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Information on EC 2.4.2.22 - xanthine phosphoribosyltransferase
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EC Tree
2.4.2.22 xanthine phosphoribosyltransferaseSpecify your search results
Word Map
- 2.4.2.22
- purine
-
salvage
- falciparum
- plasmodium
-
6-oxopurine
-
phosphoribosylation
-
phosphoribosyltransferases
-
tritrichomonas
-
prtases
-
2.4.2.8
-
cho-k1-bh4
- hgprts
-
2.7.1.20
-
psv2-gpt
- medicine
The enzyme appears in viruses and cellular organisms
Synonyms
xprt, xgprt, xanthine phosphoribosyltransferase, hgxprt, hypoxanthine-guanine-xanthine phosphoribosyltransferase, xprtase, pf hgxprt, hypoxanthine-guanine-(xanthine) phosphoribosyltransferase, ecxgprt, xanthine prt, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
5-phospho-alpha-D-ribose-1-diphosphate:xanthine phospho-D-ribosyltransferase
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-
-
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phosphoribosyltransferase, xanthine
-
-
-
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ttha0535
TtXPRT
Xan phosphoribosyltransferase
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-
-
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xanthine phosphoribosyltransferase
xanthosine 5'-phosphate pyrophosphorylase
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-
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xanthylate pyrophosphorylase
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-
-
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xanthylic pyrophosphorylase
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-
-
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XGPRT
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-
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XMP pyrophosphorylase
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-
-
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XPRT
XPRTase
additional information
XPRT
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-
-
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XPRTase
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-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine
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-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
pentosyl group transfer
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-
-
-
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PATHWAY SOURCE
PATHWAYS
BRENDA
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SYSTEMATIC NAME
IUBMB Comments
XMP:diphosphate 5-phospho-alpha-D-ribosyltransferase
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CAS REGISTRY NUMBER
COMMENTARY
9023-10-3
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
5-phospho-alpha-D-ribose 1-diphosphate + 4,6-dihydroxypyrazolo[3,4-d]pyrimidine
?
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at 0.064% of the activity with xanthine
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-
?
5-phospho-alpha-D-ribose 1-diphosphate + 5,7-dihydroxy-v-triazolo[4,5-d]pyrimidine
?
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at 16.8% of the activity with xanthine
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-
?
5-phospho-alpha-D-ribose 1-diphosphate + xanthine
9-(5-phospho-beta-D-ribosyl)xanthine + diphosphate
9-(5-phospho-beta-D-ribosyl)xanthine + diphosphate
5-phospho-alpha-D-ribose 1-diphosphate + xanthine
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-
-
-
?
guanosine + 5-phospho-alpha-D-ribose 1-diphosphate
GMP + diphosphate
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-
-
?
IMP + diphosphate
5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine
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-
-
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r
5-phospho-alpha-D-ribose 1-diphosphate + adenine
AMP + diphosphate
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at 0.25% of the activity with xanthine
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-
?
5-phospho-alpha-D-ribose 1-diphosphate + adenine
AMP + diphosphate
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less than 1% of the activity with xanthine
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-
?
5-phospho-alpha-D-ribose 1-diphosphate + guanine
GMP + diphosphate
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-
-
?
5-phospho-alpha-D-ribose 1-diphosphate + guanine
GMP + diphosphate
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-
-
?
5-phospho-alpha-D-ribose 1-diphosphate + guanine
GMP + diphosphate
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-
-
-
?
5-phospho-alpha-D-ribose 1-diphosphate + guanine
GMP + diphosphate
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-
-
-
?
5-phospho-alpha-D-ribose 1-diphosphate + guanine
GMP + diphosphate
-
-
-
-
?
5-phospho-alpha-D-ribose 1-diphosphate + guanine
GMP + diphosphate
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-
-
-
?
5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine
IMP + diphosphate
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-
-
?
5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine
IMP + diphosphate
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at 0.19% of the activity with xanthine
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-
?
5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine
IMP + diphosphate
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-
-
?
5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine
IMP + diphosphate
-
-
-
-
?
5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine
IMP + diphosphate
-
-
-
-
r
5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine
IMP + diphosphate
-
-
-
-
?
5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine
IMP + diphosphate
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-
-
-
?
5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine
IMP + diphosphate
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-
-
-
?
5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine
IMP + diphosphate
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-
-
-
?
5-phospho-alpha-D-ribose 1-diphosphate + xanthine
9-(5-phospho-beta-D-ribosyl)xanthine + diphosphate
in a sequential reaction mechanism XPRTase binds first 5-phospho-alpha-D-ribose 1-diphosphate, stabilizing its active dimeric form, and subsequently xanthine
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-
?
5-phospho-alpha-D-ribose 1-diphosphate + xanthine
9-(5-phospho-beta-D-ribosyl)xanthine + diphosphate
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-
-
?
5-phospho-alpha-D-ribose 1-diphosphate + xanthine
9-(5-phospho-beta-D-ribosyl)xanthine + diphosphate
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-
-
?
5-phospho-alpha-D-ribose 1-diphosphate + xanthine
9-(5-phospho-beta-D-ribosyl)xanthine + diphosphate
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-
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?
5-phospho-alpha-D-ribose 1-diphosphate + xanthine
9-(5-phospho-beta-D-ribosyl)xanthine + diphosphate
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-
-
?
5-phospho-alpha-D-ribose 1-diphosphate + xanthine
9-(5-phospho-beta-D-ribosyl)xanthine + diphosphate
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-
-
?
5-phospho-alpha-D-ribose 1-diphosphate + xanthine
9-(5-phospho-beta-D-ribosyl)xanthine + diphosphate
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-
-
?
5-phospho-alpha-D-ribose 1-diphosphate + xanthine
9-(5-phospho-beta-D-ribosyl)xanthine + diphosphate
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-
-
?
5-phospho-alpha-D-ribose 1-diphosphate + xanthine
9-(5-phospho-beta-D-ribosyl)xanthine + diphosphate
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-
-
-
?
5-phospho-alpha-D-ribose 1-diphosphate + xanthine
9-(5-phospho-beta-D-ribosyl)xanthine + diphosphate
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the enzyme is involved in purine nucleotide synthesis via phosphorylation of purines acquisited from the host, since Leishmania donovani is not able to perform de novo biosynthesis of purine nucleotides
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-
?
5-phospho-alpha-D-ribose 1-diphosphate + xanthine
9-(5-phospho-beta-D-ribosyl)xanthine + diphosphate
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the enzymes catalyzing the transribosylation from 5-phospho-alpha-D-ribose 1-diphosphate to guanine, hypoxanthine and xanthine are inseparable
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?
5-phospho-alpha-D-ribose 1-diphosphate + xanthine
9-(5-phospho-beta-D-ribosyl)xanthine + diphosphate
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-
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?
5-phospho-alpha-D-ribose 1-diphosphate + xanthine
9-(5-phospho-beta-D-ribosyl)xanthine + diphosphate
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-
-
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?
5-phospho-alpha-D-ribose 1-diphosphate + xanthine
9-(5-phospho-beta-D-ribosyl)xanthine + diphosphate
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-
-
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?
5-phospho-alpha-D-ribose 1-diphosphate + xanthine
XMP + diphosphate
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-
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?
5-phospho-alpha-D-ribose 1-diphosphate + xanthine
XMP + diphosphate
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-
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?
5-phospho-alpha-D-ribose 1-diphosphate + xanthine
XMP + diphosphate
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?
guanine + 5-phospho-alpha-D-ribose 1-diphosphate
GMP + diphosphate
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r
guanine + 5-phospho-alpha-D-ribose 1-diphosphate
GMP + diphosphate
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-
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r
guanine + 5-phospho-alpha-D-ribose 1-diphosphate
GMP + diphosphate
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-
-
r
guanine + 5-phospho-alpha-D-ribose 1-diphosphate
GMP + diphosphate
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-
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r
hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
IMP + diphosphate
low activity, reaction of EC 2.4.2.8
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r
hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
IMP + diphosphate
reaction of EC 2.4.2.8
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?
hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
IMP + diphosphate
reaction of EC 2.4.2.8
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r
hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
IMP + diphosphate
reaction of EC 2.4.2.8
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r
hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
IMP + diphosphate
reaction of EC 2.4.2.8
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r
xanthine + 5-phospho-alpha-D-ribose 1-diphosphate
XMP + diphosphate
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-
-
r
xanthine + 5-phospho-alpha-D-ribose 1-diphosphate
XMP + diphosphate
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-
-
?
xanthine + 5-phospho-alpha-D-ribose 1-diphosphate
XMP + diphosphate
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-
-
r
xanthine + 5-phospho-alpha-D-ribose 1-diphosphate
XMP + diphosphate
-
-
-
r
xanthine + 5-phospho-alpha-D-ribose 1-diphosphate
XMP + diphosphate
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-
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r
additional information
?
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Escherichia coli xanthine-guanine phosphoribosyltransferase (EcXGPRT) prefers guanine and xanthine
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additional information
?
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either hypoxanthine-guanine phosphoribosyltransferase or xanthine phosphoribosyltransferase is absolutely essential for purine acquisition, parasite viability, and parasite infectivity of mouse macrophages
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?
additional information
?
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xanthine phosphoribosyltransferase is involved in acquirement of purine nutrients of Leimania from the host, the enzyme is not essential for purine salvage or viability
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?
additional information
?
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substrate specificity, overview. TtXPRT is confirmed as a xanthine phosphoribosyltransferase. Furthermore, TtXPRT can also slightly recognize hypoxanthine and guanine as substrates, but the activity is low. No activity with adenine
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additional information
?
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substrate specificity, overview. TtXPRT is confirmed as a xanthine phosphoribosyltransferase. Furthermore, TtXPRT can also slightly recognize hypoxanthine and guanine as substrates, but the activity is low. No activity with adenine
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-
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additional information
?
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substrate specificity, overview. TtXPRT is confirmed as a xanthine phosphoribosyltransferase. Furthermore, TtXPRT can also slightly recognize hypoxanthine and guanine as substrates, but the activity is low. No activity with adenine
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
5-phospho-alpha-D-ribose 1-diphosphate + guanine
GMP + diphosphate
-
-
-
-
?
5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine
IMP + diphosphate
-
-
-
-
?
5-phospho-alpha-D-ribose 1-diphosphate + xanthine
9-(5-phospho-beta-D-ribosyl)xanthine + diphosphate
-
the enzyme is involved in purine nucleotide synthesis via phosphorylation of purines acquisited from the host, since Leishmania donovani is not able to perform de novo biosynthesis of purine nucleotides
-
-
?
guanine + 5-phospho-alpha-D-ribose 1-diphosphate
GMP + diphosphate
-
-
-
r
guanosine + 5-phospho-alpha-D-ribose 1-diphosphate
GMP + diphosphate
-
-
-
?
hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
IMP + diphosphate
reaction of EC 2.4.2.8
-
-
?
5-phospho-alpha-D-ribose 1-diphosphate + xanthine
XMP + diphosphate
-
-
-
?
5-phospho-alpha-D-ribose 1-diphosphate + xanthine
XMP + diphosphate
-
-
-
?
5-phospho-alpha-D-ribose 1-diphosphate + xanthine
XMP + diphosphate
-
-
-
-
?
xanthine + 5-phospho-alpha-D-ribose 1-diphosphate
XMP + diphosphate
-
-
-
r
xanthine + 5-phospho-alpha-D-ribose 1-diphosphate
XMP + diphosphate
-
-
-
?
xanthine + 5-phospho-alpha-D-ribose 1-diphosphate
XMP + diphosphate
-
-
-
r
xanthine + 5-phospho-alpha-D-ribose 1-diphosphate
XMP + diphosphate
-
-
-
r
xanthine + 5-phospho-alpha-D-ribose 1-diphosphate
XMP + diphosphate
-
-
-
r
additional information
?
-
-
either hypoxanthine-guanine phosphoribosyltransferase or xanthine phosphoribosyltransferase is absolutely essential for purine acquisition, parasite viability, and parasite infectivity of mouse macrophages
-
-
?
additional information
?
-
-
xanthine phosphoribosyltransferase is involved in acquirement of purine nutrients of Leimania from the host, the enzyme is not essential for purine salvage or viability
-
-
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Co2+
Mg2+
Mn2+
Zn2+
Mg2+
magnesium and sulfate can bind together in the active site, in the absence of other products or substrates. The magnesium interacts with a highly conserved aspartate residue
Mn2+
-
maximal catalytic activity with 0.06 mM. Substitution of Mn2+ for Mg2+ results in ca. 2fold increase in the XPRT turnover rate without altering the xanthine Km value. Replacement of Mg2+ with Mn2+ increases the 5-phospho-alpha-D-ribose 1-diphosphate Km value ca. 2fold. XPRT-catalyzed hypoxanthine phosphoribosylation reveals that substitution of Mg2+ with Mn2+ results in a ca. 4fold increase in the hypoxanthine kcat value and ca. 3fold decrease in the hypoxanthine Km value
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
(2-[(2,3-dihydroxypropyl)[2-(6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl]amino]ethyl)phosphonic acid
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(2-[3-(8-bromoguanin-9-yl)-2-(2-(bishydroxyphosphoryl)-ethoxy)propoxy]ethyl)phosphonic acid
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(2-[[2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl][2-(2-phosphonoethoxy)ethyl]amino]ethyl)phosphonic acid
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([2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methyl]-3-(2-phosphonoethoxy)propoxy]methyl)phosphonic acid
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([2-[(6-oxo-1,6-dihydro-9H-purin-9-yl)methyl]-3-(2-phosphonoethoxy)propoxy]methyl)phosphonic acid
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([3-(7-deazaguanine-9-yl)-2-((2-phosphonoethoxy)methyl)propoxy]methyl)phosphonic acid
sodium salt
([3-(7-deazahypoxanthine-9-yl)-2-((2-phosphonoethoxy)methyl)propoxy]methyl)phosphonic acid
sodium salt
([3-(8-bromoguanine-9-yl)-2-((2-phosphonoethoxy)methyl)propoxy]methyl)phosphonic acid
sodium salt
([3-(8-bromohypoxanthine-9-yl)-2-((2-phosphonoethoxy)methyl)propoxy]methyl)phosphonic acid
sodium salt
([3-(guanine-9-yl)-2-((2-phosphonoethoxy)-methyl)propoxy]methyl)phosphonic acid
sodium salt
([3-(hypoxanthine-9-yl)-2-((2-phosphonoethoxy)methyl)propoxy]methyl)phosphonic acid
sodium salt
9-[(N-phosphonoethyl-N-phosphonoethoxyethyl)-2-aminoethyl]-hypoxanthine
-
9-[(N-phosphonoethyl-N-phosphonomethoxyethyl)-2-aminoethyl]hypoxanthine
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diethyl (2S,15S)-2,15-dibenzyl-4,13-bis[[(2S)-1-ethoxy-1-oxo-3-phenylpropan-2-yl]amino]-4,13-dioxo-8-[(4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl]-6,10-dioxa-3,14-diaza-4lambda5,13lambda5-diphosphahexadecane-1,16-dioate
prodrug
diethyl (2S,15S)-2,15-dibenzyl-4,13-bis[[(2S)-1-ethoxy-1-oxo-3-phenylpropan-2-yl]amino]-4,13-dioxo-8-[(6-oxo-1,6-dihydro-9H-purin-9-yl)methyl]-6,10-dioxa-3,14-diaza-4lambda5,13lambda5-diphosphahexadecane-1,16-dioate
prodrug
diethyl (2S,15S)-2,15-dibenzyl-8-[(8-bromo-6-oxo-1,6-dihydro-9H-purin-9-yl)methyl]-4,13-bis[[(2S)-1-ethoxy-1-oxo-3-phenylpropan-2-yl]amino]-4,13-dioxo-6,10-dioxa-3,14-diaza-4lambda5,13lambda5-diphosphahexadecane-1,16-dioate
prodrug
diethyl (2S,15S)-4,13-bis[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-4,13-dioxo-8-[(6-oxo-1,6-dihydro-9H-purin-9-yl)methyl]-2,15-bis(2-phenylethyl)-6,10-dioxa-3,14-diaza-4lambda5,13lambda5-diphosphahexadecane-1,16-dioate
-
diethyl (2S,15S)-8-[(2-amino-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl]-2,15-dibenzyl-4,13-bis[[(2S)-1-ethoxy-1-oxo-3-phenylpropan-2-yl]amino]-4,13-dioxo-6,10-dioxa-3,14-diaza-4lambda5,13lambda5-diphosphahexadecane-1,16-dioate
prodrug
diethyl (2S,15S)-8-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methyl]-2,15-dibenzyl-4,13-bis[[(2S)-1-ethoxy-1-oxo-3-phenylpropan-2-yl]amino]-4,13-dioxo-6,10-dioxa-3,14-diaza-4lambda5,13lambda5-diphosphahexadecane-1,16-dioate
prodrug
diethyl (2S,15S)-8-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methyl]-2,15-dibenzyl-4,13-bis[[(2S)-1-ethoxy-1-oxo-3-phenylpropan-2-yl]amino]-4,13-dioxo-7,10-dioxa-3,14-diaza-4lambda5,13lambda5-diphosphahexadecane-1,16-dioate
prodrug
diethyl (2S,15S)-8-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methyl]-4,13-bis[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-4,13-dioxo-2,15-bis(2-phenylethyl)-6,10-dioxa-3,14-diaza-4lambda5,13lambda5-diphosphahexadecane-1,16-dioate
-
diethyl (2S,15S)-8-[(2-amino-8-bromo-6-oxo-1,6-dihydro-9H-purin-9-yl)methyl]-2,15-dibenzyl-4,13-bis[[(2S)-1-ethoxy-1-oxo-3-phenylpropan-2-yl]amino]-4,13-dioxo-7,10-dioxa-3,14-diaza-4lambda5,13lambda5-diphosphahexadecane-1,16-dioate
prodrug
[3-(guanine-9-yl)-2-((2-phosphonoethoxy)methyl)propoxy]methylphosphonic acid
-
[[2-[(6-oxo-1,6-dihydro-9H-purin-9-yl)methyl]propane-1,3-diyl]bis(oxymethylene)]bis(phosphonic acid)
[[[(4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]azanediyl]di(propane-3,1-diyl)]bis(phosphonic acid)
-