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Synonyms
hprt, hgprt, hypoxanthine-guanine phosphoribosyltransferase, hprt1, hypoxanthine phosphoribosyltransferase, hypoxanthine-guanine phosphoribosyl transferase, hypoxanthine phosphoribosyl transferase, hypoxanthine guanine phosphoribosyltransferase, hgprtase, guanine phosphoribosyltransferase,
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6-hydroxypurine phosphoribosyltransferase
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6-mercaptopurine phosphoribosyltransferase
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6-oxopurine phosphoribosyltransferase
GMP pyrophosphorylase
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guanine phosphoribosyltransferase
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guanine-hypoxanthine phosphoribosyltransferase
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guanosine 5'-phosphate pyrophosphorylase
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guanosine phosphoribosyltransferase
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guanylate pyrophosphorylase
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guanylic pyrophosphorylase
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hypoxanthine guanine phosphoribosyltransferase
hypoxanthine guanine xanthine phosphoribosyltransferase
hypoxanthine phosphoribosyl transferase
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hypoxanthine phosphoribosyltransferase
hypoxanthine phosphoribosyltransferase 1
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hypoxanthine-guanine phosphoribosyl transferase
hypoxanthine-guanine phosphoribosyltransferase
hypoxanthine-guanine phosphoribosyltransferase/adenylate kinase
hypoxanthine-guanine-(xanthine) phosphoribosyltransferase
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hypoxanthine-guanine-xanthine phosphoribosyltransferase
hypoxanthine-guanine-[xanthine]-phosphoribosyltransferase
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hypoxanthine-xanthine-guanine phosphoribosyltransferase
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IMP pyrophosphorylase
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IMP-GMP pyrophosphorylase
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inosinate pyrophosphorylase
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inosine 5'-phosphate pyrophosphorylase
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inosine monophosphate:pyrophosphate phosphoribosyltransferase
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inosinic acid pyrophosphorylase
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inosinic pyrophosphorylase
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PhHGXPRT
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Pyrococcus horikoshii HGXPRT
phosphoribosyltransferase, 6-mercaptopurine
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phosphoribosyltransferase, hypoxanthine
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plasma hypoxanthine-guanine phosphoribosyl transferase
purine-6-thiol phosphoribosyltransferase
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transphosphoribosidase
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6-oxo PRTase
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6-oxopurine phosphoribosyltransferase
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6-oxopurine phosphoribosyltransferase
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6-oxopurine PRTase
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Cthe_2254
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GPRT
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phosphoribosyltransferases for hypoxanthine and guanine are separate enzymes
GPRT
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phosphoribosyltransferases for hypoxanthine and guanine are separate enzymes
gpT-2
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HGPRT
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HGPRTase
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HGXPRT
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HGXPRTase
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HPRT
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HPRT
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phosphoribosyltransferases for hypoxanthine and guanine are separate enzymes
HPRT
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phosphoribosyltransferases for hypoxanthine and guanine are separate enzymes
HPRT1
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HPT
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hypoxanthine guanine phosphoribosyltransferase
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hypoxanthine guanine phosphoribosyltransferase
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hypoxanthine guanine phosphoribosyltransferase
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hypoxanthine guanine phosphoribosyltransferase
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hypoxanthine guanine phosphoribosyltransferase
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hypoxanthine guanine xanthine phosphoribosyltransferase
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hypoxanthine guanine xanthine phosphoribosyltransferase
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hypoxanthine guanine xanthine phosphoribosyltransferase
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hypoxanthine phosphoribosyltransferase
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hypoxanthine phosphoribosyltransferase
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hypoxanthine-guanine phosphoribosyl transferase
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hypoxanthine-guanine phosphoribosyl transferase
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hypoxanthine-guanine phosphoribosyl transferase
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hypoxanthine-guanine phosphoribosyltransferase
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hypoxanthine-guanine phosphoribosyltransferase
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hypoxanthine-guanine phosphoribosyltransferase
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hypoxanthine-guanine phosphoribosyltransferase
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hypoxanthine-guanine phosphoribosyltransferase
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hypoxanthine-guanine phosphoribosyltransferase
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hypoxanthine-guanine phosphoribosyltransferase
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hypoxanthine-guanine phosphoribosyltransferase
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hypoxanthine-guanine phosphoribosyltransferase
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hypoxanthine-guanine phosphoribosyltransferase
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hypoxanthine-guanine phosphoribosyltransferase
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hypoxanthine-guanine phosphoribosyltransferase
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hypoxanthine-guanine phosphoribosyltransferase
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hypoxanthine-guanine phosphoribosyltransferase
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hypoxanthine-guanine phosphoribosyltransferase
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hypoxanthine-guanine phosphoribosyltransferase
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hypoxanthine-guanine phosphoribosyltransferase
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hypoxanthine-guanine phosphoribosyltransferase
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hypoxanthine-guanine phosphoribosyltransferase
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hypoxanthine-guanine phosphoribosyltransferase
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hypoxanthine-guanine phosphoribosyltransferase
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hypoxanthine-guanine phosphoribosyltransferase
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hypoxanthine-guanine phosphoribosyltransferase
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hypoxanthine-guanine phosphoribosyltransferase/adenylate kinase
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hypoxanthine-guanine phosphoribosyltransferase/adenylate kinase
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hypoxanthine-guanine phosphoribosyltransferase/adenylate kinase
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hypoxanthine-guanine phosphoribosyltransferase/adenylate kinase
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hypoxanthine-guanine phosphoribosyltransferase/adenylate kinase
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hypoxanthine-guanine phosphoribosyltransferase/adenylate kinase
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hypoxanthine-guanine-xanthine phosphoribosyltransferase
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hypoxanthine-guanine-xanthine phosphoribosyltransferase
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hypoxanthine-guanine-xanthine phosphoribosyltransferase
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hypoxanthine-guanine-xanthine phosphoribosyltransferase
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hypoxanthine-guanine-xanthine phosphoribosyltransferase
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hypoxanthine-guanine-xanthine phosphoribosyltransferase
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MSMEG_6110
locus name
MtHGPRT
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PF3D7_1012400
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plasma hypoxanthine-guanine phosphoribosyl transferase
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plasma hypoxanthine-guanine phosphoribosyl transferase
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PvHGPRT
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SSO2424
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TthHPRT
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TT_C1766
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ZgHGPRT/AMPK
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additional information
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cf. EC 2.4.2.22
additional information
cf. EC 2.4.2.22
additional information
cf. EC 2.4.2.22
additional information
cf. EC 2.4.2.22
additional information
cf. EC 2.4.2.22
additional information
cf. EC 2.4.2.22
additional information
see also EC 2.4.2.22
additional information
cf. EC 2.7.4.3
additional information
cf. EC 2.7.4.3
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additional information
cf. EC 2.7.4.3
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additional information
cf. EC 2.7.4.3
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additional information
cf. EC 2.7.4.3
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additional information
cf. EC 2.7.4.3
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IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
reaction mechanism
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
kinetic mechanism
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IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
ordered bi-bi mechanism
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IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
ordered bi-bi mechanism
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IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
catalytic mechanism
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IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
catalytic mechanism
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IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
catalytic mechanism
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IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
catalytic mechanism
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
catalytic mechanism
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IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
active site structure
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IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
active site structure
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IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
active site structure
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IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
active site structure
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
active site structure
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IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
residues I99-L121 form the catalytic loop
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IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
Thr47 binds diphosphate
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IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
essential role of Ser95-Tyr96 dyade in catalysis
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IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
kinetic model
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IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
during catalysis a long flexible loop closes over the active site, functional role
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IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
guanine and 6-mercaptopurine can replace hypoxanthine
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IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
ordered bi bi kinetic mechanism with 5-phospho-alpha-D-ribose 1-diphosphate binding first followed by the purine base
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IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
ordered bi bi reaction mechanism, formation of dead-end complexes with purine substrates and diphosphate
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IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
reaction mechanism, function and influence of invariant active site loop I residues on enzyme efficiency in forward and reverse reaction
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IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
reaction mechanism, the flexible loop II, comprising 12 amino acid residues, closes over the active site of the enzyme as it approaches the transition state, the loop is required for full activity, structure-function relationship for the conserved residues
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IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
residue F36 is responsible for substrate specificity, structure-function relationship
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
residue L44 is responsible for substrate specificity, structure-function relationship
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IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
sequential mechanism with 5-phospho-alpha-D-ribose 1-diphosphate binding first, active site helix comprising D137-D153 with key active site residues K68, D137, and K165, substrate binding sites and structures, overview
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IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
substrate binding structure and mechanism, a non-proline cis-peptide may be essential for activity
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IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
binding structure involving residue K68 at the AB-dimer interface and residues V96 and D97 of the opposing subunit, overview. Residues E133 and D137 block the binding of 5-phospho-alpha-D-ribose 1-diphosphate, mechanism, overview
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IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
ordered reaction mechanism, 5-phospho-alpha-D-ribose 1-diphosphate-Mg2+ binds first followed by the purine base. After the covalent reaction, diphosphate then dissociates from the complex and the nucleoside monophosphate is released in the rate-limiting step
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
ordered reaction mechanism. The substrates bind in a functionally ordered fashion, with 5-phospho-alpha-D-ribose 1-diphosphate binding first in the forward direction and IMP or GMP first in the reverse reaction, transition state structure and 5'-phosphate binding structure on HGPRT, overview
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2-amino-6-mercaptopurine + 5-phospho-alpha-D-ribose 1-diphosphate
2-amino-6-mercaptopurine ribotide + diphosphate
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?
2-hydroxy-6-mercaptopurine + 5-phospho-alpha-D-ribose 1-diphosphate
2-hydroxy-6-mercaptopurine ribotide + diphosphate
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?
3-hydroxy-2-pyrazinecarboxamide + 5-phospho-alpha-D-ribose 1-diphosphate
3-oxo-4-(5-O-phosphono-beta-D-ribofuranosyl)-3,4-dihydropyrazine-2-carboxamide + diphosphate
T-1105, poor substrate
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?
3-hydroxy-2-pyrazinecarboxamide + 5-phospho-alpha-D-ribose 1-diphosphate
? + diphosphate
T-1105, poor substrate
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?
6-fluoro-3-hydroxy-2-pyrazinecarboxamide + 5-phospho-alpha-D-ribose 1-diphosphate
6-fluoro-3-oxo-4-(5-O-phosphono-beta-D-ribofuranosyl)-3,4-dihydropyrazine-2-carboxamide + diphosphate
T-705, poor substrate
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?
6-fluoro-3-hydroxy-2-pyrazinecarboxamide + 5-phospho-alpha-D-ribose 1-diphosphate
? + diphosphate
T-705, poor substrate
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?
6-mercaptopurine + 5-phospho-alpha-D-ribose 1-diphosphate
6-mercaptopurine riboside 5'-phosphate + diphosphate
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?
6-mercaptopurine + 5-phospho-alpha-D-ribose 1-diphosphate
6-mercaptopurine ribotide + diphosphate
6-mercaptopurine + 5-phospho-alpha-D-ribose 1-diphosphate
6-thioinosine monophosphate + diphosphate
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?
6-mercaptopurine + 5-phospho-alpha-D-ribose 1-diphosphate
thioinosinic monophosphate + diphosphate
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a thiopurine antimetabolite
a therapeutically active metabolite
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?
6-thioguanine + 5-phospho-alpha-D-ribose 1-diphosphate
6-thio-GMP + diphosphate
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?
8-azaguanine + 5-phospho-alpha-D-ribose 1-diphosphate
8-aza-IMP + diphosphate
high activity
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?
8-azahypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
8-aza-IMP + diphosphate
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?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
?
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?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
allopurinol + 5-phospho-alpha-D-ribose 1-diphosphate
?
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?
allopurinol + 5-phospho-alpha-D-ribose 1-diphosphate
allopurinol ribonucleoside 5'-monophosphate + diphosphate
GMP + diphosphate
guanine + 5-phospho-alpha-D-ribose 1-diphosphate
guanine + 5-phospho-alpha-D-ribose 1-diphosphate
GMP + diphosphate
guanosine + 5-phospho-alpha-D-ribose 1-diphosphate
GMP + diphosphate
hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
IMP + diphosphate
IMP + diphosphate
hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
xanthine + 5-phospho-alpha-D-ribose 1-diphosphate
? + diphosphate
xanthine + 5-phospho-alpha-D-ribose 1-diphosphate
xanthosine 5'-phosphate + diphosphate
xanthine + 5-phospho-alpha-D-ribose 1-diphosphate
XMP + diphosphate
XMP + diphosphate
xanthine + 5-phospho-alpha-D-ribose 1-diphosphate
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r
additional information
?
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6-mercaptopurine + 5-phospho-alpha-D-ribose 1-diphosphate
6-mercaptopurine ribotide + diphosphate
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?
6-mercaptopurine + 5-phospho-alpha-D-ribose 1-diphosphate
6-mercaptopurine ribotide + diphosphate
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?
6-mercaptopurine + 5-phospho-alpha-D-ribose 1-diphosphate
6-mercaptopurine ribotide + diphosphate
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?
6-mercaptopurine + 5-phospho-alpha-D-ribose 1-diphosphate
6-mercaptopurine ribotide + diphosphate
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?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
low activity
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?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
low activity
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?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
low activity
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?
allopurinol + 5-phospho-alpha-D-ribose 1-diphosphate
allopurinol ribonucleoside 5'-monophosphate + diphosphate
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low activity
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?
allopurinol + 5-phospho-alpha-D-ribose 1-diphosphate
allopurinol ribonucleoside 5'-monophosphate + diphosphate
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?
GMP + diphosphate
guanine + 5-phospho-alpha-D-ribose 1-diphosphate
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?
GMP + diphosphate
guanine + 5-phospho-alpha-D-ribose 1-diphosphate
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?
GMP + diphosphate
guanine + 5-phospho-alpha-D-ribose 1-diphosphate
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-
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?
GMP + diphosphate
guanine + 5-phospho-alpha-D-ribose 1-diphosphate
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r
GMP + diphosphate
guanine + 5-phospho-alpha-D-ribose 1-diphosphate
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r
GMP + diphosphate
guanine + 5-phospho-alpha-D-ribose 1-diphosphate
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r
guanine + 5-phospho-alpha-D-ribose 1-diphosphate
GMP + diphosphate
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-
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?
guanine + 5-phospho-alpha-D-ribose 1-diphosphate
GMP + diphosphate
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?
guanine + 5-phospho-alpha-D-ribose 1-diphosphate
GMP + diphosphate
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-
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r
guanine + 5-phospho-alpha-D-ribose 1-diphosphate
GMP + diphosphate
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-
-
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?
guanine + 5-phospho-alpha-D-ribose 1-diphosphate
GMP + diphosphate
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-
-
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r
guanine + 5-phospho-alpha-D-ribose 1-diphosphate
GMP + diphosphate
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-
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r
guanine + 5-phospho-alpha-D-ribose 1-diphosphate
GMP + diphosphate
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6-oxopurine salvage pathway reaction
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r
guanine + 5-phospho-alpha-D-ribose 1-diphosphate
GMP + diphosphate
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-
-
?
guanine + 5-phospho-alpha-D-ribose 1-diphosphate
GMP + diphosphate
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-
-
?
guanine + 5-phospho-alpha-D-ribose 1-diphosphate
GMP + diphosphate
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-
-
?
guanine + 5-phospho-alpha-D-ribose 1-diphosphate
GMP + diphosphate
low activity
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-
r
guanine + 5-phospho-alpha-D-ribose 1-diphosphate
GMP + diphosphate
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phosphoribosyltransferases for hypoxanthine and guanine are separate enzymes, and catalyse the 2 reactions with different specificities
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?
guanine + 5-phospho-alpha-D-ribose 1-diphosphate
GMP + diphosphate
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binds hypoxanthine 67-times less effectively than guanine and 4-times less effectively than xanthine
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?
guanine + 5-phospho-alpha-D-ribose 1-diphosphate
GMP + diphosphate
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-
-
?
guanine + 5-phospho-alpha-D-ribose 1-diphosphate
GMP + diphosphate
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-
-
?
guanine + 5-phospho-alpha-D-ribose 1-diphosphate
GMP + diphosphate
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absolutely specific for guanine
diphosphate binds at Thr70, diphosphate-binding loop sequence: LTGA
r
guanine + 5-phospho-alpha-D-ribose 1-diphosphate
GMP + diphosphate
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-
-
?
guanine + 5-phospho-alpha-D-ribose 1-diphosphate
GMP + diphosphate
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-
-
?
guanine + 5-phospho-alpha-D-ribose 1-diphosphate
GMP + diphosphate
2.4.2.8 hypoxanthine phosphoribosyltransferase
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