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Information on EC 2.4.2.38 - glycoprotein 2-beta-D-xylosyltransferase
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EC Tree
2.4.2.38 glycoprotein 2-beta-D-xylosyltransferaseIUBMB Comments
Specific for N-linked oligosaccharides (N-glycans).
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Word Map
- 2.4.2.38
- proteoglycans
- glycosaminoglycans
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desbuquois
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alpha1,3-fucosyltransferase
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laxity
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2.4.2.26
- udp-xylose
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chain-initiating
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xylosylated
- medicine
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alpha1,3-fucose
- biotechnology
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beta1,2-xylose
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o-xylosyltransferase
- synthesis
The enzyme appears in viruses and cellular organisms
Reaction Schemes
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Synonyms
xylt1, xylosyltransferase i, rcn11, xylosyltransferase-i, beta1,2-xylosyltransferase, cxt1p, xyxt1, beta-1,2-xylosyltransferase, cryptococcal xylosyltransferase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
beta 1,2-xylosyltransferase
beta-1,2-xylosyltransferase
beta-1,4-mannosylglycoprotein beta-1,2-xylosyltransferase
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beta1,2-xylosyltransferase
Cxt1p
CXT1p homolog
XylT
beta-1,2-xylosyltransferase
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CXT1p homolog
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12 to 23% identity to CTX1p from Cryptococcus neoformans serotype D
CXT1p homolog
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12 to 23% identity to CTX1p from Cryptococcus neoformans serotype D
CXT1p homolog
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12 to 23% identity to CTX1p from Cryptococcus neoformans serotype D
CXT1p homolog
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12 to 23% identity to CTX1p from Cryptococcus neoformans serotype D
CXT1p homolog
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12 to 23% identity to CTX1p from Cryptococcus neoformans serotype D
CXT1p homolog
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12 to 23% identity to CTX1p from Cryptococcus neoformans serotype D
CXT1p homolog
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12 to 23% identity to CTX1p from Cryptococcus neoformans serotype D
CXT1p homolog
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group of 5 genes (CAP1, CAP5, CAP2, CAP4, CAP10) with 20 to 30% identity to CTX1p
CXT1p homolog
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12 to 23% identity to CTX1p from Cryptococcus neoformans serotype D
CXT1p homolog
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12 to 23% identity to CTX1p from Cryptococcus neoformans serotype D
CXT1p homolog
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12 to 23% identity to CTX1p from Cryptococcus neoformans serotype D
CXT1p homolog
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12 to 23% identity to CTX1p from Cryptococcus neoformans serotype D
XylT
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
UDP-alpha-D-xylose + N4-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc]-L-asparaginyl-[protein] = UDP + N4-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc]-L-asparaginyl-[protein]
UDP-D-xylose + N4-{N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl}asparagine = UDP + N4-{N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-[beta-D-xylosyl-(1,2)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl}asparagine
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UDP-D-xylose + N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine = UDP + N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-[beta-D-xylosyl-(1->2)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine
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UDP-alpha-D-xylose + N4-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc]-L-asparaginyl-[protein] = UDP + N4-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc]-L-asparaginyl-[protein]
the catalytic domain of XylT encompasses residues Lys57-Cys534
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UDP-alpha-D-xylose + N4-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc]-L-asparaginyl-[protein] = UDP + N4-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc]-L-asparaginyl-[protein]
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
transfer of glycosyl group
transfer of glycosyl group
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transfer of glycosyl group
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N-glycan maturation, transfer of beta (1,2)-xylose
transfer of glycosyl group
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transfer of beta (1,2)-xylose, capsule synthesis
transfer of glycosyl group
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transfer of beta (1,2)-xylose, capsule synthesis
transfer of glycosyl group
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transfer of beta (1,2)-xylose, capsule synthesis
transfer of glycosyl group
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transfer of beta (1,2)-xylose, capsule synthesis
transfer of glycosyl group
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transfer of beta (1,2)-xylose, capsule synthesis
transfer of glycosyl group
transfer of beta (1,2)-xylose, capsule synthesis
transfer of glycosyl group
transfer of beta (1,2)-xylose, capsule synthesis
transfer of glycosyl group
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transfer of beta (1,2)-xylose, capsule synthesis
transfer of glycosyl group
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transfer of beta (1,2)-xylose, capsule synthesis
transfer of glycosyl group
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transfer of beta (1,2)-xylose, capsule synthesis
transfer of glycosyl group
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transfer of beta (1,2)-xylose, capsule synthesis
transfer of glycosyl group
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transfer of beta (1,2)-xylose, capsule synthesis
transfer of glycosyl group
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transfer of beta (1,2)-xylose, capsule synthesis
transfer of glycosyl group
transfer of beta (1,2)-xylose, capsule synthesis, yeast specific
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SYSTEMATIC NAME
IUBMB Comments
UDP-D-xylose:glycoprotein (D-xylose to the 3,6-disubstituted mannose of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 2-beta-D-xylosyltransferase
Specific for N-linked oligosaccharides (N-glycans).
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CAS REGISTRY NUMBER
COMMENTARY
141256-56-6
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
GlcNAcbeta1-2Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-O-octyl + UDP-xylose
?
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i.e. GnGn-octyl
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?
UDP-alpha-D-xylose + N4-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc]-L-asparaginyl-[protein]
UDP + N4-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc]-L-asparaginyl-[protein]
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?
UDP-alpha-D-xylose + xylan
?
the enzyme adds side chain xylosyl residues directly to the xylan backbone at 2-O
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?
UDP-D-xylose + alpha-D-mannosyl-(1,6)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)]-beta-D-mannosyl-O-(CH2)7-CH3
UDP + ?
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?
UDP-D-xylose + D-mannosyl-alpha-(1,3)-D-mannose
UDP + D-xylosyl-beta-(1,2)-D-mannosyl-alpha-(1,3)-D-mannose
UDP-D-xylose + galactoxylomannan
UDP + [beta-D-xylose-(1,2)]-galactoxylomannan
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JEC21/cxt1delta and CAP67/cxt1delta lacking CXT1p: almost complete loss of beta-xylose residues (1,2)-linked to mannose, unchanged amounts of beta-xylose (1,3)-linked to galactose
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?
UDP-D-xylose + galactoxylomannan
UDP + [beta-D-xylosyl-(1,2)]-galactoxylomannan
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?
UDP-D-xylose + GlcNAcbeta1-2Manalpha1-3Manbeta1-O-(CH2)7-CH3
UDP + GlcNAcbeta1-2Manalpha1-3(Xylbeta1-2)Manbeta1-O-(CH2)7-CH3
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-
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?
UDP-D-xylose + GlcNAcbeta1-2Manalpha1-6(Galbeta1-4GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAc
UDP + GlcNAcbeta1-2Manalpha1-6(Galbeta1-4GlcNAcbeta1-2Manalpha1-3)(Xylbeta1-2)Manbeta1-4GlcNAc
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?
UDP-D-xylose + GlcNAcbeta1-2Manalpha1-6(Galbeta1-4GlcNAcbeta1-2Manalpha1-3)Manbeta1-O-(CH2)7-CH3
UDP + GlcNAcbeta1-2Manalpha1-6(Galbeta1-4GlcNAcbeta1-2Manalpha1-3)(Xylbeta1-2)Manbeta1-O-(CH2)7-CH3
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?
UDP-D-xylose + GlcNAcbeta1-2Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-4(Fucalpha1-6)GlcNAc1-O-(N-benzyloxycarbonyl)-Tyr
UDP + GlcNAcbeta1-2Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)(Xylbeta1-2)Manbeta1-4GlcNAcbeta1-4(Fucalpha1-6)GlcNAc1-O-(N-benzyloxycarbonyl)-Tyr
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?
UDP-D-xylose + GlcNAcbeta1-2Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-4GlcNAc
UDP + GlcNAcbeta1-2Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)(Xylbeta1-2)Manbeta1-4GlcNAcbeta1-4GlcNAc
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?
UDP-D-xylose + GlcNAcbeta1-2Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-4GlcNAc-Asn
UDP + GlcNAcbeta1-2Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)(Xylbeta1-2)Manbeta1-4GlcNAcbeta1-4GlcNAc-Asn
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?
UDP-D-xylose + GlcNAcbeta1-2Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-4GlcNAc1-O-(N-benzyloxycarbonyl)-Tyr
UDP + GlcNAcbeta1-2Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)(Xylbeta1-2)Manbeta1-4GlcNAcbeta1-4GlcNAc1-O-(N-benzyloxycarbonyl)-Tyr
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?
UDP-D-xylose + GlcNAcbeta1-2Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-4GlcNAc1-O-(pyrid-2-yl)amine
UDP + GlcNAcbeta1-2Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)(Xylbeta1-2)Manbeta1-4GlcNAcbeta1-4GlcNAc1-O-(pyrid-2-yl)amine
UDP-D-xylose + GlcNAcbeta1-2Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-O-(CH2)7-CH3
UDP + GlcNAcbeta1-2Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)(Xylbeta1-2)Manbeta1-O-(CH2)7-CH3
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?
UDP-D-xylose + glucuronoxylomannan
UDP + [beta-D-xylose-(1,2)]-glucuronoxylomannan
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JEC21/cxt1delta and CAP67/cxt1delta lacking CXT1p: 30% decrease in amount of xylose, 39% decrease in O-2 xylose-substituted mannose, 31.5% increase in O-2-unsubstituted mannose, loss of 1/3 of beta-(1,2)-linked xylose, revealed by NMR analyses
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?
UDP-D-xylose + glucuronoxylomannan
UDP + [beta-D-xylosyl-(1,2)]-glucuronoxylomannan
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?
UDP-D-xylose + Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-4GlcNAc1-O-(N-benzyloxycarbonyl)-Tyr
UDP + Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)(Xylbeta1-2)Manbeta1-4GlcNAcbeta1-4GlcNAc1-O-(N-benzyloxycarbonyl)-Tyr
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?
UDP-D-xylose + Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-O-(CH2)7-CH3
UDP + Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)(Xylbeta1-2)Manbeta1-O-(CH2)7-CH3
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?
UDP-D-xylose + N4-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl]asparagine
UDP + N4-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-[beta-D-xylosyl-(1,2)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl]asparagine
UDP-D-xylose + N4-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl]asparagine
UDP + N4-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-[beta-D-xylosyl-(1->2)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl]asparagine
UDP-xylose + dansylated Galbeta-(1,4)-GlcNAcbeta-(1,2)-Manalpha-(1,6)-(Galbeta-(1,4)-GlcNAcbeta-(1,2)-Manalpha-(1,3))-Manbeta-(1,4)-GlcNAcbeta-(1,4)-GlcNAc
UDP + ?
UDP-xylose + mannosyl-alpha-(1,3)-mannosyl-alpha-(1,4)-galactosyl-beta-(1,6)-mannosyl-alpha-(1,2)-inositol phosphorylceramide
UDP + mannosyl-alpha-(1,3)-[xylosyl-beta-(1,2)]-mannosyl-alpha-(1,4)-galactosyl-beta-(1,6)-mannosyl-alpha-(1,2)-inositol phosphorylceramide
no transfer of xylose residues onto substrate in absence of Cxt1p (JEC21/cxt1delta) as revealed by mass spectrometry and HPTLC, mannosyl-alpha-(1,3)-mannose-alpha motif also present in substrates for capsule polysaccharide synthesis
core structure of glycosylinositol phosphorylceramides, GIPCs
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?
UDP-xylose + mannosyl-alpha-(1,6)-mannosyl-alpha-(1,3)-mannosyl-alpha-(1,4)-galactosyl-beta-(1,6)-mannosyl-alpha-(1,2)-inositol phosphorylceramide
UDP + mannosyl-alpha-(1,6)-mannosyl-alpha-(1,3)-[xylosyl-beta-(1,2)]-mannosyl-alpha-(1,4)-galactosyl-beta-(1,6)-mannosyl-alpha-(1,2)-inositol phosphorylceramide
no transfer of xylose residues onto substrate in absence of Cxt1p (JEC21/cxt1delta) as revealed by mass spectrometry and HPTLC
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?
Xylbeta1-2[Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)]Manbeta1-O-octyl + UDP-xylose
?
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i.e. MGnX-octyl
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-
?
Xylbeta1-2[Manalpha1-6(Manalpha1-3)]Manbeta1-O-octyl + UDP-xylose
?
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i.e. MMX-octyl
-
-
?
[GlcNAcbeta1-2Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-4(Fucalpha1-3)GlcNAc]-GP + UDP-xylose
?
-
i.e. GnGnF
-
-
?
[Manalpha1-6(Manalpha1-3)Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-4GlcNAc]-GP + UDP-xylose
?
-
i.e. Man5Gn
-
-
?
UDP-D-xylose + D-mannosyl-alpha-(1,3)-D-mannose
UDP + D-xylosyl-beta-(1,2)-D-mannosyl-alpha-(1,3)-D-mannose
membranes or purified enzyme, radiolabelled UDP-xylose, 8.5-12.5 mM alpha-(1,3)-mannobiose (resembles backbone or dimannose moiety of natural substrates), pH 6.5, 4 h, 20°C
product: trisaccharide with xylose moiety linked to reducing mannose of alpha-(1,3)-mannobiose as revealed by mass spectrometry, NMR and methylation linkage analyses, radiolabel detection by scintillation counting or thin layer chromatography and autoradiography or product purification by solid phase extraction
-
?
UDP-D-xylose + D-mannosyl-alpha-(1,3)-D-mannose
UDP + D-xylosyl-beta-(1,2)-D-mannosyl-alpha-(1,3)-D-mannose
membranes, radiolabelled UDP-xylose, alpha-(1,3)-mannobiose (resembles backbone or dimannose moiety of natural substrates)
product: trisaccharide with xylose moiety linked to reducing mannose of alpha-(1,3)-mannobiose, radiolabel detection by scintillation counting or thin layer chromatography and autoradiography, product purification for NMR and glycosyl linkage analyses
-
?
UDP-D-xylose + GlcNAcbeta1-2Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-4GlcNAc1-O-(pyrid-2-yl)amine
UDP + GlcNAcbeta1-2Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)(Xylbeta1-2)Manbeta1-4GlcNAcbeta1-4GlcNAc1-O-(pyrid-2-yl)amine
-
-
-
?
UDP-D-xylose + GlcNAcbeta1-2Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-4GlcNAc1-O-(pyrid-2-yl)amine
UDP + GlcNAcbeta1-2Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)(Xylbeta1-2)Manbeta1-4GlcNAcbeta1-4GlcNAc1-O-(pyrid-2-yl)amine
-
-
?
UDP-D-xylose + N4-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl]asparagine
UDP + N4-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-[beta-D-xylosyl-(1,2)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl]asparagine
-
-
-
-
?
UDP-D-xylose + N4-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl]asparagine
UDP + N4-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-[beta-D-xylosyl-(1,2)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl]asparagine
-
-
-
?
UDP-D-xylose + N4-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl]asparagine
UDP + N4-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-[beta-D-xylosyl-(1->2)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl]asparagine
-
-
-
?
UDP-D-xylose + N4-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl]asparagine
UDP + N4-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-[beta-D-xylosyl-(1->2)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl]asparagine
-
-
-
-
?
UDP-D-xylose + N4-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl]asparagine
UDP + N4-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-[beta-D-xylosyl-(1->2)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl]asparagine
-
-
-
-
?
UDP-xylose + dansylated Galbeta-(1,4)-GlcNAcbeta-(1,2)-Manalpha-(1,6)-(Galbeta-(1,4)-GlcNAcbeta-(1,2)-Manalpha-(1,3))-Manbeta-(1,4)-GlcNAcbeta-(1,4)-GlcNAc
UDP + ?
-
i.e. dansylated GnGn-peptide
-
-
?
UDP-xylose + dansylated Galbeta-(1,4)-GlcNAcbeta-(1,2)-Manalpha-(1,6)-(Galbeta-(1,4)-GlcNAcbeta-(1,2)-Manalpha-(1,3))-Manbeta-(1,4)-GlcNAcbeta-(1,4)-GlcNAc
UDP + ?
i.e. dansylated GnGn-peptide
-
-
?
additional information
?
-
substrate specificity, substrates need to possess a beta(1,2)-linked GlcNAc residue at the Man-alpha-(1,3) arm, Man-alpha-(1,6)-(Man-alpha(1,3))-Man-beta(1-R) is no acceptor substrate, integrity of a large domain located between amino acid 31 and the C-terminal lumenal region is required for activity, the cytosolic tail and the transmembrane region are not essential for activity, but the stem region and the C-terminal end are
-
-
?
additional information
?
-
-
substrate specificity, substrates need to possess a beta(1,2)-linked GlcNAc residue at the Man-alpha-(1,3) arm, Man-alpha-(1,6)-(Man-alpha(1,3))-Man-beta(1-R) is no acceptor substrate, integrity of a large domain located between amino acid 31 and the C-terminal lumenal region is required for activity, the cytosolic tail and the transmembrane region are not essential for activity, but the stem region and the C-terminal end are
-
-
?
additional information
?
-
-
transfer of D-xylose from UDP-D-xylose to the core beta-linked mannose of N-linked oligosaccharides
-
-
?
additional information
?
-
-
the enzyme is involved in the biosynthesis of glycoprotein-bound N-glycans in plants and acts at multiple stages of the plant N-glycosylation pathway, overview
-
-
?
additional information
?
-
-
the enzyme is specific for UDP-xylose, no activity with Man5-GP and MM-octyl, acceptor substrate specificity, overview
-
-
?
additional information
?
-
preferred substrate depends on wild-type strain, strain JEC21: both products detectable (mannosyl-alpha-(1,6)-mannosyl-alpha-(1,3)-[xylosyl-beta-(1,2)]-mannosyl-alpha-(1,4)-galactosyl-beta-(1,6)-mannosyl-alpha-(1,2)-inositol phosphorylceramide and mannosyl-alpha-(1,3)-[xylosyl-beta-(1,2)]-mannosyl-alpha-(1,4)-galactosyl-beta-(1,6)-mannosyl-alpha-(1,2)-inositol phosphorylceramide) at a ratio of approximately 1:1
-
-
?
additional information
?
-
-
preferred substrate depends on wild-type strain, strain JEC21: both products detectable (mannosyl-alpha-(1,6)-mannosyl-alpha-(1,3)-[xylosyl-beta-(1,2)]-mannosyl-alpha-(1,4)-galactosyl-beta-(1,6)-mannosyl-alpha-(1,2)-inositol phosphorylceramide and mannosyl-alpha-(1,3)-[xylosyl-beta-(1,2)]-mannosyl-alpha-(1,4)-galactosyl-beta-(1,6)-mannosyl-alpha-(1,2)-inositol phosphorylceramide) at a ratio of approximately 1:1
-
-
?
additional information
?
-
-
transfer of beta (1,2)-xylose, capsule synthesis
-
-
?
additional information
?
-
transfer of beta (1,2)-xylose, capsule synthesis
-
-
?
additional information
?
-
transfer of beta (1,2)-xylose, synthesis of capsule polysaccharides and fungi-specific glycosphingolipids
-
-
?
additional information
?
-
-
transfer of beta (1,2)-xylose, synthesis of capsule polysaccharides and fungi-specific glycosphingolipids
-
-
?
additional information
?
-
-
lack of CXT1p in membranes from JEC21/cxt1delta and CAP67/cxt1delta leads to dramatic reduction in D-xylose-beta-(1,2)-D-mannose-alpha-(1,3)-D-mannose synthesising activity in presence of exogenously added substrate
-
-
?
additional information
?
-
lack of CXT1p in membranes from JEC21/cxt1delta and CAP67/cxt1delta leads to dramatic reduction in D-xylose-beta-(1,2)-D-mannose-alpha-(1,3)-D-mannose synthesising activity in presence of exogenously added substrate
-
-
?
additional information
?
-
-
probably involved in the biosynthesis of the inner part of hemocyanin glycans
-
-
?
additional information
?
-
-
-
strongly reduced biosynthesis of beta 1,2-xylose-containing glycoepitopes upon knock-down of endogenous beta 1,2-xylosyltransferase using sense, antisense and RNA interference approaches
-
?
additional information
?
-
-
-
strongly reduced biosynthesis of beta 1,2-xylose-containing glycoepitopes upon knock-down of endogenous beta 1,2-xylosyltransferase using RNA interference approaches
-
?
additional information
?
-
-
-
human anti HIV monoclonal antibody 2G12 produced in absence of endogenous beta 1,2-xylosyltransferase (knock-down by RNA interference) is functional but contains N-glycan species lacking beta 1,2-xylose residues corresponding to authentic human N-glycosylation
-
?
additional information
?
-
enzyme is involved in N-glycan biosynthesis, quantification and structure analysis of N-glycans in rice leaves
-
-
?
additional information
?
-
-
enzyme is involved in N-glycan biosynthesis, quantification and structure analysis of N-glycans in rice leaves
-
-
?
additional information
?
-
the enzyme is unable to add xylosyl residues onto the arabinosyl side chains of xylan
-
-
-
additional information
?
-
the enzyme is involved in the modification of asparagine-linked oligosaccharides of maize glycoproteins with beta1,2-xylose sugar residues
-
-
?
additional information
?
-
-
the enzyme is involved in the modification of asparagine-linked oligosaccharides of maize glycoproteins with beta1,2-xylose sugar residues
-
-
?
additional information
?
-
the recombinant enzyme is able to convert a mammalian acceptor glycoprotein into an antigen binding anti-plant N-glycan antibodies, overview
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
UDP-alpha-D-xylose + N4-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc]-L-asparaginyl-[protein]
UDP + N4-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc]-L-asparaginyl-[protein]
-
-
-
-
?
UDP-alpha-D-xylose + xylan
?
the enzyme adds side chain xylosyl residues directly to the xylan backbone at 2-O
-
-
?
UDP-D-xylose + galactoxylomannan
UDP + [beta-D-xylose-(1,2)]-galactoxylomannan
-
JEC21/cxt1delta and CAP67/cxt1delta lacking CXT1p: almost complete loss of beta-xylose residues (1,2)-linked to mannose, unchanged amounts of beta-xylose (1,3)-linked to galactose
-
?
UDP-D-xylose + galactoxylomannan
UDP + [beta-D-xylosyl-(1,2)]-galactoxylomannan
-
-
-
?
UDP-D-xylose + glucuronoxylomannan
UDP + [beta-D-xylose-(1,2)]-glucuronoxylomannan
-
JEC21/cxt1delta and CAP67/cxt1delta lacking CXT1p: 30% decrease in amount of xylose, 39% decrease in O-2 xylose-substituted mannose, 31.5% increase in O-2-unsubstituted mannose, loss of 1/3 of beta-(1,2)-linked xylose, revealed by NMR analyses
-
?
UDP-D-xylose + glucuronoxylomannan
UDP + [beta-D-xylosyl-(1,2)]-glucuronoxylomannan
-
-
-
?
UDP-D-xylose + N4-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl]asparagine
UDP + N4-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-[beta-D-xylosyl-(1,2)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl]asparagine
UDP-D-xylose + N4-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl]asparagine
UDP + N4-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-[beta-D-xylosyl-(1->2)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl]asparagine
UDP-xylose + mannosyl-alpha-(1,3)-mannosyl-alpha-(1,4)-galactosyl-beta-(1,6)-mannosyl-alpha-(1,2)-inositol phosphorylceramide
UDP + mannosyl-alpha-(1,3)-[xylosyl-beta-(1,2)]-mannosyl-alpha-(1,4)-galactosyl-beta-(1,6)-mannosyl-alpha-(1,2)-inositol phosphorylceramide
no transfer of xylose residues onto substrate in absence of Cxt1p (JEC21/cxt1delta) as revealed by mass spectrometry and HPTLC, mannosyl-alpha-(1,3)-mannose-alpha motif also present in substrates for capsule polysaccharide synthesis
core structure of glycosylinositol phosphorylceramides, GIPCs
-
?
UDP-xylose + mannosyl-alpha-(1,6)-mannosyl-alpha-(1,3)-mannosyl-alpha-(1,4)-galactosyl-beta-(1,6)-mannosyl-alpha-(1,2)-inositol phosphorylceramide
UDP + mannosyl-alpha-(1,6)-mannosyl-alpha-(1,3)-[xylosyl-beta-(1,2)]-mannosyl-alpha-(1,4)-galactosyl-beta-(1,6)-mannosyl-alpha-(1,2)-inositol phosphorylceramide
no transfer of xylose residues onto substrate in absence of Cxt1p (JEC21/cxt1delta) as revealed by mass spectrometry and HPTLC
-
-
?
UDP-D-xylose + N4-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl]asparagine
UDP + N4-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-[beta-D-xylosyl-(1,2)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl]asparagine
-
-
-
-
?
UDP-D-xylose + N4-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl]asparagine
UDP + N4-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-[beta-D-xylosyl-(1,2)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl]asparagine
-
-
-
?
UDP-D-xylose + N4-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl]asparagine
UDP + N4-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-[beta-D-xylosyl-(1->2)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl]asparagine
-
-
-
?
UDP-D-xylose + N4-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl]asparagine
UDP + N4-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-[beta-D-xylosyl-(1->2)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl]asparagine
-
-
-
-
?
UDP-D-xylose + N4-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl]asparagine
UDP + N4-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-[beta-D-xylosyl-(1->2)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl]asparagine
-
-
-
-
?
additional information
?
-
-
the enzyme is involved in the biosynthesis of glycoprotein-bound N-glycans in plants and acts at multiple stages of the plant N-glycosylation pathway, overview
-
-
?
additional information
?
-
preferred substrate depends on wild-type strain, strain JEC21: both products detectable (mannosyl-alpha-(1,6)-mannosyl-alpha-(1,3)-[xylosyl-beta-(1,2)]-mannosyl-alpha-(1,4)-galactosyl-beta-(1,6)-mannosyl-alpha-(1,2)-inositol phosphorylceramide and mannosyl-alpha-(1,3)-[xylosyl-beta-(1,2)]-mannosyl-alpha-(1,4)-galactosyl-beta-(1,6)-mannosyl-alpha-(1,2)-inositol phosphorylceramide) at a ratio of approximately 1:1
-
-
?
additional information
?
-
-
preferred substrate depends on wild-type strain, strain JEC21: both products detectable (mannosyl-alpha-(1,6)-mannosyl-alpha-(1,3)-[xylosyl-beta-(1,2)]-mannosyl-alpha-(1,4)-galactosyl-beta-(1,6)-mannosyl-alpha-(1,2)-inositol phosphorylceramide and mannosyl-alpha-(1,3)-[xylosyl-beta-(1,2)]-mannosyl-alpha-(1,4)-galactosyl-beta-(1,6)-mannosyl-alpha-(1,2)-inositol phosphorylceramide) at a ratio of approximately 1:1
-
-
?
additional information
?
-
-
transfer of beta (1,2)-xylose, capsule synthesis
-
-
?
additional information
?
-
transfer of beta (1,2)-xylose, capsule synthesis
-
-
?
additional information
?
-
transfer of beta (1,2)-xylose, synthesis of capsule polysaccharides and fungi-specific glycosphingolipids
-
-
?
additional information
?
-
-
transfer of beta (1,2)-xylose, synthesis of capsule polysaccharides and fungi-specific glycosphingolipids
-
-
?
additional information
?
-
-
probably involved in the biosynthesis of the inner part of hemocyanin glycans
-
-
?
additional information
?
-
-
-
strongly reduced biosynthesis of beta 1,2-xylose-containing glycoepitopes upon knock-down of endogenous beta 1,2-xylosyltransferase using sense, antisense and RNA interference approaches
-
?
additional information
?
-
-
-
strongly reduced biosynthesis of beta 1,2-xylose-containing glycoepitopes upon knock-down of endogenous beta 1,2-xylosyltransferase using RNA interference approaches
-
?
additional information
?
-
enzyme is involved in N-glycan biosynthesis, quantification and structure analysis of N-glycans in rice leaves
-
-
?
additional information
?
-
-
enzyme is involved in N-glycan biosynthesis, quantification and structure analysis of N-glycans in rice leaves
-
-
?
additional information
?
-
the enzyme is unable to add xylosyl residues onto the arabinosyl side chains of xylan
-
-
-
additional information
?
-
the enzyme is involved in the modification of asparagine-linked oligosaccharides of maize glycoproteins with beta1,2-xylose sugar residues
-
-
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Mg2+
Mn2+
additional information
additional information
activity not dependent on divalent cations
additional information
is active in the presence of 10 mM EDTA and does not require the addition of any metal ions for activity
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
-
10 mM EDTA does not reduce endogenous activity
-
additional information
10 mM EDTA does not reduce endogenous activity
-
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenoma, Pleomorphic
Effect of Xylosyltransferase-I Silencing on Implanting Growth of Salivary Pleomorphic Adenoma.
Aortic Aneurysm, Abdominal
Xylosyltransferase I variants and their impact on abdominal aortic aneurysms.
Connective Tissue Diseases
Measurement of fibrosis marker xylosyltransferase I activity by HPLC electrospray ionization tandem mass spectrometry.
Diabetes Mellitus, Type 1
The Xylosyltransferase I Gene Polymorphism c.343G>T (p.A125S) Is a Risk Factor for Diabetic Nephropathy in Type 1 Diabetes.
Diabetic Nephropathies
Novel sequence variants in the human xylosyltransferase I gene and their role in diabetic nephropathy.
Diabetic Nephropathies
The Xylosyltransferase I Gene Polymorphism c.343G>T (p.A125S) Is a Risk Factor for Diabetic Nephropathy in Type 1 Diabetes.
Essential Hypertension
Xylosyltransferase gene variants and their role in essential hypertension.
Mucopolysaccharidosis III
Impairment of glycosaminoglycan synthesis in mucopolysaccharidosis type IIIA cells by using siRNA: a potential therapeutic approach for Sanfilippo disease.
Myopia
Mutations in DZIP1 and XYLT1 are associated with nonsyndromic early onset high myopia in the Korean population.
Neoplasm Metastasis
The effect of proteoglycans inhibited by RNA interference on metastatic characters of human salivary adenoid cystic carcinoma.
Obesity
An epigenome-wide study of body mass index and DNA methylation in blood using participants from the Sister Study cohort.
Osteoarthritis
Xylosyltransferase-I regulates glycosaminoglycan synthesis during the pathogenic process of human osteoarthritis.
Pseudoxanthoma Elasticum
Elevated xylosyltransferase I activities in pseudoxanthoma elasticum (PXE) patients as a marker of stimulated proteoglycan biosynthesis.
Renal Insufficiency
Serum xylosyltransferase I activity, the new biochemical fibrosis marker, is not affected by renal insufficiency.
Scleroderma, Systemic
Cytokine-mediated induction of human xylosyltransferase-I in systemic sclerosis skin fibroblasts.
Scleroderma, Systemic
Serum xylosyltransferase I activity, the new biochemical fibrosis marker, is not affected by renal insufficiency.
Spinal Cord Injuries
Transcriptional regulation of scar gene expression in primary astrocytes.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.055
dansylated Galbeta-(1,4)-GlcNAcbeta-(1,2)-Manalpha-(1,6)-(Galbeta-(1,4)-GlcNAcbeta-(1,2)-Manalpha-(1,3))-Manbeta-(1,4)-GlcNAcbeta-(1,4)-GlcNAc
recombinant soluble enzyme, pH 6.0, 16°C
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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
-
transfer of 300 cpm/min/mg by endogenous activity in crude membranes
additional information
transfer of 300 cpm/min/mg by endogenous activity in crude membranes
additional information
-
transfer of 890000 cpm/min/mg by endogenous, purified activity after alpha-(1,3)-mannobiose affinity chromatography
additional information
transfer of 890000 cpm/min/mg by endogenous, purified activity after alpha-(1,3)-mannobiose affinity chromatography
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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