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Information on EC 2.4.2.17 - ATP phosphoribosyltransferase and Organism(s) Arabidopsis thaliana and UniProt Accession Q9S762

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EC Tree
     2 Transferases
         2.4 Glycosyltransferases
             2.4.2 Pentosyltransferases
                2.4.2.17 ATP phosphoribosyltransferase
IUBMB Comments
Involved in histidine biosynthesis.
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This record set is specific for:
Arabidopsis thaliana
UNIPROT: Q9S762
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Word Map
The taxonomic range for the selected organisms is: Arabidopsis thaliana
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
atp-prt, atp phosphoribosyltransferase, atp-phosphoribosyltransferase, adenosine triphosphate phosphoribosyltransferase, atp phosphoribosyl transferase, atpprt, atp-phosphoribosyl transferase, atp-prtase, n-1-(5'-phosphoribosyl)-atp transferase, adenosine-triphosphate phosphoribosyltransferase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
1-(5-phospho-D-ribosyl)-ATP:pyrophosphate phospho-alpha-D-ribosyltransferase
-
-
-
-
adenosine triphosphate phosphoribosyltransferase
-
-
-
-
ATP-PRT
-
-
-
-
phosphoribosyl ATP synthetase
-
-
-
-
phosphoribosyl ATP:pyrophosphate phosphoribosyltransferase
-
-
-
-
phosphoribosyl-ATP pyrophosphorylase
-
-
-
-
phosphoribosyl-ATP:pyrophosphate-phosphoribosyl phosphotransferase
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-
-
-
phosphoribosyladenosine triphosphate pyrophosphorylase
-
-
-
-
phosphoribosyladenosine triphosphate synthetase
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-
-
-
phosphoribosyltransferase, adenosine triphosphate
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pentosyl group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
1-(5-phospho-D-ribosyl)-ATP:diphosphate phospho-alpha-D-ribosyl-transferase
Involved in histidine biosynthesis.
CAS REGISTRY NUMBER
COMMENTARY hide
9031-46-3
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-D-ribosyl)-ATP + diphosphate
show the reaction diagram
-
-
-
?
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
diphosphate + N-1-(5'-phosphoribosyl)-ATP
show the reaction diagram
first step in histidine biosynthesis
-
-
?
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-D-ribosyl)-ATP + diphosphate
show the reaction diagram
-
-
-
?
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
diphosphate + N-1-(5'-phosphoribosyl)-ATP
show the reaction diagram
first step in histidine biosynthesis
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
diphosphate + N-1-(5'-phosphoribosyl)-ATP
show the reaction diagram
first step in histidine biosynthesis
-
-
?
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
diphosphate + N-1-(5'-phosphoribosyl)-ATP
show the reaction diagram
first step in histidine biosynthesis
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,2,4-Triazole-3-alanine
-
L-histidine
feed-back inhibition
1,2,4-Triazole-3-alanine
-
L-histidine
feed-back inhibition
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.13 - 37
5-phospho-alpha-D-ribose 1-diphosphate
0.6 - 89
ATP
0.57
5-phospho-alpha-D-ribose 1-diphosphate
crude cell extracts
0.51
ATP
crude cell extracts
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
HIS1A_ARATH
411
0
44556
Swiss-Prot
Chloroplast (Reliability: 1)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
44600
calculated mass from amino acid sequence
44800
calculated mass from amino acid sequence
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
the recombinant enzymes are produced as fused proteins with a maltose-binding protein, and the purification is made by a two step amylose resin column followed by a digestion with Factor Xa
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
expression in Escherichia coli
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ohta, D.; Fujimori, K.; Mizutani, M.; Nakayama, Y.; Kunpaisal-Hashimoto, R.; Munzer, S.; Kozaki, A.
Molecular cloning and characterization of ATP-phosphoribosyl transferase from Arabidopsis, a key enzyme in the histidine biosynthetic pathway
Plant Physiol.
122
907-914
2000
Arabidopsis thaliana, Arabidopsis thaliana (Q9S762)
Manually annotated by BRENDA team