Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-alpha-D-ribosyl)-ATP + diphosphate
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-D-ribosyl)-ATP + diphosphate
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
diphosphate + N-1-(5'-phosphoribosyl)-ATP
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
N1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
N1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
additional information
?
-
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate

ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
?
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
?
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
-
r
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate

1-(5-phospho-alpha-D-ribosyl)-ATP + diphosphate
-
-
-
?
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-alpha-D-ribosyl)-ATP + diphosphate
-
-
-
-
r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-alpha-D-ribosyl)-ATP + diphosphate
-
-
-
-
r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate

1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
-
-
r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
-
-
r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
-
-
r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
-
-
r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
-
-
r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
-
-
r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
-
-
-
r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
-
-
r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
-
-
r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate

1-(5-phospho-D-ribosyl)-ATP + diphosphate
first enzyme in histidine biosynthetic pathway. ATP-PRT expression plays a major role in regulating the pool of free His and contributes to the exceptional Ni tolerance of hyperaccumulator Alyssum species
-
-
?
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-D-ribosyl)-ATP + diphosphate
-
-
-
?
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-D-ribosyl)-ATP + diphosphate
-
-
-
-
?
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-D-ribosyl)-ATP + diphosphate
-
-
-
-
?
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-D-ribosyl)-ATP + diphosphate
-
-
-
-
r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-D-ribosyl)-ATP + diphosphate
-
-
-
?
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-D-ribosyl)-ATP + diphosphate
first step in histidine biosynthesis, enzyme is regulated in a complex allosterical manner, it is a key enzyme is control of the metabolic flux through the pathway
-
-
?
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-D-ribosyl)-ATP + diphosphate
-
-
-
-
r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-D-ribosyl)-ATP + diphosphate
-
first step in histidine biosynthesis
-
-
r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-D-ribosyl)-ATP + diphosphate
-
first reaction of histidine biosynthesis
-
-
?
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-D-ribosyl)-ATP + diphosphate
-
-
-
-
r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-D-ribosyl)-ATP + diphosphate
-
-
-
?
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-D-ribosyl)-ATP + diphosphate
-
-
-
?
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-D-ribosyl)-ATP + diphosphate
first enzyme in histidine biosynthetic pathway. ATP-PRT expression plays a major role in regulating the pool of free His and contributes to the exceptional Ni tolerance of hyperaccumulator Alyssum species
-
-
?
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-D-ribosyl)-ATP + diphosphate
-
first enzyme in histidine biosynthetic pathway. ATP-PRT expression plays a major role in regulating the pool of free His and contributes to the exceptional Ni tolerance of hyperaccumulator Alyssum species
-
-
?
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-D-ribosyl)-ATP + diphosphate
-
-
-
?
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-D-ribosyl)-ATP + diphosphate
-
-
-
-
?
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-D-ribosyl)-ATP + diphosphate
-
-
-
r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-D-ribosyl)-ATP + diphosphate
-
-
-
-
r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-D-ribosyl)-ATP + diphosphate
-
-
-
-
r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-D-ribosyl)-ATP + diphosphate
-
first step in histidine biosynthesis, mechanism of regulation, overview
-
-
r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate

diphosphate + N-1-(5'-phosphoribosyl)-ATP
first step in histidine biosynthesis
-
-
?
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
diphosphate + N-1-(5'-phosphoribosyl)-ATP
-
first step in histidine biosynthesis
-
-
?
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
diphosphate + N-1-(5'-phosphoribosyl)-ATP
-
first step in histidine biosynthesis
-
-
?
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
diphosphate + N-1-(5'-phosphoribosyl)-ATP
-
-
-
-
?
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
diphosphate + N-1-(5'-phosphoribosyl)-ATP
-
first step in histidine biosynthesis
-
-
?
ATP + 5-phospho-alpha-D-ribose 1-diphosphate

N1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
-
-
r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
N1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
-
-
r
N1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate

ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
N1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
additional information

?
-
-
the enzyme comprises 4 catalytic subunits HisGs and 4 regulatory subunits HisZ with histidine as a ligand, 8 histidine binding sites at the subunit interfaces
-
-
?
additional information
?
-
-
not: ribose 5-phosphate, AMP, ADP, UTP, CTP, GTP
-
-
?
additional information
?
-
-
not: ribose 5-phosphate, AMP, ADP, UTP, CTP, GTP
-
-
?
additional information
?
-
-
not: ribose 5-phosphate, AMP, ADP, UTP, CTP, GTP
-
-
?
additional information
?
-
-
the enzyme comprises 4 catalytic subunits HisGs and 4 regulatory subunits HisZ, only the complete hetero-octameric complex is catalytically active, the complex possesses 8 histidine binding sites at the subunit interfaces and histidine as a ligand
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-D-ribosyl)-ATP + diphosphate
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
diphosphate + N-1-(5'-phosphoribosyl)-ATP
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
N1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
N1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate

ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
?
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
?
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
-
r
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate

1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
-
-
r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
-
-
r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
-
-
r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
-
-
r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
-
-
r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
-
-
r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
-
-
-
r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
-
-
r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
-
-
r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate

1-(5-phospho-D-ribosyl)-ATP + diphosphate
first enzyme in histidine biosynthetic pathway. ATP-PRT expression plays a major role in regulating the pool of free His and contributes to the exceptional Ni tolerance of hyperaccumulator Alyssum species
-
-
?
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-D-ribosyl)-ATP + diphosphate
first step in histidine biosynthesis, enzyme is regulated in a complex allosterical manner, it is a key enzyme is control of the metabolic flux through the pathway
-
-
?
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-D-ribosyl)-ATP + diphosphate
-
first step in histidine biosynthesis
-
-
r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-D-ribosyl)-ATP + diphosphate
-
first reaction of histidine biosynthesis
-
-
?
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-D-ribosyl)-ATP + diphosphate
first enzyme in histidine biosynthetic pathway. ATP-PRT expression plays a major role in regulating the pool of free His and contributes to the exceptional Ni tolerance of hyperaccumulator Alyssum species
-
-
?
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-D-ribosyl)-ATP + diphosphate
-
first enzyme in histidine biosynthetic pathway. ATP-PRT expression plays a major role in regulating the pool of free His and contributes to the exceptional Ni tolerance of hyperaccumulator Alyssum species
-
-
?
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
1-(5-phospho-D-ribosyl)-ATP + diphosphate
-
first step in histidine biosynthesis, mechanism of regulation, overview
-
-
r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate

diphosphate + N-1-(5'-phosphoribosyl)-ATP
first step in histidine biosynthesis
-
-
?
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
diphosphate + N-1-(5'-phosphoribosyl)-ATP
-
first step in histidine biosynthesis
-
-
?
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
diphosphate + N-1-(5'-phosphoribosyl)-ATP
-
first step in histidine biosynthesis
-
-
?
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
diphosphate + N-1-(5'-phosphoribosyl)-ATP
-
-
-
-
?
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
diphosphate + N-1-(5'-phosphoribosyl)-ATP
-
first step in histidine biosynthesis
-
-
?
ATP + 5-phospho-alpha-D-ribose 1-diphosphate

N1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
-
-
r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
N1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
-
-
r
N1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate

ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
N1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(4E)-4-[(4-chlorophenyl)(hydroxy)methylidene]-1-(pyridin-3-ylmethyl)-5-(3,4,5-trimethoxyphenyl)pyrrolidine-2,3-dione
binds to the cavity between the domains I and II. The terminal chlorobenzoyl group of 1 makes hydrophobic interactions with the amphiphilic pocket near the phosphoribosyl pyrophosphate binding site
1,2,4-Triazole-3-alanine
-
1-(5-phospho-alpha-D-ribosyl)-ATP
-
product inhibition, competitive to both substrates
1-(5-phospho-beta-D-ribosyl)-ATP
product inhibition
1-[(5,6-diphenyl-1,2,4-triazin-3-yl)sulfanyl]-3-(1,3-thiazol-2-yl)propan-2-one
most potent inhibitor, spans the PR-ATP binding site, exhibits greater than 50% inhibition at 0.01 mM, 40% inhibition at 0.001 mM
2-([7-[(3-hydroxyphenyl)amino]-4-nitro-2,1,3-benzoxadiazol-5-yl]amino)-5-nitrophenol
2-[(2-bromo-3,5-dinitrophenyl)carbonyl]-N-phenylhydrazinecarboxamide
4-methoxybenzyl 2-methyl-5-oxo-4,7-dithiophen-2-yl-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate
interacts with the phosphoribosyl diphosphate binding site but less strongly compared to compound 6 , exhibits greater than 50% inhibition at 0.01 mM
5-phospho-alpha-D-ribose 1-diphosphate
-
noncompetitive inhibitor with respect to both substrates in the reaction producing ATP and 5-phospho-alpha-D-ribose 1-diphosphate
adenine
-
competitive to ATP and 5-phospho-alpha-D-ribose 1-diphosphate
ATP
-
inhibits the reaction at high concentrations
beta,gamma-methylene-ATP
-
competitive with respect to N-1-(5-phosphoribosyl)-ATP, noncompetitive with respect to diphosphate; inhibitor of the reaction producing ATP and 5-phospho-alpha-D-ribose 1-diphosphate
beta-(2-thiazolyl)-DL-alanine
-
Ca2+
moderate inhibitory effect
dicoumarol
-
competitive with respect to ATP, inhibitor in both directions, diminishes yield of phosphoribosyladenosine triphosphate by acting as parasite substrate
dinitrophenol
-
diminishes yield of phosphoribosyladenosine triphosphate by acting as parasite substrate
diphosphate
-
non competitive to both substrates
ethyl [(6-nitro-1,3-benzothiazol-2-yl)amino](oxo)acetate
exhibits 39% inhibition
Guanosine 5'-diphosphate-3'-diphosphate
-
in presence of partially inhibiting concentrations of histidine guanosine 5'-diphosphate-3'-diphosphate becomes a potent inhibitor of the residual activity of ATP phosphoribosyltransferase, no inhibition in absence of histidine, inhibition is slowly reversible
Methylmercuric bromide
-
-
Mg2+
-
at high concentrations, Ki = 23 mM
Mn2+
moderate inhibitory effect
N-[3-[(6-nitro-1,3-benzothiazol-2-yl)amino]-3-oxo-1-phenylpropyl]benzamide
occupies only the phosphoribosyl diphosphate binding site, exhibits greater than 50% inhibition at 0.01 mM, 35% inhibition at 0.001 mM
p-hydroxymercuribenzoate
-
-
Pentachlorophenol
-
competitive to ATP, inhibitor in both directions, diminishes yield of phosphoribosyladenosine triphosphate by acting as parasite substrate
additional information
-
carbonylcyanide m-chlorophenylhydrazone, which is a potent inhibitor of several enzymes with adenine-containing substrates or coenzymes has no effect
-
2-([7-[(3-hydroxyphenyl)amino]-4-nitro-2,1,3-benzoxadiazol-5-yl]amino)-5-nitrophenol

exhibits 46% inhibition
2-([7-[(3-hydroxyphenyl)amino]-4-nitro-2,1,3-benzoxadiazol-5-yl]amino)-5-nitrophenol
-
has whole-cell activity at 0.012 mM
2-[(2-bromo-3,5-dinitrophenyl)carbonyl]-N-phenylhydrazinecarboxamide

exhibits 71% inhibition
2-[(2-bromo-3,5-dinitrophenyl)carbonyl]-N-phenylhydrazinecarboxamide
-
has whole-cell activity at 0.025 mM
ADP

competitive to ATP
ADP
orthosteric inhibition
ADP
-
competitive to ATP, in the presence of histidine inhibition by AMP and ADP becomes positively cooperative and much more potent
Ag+

-
AMP

competitive inhibition
AMP
competitive inhibition
AMP
about 10% inhibition at 0.25 mM
AMP
-
linear competitive inhibitor with respect to ATP, stabilizes the enzyme to thermal inactivation, protect the ordered enzymatic structure against thermodenaturation
AMP
binding structure and inhibition mode
AMP
-
inhibits the enzyme complex together with histidine to the T-state