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Disease on EC 2.4.2.19 - nicotinate-nucleotide diphosphorylase (carboxylating)

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acute Kidney Injury
De novo NAD+ biosynthetic impairment in acute kidney injury in humans.
Basal Ganglia Diseases
Immunohistochemical localization of quinolinic acid phosphoribosyltransferase in the human neostriatum.
Breast Neoplasms
Quinolinate Phosphoribosyltransferase Promotes Invasiveness of Breast Cancer Through Myosin Light Chain Phosphorylation.
Carcinoma
Determination of NAD pyrophosphorylase activity in biological samples.
Carcinoma, Hepatocellular
Biochemical mechanisms of resistance to tiazofurin.
Dementia
QPRTase modified N-doped carbon quantum dots: A fluorescent bioprobe for selective detection of neurotoxin quinolinic acid in human serum.
Glioma
The endogenous tryptophan metabolite and NAD+ precursor quinolinic acid confers resistance of gliomas to oxidative stress.
Hepatitis C
Quinolinate Phosphoribosyltransferase is an Antiviral Host Factor Against Hepatitis C Virus Infection.
Huntington Disease
Characterization of quinolinic acid phosphoribosyltransferase in human blood and observations in Huntington's disease.
Quinolinic acid phosphoribosyltransferase in human and rat brain: activity in Huntington's disease and in quinolinate-lesioned rat striatum.
Leukemia
Biochemical mechanisms of resistance to tiazofurin.
Leukemia, Myeloid, Acute
Anti-apoptotic quinolinate phosphoribosyltransferase (QPRT) is a target gene of Wilms' tumor gene 1 (WT1) protein in leukemic cells.
Neoplasms
Cancer cell metabolic plasticity allows resistance to NAMPT inhibition but invariably induces dependence on LDHA.
Studies on the mechanism of action of tiazofurin metabolism to an analog of NAD with potent IMP dehydrogenase-inhibitory activity.
Nervous System Diseases
QPRTase modified N-doped carbon quantum dots: A fluorescent bioprobe for selective detection of neurotoxin quinolinic acid in human serum.
Quinolinic-phosphoribosyl transferase activity is decreased in epileptic human brain tissue.
Neuroblastoma
Loss of the Chr16p11.2 ASD candidate gene QPRT leads to aberrant neuronal differentiation in the SH-SY5Y neuronal cell model.
Olivopontocerebellar Atrophies
Quinolinic acid catabolism is increased in cerebellum of patients with dominantly inherited olivopontocerebellar atrophy.
Tuberculosis
Biochemical characterization of quinolinic acid phosphoribosyltransferase from Mycobacterium tuberculosis H37Rv and inhibition of its activity by pyrazinamide.
Crystal structure of quinolinic acid phosphoribosyltransferase from Mmycobacterium tuberculosis: a potential TB drug target.
Crystal structure of Sus scrofa quinolinate phosphoribosyltransferase in complex with nicotinate mononucleotide.
Virus Diseases
Quinolinate Phosphoribosyltransferase is an Antiviral Host Factor Against Hepatitis C Virus Infection.
Wilms Tumor
Anti-apoptotic quinolinate phosphoribosyltransferase (QPRT) is a target gene of Wilms' tumor gene 1 (WT1) protein in leukemic cells.