Sweet role of platelet endothelial cell adhesion molecule in understanding angiogenesis.
Brain Neoplasms
The expression of CMP-NeuAc: Gal beta 1,4GlcNAc alpha 2,6 sialyltransferase [EC 2.4.99.1] and glycoproteins bearing alpha 2,6-linked sialic acids in human brain tumours.
The expression of Gal beta 1,4GlcNAc alpha 2,6 sialyltransferase and alpha 2,6-linked sialoglycoconjugates in human brain tumors.
Breast Neoplasms
?-Galactoside ?2,6-sialyltranferase 1 promotes transforming growth factor-?-mediated epithelial-mesenchymal transition.
An In Vivo Functional Screen Identifies ST6GalNAc2 Sialyltransferase as a Breast Cancer Metastasis Suppressor.
Mouse ST6Gal sialyltransferase gene expression during mammary gland lactation.
Multiplex reverse transcription polymerase chain reaction assessment of sialyltransferase expression in human breast cancer.
Prognostic value of tumoral sialyltransferase expression and circulating E-selectin concentrations in node-negative breast cancer patients.
Regulation of sialyltransferase expression by estradiol and 4-OH-tamoxifen in the human breast cancer cell MCF-7.
Sticking to Sugars at the Metastatic Site: Sialyltransferase ST6GalNAc2 Acts as a Breast Cancer Metastasis Suppressor.
Carcinogenesis
Downregulation of a human colonic sialyltransferase by a secondary bile acid and a phorbol ester.
miR-182 and miR-135b Mediate the Tumorigenesis and Invasiveness of Colorectal Cancer Cells via Targeting ST6GALNAC2 and PI3K/AKT Pathway.
Mouse ST6Gal sialyltransferase gene expression during mammary gland lactation.
Resveratrol Inhibits the Tumorigenesis of Follicular Thyroid Cancer via ST6GAL2-Regulated Activation of the Hippo Signaling Pathway.
Carcinoma
?-Galactoside ?2,6-sialyltranferase 1 promotes transforming growth factor-?-mediated epithelial-mesenchymal transition.
Altered mRNA expression of sialyltransferase in squamous cell carcinomas of the cervix.
Differentiation -dependent expression of human beta-galactoside alpha 2,6-sialyltransferase mRNA in colon carcinoma CaCo-2 cells.
Enhanced expression of alpha 2,6-sialyltransferase ST6Gal I in cervical squamous cell carcinoma.
Expression of sialyltransferase family members in cervix squamous cell carcinoma correlates with lymph node metastasis.
Expression of ST3Gal, ST6Gal, ST6GalNAc and ST8Sia in human hepatic carcinoma cell lines, HepG-2 and SMMC-7721 and normal hepatic cell line, L-02.
Expression patterns of ?2,3-sialyltransferase I and ?2,6-sialyltransferase I in human cutaneous epithelial lesions.
Glycosylation is an Androgen-Regulated Process Essential for Prostate Cancer Cell Viability.
Influences of two significant variants located in the ST6GAL1 3'-untranslated region on lung carcinoma susceptibility in the Chinese Han population.
Mouse ST6Gal sialyltransferase gene expression during mammary gland lactation.
Prognostic role of the sialyltransferase ST6GAL1 in ovarian cancer.
Significance of ?-Galactoside ?2,6 Sialyltranferase 1 in Cancers.
[Combinatorial effects of ST6Gal I siRNA and antisense oligonucleotide-mediated gene silence on metastasis ability of cervical carcinoma cells]
[Effect of ST6Gal I siRNA-mediated gene silencing on the adhesion and invasion of SW480 cells]
[Effects of ST6Gal I antisense oligonucleotide-mediated gene silencing on cell adhesion and invasiveness of hela cells]
[ST6Gal I siRNA and antisense oligonucleotide-mediated gene silencing lowers the metastatic potential of colonic carcinoma cells]
Carcinoma, Basal Cell
Expression patterns of ?2,3-sialyltransferase I and ?2,6-sialyltransferase I in human cutaneous epithelial lesions.
Carcinoma, Ehrlich Tumor
Cultured Ehrlich ascites tumor cells show increased N-linked alpha 2,6-sialyltransferase activity.
Carcinoma, Hepatocellular
Biosynthesis and intracellular transport of alpha-2,6-sialyltransferase in rat hepatoma cells.
Cell-specific expression of human beta-galactoside alpha 2,6-sialyltransferase transcripts differing in the 5' untranslated region.
Correlation and prognostic significance of beta-galactoside alpha-2,6-sialyltransferase and serum monosialylated alpha-fetoprotein in hepatocellular carcinoma.
Differences in CD75s- and iso-CD75s-ganglioside content and altered mRNA expression of sialyltransferases ST6GAL1 and ST3GAL6 in human hepatocellular carcinomas and nontumoral liver tissues.
Differential expression of beta-galactoside alpha2,6 sialyltransferase and sialoglycans in normal and cirrhotic liver and hepatocellular carcinoma.
Differentiation -dependent expression of human beta-galactoside alpha 2,6-sialyltransferase mRNA in colon carcinoma CaCo-2 cells.
Hepatic acute phase induction of murine beta-galactoside alpha 2,6 sialyltransferase (ST6Gal I) is IL-6 dependent and mediated by elevation of exon H-containing class of transcripts.
miR-9 inhibits the metastatic ability of hepatocellular carcinoma via targeting beta galactoside alpha-2,6-sialyltransferase 1.
Organization of the beta-galactoside alpha 2,6-sialyltransferase gene. Evidence for the transcriptional regulation of terminal glycosylation.
Regulation of expression of beta-galactoside alpha 2,6-sialyltransferase in a rat tumor, Zajdela ascitic hepatoma.
Serum and host liver activities of glycosidases and sialyltransferases in animals bearing transplantable tumors.
ST6GAL1 Is a Novel Serum Biomarker for Lenvatinib-Susceptible FGF19-Driven Hepatocellular Carcinoma.
The specific release of sialytransferase activity by human hepatoma cell lines.
Carcinoma, Squamous Cell
Altered mRNA expression of sialyltransferase in squamous cell carcinomas of the cervix.
Enhanced expression of alpha 2,6-sialyltransferase ST6Gal I in cervical squamous cell carcinoma.
Expression of sialyltransferase family members in cervix squamous cell carcinoma correlates with lymph node metastasis.
Expression patterns of ?2,3-sialyltransferase I and ?2,6-sialyltransferase I in human cutaneous epithelial lesions.
Chordoma
The expression of Gal beta 1,4GlcNAc alpha 2,6 sialyltransferase and alpha 2,6-linked sialoglycoconjugates in human brain tumors.
Colonic Neoplasms
Adhesion of ST6Gal I-mediated human colon cancer cells to fibronectin contributes to cell survival by integrin beta1-mediated paxillin and AKT activation.
alpha2,6-hyposialylation of c-Met abolishes cell motility of ST6Gal-I-knockdown HCT116 cells.
Beta-galactoside alpha2,6 sialyltransferase in human colon cancer: contribution of multiple transcripts to regulation of enzyme activity and reactivity with Sambucus nigra agglutinin.
Biosynthesis of the cancer-related sialyl-alpha 2,6-lactosaminyl epitope in colon cancer cell lines expressing beta-galactoside alpha 2,6-sialyltransferase under a constitutive promoter.
Cleavage of ST6Gal I by radiation-induced BACE1 inhibits golgi-anchored ST6Gal I-mediated sialylation of integrin ?1 and migration in colon cancer cells.
Differential expression of ST6GAL1 in the tumor progression of colorectal cancer.
Differential expression of the hepatic transcript of beta-galactoside alpha2,6-sialyltransferase in human colon cancer cell lines.
Enhanced CMP-NeuAc:Gal beta 1,4GlcNAc-R alpha 2,6 sialyltransferase activity of human colon cancer xenografts in athymic nude mice and of xenograft-derived cell lines.
Expression of beta-galactoside alpha 2,6-sialyltransferase does not alter the susceptibility of human colon cancer cells to NK-mediated cell lysis.
Human colon cancer cell lines permanently expressing alpha 2,6-sialylated sugar chains by transfection with rat beta-galactoside alpha 2,6 sialyltransferase cDNA.
Impact of sialyltransferase ST6GAL1 overexpression on different colon cancer cell types.
Involvement of ST6Gal I in the biosynthesis of a unique human colon cancer biomarker candidate, alpha2,6-sialylated blood group type 2H (ST2H) antigen.
Phenotypic changes induced by expression of beta-galactoside alpha2,6 sialyltransferase I in the human colon cancer cell line SW948.
Protein sialylation by sialyltransferase involves radiation resistance.
Suppression of a sialyltransferase by antisense DNA reduces invasiveness of human colon cancer cells in vitro.
Transcriptional regulation of human beta-galactoside alpha2,6-sialyltransferase (hST6Gal I) gene in colon adenocarcinoma cell line.
Colorectal Neoplasms
Clinical correlations of alpha2,6-sialyltransferase expression in colorectal cancer patients.
Differential expression of ST6GAL1 in the tumor progression of colorectal cancer.
Elevation of ST6Gal I activity in malignant and transitional tissue in human colorectal cancer.
Enhancement by Nano-Diamino-Tetrac of Antiproliferative Action of Gefitinib on Colorectal Cancer Cells: Mediation by EGFR Sialylation and PI3K Activation.
Inhibition of Gal beta1, 4GlcNAc alpha2,6 sialyltransferase expression by antisense-oligodeoxynucleotides.
miR-182 and miR-135b Mediate the Tumorigenesis and Invasiveness of Colorectal Cancer Cells via Targeting ST6GALNAC2 and PI3K/AKT Pathway.
Preparation and characterization of differently aggregated colorectal carcinoma cell subpopulations from surgical specimens.
Silencing of ST6Gal I enhances colorectal cancer metastasis by down-regulating KAI1 via exosome-mediated exportation and thereby rescues integrin signaling.
Synthesis and expression of CDw75 antigen in human colorectal cancer.
The expression of soluble and cell-bound alpha 2,6 sialyltransferase in human colonic carcinoma CaCo-2 cells correlates with the degree of enterocytic differentiation.
Upregulation of microRNA-135b and microRNA-182 promotes chemoresistance of colorectal cancer by targeting ST6GALNAC2 via PI3K/AKT pathway.
Craniopharyngioma
The expression of Gal beta 1,4GlcNAc alpha 2,6 sialyltransferase and alpha 2,6-linked sialoglycoconjugates in human brain tumors.
Eosinophilia
Altered eosinophil profile in mice with ST6Gal-1 deficiency: an additional role for ST6Gal-1 generated by the P1 promoter in regulating allergic inflammation.
Fatty Liver
Disruption of hepatocyte Sialylation drives a T cell-dependent pro-inflammatory immune tone.
Glioblastoma
The Role of DNA Methylation in ST6Gal1 Expression in Gliomas.
Glioma
Alpha2,6-sialylation of cell-surface N-glycans inhibits glioma formation in vivo.
alpha2,6-Sialyltransferase gene transfection into a human glioma cell line (U373 MG) results in decreased invasivity.
Focused microarray analysis of glyco-gene expression in human glioblastomas.
Overexpression of ST6GalNAcV, a ganglioside-specific alpha2,6-sialyltransferase, inhibits glioma growth in vivo.
The expression of CMP-NeuAc: Gal beta 1,4GlcNAc alpha 2,6 sialyltransferase [EC 2.4.99.1] and glycoproteins bearing alpha 2,6-linked sialic acids in human brain tumours.
The Role of DNA Methylation in ST6Gal1 Expression in Gliomas.
Transfection of 2,6 and 2,3-sialyltransferase genes and GlcNAc-transferase genes into human glioma cell line U-373 MG affects glycoconjugate expression and enhances cell death.
Glomerulonephritis, IGA
ST6Gal1 is up-regulated and associated with aberrant IgA1 glycosylation in IgA nephropathy: An integrated analysis of the transcriptome.
ST6GAL1 polymorphisms influence susceptibility and progression of IgA nephropathy in a Chinese Han population.
Study of correlation between polymorphism of ST6GALNAC2 and susceptibility to IgA nephropathy.
Variants of the ST6GALNAC2 promoter influence transcriptional activity and contribute to genetic susceptibility to IgA nephropathy.
Hepatitis C
Molecular insights into beta-galactoside alpha2,6-sialyltransferase secretion in vivo.
Infections
?2,6-linked sialic acid serves as a high-affinity receptor for cancer oncolytic virotherapy with Newcastle disease virus.
Sendai virus utilizes specific sialyloligosaccharides as host cell receptor determinants.
Systemic ST6Gal-1 Is a Pro-survival Factor for Murine Transitional B Cells.
Influenza, Human
Antiviral effects of Psidium guajava Linn. (guava) tea on the growth of clinical isolated H1N1 viruses: its role in viral hemagglutination and neuraminidase inhibition.
Effective replication of human influenza viruses in mice lacking a major alpha2,6 sialyltransferase.
Enhanced expression of an alpha2,6-linked sialic acid on MDCK cells improves isolation of human influenza viruses and evaluation of their sensitivity to a neuraminidase inhibitor.
Overexpression of the alpha-2,6-sialyltransferase in MDCK cells increases influenza virus sensitivity to neuraminidase inhibitors.
Prediction of the Pharmacodynamically-linked Variable of Oseltamivir Carboxylate for Influenza A Virus Using an In Vitro Hollow Fiber Infection Model System.
The generation of influenza-specific humoral responses is impaired in ST6Gal I-deficient mice.
Insulin Resistance
Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci.
Keratoacanthoma
Expression patterns of ?2,3-sialyltransferase I and ?2,6-sialyltransferase I in human cutaneous epithelial lesions.
Keratosis, Actinic
Expression patterns of ?2,3-sialyltransferase I and ?2,6-sialyltransferase I in human cutaneous epithelial lesions.
Kidney Failure, Chronic
Increased levels of GALbeta1-4GLCNACalpha2-6 sialyltransferase pretransplant predict delayed graft function in kidney transplant recipients.
Leukemia
Effects of inducers of differentiation on protein kinase C and CMP-N-acetylneuraminic acid:lactosylceramide sialyltransferase activities of HL-60 leukemia cells.
Lactosylceramide alpha2,3-sialyltransferase is induced via a PKC/ERK/CREB-dependent pathway in K562 human leukemia cells.
Retraction: Reversal Effect of ST6GAL 1 on Multidrug Resistance in Human Leukemia by Regulating the PI3K/Akt Pathway and the Expression of P-gp and MRP1.
Reversal effect of ST6GAL 1 on multidrug resistance in human leukemia by regulating the PI3K/Akt pathway and the expression of P-gp and MRP1.
Serum and host liver activities of glycosidases and sialyltransferases in animals bearing transplantable tumors.
Leukemia, Erythroblastic, Acute
Selective Exo-Enzymatic Labeling Detects Increased Cell Surface Sialoglycoprotein Expression upon Megakaryocytic Differentiation.
Liver Cirrhosis
Cytidine-5'-monophosphate-N-acetylneuraminic acid. Asialoglycoprotein sialic acid transferase activity in liver and serum of patients with juvenile hepatic cirrhosis and alpha-1-antitrypsin deficiency.
Liver Diseases
Disruption of hepatocyte Sialylation drives a T cell-dependent pro-inflammatory immune tone.
Down-regulation of liver Galbeta1, 4GlcNAc alpha2, 6-sialyltransferase gene by ethanol significantly correlates with alcoholic steatosis in humans.
Liver Diseases, Alcoholic
Down-regulation of liver Galbeta1, 4GlcNAc alpha2, 6-sialyltransferase gene by ethanol significantly correlates with alcoholic steatosis in humans.
Liver Neoplasms
Characterization of P1 promoter activity of the beta-galactoside alpha2,6-sialyltransferase I gene (siat 1) in cervical and hepatic cancer cell lines.
Lung Neoplasms
Influences of two significant variants located in the ST6GAL1 3'-untranslated region on lung carcinoma susceptibility in the Chinese Han population.
Modification of ?2,6-sialylation mediates the invasiveness and tumorigenicity of non-small cell lung cancer cells in vitro and in vivo via Notch1/Hes1/MMPs pathway.
Lymphatic Metastasis
Expression of sialyltransferase family members in cervix squamous cell carcinoma correlates with lymph node metastasis.
Lymphoma
Glycosylation in lymphoma: Biology and glycotherapy.
Lymphoma, Large-Cell, Anaplastic
Glycosylation in lymphoma: Biology and glycotherapy.
Medulloblastoma
The expression of Gal beta 1,4GlcNAc alpha 2,6 sialyltransferase and alpha 2,6-linked sialoglycoconjugates in human brain tumors.
Melanoma
Melanoma Cell Galectin-1 Ligands Functionally Correlate with Malignant Potential.
Meningioma
The expression of CMP-NeuAc: Gal beta 1,4GlcNAc alpha 2,6 sialyltransferase [EC 2.4.99.1] and glycoproteins bearing alpha 2,6-linked sialic acids in human brain tumours.
The expression of Gal beta 1,4GlcNAc alpha 2,6 sialyltransferase and alpha 2,6-linked sialoglycoconjugates in human brain tumors.
Mouth Neoplasms
"Aberrant sialylation plays a significant role in oral squamous cell carcinoma progression".
Tissue and serum alpha2-3- and alpha2-6-linkage specific sialylation changes in oral carcinogenesis.
Multiple Myeloma
B cells suppress medullary granulopoiesis by an extracellular glycosylation-dependent mechanism.
Neoplasm Metastasis
An In Vivo Functional Screen Identifies ST6GalNAc2 Sialyltransferase as a Breast Cancer Metastasis Suppressor.
Caveolin-1 facilitates cell migration by upregulating nuclear receptor 4A2/retinoid X receptor ?-mediated ?-galactoside ?2,6-sialyltransferase I expression in human hepatocarcinoma cells.
Expression of sialyltransferase family members in cervix squamous cell carcinoma correlates with lymph node metastasis.
Expression patterns of ?2,3-sialyltransferase I and ?2,6-sialyltransferase I in human cutaneous epithelial lesions.
Prognostic role of the sialyltransferase ST6GAL1 in ovarian cancer.
Silencing of ST6Gal I enhances colorectal cancer metastasis by down-regulating KAI1 via exosome-mediated exportation and thereby rescues integrin signaling.
ST6GAL1: A key player in cancer.
Sticking to Sugars at the Metastatic Site: Sialyltransferase ST6GalNAc2 Acts as a Breast Cancer Metastasis Suppressor.
The expression of CMP-NeuAc: Gal beta 1,4GlcNAc alpha 2,6 sialyltransferase [EC 2.4.99.1] and glycoproteins bearing alpha 2,6-linked sialic acids in human brain tumours.
The expression of Gal beta 1,4GlcNAc alpha 2,6 sialyltransferase and alpha 2,6-linked sialoglycoconjugates in human brain tumors.
Transition state-based ST6Gal I inhibitors: Mimicking the phosphodiester linkage with a triazole or carbamate through an enthalpy-entropy compensation.
[Combinatorial effects of ST6Gal I siRNA and antisense oligonucleotide-mediated gene silence on metastasis ability of cervical carcinoma cells]
Neoplasms
?-Galactoside ?2,6-sialyltranferase 1 promotes transforming growth factor-?-mediated epithelial-mesenchymal transition.
?2,3-sialyltransferase type I regulates migration and peritoneal dissemination of ovarian cancer cells.
?2,6-linked sialic acid serves as a high-affinity receptor for cancer oncolytic virotherapy with Newcastle disease virus.
A quantitative study of the Golgi retention of glycosyltransferases.
alpha 2-6-Linked sialic acids on N-glycans modulate carcinoma differentiation in vivo.
Alpha2,6-sialylation of cell-surface N-glycans inhibits glioma formation in vivo.
An In Vivo Functional Screen Identifies ST6GalNAc2 Sialyltransferase as a Breast Cancer Metastasis Suppressor.
B cells suppress medullary granulopoiesis by an extracellular glycosylation-dependent mechanism.
Binding of human plasma sialoglycoproteins by the B cell-specific lectin CD22. Selective recognition of immunoglobulin M and haptoglobin.
CD22-mediated cell adhesion to cytokine-activated human endothelial cells. Positive and negative regulation by alpha 2-6-sialylation of cellular glycoproteins.
CDw75 antigen expression in human gastric carcinoma and adjacent mucosa.
Characterization of the second type of human beta-galactoside alpha 2,6-sialyltransferase (ST6Gal II), which sialylates Galbeta 1,4GlcNAc structures on oligosaccharides preferentially. Genomic analysis of human sialyltransferase genes.
Cleavage of ST6Gal I by radiation-induced BACE1 inhibits golgi-anchored ST6Gal I-mediated sialylation of integrin ?1 and migration in colon cancer cells.
Clinical correlations of alpha2,6-sialyltransferase expression in colorectal cancer patients.
Correlation and prognostic significance of beta-galactoside alpha-2,6-sialyltransferase and serum monosialylated alpha-fetoprotein in hepatocellular carcinoma.
Correlation between Heterogeneous Expression of Sialyltransferases and MUC16 in Ovarian Tumor Tissues.
Correlation of serum, tumor, and liver serum glycoprotein: N-acetylneuraminic acid transferase activity with growth of the R3230AC mammary tumor in rats and relationship of the serum activity to tumor burden.
Cultured Ehrlich ascites tumor cells show increased N-linked alpha 2,6-sialyltransferase activity.
Differences in CD75s- and iso-CD75s-ganglioside content and altered mRNA expression of sialyltransferases ST6GAL1 and ST3GAL6 in human hepatocellular carcinomas and nontumoral liver tissues.
Differences in the isoelectric focusing patterns of gamma-glutamyl transpeptidase from normal and cancerous rat mammary tissue.
Different sialyltransferase activities in human colorectal carcinoma cells from surgical specimens detected by specific glycoprotein and glycolipid acceptors.
Differential expression of alpha2,6-sialyltransferase in colon tumors recognized by a monoclonal antibody.
Differential expression of ST6GAL1 in the tumor progression of colorectal cancer.
Elevation of ST6Gal I activity in malignant and transitional tissue in human colorectal cancer.
Enhanced expression of alpha 2,6-sialyltransferase ST6Gal I in cervical squamous cell carcinoma.
Epigenetic inactivation of ST6GAL1 in human bladder cancer.
Expression of sialyltransferase family members in cervix squamous cell carcinoma correlates with lymph node metastasis.
Expression patterns of ?2,3-sialyltransferase I and ?2,6-sialyltransferase I in human cutaneous epithelial lesions.
Extrinsic sialylation is dynamically regulated by systemic triggers in vivo.
Glyco-genes change expression in cancer through aberrant methylation.
Impact of sialyltransferase ST6GAL1 overexpression on different colon cancer cell types.
Increased alpha2,6 sialylation of N-glycans in a transgenic mouse model of hepatocellular carcinoma.
miR-182 and miR-135b Mediate the Tumorigenesis and Invasiveness of Colorectal Cancer Cells via Targeting ST6GALNAC2 and PI3K/AKT Pathway.
Multiplex reverse transcription polymerase chain reaction assessment of sialyltransferase expression in human breast cancer.
Overexpression of ST6GalNAcV, a ganglioside-specific alpha2,6-sialyltransferase, inhibits glioma growth in vivo.
Phenotypic changes induced by expression of beta-galactoside alpha2,6 sialyltransferase I in the human colon cancer cell line SW948.
Preparation and characterization of differently aggregated colorectal carcinoma cell subpopulations from surgical specimens.
Prognostic role of the sialyltransferase ST6GAL1 in ovarian cancer.
Prognostic value of tumoral sialyltransferase expression and circulating E-selectin concentrations in node-negative breast cancer patients.
Regulation of expression of beta-galactoside alpha 2,6-sialyltransferase in a rat tumor, Zajdela ascitic hepatoma.
Regulation of ST6GAL1 sialyltransferase expression in cancer cells.
Significance of ?-Galactoside ?2,6 Sialyltranferase 1 in Cancers.
Sox2 promotes expression of the ST6Gal-I glycosyltransferase in ovarian cancer cells.
ST6GAL1 Is a Novel Serum Biomarker for Lenvatinib-Susceptible FGF19-Driven Hepatocellular Carcinoma.
ST6GAL1: A key player in cancer.
Sticking to Sugars at the Metastatic Site: Sialyltransferase ST6GalNAc2 Acts as a Breast Cancer Metastasis Suppressor.
Synthesis and expression of CDw75 antigen in human colorectal cancer.
Systemic ST6Gal-1 Is a Pro-survival Factor for Murine Transitional B Cells.
The ?-galactoside ?2,6-sialyltranferase 1 (ST6GAL1) inhibits the colorectal cancer metastasis by stabilizing intercellular adhesion molecule-1 via sialylation.
The expression of CMP-NeuAc: Gal beta 1,4GlcNAc alpha 2,6 sialyltransferase [EC 2.4.99.1] and glycoproteins bearing alpha 2,6-linked sialic acids in human brain tumours.
The expression of Gal beta 1,4GlcNAc alpha 2,6 sialyltransferase and alpha 2,6-linked sialoglycoconjugates in human brain tumors.
The glycosyltransferase ST6Gal-I is enriched in cancer stem-like cells in colorectal carcinoma and contributes to their chemo-resistance.
The HOTAIR/miR-214/ST6GAL1 crosstalk modulates colorectal cancer procession through mediating sialylated c-Met via JAK2/STAT3 cascade.
The presence and clinical implications of ?-2,6-galactose-linked sialic acids in non-small-cell lung cancer brain metastases--preliminary study.
Transition state-based ST6Gal I inhibitors: Mimicking the phosphodiester linkage with a triazole or carbamate through an enthalpy-entropy compensation.
Non-alcoholic Fatty Liver Disease
Disruption of hepatocyte Sialylation drives a T cell-dependent pro-inflammatory immune tone.
Obesity
Use of a gene score of multiple low-modest effect size variants can predict the risk of obesity better than the individual SNPs.
Ovarian Neoplasms
?2,3-sialyltransferase type I regulates migration and peritoneal dissemination of ovarian cancer cells.
Altered mRNA expressions of sialyltransferases in ovarian cancers.
Correlation between Heterogeneous Expression of Sialyltransferases and MUC16 in Ovarian Tumor Tissues.
Glycoproteomic identification of potential glycoprotein biomarkers in ovarian cancer proximal fluids.
Prognostic role of the sialyltransferase ST6GAL1 in ovarian cancer.
Pneumonia
Altered eosinophil profile in mice with ST6Gal-1 deficiency: an additional role for ST6Gal-1 generated by the P1 promoter in regulating allergic inflammation.
Polycythemia Vera
[Glycoprotein sialylation and NEU1 and ST6GAL1 expressions in erythremia].
Pre-Eclampsia
Alpha 2,6-sialyltransferase I expression in the placenta of patients with preeclampsia.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
The regulatory ZFAS1/miR-150/ST6GAL1 crosstalk modulates sialylation of EGFR via PI3K/Akt pathway in T-cell acute lymphoblastic leukemia.
Pregnancy, Ectopic
Cigarette smoking alters sialylation in the Fallopian tube of women, with implications for the pathogenesis of ectopic pregnancy.
Prostatic Neoplasms
Glycosylation is a global target for androgen control in prostate cancer cells.
Sialyltransferase-Based Chemoenzymatic Histology for the Detection of N- and O-Glycans.
Proteinuria
ST6Gal1 is up-regulated and associated with aberrant IgA1 glycosylation in IgA nephropathy: An integrated analysis of the transcriptome.
Psoriasis
Identification of PTPN22, ST6GAL1 and JAZF1 as psoriasis risk genes demonstrates shared pathogenesis between psoriasis and diabetes.
Pulmonary Disease, Chronic Obstructive
Recombinant Sialyltransferase Infusion Mitigates Infection-Driven Acute Lung Inflammation.
ST6GAL1 and ?2-6 Sialylation Regulates IL-6 Expression and Secretion in Chronic Obstructive Pulmonary Disease.
Pulmonary Eosinophilia
Altered eosinophil profile in mice with ST6Gal-1 deficiency: an additional role for ST6Gal-1 generated by the P1 promoter in regulating allergic inflammation.
Renal Insufficiency
Increased levels of GALbeta1-4GLCNACalpha2-6 sialyltransferase pretransplant predict delayed graft function in kidney transplant recipients.
Retinal Degeneration
[Molecular cell glycobiology of the retina]
Sinusitis
Reduced sialylation of glycoproteins in nasal glands of patients with chronic sinusitis.
Stomach Neoplasms
Altered mRNA expressions of sialyltransferases in human gastric cancer tissues.
ST6Gal1 targets the ectodomain of ErbB2 in a site-specific manner and regulates gastric cancer cell sensitivity to trastuzumab.
Thyroid Neoplasms
Sialylation of human thyrotropin receptor improves and prolongs its cell-surface expression.
Urinary Bladder Neoplasms
Epigenetic inactivation of ST6GAL1 in human bladder cancer.
Uterine Cervical Neoplasms
Altered mRNA expression of sialyltransferase in squamous cell carcinomas of the cervix.
Expression of sialyltransferase family members in cervix squamous cell carcinoma correlates with lymph node metastasis.
Promoter Polymorphisms of ST3GAL4 and ST6GAL1 Genes and Associations with Risk of Premalignant and Malignant Lesions of the Cervix.
[Effects of ST6Gal I antisense oligonucleotide-mediated gene silencing on cell adhesion and invasiveness of hela cells]
Virus Diseases
Koala and wombat gammaherpesviruses encode the first known viral nucleoside triphosphate diphosphohydrolase (NTPDase) homologs and are phylogenetically divergent from all known gammaherpesviruses.
The generation of influenza-specific humoral responses is impaired in ST6Gal I-deficient mice.