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Information on EC 2.4.2.63 - EGF-domain serine xylosyltransferase

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EC Tree
     2 Transferases
         2.4 Glycosyltransferases
             2.4.2 Pentosyltransferases
                2.4.2.63 EGF-domain serine xylosyltransferase
IUBMB Comments
The enzyme, found in animals and insects, xylosylates at the serine in the C-X-S-X-P-C motif of epidermal growth factor-like (EGF-like) domains. The enzyme is bifunctional also being active with UDP-alpha-glucose as donor (EC 2.4.1.376, EGF-domain serine glucosyltransferase).
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Word Map
  • 2.4.2.63
  • egypt
  • sham-operated
  • cairo
  • ventricular
  • sprague-dawley
  • saline
  • traumatic
  • egyptian
  • bilateral
  • hemorrhage
  • resuscitation
  • injured
  • ischemia
  • infarct
  • occlusion
  • trauma
  • depart
  • reperfusion
  • anesthetize
  • maze
  • admitted
  • ipsilateral
  • burn
  • post-injury
  • anesthesia
  • echocardiography
  • laparotomy
  • auditory
  • ringer
  • trauma-hemorrhage
  • contusion
  • percussion
  • postburn
  • hypoxia-ischemia
  • normothermia
  • time-matched
  • pressure-overloaded
The enzyme appears in viruses and cellular organisms
Reaction Schemes
+
[protein with EGF-like domain]-L-serine
=
+
[protein with EGF-like domain]-3-O-(beta-D-xylosyl)-L-serine
Synonyms
CG9996, glucoside xylosyltransferase, Poglut, POGLUT1, Poxylt, protein O-xylosyltransferase, protein-O-glucosyltransferase 1, Rumi, Shams, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-alpha-D-xylose + [protein with EGF-like domain]-L-serine = UDP + [protein with EGF-like domain]-3-O-(beta-D-xylosyl)-L-serine
show the reaction diagram
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