Disease on EC 2.4.2.B16 - protein-long-chain fatty-acyl-lysine deacylase (NAD+)

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DISEASE
TITLE OF PUBLICATION
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Acne Vulgaris
Sirtuin6 inhibits c-triggered inflammation through TLR4 abrogation regulated by ROS and TRPV1/CGRP.
Acute Kidney Injury
Overexpressed SIRT6 attenuates cisplatin-induced acute kidney injury by inhibiting ERK1/2 signaling.
Sirtuin 6 overexpression relieves sepsis-induced acute kidney injury by promoting autophagy.
Acute Lung Injury
Sirtuin 6 mitigated LPS-induced human umbilical vein endothelial cells inflammatory responses through modulating nuclear factor erythroid 2-related factor 2.
Adenocarcinoma
SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b.
Adenocarcinoma of Lung
SIRT6 expression is associated with poor prognosis and chemosensitivity in patients with non-small cell lung cancer.
Adenoviridae Infections
SIRT6 Suppresses NFATc4 Expression and Activation in Cardiomyocyte Hypertrophy.
Alzheimer Disease
Emerging Roles of Sirtuin 6 in Alzheimer's Disease.
Neuroprotective Functions for the Histone Deacetylase SIRT6.
The protein-interaction network with functional roles in tumorigenesis, neurodegeneration, and aging.
Arthritis
Myeloid sirtuin 6 deficiency accelerates experimental rheumatoid arthritis by enhancing macrophage activation and infiltration into synovium.
Sirt2 suppresses inflammatory responses in collagen-induced arthritis.
Arthritis, Experimental
Overexpression of sirtuin 6 suppresses inflammatory responses and bone destruction in mice with collagen-induced arthritis.
Arthritis, Rheumatoid
Myeloid sirtuin 6 deficiency accelerates experimental rheumatoid arthritis by enhancing macrophage activation and infiltration into synovium.
SIRT6 regulates the cigarette smoke-induced signalling in rheumatoid arthritis synovial fibroblasts.
Atherosclerosis
Deletion of sirtuin 6 accelerates endothelial dysfunction and atherosclerosis in apolipoprotein E-deficient mice.
Epigenetic regulation of NKG2D ligands is involved in exacerbated atherosclerosis development in Sirt6 heterozygous mice.
ITCH modulates SIRT6 and SREBP2 to influence lipid metabolism and atherosclerosis in ApoE null mice.
SIRT6 protects against endothelial dysfunction and atherosclerosis in mice.
SIRT6 reduces macrophage foam cell formation by inducing autophagy and cholesterol efflux under ox-LDL condition.
The sirtuin family members SIRT1, SIRT3 and SIRT6: Their role in vascular biology and atherogenesis.
Bone Diseases, Metabolic
Evidence for excessive osteoclast activation in SIRT6 null mice.
Sirt6 cooperates with Blimp1 to positively regulate osteoclast differentiation.
SIRT6 deficiency culminates in low-turnover osteopenia.
Bone Resorption
Evidence for excessive osteoclast activation in SIRT6 null mice.
Phenotypic research on senile osteoporosis caused by SIRT6 deficiency.
SIRT6 deficiency culminates in low-turnover osteopenia.
Sirtuin 6 in preosteoclasts suppresses age- and estrogen deficiency-related bone loss by stabilizing estrogen receptor ?.
Sirtuin 6 suppresses hypoxia-induced inflammatory response in human osteoblasts via inhibition of reactive oxygen species production and glycolysis-A therapeutic implication in inflammatory bone resorption.
Brain Ischemia
Autophagy induction by SIRT6 is involved in oxidative stress-induced neuronal damage.
Decreased expression of sirtuin 6 is associated with release of high mobility group box-1 after cerebral ischemia.
Breast Neoplasms
CK2?/CSNK2A1 Phosphorylates SIRT6 and Is Involved in the Progression of Breast Carcinoma and Predicts Shorter Survival of Diagnosed Patients.
Downregulation of FOXO6 in breast cancer promotes epithelial-mesenchymal transition and facilitates migration and proliferation of cancer cells.
Expression of FOXM1 and related proteins in breast cancer molecular subtypes.
High-throughput screening of Sirtuin family of genes in breast cancer.
MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer.
SIRT6 modulates paclitaxel and epirubicin resistance and survival in breast cancer.
SIRT6 Recruits SNF2H to DNA Break Sites, Preventing Genomic Instability through Chromatin Remodeling.
SIRT6 Suppresses Cancer Stem-like Capacity in Tumors with PI3K Activation Independently of Its Deacetylase Activity.
Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells.
Targeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer.
The Promoter Methylation Status and mRNA Expression Levels of CTCF and SIRT6 in Sporadic Breast Cancer.
The RUNX2 Transcription Factor Negatively Regulates SIRT6 Expression to Alter Glucose Metabolism in Breast Cancer Cells.
[Function of SIRT6 in tumor initiation and progression].
Carcinogenesis
A crucial role of SUMOylation in modulating Sirt6 deacetylation of H3 at lysine 56 and its tumor suppressive activity.
A Review of the Recent Advances Made with SIRT6 and its Implications on Aging Related Processes, Major Human Diseases, and Possible Therapeutic Targets.
Downregulated SIRT6 and upregulated NMNAT2 are associated with the presence, depth and stage of colorectal cancer.
Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells.
MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer.
MiR-125b attenuates human hepatocellular carcinoma malignancy through targeting SIRT6.
Molecular Insights into the Interaction of RONS and Thieno[3,2-c]pyran Analogs with SIRT6/COX-2: A Molecular Dynamics Study.
Overexpression of Sirt6 is a novel biomarker of malignant human colon carcinoma.
Rejuvenating sirtuins: the rise of a new family of cancer drug targets.
SIRT6 deacetylates PKM2 to suppress its nuclear localization and oncogenic functions.
SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage.
SIRT6 Is a Target of Regulation by UBE3A That Contributes to Liver Tumorigenesis in an ANXA2-Dependent Manner.
SIRT6 Is Involved in the Progression of Ovarian Carcinomas via ?-Catenin-Mediated Epithelial to Mesenchymal Transition.
SIRT6 overexpression potentiates apoptosis evasion in hepatocellular carcinoma via BCL2-associated X protein-dependent apoptotic pathway.
SIRT6 promotes COX-2 expression and acts as an oncogene in skin cancer.
Sirtuin 6 inhibits colon cancer progression by modulating PTEN/AKT signaling.
The complex role of SIRT6 in carcinogenesis.
The histone deacetylase SIRT6: at the crossroads between epigenetics, metabolism and disease.
USP10 antagonizes c-Myc transcriptional activation through SIRT6 stabilization to suppress tumor formation.
[Function of SIRT6 in tumor initiation and progression].
Carcinoma
Expression and function of SIRT6 in muscle invasive urothelial carcinoma of the bladder.
Overexpression of Sirt6 is a novel biomarker of malignant human colon carcinoma.
SIRT6 expression is associated with poor prognosis and chemosensitivity in patients with non-small cell lung cancer.
SIRT6 Is Involved in the Progression of Ovarian Carcinomas via ?-Catenin-Mediated Epithelial to Mesenchymal Transition.
SIRT6 promotes COX-2 expression and acts as an oncogene in skin cancer.
Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells.
The inhibition of c-MYC transcription factor modulates the expression of glycolytic and glutaminolytic enzymes in FaDu hypopharyngeal carcinoma cells.
The potential of SIRT6 and SIRT7 as circulating markers for head and neck squamous cell carcinoma.
Carcinoma, Ductal
The Promoter Methylation Status and mRNA Expression Levels of CTCF and SIRT6 in Sporadic Breast Cancer.
Carcinoma, Hepatocellular
Coordination of FOXA2 and SIRT6 suppresses the hepatocellular carcinoma progression through ZEB2 inhibition.
Deacetylation of Ku70 by SIRT6 attenuates Bax-mediated apoptosis in hepatocellular carcinoma.
Identification of a cellularly active SIRT6 allosteric activator.
MiR-125b attenuates human hepatocellular carcinoma malignancy through targeting SIRT6.
Overexpression of SIRT6 attenuates the tumorigenicity of hepatocellular carcinoma cells.
Reciprocal Regulation between SIRT6 and miR-122 Controls Liver Metabolism and Predicts Hepatocarcinoma Prognosis.
SIRT6 deacetylates PKM2 to suppress its nuclear localization and oncogenic functions.
SIRT6 dependent genetic and epigenetic alterations are associated with poor clinical outcome in HCC patients.
SIRT6 Depletion Sensitizes Human Hepatoma Cells to Chemotherapeutics by Downregulating MDR1 Expression.
SIRT6 Depletion Suppresses Tumor Growth by Promoting Cellular Senescence Induced by DNA Damage in HCC.
SIRT6 Is a Target of Regulation by UBE3A That Contributes to Liver Tumorigenesis in an ANXA2-Dependent Manner.
SIRT6 overexpression potentiates apoptosis evasion in hepatocellular carcinoma via BCL2-associated X protein-dependent apoptotic pathway.
Sirt6 suppresses hepatocellular carcinoma cell growth via inhibiting the extracellular signal?regulated kinase signaling pathway.
Sirtuin 6 contributes to migration and invasion of osteosarcoma cells via the ERK1/2/MMP9 pathway.
Sirtuin 6 promotes transforming growth factor-?1/H2 O2 /HOCl-mediated enhancement of hepatocellular carcinoma cell tumorigenicity by suppressing cellular senescence.
The histone acetyltransferase hMOF suppresses hepatocellular carcinoma growth.
Carcinoma, Intraductal, Noninfiltrating
The Promoter Methylation Status and mRNA Expression Levels of CTCF and SIRT6 in Sporadic Breast Cancer.
Carcinoma, Non-Small-Cell Lung
Astragaloside IV sensitizes non-small cell lung cancer cells to gefitinib potentially via regulation of SIRT6.
Cyclic AMP Signaling Reduces Sirtuin 6 Expression in Non-small Cell Lung Cancer Cells by Promoting Ubiquitin-Proteasomal Degradation via Inhibition of the Raf-MEK-ERK Pathway.
Downregulation of SIRT6 is associated with poor prognosis in patients with non-small cell lung cancer.
Radiosensitization effect of overexpression of adenovirus-mediated SIRT6 on A549 non-small cell lung cancer cells.
RASSF1A and SIRT6 in non-small cell lung cancer: Relationship with clinical outcome.
SIRT6 drives epithelial-to-mesenchymal transition and metastasis in non-small cell lung cancer via snail-dependent transrepression of KLF4.
SIRT6 expression is associated with poor prognosis and chemosensitivity in patients with non-small cell lung cancer.
Sirtuin 6 contributes to migration and invasion of osteosarcoma cells via the ERK1/2/MMP9 pathway.
Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells.
Sirtuin SIRT6 suppresses cell proliferation through inhibition of Twist1 expression in non-small cell lung cancer.
Upregulation of SIRT6 predicts poor prognosis and promotes metastasis of non-small cell lung cancer via the ERK1/2/MMP9 pathway.
Carcinoma, Squamous Cell
SIRT6 promotes COX-2 expression and acts as an oncogene in skin cancer.
The potential of SIRT6 and SIRT7 as circulating markers for head and neck squamous cell carcinoma.
Cardiomegaly
Epigenetic regulation of NKG2D ligands is involved in exacerbated atherosclerosis development in Sirt6 heterozygous mice.
Nmnat2 protects cardiomyocytes from hypertrophy via activation of SIRT6.
SIRT6 suppresses isoproterenol-induced cardiac hypertrophy through activation of autophagy.
SIRT6 Suppresses NFATc4 Expression and Activation in Cardiomyocyte Hypertrophy.
SIRT6 suppresses phenylephrine-induced cardiomyocyte hypertrophy though inhibiting p300.
Sirtuin 6 protects cardiomyocytes from hypertrophy in vitro via inhibition of NF-?B-dependent transcriptional activity.
The histone deacetylase SIRT6: at the crossroads between epigenetics, metabolism and disease.
The role of sirtuins in cardiac disease.
The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun.
Cardiomyopathy, Hypertrophic
A sirtuin link between metabolism and heart disease.
Cardiovascular Diseases
Cardioprotective Effects of SIRT6 in a Mouse Model of Transverse Aortic Constriction-Induced Heart Failure.
Deletion of sirtuin 6 accelerates endothelial dysfunction and atherosclerosis in apolipoprotein E-deficient mice.
Epigenetic regulation of NKG2D ligands is involved in exacerbated atherosclerosis development in Sirt6 heterozygous mice.
Multiple pathways of SIRT6 at the crossroads in the control of longevity, cancer, and cardiovascular diseases.
Sequence Variants of SIRT6 Gene Promoter in Myocardial Infarction.
SIRT1 and SIRT6 Signaling Pathways in Cardiovascular Disease Protection.
Sirtuins and Insulin Resistance.
Colitis
Sirtuin-6 preserves R-spondin-1 expression and increases resistance of intestinal epithelium to injury in mice.
Colonic Neoplasms
Downregulation of SIRT6 by miR-34c-5p is associated with poor prognosis and promotes colon cancer proliferation through inhibiting apoptosis via the JAK2/STAT3 signaling pathway.
Epidermal growth factor receptor mediated proliferation depends on increased lipid droplet density regulated via a negative regulatory loop with FOXO3/Sirtuin6.
Overexpression of Sirt6 is a novel biomarker of malignant human colon carcinoma.
PKC? Phosphorylates SIRT6 to Mediate Fatty Acid ?-Oxidation in Colon Cancer Cells.
Sirtuin 6 inhibits colon cancer progression by modulating PTEN/AKT signaling.
USP10 antagonizes c-Myc transcriptional activation through SIRT6 stabilization to suppress tumor formation.
Colorectal Neoplasms
Downregulated SIRT6 and upregulated NMNAT2 are associated with the presence, depth and stage of colorectal cancer.
SIRT6 inhibits colorectal cancer stem cell proliferation by targeting CDC25A.
Corneal Opacity
Sirt6 deficiency impairs corneal epithelial wound healing.
Coronary Artery Disease
Two tagSNPs rs352493 and rs3760908 within SIRT6 Gene Are Associated with the Severity of Coronary Artery Disease in a Chinese Han Population.
Dengue
SIRT6 Acts as a Negative Regulator in Dengue Virus-Induced Inflammatory Response by Targeting the DNA Binding Domain of NF-?B p65.
Diabetes Mellitus
Pharmacological Sirt6 inhibition improves glucose tolerance in a type 2 diabetes mouse model.
SIRT6 expression and oxidative DNA damage in individuals with prediabetes and type 2 diabetes mellitus.
Sirtuin 6 nuclear localization at cortical brain level of young diabetic mice: An immunohistochemical study.
Sirtuins and Insulin Resistance.
Diabetes Mellitus, Type 2
Ergothioneine oxidation in the protection against high-glucose induced endothelial senescence: Involvement of SIRT1 and SIRT6.
Fluvastatin activates sirtuin 6 to regulate sterol regulatory element-binding proteins and AMP-activated protein kinase in HepG2 cells.
Pharmacological Sirt6 inhibition improves glucose tolerance in a type 2 diabetes mouse model.
SIRT6 expression and oxidative DNA damage in individuals with prediabetes and type 2 diabetes mellitus.
Sirtuin 6, a possible therapeutic target for type 2 diabetes.
Sirtuins and Insulin Resistance.
Diabetic Nephropathies
Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling.
Diabetic Retinopathy
Epigenetic control of early neurodegenerative events in diabetic retinopathy by the histone deacetylase SIRT6.
Oxidative stress induces endothelial cell senescence via downregulation of Sirt6.
Endometrial Neoplasms
Molecular markers of endometrial carcinoma detected in uterine aspirates.
Putative tumor suppression function of SIRT6 in endometrial cancer.
Esophageal Neoplasms
Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells.
Fatty Liver
Fluvastatin activates sirtuin 6 to regulate sterol regulatory element-binding proteins and AMP-activated protein kinase in HepG2 cells.
Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis.
Sirtuins and Insulin Resistance.
The Role of Sirt6 in Obesity and Diabetes.
Fetal Death
An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality.
Fetal Diseases
High glucose-induced oxidative stress represses sirtuin deacetylase expression and increases histone acetylation leading to neural tube defects.
Glioblastoma
SIRT6 suppresses glioma cell growth via induction of apoptosis, inhibition of oxidative stress and suppression of JAK2/STAT3 signaling pathway activation.
Glioma
Histone deacetylase SIRT6 inhibits glioma cell growth through down-regulating NOTCH3 expression.
Mammalian target of rapamycin complex 2 (mTORC2) controls glycolytic gene expression by regulating Histone H3 Lysine 56 acetylation.
SIRT6 suppresses glioma cell growth via induction of apoptosis, inhibition of oxidative stress and suppression of JAK2/STAT3 signaling pathway activation.
Suppression of SIRT6 by miR-33a facilitates tumor growth of glioma through apoptosis and oxidative stress resistance.
The histone deacetylase SIRT6 suppresses the expression of the RNA-binding protein PCBP2 in glioma.
Glucose Intolerance
Deletion of Hepatic FoxO1/3/4 Genes in Mice Significantly Impacts on Glucose Metabolism through Downregulation of Gluconeogenesis and Upregulation of Glycolysis.
SIRT6-mediated transcriptional suppression of Txnip is critical for pancreatic beta cell function and survival in mice.
Heart Diseases
A Review of the Recent Advances Made with SIRT6 and its Implications on Aging Related Processes, Major Human Diseases, and Possible Therapeutic Targets.
Chromatin and beyond: the multitasking roles for SIRT6.
Multiple pathways of SIRT6 at the crossroads in the control of longevity, cancer, and cardiovascular diseases.
SIRT1 and SIRT6 Signaling Pathways in Cardiovascular Disease Protection.
The sirtuin 6 prevents angiotensin II-mediated myocardial fibrosis and injury by targeting AMPK-ACE2 signaling.
Heart Failure
A sirtuin link between metabolism and heart disease.
Cardioprotective Effects of SIRT6 in a Mouse Model of Transverse Aortic Constriction-Induced Heart Failure.
Epigenetic regulation of NKG2D ligands is involved in exacerbated atherosclerosis development in Sirt6 heterozygous mice.
The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun.
Hematologic Neoplasms
Expression Levels of Warburg-Effect Related microRNAs Correlate with each Other and that of Histone Deacetylase Enzymes in Adult Hematological Malignancies with Emphasis on Acute Myeloid Leukemia.
Strong Correlation between the Expression Levels of HDAC4 and SIRT6 in Hematological Malignancies of the Adults.
Hodgkin Disease
Low Rap1-interacting factor 1 and sirtuin 6 expression predict poor outcome in radiotherapy-treated Hodgkin lymphoma patients.
Hypercholesterolemia
Fluvastatin activates sirtuin 6 to regulate sterol regulatory element-binding proteins and AMP-activated protein kinase in HepG2 cells.
Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6.
Hyperglycemia
Effects of hyperglycemia and aging on nuclear sirtuins and DNA damage of mouse hepatocytes.
Hypersensitivity
SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair.
Hypertrophy, Left Ventricular
Protective effects of sirtuins in cardiovascular diseases: from bench to bedside.
Hypoglycemia
Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity.
SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice.
SIRT6 dependent genetic and epigenetic alterations are associated with poor clinical outcome in HCC patients.
The Role of Sirt6 in Obesity and Diabetes.
Idiopathic Pulmonary Fibrosis
Sirtuin 6 inhibits epithelial to mesenchymal transition during idiopathic pulmonary fibrosis via inactivating TGF-?1/Smad3 signaling.
Sirtuin 6 inhibits myofibroblast differentiation via inactivating transforming growth factor-?1/Smad2 and nuclear factor-?B signaling pathways in human fetal lung fibroblasts.
Infarction, Middle Cerebral Artery
Decreased expression of sirtuin 6 is associated with release of high mobility group box-1 after cerebral ischemia.
Infection
SIRT6 Acts as a Negative Regulator in Dengue Virus-Induced Inflammatory Response by Targeting the DNA Binding Domain of NF-?B p65.
Sirtuin 6 Attenuates Kaposi's Sarcoma-associated herpesvirus (KSHV) Reactivation via Suppressing the Ori-Lyt Activity and Expression of RTA.
Infertility
SIRT6 in mouse spermatogenesis is modulated by diet-induced obesity.
Insulin Resistance
Distinctive Roles of Sirtuins on Diabetes, Protective or Detrimental?
Enhanced insulin sensitivity in skeletal muscle and liver by physiological overexpression of SIRT6.
Fabp4-Cre-mediated Sirt6 deletion impairs adipose tissue function and metabolic homeostasis in mice.
Fat-Specific Sirt6 Ablation Sensitizes Mice to High-Fat Diet-Induced Obesity and Insulin Resistance by Inhibiting Lipolysis.
Myeloid Sirtuin 6 Deficiency Causes Insulin Resistance in High-Fat Diet-Fed Mice by Eliciting Macrophage Polarization Toward an M1 Phenotype.
SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice.
SIRT6 regulates metabolic homeostasis in skeletal muscle through activation of AMPK.
Sirtuins and Insulin Resistance.
The Role of Sirt6 in Obesity and Diabetes.
Ubiquitin-Specific Peptidase 10 (USP10) Inhibits Hepatic Steatosis, Insulin Resistance, and Inflammation Through Sirt6.
Intervertebral Disc Degeneration
Sirt6 overexpression suppresses senescence and apoptosis of nucleus pulposus cells by inducing autophagy in a model of intervertebral disc degeneration.
Sirtuin 6 prevents matrix degradation through inhibition of the NF-?B pathway in intervertebral disc degeneration.
Kidney Diseases
Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling.
Sirtuins in Renal Health and Disease.
Leukemia
Chromosomal organization and fluorescence in situ hybridization of the human Sirtuin 6 gene.
Expression Levels of Warburg-Effect Related microRNAs Correlate with each Other and that of Histone Deacetylase Enzymes in Adult Hematological Malignancies with Emphasis on Acute Myeloid Leukemia.
Strong Correlation between the Expression Levels of HDAC4 and SIRT6 in Hematological Malignancies of the Adults.
Leukemia, Myeloid, Acute
Depletion of SIRT6 enzymatic activity increases acute myeloid leukemia cells' vulnerability to DNA-damaging agents.
MYC upregulated LINC00319 promotes human acute myeloid leukemia (AML) cells growth through stabilizing SIRT6.
Liver Diseases
A Review of the Recent Advances Made with SIRT6 and its Implications on Aging Related Processes, Major Human Diseases, and Possible Therapeutic Targets.
Fluvastatin activates sirtuin 6 to regulate sterol regulatory element-binding proteins and AMP-activated protein kinase in HepG2 cells.
Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis.
Oxidative Stress Induced by Excess of Adiposity Is Related to a Downregulation of Hepatic SIRT6 Expression in Obese Individuals.
SIRT6 dependent genetic and epigenetic alterations are associated with poor clinical outcome in HCC patients.
Sirtuins and Insulin Resistance.
The histone deacetylase SIRT6: at the crossroads between epigenetics, metabolism and disease.
Liver Neoplasms
Histone deacetylase SIRT6 regulates chemosensitivity in liver cancer cells via modulation of FOXO3 activity.
SIRT6 dependent genetic and epigenetic alterations are associated with poor clinical outcome in HCC patients.
SIRT6 Depletion Suppresses Tumor Growth by Promoting Cellular Senescence Induced by DNA Damage in HCC.
SIRT6 overexpression potentiates apoptosis evasion in hepatocellular carcinoma via BCL2-associated X protein-dependent apoptotic pathway.
[Function of SIRT6 in tumor initiation and progression].
Lung Neoplasms
Astragaloside IV sensitizes non-small cell lung cancer cells to gefitinib potentially via regulation of SIRT6.
Cyclic AMP Signaling Reduces Sirtuin 6 Expression in Non-small Cell Lung Cancer Cells by Promoting Ubiquitin-Proteasomal Degradation via Inhibition of the Raf-MEK-ERK Pathway.
Downregulation of SIRT6 is associated with poor prognosis in patients with non-small cell lung cancer.
MicroRNA-186 suppresses lung cancer progression by targeting SIRT6.
Radiosensitization effect of overexpression of adenovirus-mediated SIRT6 on A549 non-small cell lung cancer cells.
RASSF1A and SIRT6 in non-small cell lung cancer: Relationship with clinical outcome.
SIRT6 drives epithelial-to-mesenchymal transition and metastasis in non-small cell lung cancer via snail-dependent transrepression of KLF4.
SIRT6 expression is associated with poor prognosis and chemosensitivity in patients with non-small cell lung cancer.
Sirtuin 6 contributes to migration and invasion of osteosarcoma cells via the ERK1/2/MMP9 pathway.
Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells.
Sirtuin SIRT6 suppresses cell proliferation through inhibition of Twist1 expression in non-small cell lung cancer.
Upregulation of SIRT6 predicts poor prognosis and promotes metastasis of non-small cell lung cancer via the ERK1/2/MMP9 pathway.
[Function of SIRT6 in tumor initiation and progression].
Lymphoma, B-Cell
Sirtuin 6 protects the heart from hypoxic damage.
Malaria
Sir2a regulates rDNA transcription and multiplication rate in the human malaria parasite Plasmodium falciparum.
Melanoma
Aberrant SIRT6 expression contributes to melanoma growth: Role of the autophagy paradox and IGF-AKT signaling.
SIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK inhibitors via IGF signalling.
SIRT6 histone deacetylase functions as a potential oncogene in human melanoma.
Metabolic Diseases
Fluvastatin activates sirtuin 6 to regulate sterol regulatory element-binding proteins and AMP-activated protein kinase in HepG2 cells.
Hepatocyte-specific Sirt6 deficiency impairs ketogenesis.
SIRT6 protects against pathological damage caused by diet-induced obesity.
SIRT6: Novel Mechanisms and Links to Aging and Disease.
Sirtuin 6, a possible therapeutic target for type 2 diabetes.
The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha.
Metabolic Syndrome
Oxidative Stress Induced by Excess of Adiposity Is Related to a Downregulation of Hepatic SIRT6 Expression in Obese Individuals.
Pivotal role of Sirt6 in the crosstalk among ageing, metabolic syndrome and osteoarthritis.
SIRT6 protects against pathological damage caused by diet-induced obesity.
Multiple Myeloma
Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells.
Muscular Atrophy
The histone deacetylase SIRT6 blocks myostatin expression and development of muscle atrophy.
Myocardial Infarction
Sequence Variants of SIRT6 Gene Promoter in Myocardial Infarction.
Nasal Polyps
Glycyrrhetinic acid suppressed hmgb1 release by up-regulation of Sirt6 in nasal inflammation.
Sirtuin 6 modulates hypoxia-induced autophagy in nasal polyp fibroblasts via inhibition of glycolysis.
Nasopharyngeal Carcinoma
SIRT6 overexpression induces apoptosis of nasopharyngeal carcinoma by inhibiting NF-?B signaling.
Neoplasm Metastasis
Downregulated SIRT6 and upregulated NMNAT2 are associated with the presence, depth and stage of colorectal cancer.
Downregulation of FOXO6 in breast cancer promotes epithelial-mesenchymal transition and facilitates migration and proliferation of cancer cells.
Downregulation of SIRT6 is associated with poor prognosis in patients with non-small cell lung cancer.
Overexpression of Sirt6 is a novel biomarker of malignant human colon carcinoma.
RASSF1A and SIRT6 in non-small cell lung cancer: Relationship with clinical outcome.
SIRT6 drives epithelial-to-mesenchymal transition and metastasis in non-small cell lung cancer via snail-dependent transrepression of KLF4.
SIRT6 is upregulated and associated with cancer aggressiveness in papillary thyroid cancer via BRAF/ERK/Mcl?1 pathway.
SIRT6 Loss Promotes PDAC Progression by Epigenetic Induction of LIN28B.
SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b.
Sirtuin 6 contributes to migration and invasion of osteosarcoma cells via the ERK1/2/MMP9 pathway.
The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses.
Upregulation of SIRT6 predicts poor prognosis and promotes metastasis of non-small cell lung cancer via the ERK1/2/MMP9 pathway.
Neoplasms
A Chemical Biology Approach to Reveal Sirt6-targeted Histone H3 Sites in Nucleosomes.
A crucial role of SUMOylation in modulating Sirt6 deacetylation of H3 at lysine 56 and its tumor suppressive activity.
A miR-34a-SIRT6 axis in the squamous cell differentiation network.
A Review of the Recent Advances Made with SIRT6 and its Implications on Aging Related Processes, Major Human Diseases, and Possible Therapeutic Targets.
Aberrant SIRT6 expression contributes to melanoma growth: Role of the autophagy paradox and IGF-AKT signaling.
Astragaloside IV sensitizes non-small cell lung cancer cells to gefitinib potentially via regulation of SIRT6.
Biochemical characterization of sirtuin 6 in the brain and its involvement in oxidative stress response.
C. elegans sirtuin SIR-2.4 and its mammalian homolog SIRT6 in stress response.
Chromatin and beyond: the multitasking roles for SIRT6.
CK2?/CSNK2A1 Phosphorylates SIRT6 and Is Involved in the Progression of Breast Carcinoma and Predicts Shorter Survival of Diagnosed Patients.
Decreased expression of SIRT6 promotes tumor cell growth correlates closely with poor prognosis of ovarian cancer.
Differential expression of the sirtuin family in renal cell carcinoma: Aspects of carcinogenesis and prognostic significance.
Discovery of novel and selective SIRT6 inhibitors.
Downregulated SIRT6 and upregulated NMNAT2 are associated with the presence, depth and stage of colorectal cancer.
Downregulation of FOXO6 in breast cancer promotes epithelial-mesenchymal transition and facilitates migration and proliferation of cancer cells.
Downregulation of SIRT6 is associated with poor prognosis in patients with non-small cell lung cancer.
E2F1 enhances glycolysis through suppressing Sirt6 transcription in cancer cells.
Epigenetic regulation of NKG2D ligands is involved in exacerbated atherosclerosis development in Sirt6 heterozygous mice.
Expression and function of SIRT6 in muscle invasive urothelial carcinoma of the bladder.
Expression of SIRT2 and SIRT6 in retinoblastoma.
Expression of sirtuins 1, 6, tumor necrosis factor, and interferon-? in psoriatic patients.
Fluvastatin activates sirtuin 6 to regulate sterol regulatory element-binding proteins and AMP-activated protein kinase in HepG2 cells.
Glycyrrhetinic acid suppressed hmgb1 release by up-regulation of Sirt6 in nasal inflammation.
Identification of a cellularly active SIRT6 allosteric activator.
Identification of and Molecular Basis for SIRT6 Loss-of-Function Point Mutations in Cancer.
Inhibition of SIRT6 in prostate cancer reduces cell viability and increases sensitivity to chemotherapeutics.
Interplay between sirtuins, MYC and hypoxia-inducible factor in cancer-associated metabolic reprogramming.
Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin.
MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer.
MicroRNA-186 suppresses lung cancer progression by targeting SIRT6.
MiR-125b attenuates human hepatocellular carcinoma malignancy through targeting SIRT6.
Molecular Insights into the Interaction of RONS and Thieno[3,2-c]pyran Analogs with SIRT6/COX-2: A Molecular Dynamics Study.
Multiple pathways of SIRT6 at the crossroads in the control of longevity, cancer, and cardiovascular diseases.
Multiple Regulatory Layers of SREBP1/2 by SIRT6.
Neuroblastoma cells undergo transcriptomic alterations upon dissemination into the bone marrow and subsequent tumor progression.
Overexpression of Sirt6 is a novel biomarker of malignant human colon carcinoma.
Oxidative Stress Induced by Excess of Adiposity Is Related to a Downregulation of Hepatic SIRT6 Expression in Obese Individuals.
Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells.
Pharmacological Sirt6 inhibition improves glucose tolerance in a type 2 diabetes mouse model.
PKC? Phosphorylates SIRT6 to Mediate Fatty Acid ?-Oxidation in Colon Cancer Cells.
Proteomic analysis of the SIRT6 interactome: novel links to genome maintenance and cellular stress signaling.
Putative tumor suppression function of SIRT6 in endometrial cancer.
Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics.
RASSF1A and SIRT6 in non-small cell lung cancer: Relationship with clinical outcome.
Rejuvenating sirtuins: the rise of a new family of cancer drug targets.
Scientometric Analysis of SIRT6 Studies.
SIRT6 deacetylase activity regulates NAMPT activity and NAD(P)(H) pools in cancer cells.
SIRT6 dependent genetic and epigenetic alterations are associated with poor clinical outcome in HCC patients.
SIRT6 Depletion Suppresses Tumor Growth by Promoting Cellular Senescence Induced by DNA Damage in HCC.
SIRT6 expression is associated with poor prognosis and chemosensitivity in patients with non-small cell lung cancer.
SIRT6 inhibits growth of gastric cancer by inhibiting JAK2/STAT3 pathway.
SIRT6 inhibits proliferation and invasion in osteosarcoma cells by targeting N-cadherin.
SIRT6 inhibits TNF-?-induced inflammation of vascular adventitial fibroblasts through ROS and Akt signaling pathway.
SIRT6 Is Involved in the Progression of Ovarian Carcinomas via ?-Catenin-Mediated Epithelial to Mesenchymal Transition.
SIRT6 is upregulated and associated with cancer aggressiveness in papillary thyroid cancer via BRAF/ERK/Mcl?1 pathway.
SIRT6 modulates paclitaxel and epirubicin resistance and survival in breast cancer.
SIRT6 overexpression induces apoptosis of nasopharyngeal carcinoma by inhibiting NF-?B signaling.
SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells.
SIRT6 overexpression potentiates apoptosis evasion in hepatocellular carcinoma via BCL2-associated X protein-dependent apoptotic pathway.
SIRT6 promotes COX-2 expression and acts as an oncogene in skin cancer.
SIRT6 puts cancer metabolism in the driver's seat.
SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation.
SIRT6 regulates the cigarette smoke-induced signalling in rheumatoid arthritis synovial fibroblasts.
SIRT6 regulates TNF-? secretion through hydrolysis of long-chain fatty acyl lysine.
SIRT6 Suppresses Cancer Stem-like Capacity in Tumors with PI3K Activation Independently of Its Deacetylase Activity.
SIRT6 suppresses glioma cell growth via induction of apoptosis, inhibition of oxidative stress and suppression of JAK2/STAT3 signaling pathway activation.
Sirt6 suppresses hepatocellular carcinoma cell growth via inhibiting the extracellular signal?regulated kinase signaling pathway.
SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b.
SIRT6: A master epigenetic gatekeeper of glucose metabolism.
SIRT6: A Promising Target for Cancer Prevention and Therapy.
SIRT6: Novel Mechanisms and Links to Aging and Disease.
Sirtuin 6 Attenuates Kaposi's Sarcoma-associated herpesvirus (KSHV) Reactivation via Suppressing the Ori-Lyt Activity and Expression of RTA.
Sirtuin 6 contributes to migration and invasion of osteosarcoma cells via the ERK1/2/MMP9 pathway.
Sirtuin 6 inhibits colon cancer progression by modulating PTEN/AKT signaling.
Sirtuin 6 inhibits epithelial to mesenchymal transition during idiopathic pulmonary fibrosis via inactivating TGF-?1/Smad3 signaling.
Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells.
Sirtuin 6 promotes transforming growth factor-?1/H2 O2 /HOCl-mediated enhancement of hepatocellular carcinoma cell tumorigenicity by suppressing cellular senescence.
Sirtuin 6, a possible therapeutic target for type 2 diabetes.
Sirtuin SIRT6 suppresses cell proliferation through inhibition of Twist1 expression in non-small cell lung cancer.
Sirtuin-6 deficiency exacerbates diabetes-induced impairment of wound healing.
Stem Cells and Progenitors in Human Peripheral Blood Get Activated by Extremely Active Resveratrol (XAR™).
Suppression of SIRT6 by miR-33a facilitates tumor growth of glioma through apoptosis and oxidative stress resistance.
Targeting aberrant cancer metabolism - The role of sirtuins.
The complex role of SIRT6 in carcinogenesis.
The dual role of sirtuins in cancer.
The expression levels of the sirtuins in patients with BCC.
The histone deacetylase SIRT6 blocks myostatin expression and development of muscle atrophy.
The histone deacetylase SIRT6 inhibits ovarian cancer cell proliferation via down-regulation of Notch 3 expression.
The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism.
The histone deacetylase SIRT6 suppresses the expression of the RNA-binding protein PCBP2 in glioma.
The histone deacetylase SIRT6: at the crossroads between epigenetics, metabolism and disease.
The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses.
The Promoter Methylation Status and mRNA Expression Levels of CTCF and SIRT6 in Sporadic Breast Cancer.
The role of SIRT6 in tumors.
The RUNX2 Transcription Factor Negatively Regulates SIRT6 Expression to Alter Glucose Metabolism in Breast Cancer Cells.
Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion.
Upregulation of SIRT6 predicts poor prognosis and promotes metastasis of non-small cell lung cancer via the ERK1/2/MMP9 pathway.
USP10 antagonizes c-Myc transcriptional activation through SIRT6 stabilization to suppress tumor formation.
[Effects of SIRT6 in cardiovascular, cancer and metabolic diseases].
[Function of SIRT6 in tumor initiation and progression].
Neuroblastoma
Inhibition of Sirtuin 6 Induces Neuroblastoma Differentiation.
Sirtuin 6 protects the brain from cerebral ischemia/reperfusion injury through NRF2 activation.
Neurodegenerative Diseases
A Review of the Recent Advances Made with SIRT6 and its Implications on Aging Related Processes, Major Human Diseases, and Possible Therapeutic Targets.
Nevus, Pigmented
Aberrant SIRT6 expression contributes to melanoma growth: Role of the autophagy paradox and IGF-AKT signaling.
Non-alcoholic Fatty Liver Disease
Hepatocyte-specific sirtuin 6 deletion predisposes to nonalcoholic steatohepatitis by up-regulation of Bach1, an Nrf2 repressor.
Obesity
Altered levels of sirtuin genes (SIRT1, SIRT2, SIRT3 and SIRT6) and their target genes in adipose tissue from individual with obesity.
Chromatin and beyond: the multitasking roles for SIRT6.
Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat.
Enhanced insulin sensitivity in skeletal muscle and liver by physiological overexpression of SIRT6.
Fat-Specific Sirt6 Ablation Sensitizes Mice to High-Fat Diet-Induced Obesity and Insulin Resistance by Inhibiting Lipolysis.
Multiple Regulatory Layers of SREBP1/2 by SIRT6.
Myeloid Sirtuin 6 Deficiency Causes Insulin Resistance in High-Fat Diet-Fed Mice by Eliciting Macrophage Polarization Toward an M1 Phenotype.
Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity.
Oxidative Stress Induced by Excess of Adiposity Is Related to a Downregulation of Hepatic SIRT6 Expression in Obese Individuals.
Pivotal role of Sirt6 in the crosstalk among ageing, metabolic syndrome and osteoarthritis.
Reciprocal Regulation between SIRT6 and miR-122 Controls Liver Metabolism and Predicts Hepatocarcinoma Prognosis.
SIRT6 in mouse spermatogenesis is modulated by diet-induced obesity.
SIRT6 Is Essential for Adipocyte Differentiation by Regulating Mitotic Clonal Expansion.
SIRT6 protects against pathological damage caused by diet-induced obesity.
Sirtuin 6, a possible therapeutic target for type 2 diabetes.
Sirtuins and Insulin Resistance.
The complex role of SIRT6 in carcinogenesis.
The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha.
The Role of Sirt6 in Obesity and Diabetes.
Two tagSNPs rs352493 and rs3760908 within SIRT6 Gene Are Associated with the Severity of Coronary Artery Disease in a Chinese Han Population.
Obstetric Labor, Premature
SIRT6 is decreased with preterm labor and regulates key terminal effector pathways of human labor in fetal membranes.
Osteoarthritis
Myeloid sirtuin 6 deficiency accelerates experimental rheumatoid arthritis by enhancing macrophage activation and infiltration into synovium.
Osteoarthritis: SIRT6 prevents chondrocyte senescence and DNA damage.
Overexpression of Sirtuin 6 suppresses cellular senescence and NF-?B mediated inflammatory responses in osteoarthritis development.
Pivotal role of Sirt6 in the crosstalk among ageing, metabolic syndrome and osteoarthritis.
Osteoporosis
Phenotypic research on senile osteoporosis caused by SIRT6 deficiency.
SIRT6 deficiency culminates in low-turnover osteopenia.
Sirtuin 6 in preosteoclasts suppresses age- and estrogen deficiency-related bone loss by stabilizing estrogen receptor ?.
Osteosarcoma
FOXN3 is downregulated in osteosarcoma and transcriptionally regulates SIRT6, and suppresses migration and invasion in osteosarcoma.
SIRT6 inhibits proliferation and invasion in osteosarcoma cells by targeting N-cadherin.
Sirtuin 6 contributes to migration and invasion of osteosarcoma cells via the ERK1/2/MMP9 pathway.
Ovarian Neoplasms
Decreased expression of SIRT6 promotes tumor cell growth correlates closely with poor prognosis of ovarian cancer.
SIRT6 Is Involved in the Progression of Ovarian Carcinomas via ?-Catenin-Mediated Epithelial to Mesenchymal Transition.
The histone deacetylase SIRT6 inhibits ovarian cancer cell proliferation via down-regulation of Notch 3 expression.
Overnutrition
The Role of Sirt6 in Obesity and Diabetes.
Pancreatic Neoplasms
Epigenomic therapies: the potential of targeting SIRT6 for the treatment of pancreatic cancer.
SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b.
The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses.
Paralysis
The Oxidative State of Cysteine Thiol 144 Regulates the SIRT6 Glucose Homeostat.
Parkinson Disease
Nicotine promotes neuron survival and partially protects from Parkinson's disease by suppressing SIRT6.
Periapical Periodontitis
Sirtuin 6 attenuates periapical lesion propagation by modulating hypoxia-induced chemokine (C-C motif) ligand 2 production in osteoblasts.
Prediabetic State
SIRT6 expression and oxidative DNA damage in individuals with prediabetes and type 2 diabetes mellitus.
Progeria
Restoring SIRT6 Expression in Hutchinson-Gilford Progeria Syndrome Cells Impedes Premature Senescence and Formation of Dysmorphic Nuclei.
Prostatic Neoplasms
Inhibition of SIRT6 in prostate cancer reduces cell viability and increases sensitivity to chemotherapeutics.
Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
A sirtuin link between metabolism and heart disease.
Characterization of physiological defects in adult SIRT6-/- mice.
Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat.
Epigenetic control of early neurodegenerative events in diabetic retinopathy by the histone deacetylase SIRT6.
FoxO3 transcription factor and Sirt6 deacetylase regulate LDL-cholesterol homeostasis via control of the proprotein convertase subtilisin/kexin type 9 (Pcsk9) gene expression.
Hepatocyte-specific Sirt6 deficiency impairs ketogenesis.
Lamin A Is an Endogenous SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair.
Myeloid sirtuin 6 deficiency accelerates experimental rheumatoid arthritis by enhancing macrophage activation and infiltration into synovium.
Myeloid Sirtuin 6 Deficiency Causes Insulin Resistance in High-Fat Diet-Fed Mice by Eliciting Macrophage Polarization Toward an M1 Phenotype.
Phenotypic research on senile osteoporosis caused by SIRT6 deficiency.
Progression of chronic liver inflammation and fibrosis driven by activation of c-JUN signaling in Sirt6 mutant mice.
SIRT6 deficiency culminates in low-turnover osteopenia.
Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling.
Sirt6 deficiency impairs corneal epithelial wound healing.
SIRT6 deficiency results in developmental retardation in cynomolgus monkeys.
Sirt6 deficiency results in progression of glomerular injury in the kidney.
SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice.
SIRT6 Is Essential for Adipocyte Differentiation by Regulating Mitotic Clonal Expansion.
SIRT6 is required for normal retinal function.
SIRT6 regulates metabolic homeostasis in skeletal muscle through activation of AMPK.
SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2.
SIRT6 Suppresses NFATc4 Expression and Activation in Cardiomyocyte Hypertrophy.
SIRT6-mediated transcriptional suppression of Txnip is critical for pancreatic beta cell function and survival in mice.
Sirtuin-6 deficiency exacerbates diabetes-induced impairment of wound healing.
The histone deacetylase SIRT6: at the crossroads between epigenetics, metabolism and disease.
The Role of Sirt6 in Obesity and Diabetes.
Ubiquitin-Specific Peptidase 10 (USP10) Inhibits Hepatic Steatosis, Insulin Resistance, and Inflammation Through Sirt6.
Proteinuria
Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling.
Sirt6 deficiency results in progression of glomerular injury in the kidney.
Psoriasis
Expression of sirtuins 1, 6, tumor necrosis factor, and interferon-? in psoriatic patients.
Pulmonary Disease, Chronic Obstructive
Autophagy induction by SIRT6 through attenuation of insulin-like growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence.
Oxidative stress dependent microRNA-34a activation via PI3K? reduces the expression of sirtuin-1 and sirtuin-6 in epithelial cells.
Role of sirtuins in chronic obstructive pulmonary disease.
Pulpitis
Protective effects of SIRT6 against lipopolysaccharide (LPS) are mediated by deacetylation of Ku70.
SIRT6 protects against lipopolysaccharide (LPS)-induced apoptosis in human dental pulp cells by deacetylation of Ku70.
Rectal Neoplasms
SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage.
Renal Insufficiency
Calorie Restriction-induced SIRT6 Activation Delays Aging by Suppressing NF-?B Signaling.
Retinal Degeneration
Reprogramming metabolism by targeting sirtuin 6 attenuates retinal degeneration.
Role of Sirtuins in Retinal Function Under Basal Conditions.
Retinoblastoma
Expression of SIRT2 and SIRT6 in retinoblastoma.
Sepsis
Cysteine thiol oxidation on SIRT2 regulates inflammation in obese mice with sepsis.
Sequential actions of SIRT1-RELB-SIRT3 coordinate nuclear-mitochondrial communication during immunometabolic adaptation to acute inflammation and sepsis.
Sirtuin 6 overexpression relieves sepsis-induced acute kidney injury by promoting autophagy.
The Oxidative State of Cysteine Thiol 144 Regulates the SIRT6 Glucose Homeostat.
Skin Neoplasms
Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics.
SIRT6 promotes COX-2 expression and acts as an oncogene in skin cancer.
Squamous Cell Carcinoma of Head and Neck
The potential of SIRT6 and SIRT7 as circulating markers for head and neck squamous cell carcinoma.
Starvation
SIRT6 knockout cells resist apoptosis initiation but not progression: a computational method to evaluate the progression of apoptosis.
Stomach Neoplasms
Association of sirtuins with clinicopathological parameters and overall survival in gastric cancer.
SIRT6 inhibits growth of gastric cancer by inhibiting JAK2/STAT3 pathway.
Stroke
Sirtuin 6 protects the brain from cerebral ischemia/reperfusion injury through NRF2 activation.
Thyroid Cancer, Papillary
SIRT6 is upregulated and associated with cancer aggressiveness in papillary thyroid cancer via BRAF/ERK/Mcl?1 pathway.
SIRT6/HIF-1? axis promotes papillary thyroid cancer progression by inducing epithelial-mesenchymal transition.
Triple Negative Breast Neoplasms
Expression of FOXM1 and related proteins in breast cancer molecular subtypes.
Tuberculosis
Studies on the binding of modest modulators of the human enzyme, Sirtuin 6, using STD-NMR.
Urinary Bladder Neoplasms
Expression and function of SIRT6 in muscle invasive urothelial carcinoma of the bladder.
Vascular Diseases
Anti-inflammatory properties of sirtuin 6 in human umbilical vein endothelial cells.
Werner Syndrome
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin.