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Information on EC 2.4.2.59 - sulfide-dependent adenosine diphosphate thiazole synthase

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IUBMB Comments
This iron dependent enzyme, found in most archaea, is involved in the biosynthesis of thiamine phosphate. The homologous enzyme from plants and fungi (EC 2.4.2.60, cysteine-dependent adenosine diphosphate thiazole synthase) uses an intrinsic cysteine as sulfur donor and, unlike the archaeal enzyme, is a single turn-over enzyme.
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The expected taxonomic range for this enzyme is: Archaea, Eukaryota
Synonyms
Thi4, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
NAD+ + glycine + sulfide = nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 3 H2O
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PATHWAY SOURCE
PATHWAYS
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