Reference on EC 2.4.2.64 - tRNA-guanosine34 queuine transglycosylase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Haumont, E.; Droogmans, L.; Grosjean, H.
Enzymatic formation of queuosine and of glycosyl queuosine in yeast tRNAs microinjected into Xenopus laevis oocytes. The effect of the anticodon loop sequence
Eur. J. Biochem.
168
219-225
1987
Xenopus laevis
Kung, F.L.; Garcia, G.A.
tRNA-guanine transglycosylase from Escherichia coli: recognition of full-length 'queuine-cognate' tRNAs
FEBS Lett.
431
427-432
1998
Escherichia coli
Deshpande, K.L.; Seubert, P.H.; Tillman, D.M.; Farkas, W.R.; Katze, J.R.
Cloning and characterization of cDNA encoding the rabbit tRNA-guanine transglycosylase 60-kilodalton subunit
Arch. Biochem. Biophys.
326
1-7
1996
Oryctolagus cuniculus
Goodenough-Lashua, D.M.; Garcia, G.A.
tRNA-guanine transglycosylase from E. coli: a ping-pong kinetic mechanism is consistent with nucleophilic catalysis
Bioorg. Chem.
31
331-344
2003
Escherichia coli, Shigella flexneri
Brenk, R.; Stubbs, M.T.; Heine, A.; Reuter, K.; Klebe, G.
Flexible adaptations in the structure of the tRNA-modifying enzyme tRNA-guanine transglycosylase and their implications for substrate selectivity, reaction mechanism and structure-based drug design
ChemBioChem
4
1066-1077
2003
Zymomonas mobilis (P28720)
Todorov, K.A.; Garcia, G.A.
Role of aspartate 143 in Escherichia coli tRNA-guanine transglycosylase: alteration of heterocyclic substrate specificity
Biochemistry
45
617-625
2006
Escherichia coli
Chen, Y.C.; Kelly, V.P.; Stachura, S.V.; Garcia, G.A.
Characterization of the human tRNA-guanine transglycosylase: Confirmation of the heterodimeric subunit structure
RNA
16
958-968
2010
Homo sapiens (Q9BXR0), Homo sapiens
Eric Thomas, C.; Chen, Y.C.; Garcia, G.A.
Differential heterocyclic substrate recognition by, and pteridine inhibition of E. coli and human tRNA-guanine transglycosylases
Biochem. Biophys. Res. Commun.
410
34-39
2011
Escherichia coli, Homo sapiens (Q9BXR0)
Barandun, L.J.; Immekus, F.; Kohler, P.C.; Ritschel, T.; Heine, A.; Orlando, P.; Klebe, G.; Diederich, F.
High-affinity inhibitors of Zymomonas mobilis tRNA-guanine transglycosylase through convergent optimization
Acta Crystallogr. Sect. D
69
1798-1807
2013
Zymomonas mobilis (P28720)
Shindo-Okada, N.; Okada, N.; Ohgi, T.; Goto, T.; Nishimura, S.
Transfer ribonucleic acid guanine transglycosylase isolated from rat liver
Biochemistry
19
395-400
1980
Rattus norvegicus
Behrens, C.; Biela, I.; Petiot-Becard, S.; Botzanowski, T.; Cianferani, S.; Sager, C.P.; Klebe, G.; Heine, A.; Reuter, K.
Homodimer architecture of QTRT2, the noncatalytic subunit of the eukaryotic tRNA-guanine transglycosylase
Biochemistry
57
3953-3965
2018
Mus musculus (Q9JMA2 AND B8ZXI1), Mus musculus
Farkas, W.; Jacobson, K.; Katze, J.
Substrate and inhibitor specificity of tRNA-guanine ribosyltransferase
Biochim. Biophys. Acta
781
64-75
1984
Oryctolagus cuniculus, Mus musculus (Q9JMA2 AND B8ZXI1)
Johannsson, S.; Neumann, P.; Ficner, R.
Crystal structure of the human tRNA guanine transglycosylase catalytic subunit QTRT1
Biomolecules
8
81
2018
Homo sapiens (Q9BXR0 AND Q9H974), Homo sapiens
Ishiwata, S.; Ozawa, Y.; Katayama, J.; Kaneko, S.; Shindo, H.; Tomioka, Y.; Ishiwata, T.; Asano, G.; Ikegawa, S.; Mizugaki, M.
Elevated expression level of 60-kDa subunit of tRNA-guanine transglycosylase in colon cancer
Cancer Lett.
212
113-119
2004
Homo sapiens
-
Zhang, J.; Lu, R.; Zhang, Y.; Matuszek, Z.; Zhang, W.; Xia, Y.; Pan, T.; Sun, J.
tRNA queuosine modification enzyme modulates the growth and microbiome recruitment to breast tumors
Cancers (Basel)
12
628
2020
Homo sapiens (Q9BXR0 AND Q9H974)
Alqasem, M.; Fergus, C.; Southern, J.; Connon, S.; Kelly, V.
The eukaryotic tRNA-guanine transglycosylase enzyme inserts queuine into tRNA Via a sequential bi-bi mechanism
Chem. Commun. (Camb.)
56
3915-3918
2020
Homo sapiens (Q9BXR0 AND Q9H974)
Carbon, P.; Haumont, E.; Fournier, M.; de Henau, S.; Grosjean, H.
Site-directed in vitro replacement of nucleosides in the anticodon loop of tRNA application to the study of structural requirements for queuine insertase activity
EMBO J.
2
1093-1097
1983
Xenopus laevis
-
Romier, C.; Meyer, J.E.W.; Suck, D.
Slight sequence variations of a common fold explain the substrate specificities of tRNA-guanine transglycosylases from the three kingdoms
FEBS Lett.
416
93-98
1997
Synechocystis sp., Caenorhabditis elegans, Haemophilus influenzae, Helicobacter pylori, Homo sapiens, Mus musculus, Shigella flexneri, Thermotoga maritima
-
Meyer, E.A.; Donati, N.; Guillot, M.; Schweizer, W.B.; Diederich, F.; Stengl, B.; Brenk, R.; Reuter, K.; Klebe, G.
Synthesis, biological evaluation, and crystallographic studies of extended guanine-based (lin-benzoguanine) inhibitors for tRNA-guanine transglycosylase (TGT)
Helv. Chim. Acta
89
573-597
2006
Zymomonas mobilis
-
Farkas, W.; Bruce Jacobson, K.
tRNA-guanine transglycosylase and guanine-accepting transfer RNAs of Drosophila melanogaster
Insect Biochem.
10
183-188
1980
Drosophila melanogaster, Oryctolagus cuniculus
-
Ishiwata, S.; Katayama, J.; Shindo, H.; Ozawa, Y.; Itoh, K.; Mizugaki, M.
Increased expression of queuosine synthesizing enzyme, tRNA-guanine transglycosylase, and queuosine levels in tRNA of leukemic cells
J. Biochem.
129
13-17
2001
Homo sapiens
-
Walden Jr., T.; Howes, N.; Farkas, W.
Purification and properties of guanine, queuine-tRNA transglycosylase from wheat germ
J. Biol. Chem.
257
13218-13222
1982
Triticum aestivum
Boland, C.; Hayes, P.; Santa-Maria, I.; Nishimura, S.; Kelly, V.
Queuosine formation in eukaryotic tRNA occurs via a mitochondria-localized heteromeric transglycosylase
J. Biol. Chem.
284
18218-18227
2009
Mus musculus (Q9JMA2 AND B8ZXI1), Mus musculus
Chen, Y.; Brooks, A.; Goodenough-Lashua, D.; Kittendorf, J.; Showalter, H.; Garcia, G.
Evolution of eukaryal tRNA-guanine transglycosylase Insight gained from the heterocyclic substrate recognition by the wild-type and mutant human and Escherichia coli tRNA-guanine transglycosylases
Nucleic Acids Res.
39
2834-2844
2011
Homo sapiens (Q9BXR0 AND Q9H974)
Biela, I.; Tidten-Luksch, N.; Immekus, F.; Glinca, S.; Nguyen, T.; Gerber, H.; Heine, A.; Klebe, G.; Reuter, K.
Investigation of specificity determinants in bacterial tRNA-guanine transglycosylase reveals queuine, the substrate of its eucaryotic counterpart, as inhibitor
PLoS ONE
8
e64240
2013
Homo sapiens (Q9BXR0 AND Q9H974)
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