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Disease on EC 2.4.2.3 - uridine phosphorylase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acidosis
Impaired renal H+ secretion and NH3 production in mineralocorticoid-deficient glucocorticoid-replete dogs.
Renal tubular acidosis.
Adenocarcinoma
Differential effects of 2,2'-anhydro-5-ethyluridine, a uridine phosphorylase inhibitor, on the antitumor activity of 5-fluorouridine and 5-fluoro-2'-deoxyuridine.
Purification, cloning, and expression of murine uridine phosphorylase.
Anemia
Inhibition of uridine phosphorylase: synthesis and structure-activity relationships of aryl-substituted 5-benzyluracils and 1-[(2-hydroxyethoxy)methyl]-5-benzyluracils.
Breast Neoplasms
Activation of Stat1, IRF-1, and NF-kappaB is required for the induction of uridine phosphorylase by tumor necrosis factor-alpha and interferon-gamma.
Expression of uridine and thymidine phosphorylase genes in human breast carcinoma.
Fluoropyrimidine sensitivity of human MCF-7 breast cancer cells stably transfected with human uridine phosphorylase.
Modulation of uridine phosphorylase gene expression by tumor necrosis factor-alpha enhances the antiproliferative activity of the capecitabine intermediate 5'-deoxy-5-fluorouridine in breast cancer cells.
p53-dependent suppression of uridine phosphorylase gene expression through direct promoter interaction.
Uridine phosphorylase (-/-) murine embryonic stem cells clarify the key role of this enzyme in the regulation of the pyrimidine salvage pathway and in the activation of fluoropyrimidines.
Uridine phosphorylase 1 associates to biological and clinical significance in thyroid carcinoma cell lines.
Uridine phosphorylase in breast cancer: a new prognostic factor?
Bronchial Spasm
[Anaphylactic shock during the use of high doses of aprotinin in cardiac surgery]
Carcinogenesis
Relative mRNA expression of prostate-derived E-twenty-six factor and E-twenty-six variant 4 transcription factors, and of uridine phosphorylase-1 and thymidine phosphorylase enzymes, in benign and malignant prostatic tissue.
Uridine homeostatic disorder leads to DNA damage and tumorigenesis.
Carcinoma
Cytokines induce uridine phosphorylase in mouse colon 26 carcinoma cells and make the cells more susceptible to 5'-deoxy-5-fluorouridine.
Effects of combined administration of DPD-inhibitory oral fluoropyrimidine, S-1, plus paclitaxel on gene expressions of fluoropyrimidine metabolism-related enzymes in human gastric xenografts.
Potentiation of 5-fluoro-2'-deoxyuridine antineoplastic activity by the uridine phosphorylase inhibitors benzylacyclouridine and benzyloxybenzylacyclouridine.
Specific activities of uridine phosphorylase and uridine kinase in Ehrlich ascites carcinoma cells and 6-azauracil- and 6-azauridine-treated sublines in successive transplant generations.
Uridine phosphorylase and uridine kinase activities of the Ehrlich ascites carcinoma.
Uridine phosphorylase is a potential prognostic factor in patients with oral squamous cell carcinoma.
Carcinoma, Hepatocellular
Uridine homeostatic disorder leads to DNA damage and tumorigenesis.
Uridine phosphorylase from Novikoff rat hepatoma cells: purification, kinetic properties, and its role in uracil anabolism.
Colonic Neoplasms
Differential effects of 2,2'-anhydro-5-ethyluridine, a uridine phosphorylase inhibitor, on the antitumor activity of 5-fluorouridine and 5-fluoro-2'-deoxyuridine.
[Analysis of the salvage synthesis within biosynthesis of nucleic acid route in colon cancer]
Colorectal Neoplasms
Cloning and expression of human uridine phosphorylase.
Gene expression of 5-fluorouracil metabolic enzymes in primary colorectal cancer and corresponding liver metastasis.
Real-time RT-PCR (TaqMan) of tumor mRNA to predict sensitivity of specimens to 5-fluorouracil.
Upregulation of enzymes metabolizing 5-fluorouracil in colorectal cancer.
Communicable Diseases
X-ray structure of Salmonella typhimurium uridine phosphorylase complexed with 5-fluorouracil and molecular modelling of the complex of 5-fluorouracil with uridine phosphorylase from Vibrio cholerae.
Coronary Disease
[Analysis of the misdiagnoses of obliterative pulmonary hypertension]
Diabetes Mellitus, Type 1
A perfect storm: Genetics and anticommensal antibodies shore up type 1 diabetes.
Dyslipidemias
Low urine pH affects the development of metabolic syndrome, associative with the increase of dyslipidemia and dysglycemia: Nationwide cross-sectional study (KNHANES 2013-2015) and a single-center retrospective cohort study.
Exanthema
[Anaphylactic shock during the use of high doses of aprotinin in cardiac surgery]
Glioma
Uridine phosphorylase 1 is a novel immune-related target and predicts worse survival in brain glioma.
Head and Neck Neoplasms
Uridine phosphorylase 1 associates to biological and clinical significance in thyroid carcinoma cell lines.
Heart Defects, Congenital
[Analysis of the misdiagnoses of obliterative pulmonary hypertension]
Heart Valve Diseases
[Analysis of the misdiagnoses of obliterative pulmonary hypertension]
Hypertension
Low urine pH affects the development of metabolic syndrome, associative with the increase of dyslipidemia and dysglycemia: Nationwide cross-sectional study (KNHANES 2013-2015) and a single-center retrospective cohort study.
Hypocalcemia
Measurement of urine pH and net acid excretion and their association with urine calcium excretion in periparturient dairy cows.
Hypotension
[Anaphylactic shock during the use of high doses of aprotinin in cardiac surgery]
Infections
Structural and catalytic analysis of two diverse uridine phosphorylases in Phytophthora capsici.
Leukemia
Role of uridine phosphorylase for antitumor activity of 5'-deoxy-5-fluorouridine.
[Activities of enzymes converting 5-fluorouracil to 5-fluorouridine-5' monophosphate and 5-fluorodeoxyuridine-5' monophosphate in subcultured cell lines and solid tumor tissues]
Liver Cirrhosis
Therapeutic effect of uridine phosphorylase 1 (UPP1) inhibitor on liver fibrosis in vitro and in vivo.
Lung Neoplasms
In vitro simulation study of individualized chemotherapy in lung cancer.
Lymphoma
Inhibition of nucleoside transport in murine lymphoma L5178Y cells and human erythrocytes by the uridine phosphorylase inhibitors 5-benzylacyclouridine and 5-benzyloxybenzylacyclouridine.
Uridine homeostatic disorder leads to DNA damage and tumorigenesis.
Melanoma
High uridine phosphorylase activity in human melanoma tumor.
Metabolic Syndrome
Low urine pH affects the development of metabolic syndrome, associative with the increase of dyslipidemia and dysglycemia: Nationwide cross-sectional study (KNHANES 2013-2015) and a single-center retrospective cohort study.
Mucositis
Human uridine phosphorylase-1 inhibitors: a new approach to ameliorate 5-fluorouracil-induced intestinal mucositis.
Myocardial Infarction
Prognostic value of spot testing urine pH as a novel marker in patients with ST-segment elevation myocardial infarction.
Neoplasm Metastasis
Predictive molecular markers for colorectal cancer patients with resected liver metastasis and adjuvant chemotherapy.
Relative mRNA expression of prostate-derived E-twenty-six factor and E-twenty-six variant 4 transcription factors, and of uridine phosphorylase-1 and thymidine phosphorylase enzymes, in benign and malignant prostatic tissue.
Uridine phosphorylase is a potential prognostic factor in patients with oral squamous cell carcinoma.
Neoplasms
19F NMR monitoring of in vivo tumor metabolism after biochemical modulation of 5-fluorouracil by the uridine phosphorylase inhibitor 5-benzylacyclouridine.
Activation of Stat1, IRF-1, and NF-kappaB is required for the induction of uridine phosphorylase by tumor necrosis factor-alpha and interferon-gamma.
Activity and substrate specificity of pyrimidine phosphorylases and their role in fluoropyrimidine sensitivity in colon cancer cell lines.
Augmentation of antitumor activity of 5'-deoxy-5-fluorouridine by thymosin fraction 5 in mouse bladder cancer cells in vitro and in vivo.
Cloning and expression of human uridine phosphorylase.
Development of inhibitors of pyrimidine metabolism.
Differential expression of uridine phosphorylase in tumors contributes to an improved fluoropyrimidine therapeutic activity.
Effect of administration of 5-(phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase, on the anti-tumor efficacy of 5-fluoro-2'-deoxyuridine against murine colon tumor C26-10.
Enhancement of 5-fluoro-2'-deoxyuridine antitumor efficacy by the uridine phosphorylase inhibitor 5-(benzyloxybenzyl)barbituric acid acyclonucleoside.
Enzymatic activities of uridine and thymidine phosphorylase in normal and cancerous uterine cervical tissues.
Expression of uridine and thymidine phosphorylase genes in human breast carcinoma.
Expression, characterization, and detection of human uridine phosphorylase and identification of variant uridine phosphorolytic activity in selected human tumors.
Fluoropyrimidine sensitivity of human MCF-7 breast cancer cells stably transfected with human uridine phosphorylase.
High uridine phosphorylase activity in human melanoma tumor.
Homeostatic control of uridine and the role of uridine phosphorylase: a biological and clinical update.
In silico/in vitro study of hybrid D-modified steroidal alkylator anticancer activity using uridine phosphorylase as target protein.
Induction of thymidine phosphorylase by interferon and taxanes occurs only in human cancer cells with low thymidine phosphorylase activity.
Induction of thymidine phosphorylase expression and enhancement of efficacy of capecitabine or 5'-deoxy-5-fluorouridine by cyclophosphamide in mammary tumor models.
Irreversible enzyme inhibitors. 202. Candidate active-site-directed irreversible inhibitors of 5-fluoro-2'-deoxyuridine phosphorylase from Walker 256 rat tumor derived from 1-benzyl-5-(3-ethoxybenzyl)uracil.
Modulation of 5-fluorouracil host-toxicity and chemotherapeutic efficacy against human colon tumors by 5-(Phenylthio)acyclouridine, a uridine phosphorylase inhibitor.
Modulation of uridine phosphorylase gene expression by tumor necrosis factor-alpha enhances the antiproliferative activity of the capecitabine intermediate 5'-deoxy-5-fluorouridine in breast cancer cells.
peroxisome proliferator-activated receptor gamma coactivator-1alpha enhances antiproliferative activity of 5'-deoxy-5-fluorouridine in cancer cells through induction of uridine phosphorylase.
Phase I clinical and pharmacological studies of benzylacyclouridine, a uridine phosphorylase inhibitor.
Predictive molecular markers for colorectal cancer patients with resected liver metastasis and adjuvant chemotherapy.
Purification, cloning, and expression of murine uridine phosphorylase.
Real-time RT-PCR (TaqMan) of tumor mRNA to predict sensitivity of specimens to 5-fluorouracil.
Relative mRNA expression of prostate-derived E-twenty-six factor and E-twenty-six variant 4 transcription factors, and of uridine phosphorylase-1 and thymidine phosphorylase enzymes, in benign and malignant prostatic tissue.
Role of uridine phosphorylase for antitumor activity of 5'-deoxy-5-fluorouridine.
Role of uridine phosphorylase in the anabolism of 5-fluorouracil.
Synthesis and biological activity of 5'-substituted 5-fluoropyrimidine nucleosides.
Synthesis of [18F]Xeloda as a novel potential PET radiotracer for imaging enzymes in cancers.
The kinetic mechanism of human uridine phosphorylase 1: Towards the development of enzyme inhibitors for cancer chemotherapy.
The role of interferon-alpha as a modulator of fluorouracil and leucovorin.
Transcription and activity of 5-fluorouracil converting enzymes in fluoropyrimidine resistance in colon cancer in vitro.
Up-regulated expression of the uridine phosphorylase gene in human gastric tumors is correlated with a favorable prognosis.
Upregulation of enzymes metabolizing 5-fluorouracil in colorectal cancer.
Uridine homeostatic disorder leads to DNA damage and tumorigenesis.
Uridine phosophorylase: an important enzyme in pyrimidine metabolism and fluoropyrimidine activation.
Uridine phosphorylase (-/-) murine embryonic stem cells clarify the key role of this enzyme in the regulation of the pyrimidine salvage pathway and in the activation of fluoropyrimidines.
Uridine phosphorylase 1 associates to biological and clinical significance in thyroid carcinoma cell lines.
Uridine phosphorylase 1 is a novel immune-related target and predicts worse survival in brain glioma.
Uridine phosphorylase in breast cancer: a new prognostic factor?
Uridine phosphorylase is a potential prognostic factor in patients with oral squamous cell carcinoma.
X-ray structure of Salmonella typhimurium uridine phosphorylase complexed with 5-fluorouracil and molecular modelling of the complex of 5-fluorouracil with uridine phosphorylase from Vibrio cholerae.
[5'-Deoxy-5-fluorouridine enzymatic activation from the masked compound to 5-fluorouracil in human malignant tissues]
[Activities of enzymes converting 5-fluorouracil to 5-fluorouridine-5' monophosphate and 5-fluorodeoxyuridine-5' monophosphate in subcultured cell lines and solid tumor tissues]
[Influence on 5-fluorouracil metabolism by combination of interferon-alpha and 5-fluorouracil against human hepatocellular carcinoma xenografts]
[Mode of action of fluoropyrimidines, in relation to their clinical application]
Nephrolithiasis
Fasting versus 24-h urine pH in the evaluation of nephrolithiasis.
Nephrotic Syndrome
High (?6.5) Spontaneous and Persistent Urinary pH Is Protective of Renal Function at Baseline and during Disease Course in Idiopathic Membranous Nephropathy.
Obesity, Abdominal
Low urine pH affects the development of metabolic syndrome, associative with the increase of dyslipidemia and dysglycemia: Nationwide cross-sectional study (KNHANES 2013-2015) and a single-center retrospective cohort study.
Pancreatic Neoplasms
In silico/in vitro study of hybrid D-modified steroidal alkylator anticancer activity using uridine phosphorylase as target protein.
Pancreatitis
[Autoimmune pancreatitis: Report of 10 cases]
Prostatic Neoplasms
Benzylacyclouridine enhances 5-fluorouracil cytotoxicity against human prostate cancer cell lines.
Sarcoma 180
Biological activity of the potent uridine phosphorylase inhibitor 5-ethyl-2,2'-anhydrouridine.
Synthesis of 1-[[2-hydroxy-1-(hydroxymethyl)ethoxy] methyl]-5-benzyluracil and its amino analogue, new potent uridine phosphorylase inhibitors with high water solubility.
Sleep Apnea Syndromes
Lower urinary pH is useful for predicting renovascular disorder onset in patients with diabetes.
Squamous Cell Carcinoma of Head and Neck
Uridine phosphorylase is a potential prognostic factor in patients with oral squamous cell carcinoma.
Thyroid Neoplasms
Uridine phosphorylase 1 associates to biological and clinical significance in thyroid carcinoma cell lines.