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EC Tree
IUBMB Comments Acts (in the reverse direction) on uracil and other pyrimidines and pteridines containing a 2,4-diketo structure.
The expected taxonomic range for this enzyme is: Bos taurus
Synonyms
2,4-dioxotetrahydropyrimidine-nucleotide:pyrophosphate phospho-alpha-D-ribosyltransferase, dioxotetrahydropyrimidine phosphoribosyl transferase, dioxotetrahydropyrimidine ribonucleotide pyrophosphorylase, dioxotetrahydropyrimidine-ribonucleotide pyrophosphorylase, phosphoribosyltransferase, dioxotetrahydropyrimidine, uracil pyrophosphorylase,
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2,4-dioxotetrahydropyrimidine-nucleotide:pyrophosphate phospho-alpha-D-ribosyltransferase
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dioxotetrahydropyrimidine phosphoribosyl transferase
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dioxotetrahydropyrimidine ribonucleotide pyrophosphorylase
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dioxotetrahydropyrimidine-ribonucleotide pyrophosphorylase
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phosphoribosyltransferase, dioxotetrahydropyrimidine
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uracil pyrophosphorylase
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a 2,4-dioxotetrahydropyrimidine D-ribonucleotide + diphosphate = a 2,4-dioxotetrahydropyrimidine + 5-phospho-alpha-D-ribose 1-diphosphate
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pentosyl group transfer
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2,4-dioxotetrahydropyrimidine-D-ribonucleotide:diphosphate phospho-alpha-D-ribosyltransferase
Acts (in the reverse direction) on uracil and other pyrimidines and pteridines containing a 2,4-diketo structure.
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uric acid + 5-phospho-alpha-D-ribose 1-diphosphate
3-ribosyluric acid 5'-phosphate + diphosphate
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xanthine + 5-phospho-alpha-D-ribose 1-diphosphate
3-ribosylxanthine 5'-phosphate + diphosphate
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additional information
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enzyme also synthesizes a number of pyrimidine ribonucleotides from the corresponding base, e.g. uracil, orotic acid, thymine, 6-azathymine, 6-azauracil, 5-fluorouracil or 5-iodouracil and diphosphorylribose phosphate
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Mg2+
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required at 2 mM or higher for maximal activity
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3-ribosylxanthine 5'-phosphate
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xanthine and uracil pyrophosphorylase
UMP
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xanthine and uracil pyrophosphorylase
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6
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for uric acid reaction
7.6 - 8.6
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for xanthine reaction
8 - 9.2
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for orotic acid reaction
9.5
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for uracil reaction
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brenda
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brenda
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50
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pH 6.0, 40 min, 12-22% loss of activity
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purified 5400fold, ammonium sulfate fractionation, chromatography on DEAE-cellulose, treatment with Alumina CY Gel, calcium phosphate gel adsorption and elution and purification with hydroxylapatite
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Hatfield, D.; Wyngaarden, J.B.
3-Ribosylpurines. I.Synthesis of (3-ribosyluric acid) 5“phosphate and (3-ribosylxanthine) 5“phosphate by a pyrimidine ribonucleotide pyrophosphorylase
J. Biol. Chem.
239
2580-2586
1964
Bos taurus
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