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Information on EC - NAD+-diphthamide ADP-ribosyltransferase

for references in articles please use BRENDA:EC2.4.2.36
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EC Tree
     2 Transferases
         2.4 Glycosyltransferases
             2.4.2 Pentosyltransferases
       NAD+-diphthamide ADP-ribosyltransferase
IUBMB Comments
Diphtheria toxin and some other bacterial toxins catalyse this reaction, which inactivates translation elongation factor 2 (EF2). The acceptor is diphthamide, a unique modification of a histidine residue in the elongation factor found in archaebacteria and all eukaryotes, but not in eubacteria. cf. EC NAD(P)+---protein-arginine ADP-ribosyltransferase. The relevant histidine of EF2 is His715 in mammals, His699 in yeast and His600 in Pyrococcus horikoshii.
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
(adenosine diphosphoribose)transferase, nicotinamide adenine dinucleotide-elongation factor 2, ADP-ribosyltransferase, cholera toxin, cholix, cholix toxin, chxA, CTB, diphthamide-specific ADPRT, diphthamide-specific mono-ADP-ribosylating toxin, EHI 155600, more
NAD+ + diphthamide-[translation elongation factor 2] = nicotinamide + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2]
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