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EC Tree
IUBMB Comments Also acts on 5'-deoxyadenosine and other analogues having 5'-deoxy groups.
The taxonomic range for the selected organisms is: Mus musculus The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
methylthioadenosine phosphorylase, 5'-methylthioadenosine phosphorylase, mta phosphorylase, mtap protein, 5'-deoxy-5'-methylthioadenosine phosphorylase, ssmtapii, ssmtap, mtapase, mesado phosphorylase, pfmtap,
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5'-deoxy-5'-methylthioadenosine:orthophosphate methylthioribosyltransferase
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5'-methylthioadenosine phosphorylase
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5'-deoxy-5'-methylthioadenosine phosphorylase
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5'-methylthioadenosine nucleosidase
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5'-methylthioadenosine phosphorylase
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MeSAdo phosphorylase
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MeSAdo/Ado phosphorylase
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methylthioadenosine nucleoside phosphorylase
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methylthioadenosine phosphorylase
MTA phosphorylase
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phosphorylase, methylthioadenosine
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methylthioadenosine phosphorylase
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methylthioadenosine phosphorylase
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pentosyl group transfer
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S-methyl-5'-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase
Also acts on 5'-deoxyadenosine and other analogues having 5'-deoxy groups.
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5'-methylthioadenosine + phosphate
adenine + 5-methylthio-D-ribose 1-phosphate
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r
5'-deoxy-5'-methylthioadenosine + phosphate
adenine + 5-methylthio-D-ribose 1-phosphate
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-
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r
5'-deoxyadenosine + phosphate
adenine + 5-deoxy-D-ribose 1-phosphate
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phosphate-dependent
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r
5'-methylthioadenosine + phosphate
adenine + 5-methylthio-D-ribose 1-phosphate
5'-methylthioadenosine + phosphate
adenine + 5-methylthio-D-ribose 1-phosphate
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-
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?
5'-methylthioadenosine + phosphate
adenine + 5-methylthio-D-ribose 1-phosphate
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r
5'-methylthioadenosine + phosphate
adenine + 5-methylthio-D-ribose 1-phosphate
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involved in salvage of adenine and methionine from 5'-methylthioadenosine
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?
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5'-methylthioadenosine + phosphate
adenine + 5-methylthio-D-ribose 1-phosphate
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involved in salvage of adenine and methionine from 5'-methylthioadenosine
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?
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hydrogen peroxide
reversible inactivation, 60% decrease of enzymatic activity at 0.5 mM hydrogen peroxide
tert-butyl hydroperoxide
0.01 mM
2-bromo-9-(1,3-dihydroxy-2-propoxymethyl)adenine
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strong
2-bromo-9-(2-hydroxyethoxymethyl)adenine
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2-chloro-9-(1,3-dihydroxy-2-propoxymethyl)adenine
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strong
2-chloro-9-(2-hydroxyethoxymethyl)adenine
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2-iodo-9-(1,3-dihydroxy-2-propoxymethyl)adenine
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strong
2-iodo-9-(2-hydroxyethoxymethyl)adenine
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5'-Deoxy-5'-chloroformycin
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competitive
9-(phosphonoalkyl)adenine
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9-(phosphonoheptyl)adenine
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9-[(1-Hydroxy-3-iodo-2-propoxy)methyl]adenine
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competitive
additional information
MTAP is inactivated in the liver of lipopolysaccharide-challenged mice
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0.004
5'-deoxy-5'-methylthioadenosine
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0.0002 - 0.0007
2-bromo-9-(1,3-dihydroxy-2-propoxymethyl)adenine
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0.001 - 0.01
2-bromo-9-(2-hydroxyethoxymethyl)adenine
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0.0002 - 0.0007
2-chloro-9-(1,3-dihydroxy-2-propoxymethyl)adenine
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0.001 - 0.01
2-chloro-9-(2-hydroxyethoxymethyl)adenine
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0.0002 - 0.0007
2-iodo-9-(1,3-dihydroxy-2-propoxymethyl)adenine
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0.001 - 0.01
2-iodo-9-(2-hydroxyethoxymethyl)adenine
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0.015
9-(phosphonoheptyl)adenine
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low phosphate concentration of 3.5 mM
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UniProt
brenda
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brenda
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additional information
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RRK081 cells, heterozygous for the MtaplacZ allele
brenda
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malfunction
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mice homozygous for a MTAP null allele (MtaplacZ) have an embryonic lethal phenotype dying around day 8 postconception. Mtap/MtaplacZ heterozygotes are born at Mendelian frequencies and appear indistinguishable from wild-type mice during the first year of life, but tend to die prematurely with a median survival of 585 days. These animals have greatly enlarged spleens, altered thymic histology, and lymphocytic infiltration of their livers, consistent with lymphoma
physiological function
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Mtap is essential during embryogenesis. Mtap is a tumor suppressor gene independent of CDKN2A and ARF
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MTAP_MOUSE
283
0
31062
Swiss-Prot
other Location (Reliability: 2 )
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C136S
mutant is insensitive to oxidative inhibition
C223S
mutant is insensitive to oxidative inhibition
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Ni2+-Sepharose column chromatography
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expressed in Escherichia coli BL21(DE3) cells
RRK081 embryonic stem cells, containing a gene-trap vector inserted between exon 3 and exon 4 of the mouse Mtap locus (MtaplacZ) injected into mouse blastocysts derived from C57BL/6 animals, embryos implanted in pseudopregnant females
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lymphoma-infiltrated tissues tend to have reduced levels of Mtap mRNA and MTAP protein in addition to unaltered levels of methyldeoxycytidine. Loss of MTAP expression is independent from loss of CDKN2A expression
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Savarese, T.M.; Harrington, S.; Nakamura, C.; Chen, Z.H.; Kumar, P.; Mikkilineni, A.; Abushanab, E.; Chu, S.H.; Parks, R.E.
5'-Deoxy-5'-methylthioadenosine phosphorylase. V. Acycloadenosine derivatives as inhibitors of the enzyme
Biochem. Pharmacol.
40
2465-2471
1990
Homo sapiens, Mus musculus
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Savarese, T.M.; Crabtree, G.W.; Parks, R.E.
5'-Methylthioadenosine phosphorylase. I. Substrate activity of 5'-deoxyadenosine with the enzyme from Sarcoma 180 cells
Biochem. Pharmacol.
30
189-199
1981
Mus musculus
brenda
Fernandez-Irigoyen, J.; Santamaria, M.; Sanchez-Quiles, V.; Latasa, M.U.; Santamaria, E.; Munoz, J.; Sanchez Del Pino, M.M.; Valero, M.L.; Prieto, J.; Avila, M.A.; Corrales, F.J.
Redox regulation of methylthioadenosine phosphorylase in liver cells: molecular mechanism and functional implications
Biochem. J.
411
457-465
2008
Homo sapiens, Mus musculus (Q9CQ65)
brenda
Kadariya, Y.; Yin, B.; Tang, B.; Shinton, S.A.; Quinlivan, E.P.; Hua, X.; Klein-Szanto, A.; Al-Saleem, T.I.; Bassing, C.H.; Hardy, R.R.; Kruger, W.D.
Mice heterozygous for germ-line mutations in methylthioadenosine phosphorylase (MTAP) die prematurely of T-cell lymphoma
Cancer Res.
69
5961-5969
2009
Mus musculus
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