Reference on EC 2.4.2.14 - amidophosphoribosyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Caskey, C.T.; Ashton, D.M.; Wyngaarden, J.B.
The enzymology of feedback inhibition of glutamine phosphoribosylpyrophosphate amidotransferase by purine ribonucleotides
J. Biol. Chem.
239
2570-2579
1964
Columba livia, Rattus norvegicus
Hartman, S.C.; Buchanan, J.M.
Biosynthesis of purines. XXI. 5-phosphoribosylpyrophosphate amidotransferase
J. Biol. Chem.
233
451-455
1958
Columba livia
Messenger, L.J.; Zalkin, H.
Glutamine phosphoribosylpyrophosphate amidotransferase from Escherichia coli. Purification and properties
J. Biol. Chem.
254
3382-3392
1979
Escherichia coli
Wong, J.Y.; Bernlohr, D.A.; Turnbough, C.L.; Switzer, R.L.
Purification and properties of glutamine phosphoribosylpyrophosphate amidotransferase from Bacillus subtilis
Biochemistry
20
5669-5674
1981
Bacillus subtilis
Wong, J.Y.; Switzer, R.L.
Affinity chromatography of Bacillus subtilis glutamine phosphoribosylpyrophosphate amidotransferase
Arch. Biochem. Biophys.
196
134-137
1979
Bacillus subtilis
Liras, A.; Argomaniz, L.; Llorente, P.
Presence, preliminary properties and partial purification of 5-phosphoribosylpyrophosphate amidotransferase from Artemia sp
Biochim. Biophys. Acta
1033
114-117
1990
Artemia sp.
Tsuda, M.; Katunuma, N.; Weber, G.
Rat liver glutamine 5-phosphoribosyl-1-pyrophosphate amidotransferase [EC 2.4.2.14]. Purification and properties
J. Biochem.
85
1347-1354
1979
Rattus norvegicus
Wood, A.W.; Seegmiller, J.E.
Properties of 5-phosphoribosyl-1-pyrophosphate amidotransferase from human lymphoblasts
J. Biol. Chem.
248
138-143
1973
Homo sapiens
Bernlohr, D.A.; Switzer, R.L.
Reaction of Bacillus subtilis glutamine phosphoribosylpyrophosphate amidotransferase with oxygen: chemistry and regulation by ligands
Biochemistry
20
5675-5681
1981
Bacillus subtilis
Holmes, E.W.
Kinetic, physical, and regulatory properties of amidophosphoribosyltransferase
Adv. Enzyme Regul.
19
215-231
1981
Bacillus subtilis, Cricetulus griseus, Columba livia, Escherichia coli, Homo sapiens, Mus musculus, Rattus norvegicus
Zalkin, H.
Structure, function, and regulation of amidophosphoribosyltransferase from prokaryotes
Adv. Enzyme Regul.
21
225-237
1983
Bacillus subtilis, Gallus gallus, Escherichia coli
Itoh, R.; Holmes, E.W.; Wyngaarden, J.B.
Pigeon liver amidophosphoribosyltransferase. Ligand-induced alterations in molecular and kinetic properties
J. Biol. Chem.
251
2234-2240
1976
Columba livia
Holmes, E.W.; McDonald, J.A.; McCord, J.M.; Wyngaarden, J.B.; Kelley, W.N.
Human glutamine phosphoribosylpyrophosphate amidotransferase. Kinetic and regulatory properties
J. Biol. Chem.
248
144-150
1973
Homo sapiens
King, G.L.; Boounous, C.G.; Holmes, E.W.
Human placental amidophosphoribosyltransferase. Comparison of the kinetics of glutamine and ammonia utilization
J. Biol. Chem.
253
3933-3938
1978
Homo sapiens
Onate, Y.A.; Vollmer, S.J.; Switzer, R.L.; Johnson, M.K.
Spectroscopic characterization of the iron-sulfur cluster in Bacillus subtilis glutamine phosphoribosylpyrophosphate amidotransferase
J. Biol. Chem.
264
18386-18391
1989
Bacillus subtilis
Reynoldds, P.H.S.; Blevins, D.G.; Randall, D.D.
5-Phosphoribosylpyrophosphate amidotransferase from soybean root nodules: kinetic and regulatory properties
Arch. Biochem. Biophys.
229
623-631
1984
Glycine max
Nagy, M.; Reichert, U.; Ribet, A.M.
Regulation of purine metabolism in Schizosaccharomyces pombe. IV. Variations in the stability and kinetic parameters of amidophosphoribosyltransferase depending on growth phase and growth conditions
Biochim. Biophys. Acta
370
85-95
1974
Schizosaccharomyces pombe
Itoh, R.; Gorai, I.; Usami, C.; Tsushima, K.
Chicken liver amidophosphoribosyltransferase. Ligand-induced alterations in molecular properties
Biochim. Biophys. Acta
581
142-152
1979
Gallus gallus
Zhou, G.; Charbonneau, H.; Colman, R.F.; Zalkin, H.
Identification of sites for feedback regulation of glutamine 5-phosphoribosylpyrophosphate amidotransferase by nucleotides and relationship to residues important for catalysis
J. Biol. Chem.
268
10471-10481
1993
Escherichia coli
Taha, T.S.; Deits, T.L.
Detection of glycinamide ribonucleotide by HPLC with pulsed amperometry: application to the assay for glutamine: 5-phosphoribosyl-1-pyrophosphate amidotransferase (EC 2.4.2.14)
Anal. Biochem.
213
323-328
1993
Glycine max
Zhou, G.; Smith, J.L.; Zalkin, H.
Binding of purine nucleotides to two regulatory sites results in synergistic feedback inhibition of glutamine 5-phosphoribosylpyrophosphate amidotransferase
J. Biol. Chem.
269
6784-6789
1994
Escherichia coli
Kim, J.H.; Wolle, D.; Haridas, K.; Parry, R.J.; Smith, J.L.; Zalkin, H.
A stable carbocyclic analog of 5-phosphoribosyl-1-pyrophosphate to probe the mechanism of catalysis and regulation of glutamine phosphoribosylpyrophosphate amidotransferase
J. Biol. Chem.
270
17394-17399
1995
Escherichia coli
Kim, J.H.; Krahn, J.M.; Tomchick, D.R.; Smith, J.L.; Zalkin, H.
Structure and function of the glutamine phosphoribosylpyrophosphate amidotransferase glutamine site and communication with the phosphoribosylpyrophosphate site
J. Biol. Chem.
271
15549-15557
1996
Escherichia coli
Schoettle, S.L.; Crisp, L.B.; Szabados, E.; Christopherson, R.I.
Mechanisms of inhibition of amido phosphoribosyltransferase from mouse L1210 leukemia cells
Biochemistry
36
6377-6383
1997
Mus musculus
Chen, S.; Tomchick, D.R.; Wolle, D.; Hu, P.; Smith, J.L.; Switzer, R.L.; Zalkin, H.
Mechanism of the synergistic end-product regulation of Bacillus subtilis glutamine phosphoribosylpyrophosphate amidotransferase by nucleotides
Biochemistry
36
10718-10726
1997
Bacillus subtilis (P00497), Bacillus subtilis
Muchmore, C.R.; Krahn, J.M.; Kim, J.H.; Zalkin, H.; Smith, J.L.
Crystal structure of glutamine phosphoribosylpyrophosphate amidotransferase from Escherichia coli
Protein Sci.
7
39-51
1998
Bacillus subtilis, Escherichia coli
Kian, I.A.; Etingof, R.N.
Purine biosynthesis de novo in bovine retina: purification and characterization of amidophosphoribosyl transferase and phosphoribosyl pyrophosphate synthetase
Biochemistry
64
648-651
1999
Bos taurus
Bera, A.K.; Chen, S.; Smith, J.L.; Zalkin, H.
Temperature-dependent function of the glutamine phosphoribosylpyrophosphate amidotransferase ammonia channel and coupling with glycinamide ribonucleotide synthetase in a hyperthermophile
J. Bacteriol.
182
3734-3739
2000
Aquifex aeolicus
Yamaoka, T.; Yano, M.; Kondo, M.; Sasaki, H.; Hino, S.; Katashima, R.; Moritani, M.; Itakura, M.
Feedback inhibition of amidophosphoribosyltransferase regulates the rate of cell growth via purine nucleotide, DNA, and protein syntheses
J. Biol. Chem.
276
21285-21291
2001
Homo sapiens
Jimenez, A.; Santos, M.A.; Pompejus, M.; Revuelta, J.L.
Metabolic engineering of the purine pathway for riboflavin production in Ashbya gossypii
Appl. Environ. Microbiol.
71
5743-5751
2005
Eremothecium gossypii
Browne, B.A.; Ramos, A.I.; Downs, D.M.
PurF-independent phosphoribosyl amine formation in yjgF mutants of Salmonella enterica utilizes the tryptophan biosynthetic enzyme complex anthranilate synthase-phosphoribosyltransferase
J. Bacteriol.
188
6786-6792
2006
Salmonella enterica
Koenigsknecht, M.J.; Ramos, I.; Downs, D.M.
Glutamine phosphoribosylpyrophosphate amidotransferase-independent phosphoribosyl amine synthesis from ribose 5-phosphate and glutamine or asparagine
J. Biol. Chem.
282
28379-28384
2007
no activity in Escherichia coli, no activity in Salmonella sp., no activity in Escherichia coli DM1293
Patrick, W.M.; Matsumura, I.
A study in molecular contingency: glutamine phosphoribosylpyrophosphate amidotransferase is a promiscuous and evolvable phosphoribosylanthranilate isomerase
J. Mol. Biol.
377
323-336
2008
Escherichia coli K-12 (P0AG16)
Walsh, T.A.; Bauer, T.; Neal, R.; Merlo, A.O.; Schmitzer, P.R.; Hicks, G.R.; Honma, M.; Matsumura, W.; Wolff, K.; Davies, J.P.
Chemical genetic identification of glutamine phosphoribosylpyrophosphate amidotransferase as the target for a novel bleaching herbicide in Arabidopsis
Plant Physiol.
144
1292-1304
2007
Arabidopsis thaliana (Q9SI61), Arabidopsis thaliana (Q9STG9), Arabidopsis thaliana (Q9T0J5)
Wang, X.S.; Roitberg, A.E.; Richards, N.G.
Computational studies of ammonia channel function in glutamine 5-phosphoribosylpyrophosphate amidotransferase
Biochemistry
48
12272-12282
2009
Escherichia coli (P0AG16), Escherichia coli
Qin, L.; Gong, X.; Xie, J.; Jiang, D.; Cheng, J.; Li, G.; Huang, J.; Fu, Y.
Phosphoribosylamidotransferase, the first enzyme for purine de novo synthesis, is required for conidiation in the sclerotial mycoparasite Coniothyrium minitans
Fungal Genet. Biol.
48
956-965
2011
Paraphaeosphaeria minitans (F2XMV3), Paraphaeosphaeria minitans, Paraphaeosphaeria minitans ZS-1 (F2XMV3)
Batool, S.; Nawaz, M.S.; Kamal, M.A.
In silico analysis of the amido phosphoribosyltransferase inhibition by PY873, PY899 and a derivative of isophthalic acid
Invest. New Drugs
31
1355-1363
2013
Homo sapiens (Q06203), Homo sapiens
Goswami, M.; Chen, G.; Chakravarthi, B.; Pathi, S.; Anand, S.; Carskadon, S.; Giordano, T.; Chinnaiyan, A.; Thomas, D.; Palanisamy, N.; Beer, D.; Varambally, S.
Role and regulation of coordinately expressed de novo purine biosynthetic enzymes PPAT and PAICS in lung cancer
Oncotarget
6
23445-23461
2015
Homo sapiens (Q06203)
Coleto, I.; Trenas, A.T.; Erban, A.; Kopka, J.; Alamillo, M.P.
Functional specialization of one copy of glutamine phosphoribosyl pyrophosphate amidotransferase in ureide production from symbiotically fixed nitrogen in Phaseolus vulgaris
Plant Cell Environ.
39
1767-1779
2016
Phaseolus vulgaris
Bibi, N.; Parveen, Z.; Nawaz, M.S.; Kamal, M.A.
In silico structure modeling and molecular docking analysis of phosphoribosyl pyrophosphate amidotransferase (PPAT) with antifolate inhibitors
Curr. Cancer Drug Targets
19
408-416
2019
Homo sapiens (Q06203), Homo sapiens
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