Information on EC 2.4.2.55 - nicotinate D-ribonucleotide:phenol phospho-D-ribosyltransferase

for references in articles please use BRENDA:EC2.4.2.55
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The expected taxonomic range for this enzyme is: Sporomusa ovata

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EC NUMBER
COMMENTARY hide
2.4.2.55
-
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RECOMMENDED NAME
GeneOntology No.
nicotinate D-ribonucleotide:phenol phospho-D-ribosyltransferase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
nicotinate D-ribonucleotide + phenol = nicotinate + phenyl 5-phospho-alpha-D-ribofuranoside
show the reaction diagram
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
nicotinate D-ribonucleotide:phenol phospho-D-ribosyltransferase
The enzyme is involved in the biosynthesis of phenolic cobamides in the Gram-positive bacterium Sporomusa ovata. It can also transfer the phospho-D-ribosyl group to 4-methylphenol and 5,6-dimethylbenzimidazole. The related EC 2.4.2.21, nicotinate-nucleotide dimethylbenzimidazole phosphoribosyltransferase, also transfers the phospho-D-ribosyl group from nicotinate D-ribonucleotide to 5,6-dimethylbenzimidazole, but shows no activity with 4-methylphenol or phenol.
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
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Manually annotated by BRENDA team
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
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the enzyme is involved in the biosynthesis of phenolic cobamides in Sporomusa ovata
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
beta-nicotinate D-ribonucleotide + 4-cresol
nicotinate + 4-methylphenyl 5-phospho-alpha-D-ribofuranoside
show the reaction diagram
beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole
nicotinate + alpha-ribazole 5'-phosphate
show the reaction diagram
beta-nicotinate D-ribonucleotide + phenol
nicotinate + phenyl 5-phospho-alpha-D-ribofuranoside
show the reaction diagram
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
beta-nicotinate D-ribonucleotide + 4-cresol
nicotinate + 4-methylphenyl 5-phospho-alpha-D-ribofuranoside
show the reaction diagram
-
the enzyme is involved in the biosynthesis of phenolic cobamides in Sporomusa ovata
-
-
?
beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole
nicotinate + alpha-ribazole 5'-phosphate
show the reaction diagram
-
the enzyme is involved in the biosynthesis of phenolic cobamides in Sporomusa ovata
-
-
?
beta-nicotinate D-ribonucleotide + phenol
nicotinate + phenyl 5-phospho-alpha-D-ribofuranoside
show the reaction diagram
-
the enzyme is involved in the biosynthesis of phenolic cobamides in Sporomusa ovata
-
-
?
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.019
-
pH 9.0, 37°C
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
36650
-
1 * 36650 (ArsA) + 1 * 361800 (ArsB), calculated from sequence
66000
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gel filtration
361800
-
1 * 36650 (ArsA) + 1 * 361800 (ArsB), calculated from sequence
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SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
heterodimer
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1 * 36650 (ArsA) + 1 * 361800 (ArsB), calculated from sequence
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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LINKS TO OTHER DATABASES (specific for EC-Number 2.4.2.55)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)