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Reference on EC 2.4.2.10 - orotate phosphoribosyltransferase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Floyd, E.E.; Jones, M.E.
Isolation and characterization of the orotidine 5'-monophosphate decarboxylase domain of the multifunctional protein uridine 5'-monophosphate synthase
J. Biol. Chem.
260
9443-9451
1985
Mus musculus
Manually annotated by BRENDA team
Yablonski, M.J.; Pasek, D.A.; Han, B.D.; Jones, M.E.; Traut, T.W.
Intrinsic activity and stability of bifunctional human UMP synthase and its two separate catalytic domains, orotate phosphoribosyltransferase and orotidine-5'-phosphate decarboxylase
J. Biol. Chem.
271
10704-10708
1996
Homo sapiens
Manually annotated by BRENDA team
Jones, M.E.; Kavipurapu, P.R.; Traut, T.W.
Orotate phosphoribosyltransferase: orotidylate decarboxylase (Ehrlich ascites cell)
Methods Enzymol.
51
155-167
1978
Mus musculus
Manually annotated by BRENDA team
McClard, R.W.; Black, M.J.; Livingstone, L.R.; Jones, M.E.
Isolation and initial characterization of the single polypeptide that synthesizes uridine 5-monophosphate from orotate in Ehrlich ascites carcinoma. Purification by tandem affinity chromatography of uridine-5-monophosphate synthase
Biochemistry
19
4699-4706
1980
Mus musculus
Manually annotated by BRENDA team
Bhatia, M.B.; Grubmeyer, C.
The role of divalent magnesium in activating the reaction catalyzed by orotate phosphoribosyltransferase
Arch. Biochem. Biophys.
303
321-325
1993
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Yoshimoto, A.; Amaya, T.; Kobayashi, K.; Tomita, K.
Orotate phosphoribosyltransferase (yeast)
Methods Enzymol.
51
69-74
1978
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Victor, J.; Leo-Mensah, A.; Sloan, D.L.
Divalent metal ion activation of the yeast orotate phosphoribosyltransferase catalyzed reaction
Biochemistry
18
3597-3604
1979
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Reyes, P.; Sandquist, R.B.
Purification of orotate phosphoribosyltransferase and orotidylate decarboxylase by affinity chromatography on Sepharose dye derivatives
Anal. Biochem.
88
522-531
1978
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Victor, J.; Greenberg, L.B.; Sloan, D.L.
Studies of the kinetic mechanism of orotate phosphoribosyltransferase from yeast
J. Biol. Chem.
254
2647-2655
1979
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Shimosaka, M.; Fukuda, Y.; Murata, K.; Kimura, A.
Purification and properties of orotate phosphoribosyltransferases from Escherichia coli K-12, and its derivative purine-sensitive mutant
J. Biochem.
98
1689-1697
1985
Escherichia coli
Manually annotated by BRENDA team
Dodin, G.
A rapid purification by affinity chromatography of orotate phosphoribosyltransferase from Escherichia coli K-12
FEBS Lett.
134
20-24
1981
Escherichia coli
Manually annotated by BRENDA team
Rathod, P.K.; Reyes, P.
Orotidylate-metabolizing enzymes of the human malarial parasite, Plasmodium falciparum, differ from host cell enzymes
J. Biol. Chem.
258
2852-2855
1983
Homo sapiens, Plasmodium falciparum, Plasmodium falciparum FCB
Manually annotated by BRENDA team
Bhatia, M.B.; Vinitsky, A.; Grubmeyer, C.
Kinetic mechanism of orotate phosphoribosyltransferase from Salmonella typhimurium
Biochemistry
29
10480-10487
1990
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Scapin, G.; Sacchettini, J.C.; Dessen, A.; Bhatia, M.; Grubmeyer, C.
Primary structure and crystallization of orotate phosphoribosyltransferase from Salmonella typhimurium
J. Mol. Biol.
230
1304-1308
1993
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Ashihara, H.
Orotate Phosphoribosyltransferase and orotidine-5'-monophosphate decarboxylase of black gram (phaseolus mungo) seedlings
Z. Pflanzenphysiol.
87
225-241
1978
Vigna mungo
-
Manually annotated by BRENDA team
Ozturk, D.H.; Dorfman, R.H.; Scapin, G.; Sacchettini, J.C.; Grubmeyer, C.
Structure and Function of Salmonella typhimurium Orotate Phosphoribosyltransferase: Protein Complementation Reveals Shared Active Sites
Biochemistry
34
10764-10770
1995
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Javaid, Z.Z.; el Kouni, M.H.; Iltzsch, M.H.
Pyrimidine nucleobase ligands of orotate phosphoribosyltransferase from Toxoplasma gondii
Biochem. Pharmacol.
58
1457-1466
1999
Toxoplasma gondii
Manually annotated by BRENDA team
Tao, W.; Grubmeyer, C.; Blanchard, J.S.
Transition state structure of Salmonella typhimurium orotate phosphoribosyltransferase
Biochemistry
35
14-21
1996
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Hamana, H.; Shinozawa, T.
Effects of C-terminal deletion on the activity and thermostability of orotate phosphoribosyltransferase from Thermus thermophilus
J. Biochem.
125
109-114
1999
Thermus thermophilus
Manually annotated by BRENDA team
Bunnak, J.; Hamana, H.; Ogino, Y.; Saheki, T.; Yamagishi, A.; Oshima, T.; Date, T.; Shinozawa, T.
Orotate phosphoribosyltransferase from Thermus thermophilus: Overexpression in Escherichia coli, purification and characterization
J. Biochem.
118
1261-1267
1995
Thermus thermophilus
Manually annotated by BRENDA team
Krungkrai, J.; Wutipraditkul, N.; Prapunwattana, P.; Krungkrai, S.R.; Rochanakij, S.
A nonradioactive high-performance liquid chromatographic microassay for uridine 5'-monophosphate synthase, orotate phosphoribosyltransferase, and orotidine 5'-monophosphate decarboxylase
Anal. Biochem.
299
162-168
2001
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Bayles, D.O.; Fennington, G.J., Jr.; Hughes, T.A.
Sequence and phylogenetic analysis of the Rhizobium leguminosarum biovar trifolii pyrE gene, overproduction, purification and characterization of orotate phosphoribosyltransferase
Gene
195
329-336
1997
Rhizobium leguminosarum
Manually annotated by BRENDA team
Witte, J.F.; Tsou, R.; McClard, R.W.
Cloning, overproduction, and purification of native and mutant recombinant yeast orotate phosphoribosyltransferase and the demonstration from magnetization inversion transfer that a proposed oxocarbocation intermediate does not have a kinetic lifetime
Arch. Biochem. Biophys.
361
106-112
1999
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Henriksen, A.; Aghajari, N.; Jensen, K.F.; Gajhede, M.
A flexible loop at the dimer interface is a part of the active site of the adjacent monomer of Escherichia coli orotate phosphoribosyltransferase
Biochemistry
35
3803-3809
1996
Escherichia coli
Manually annotated by BRENDA team
Scapin, G.; Grubmeyer, C.; Sacchettini, J.C.
Crystal structure of orotate phosphoribosyltransferase
Biochemistry
33
1287-1294
1994
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Krungkrai, S.R.; Prapunwattana, P.; Horii, T.; Krungkrai, J.
Orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase exist as multienzyme complex in human malaria parasite Plasmodium falciparum
Biochem. Biophys. Res. Commun.
318
1012-1018
2004
Plasmodium falciparum
Manually annotated by BRENDA team
Krungkrai, S.R.; DelFraino, B.J.; Smiley, J.A.; Prapunwattana, P.; Mitamura, T.; Horii, T.; Krungkrai, J.
A novel enzyme complex of orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase in human malaria parasite Plasmodium falciparum: physical association, kinetics, and inhibition characterization
Biochemistry
44
1643-1652
2005
Plasmodium falciparum (Q8T6J6), Plasmodium falciparum
Manually annotated by BRENDA team
Takeno, S.; Sakuradani, E.; Murata, S.; Inohara-Ochiai, M.; Kawashima, H.; Ashikari, T.; Shimizu, S.
Cloning and sequencing of the ura3 and ura5 genes, and isolation and characterization of uracil auxotrophs of the fungus Mortierella alpina 1S-4
Biosci. Biotechnol. Biochem.
68
277-285
2004
Mortierella alpina, Mortierella alpina 1S-4
Manually annotated by BRENDA team
Mizutani, Y.; Wada, H.; Fukushima, M.; Yoshida, O.; Nakanishi, H.; Li, Y.N.; Miki, T.
Prognostic significance of orotate phosphoribosyltransferase activity in bladder carcinoma
Cancer
100
723-731
2004
Homo sapiens
Manually annotated by BRENDA team
Sakamoto, K.; Sugimoto, Y.; Miyadera, K.; Oka, T.; Fukushima, M.
Preparation of anti-orotate phosphoribosyltransferase antibody and its application to immunochemical detection in human tumor cells
Int. J. Mol. Med.
16
245-249
2005
Homo sapiens
Manually annotated by BRENDA team
Krungkrai, S.R.; Aoki, S.; Palacpac, N.M.; Sato, D.; Mitamura, T.; Krungkrai, J.; Horii, T.
Human malaria parasite orotate phosphoribosyltransferase: functional expression, characterization of kinetic reaction mechanism and inhibition profile
Mol. Biochem. Parasitol.
134
245-255
2004
Plasmodium falciparum (Q8N0R1), Plasmodium falciparum
Manually annotated by BRENDA team
Kim, M.K.; Song, H.E.; Kim, Y.S.; Rho, S.H.; Im, Y.J.; Lee, J.H.; Kang, G.B.; Eom, S.H.
Crystallization and preliminary X-ray crystallographic analysis of orotate phosphoribosyltransferase from Helicobacter pylori
Mol. Cells
15
361-363
2003
Helicobacter pylori
Manually annotated by BRENDA team
McClard, R.W.; Holets, E.A.; MacKinnon, A.L.; Witte, J.F.
Half-of-sites binding of orotidine 5-phosphate and alpha-D-5-phosphorylribose 1-diphosphate to orotate phosphoribosyltransferase from Saccharomyces cerevisiae supports a novel variant of the Theorell-Chance mechanism with alternating site catalysis
Biochemistry
45
5330-5342
2006
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Sakurai, Y.; Sakamoto, K.; Sugimoto, Y.; Yoshida, I.; Masui, T.; Tonomura, S.; Inaba, K.; Shoji, M.; Nakamura, Y.; Uyama, I.; Komori, Y.; Ochiai, M.; Matsuura, S.; Tanaka, H.; Oka, T.; Fukushima, M.
Orotate phosphoribosyltransferase levels measured by a newly established enzyme-linked immunosorbent assay in gastric carcinoma
Cancer Sci.
97
492-498
2006
Homo sapiens
Manually annotated by BRENDA team
Matsusaka, S.; Yamasaki, H.; Fukushima, M.; Wakabayashi, I.
Upregulation of enzymes metabolizing 5-fluorouracil in colorectal cancer
Chemotherapy
53
36-41
2007
Homo sapiens
Manually annotated by BRENDA team
Ichikawa, W.; Takahashi, T.; Suto, K.; Sasaki, Y.; Hirayama, R.
Orotate phosphoribosyltransferase gene polymorphism predicts toxicity in patients treated with bolus 5-fluorouracil regimen
Clin. Cancer Res.
12
3928-3934
2006
Homo sapiens
Manually annotated by BRENDA team
Ochiai, T.; Nishimura, K.; Noguchi, H.; Kitajima, M.; Tsukada, A.; Watanabe, E.; Nagaoka, I.; Futagawa, S.
Prognostic impact of orotate phosphoribosyl transferase among 5-fluorouracil metabolic enzymes in resectable colorectal cancers treated by oral 5-fluorouracil-based adjuvant chemotherapy
Int. J. Cancer
118
3084-3088
2006
Homo sapiens
Manually annotated by BRENDA team
Kawai, K.; Watabe, S.; Matsuda, M.; Sakamoto, K.; Kamano, T.
Correlation between expression of orotate phosphoribosyl transferase and 5-fluorouracil sensitivity, as measured by apoptosis index in colorectal cancer tissue
Int. J. Gastrointest. Cancer
35
197-203
2005
Homo sapiens
Manually annotated by BRENDA team
Oeda, M.; Yoshida, K.; Sanada, Y.; Wada, Y.; Suzuki, T.; Mizuiri, H.; Konishi, K.; Shigematsu, H.; Tanabe, K.; Fukushima, M.
The expression profiles of orotate phosphoribosyltransferase and dihydropyrimidine dehydrogenase in gastric cancer and their clinical significance
Oncol. Rep.
16
1165-1172
2006
Homo sapiens
Manually annotated by BRENDA team
Taomoto, J.; Yoshida, K.; Wada, Y.; Tanabe, K.; Konishi, K.; Tahara, H.; Fukushima, M.
Overexpression of the orotate phosphoribosyl-transferase gene enhances the effect of 5-fluorouracil on gastric cancer cell lines
Oncology
70
458-464
2006
Homo sapiens
Manually annotated by BRENDA team
Sanada, Y.; Yoshida, K.; Ohara, M.; Tsutani, Y.
Expression of orotate phosphoribosyltransferase (OPRT) in hepatobiliary and pancreatic carcinoma
Pathol. Oncol. Res.
13
105-113
2007
Homo sapiens
Manually annotated by BRENDA team
Tokunaga, Y.; Sasaki, H.; Saito, T.
Clinical role of orotate phosphoribosyl transferase and dihydropyrimidine dehydrogenase in colorectal cancer treated with postoperative fluoropyrimidine
Surgery
141
346-353
2007
Homo sapiens
Manually annotated by BRENDA team
Santiago, M.F.; West, T.P.
Control of pyrimidine formation in Pseudomonas putida ATCC 17536
Can. J. Microbiol.
48
1076-1081
2002
Pseudomonas putida
Manually annotated by BRENDA team
Ogiuchi, Y.; Maruoka, Y.; Ando, T.; Kobayashi, M.; Ogiuchi, H.
Thymidylate synthase, thymidine phosphorylase and orotate phosphoribosyl transferase levels as predictive factors of chemotherapy in oral squamous cell carcinoma
Acta Histochem. Cytochem.
41
39-46
2008
Homo sapiens
Manually annotated by BRENDA team
Sakamoto, E.; Nagase, H.; Kobunai, T.; Oie, S.; Oka, T.; Fukushima, M.; Oka, T.
Orotate phosphoribosyltransferase expression level in tumors is a potential determinant of the efficacy of 5-fluorouracil
Biochem. Biophys. Res. Commun.
363
216-222
2007
Homo sapiens
Manually annotated by BRENDA team
Gonzalez-Segura, L.; Witte, J.F.; McClard, R.W.; Hurley, T.D.
Ternary complex formation and induced asymmetry in orotate phosphoribosyltransferase
Biochemistry
46
14075-14086
2007
Saccharomyces cerevisiae (P13298), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Ishikawa, M.; Miyauchi, T.; Kashiwagi, Y.
Clinical implications of thymidylate synthetase, dihydropyrimidine dehydrogenase and orotate phosphoribosyl transferase activity levels in colorectal carcinoma following radical resection and administration of adjuvant 5-FU chemotherapy
BMC Cancer
8
188
2008
Homo sapiens
Manually annotated by BRENDA team
Kai, K.; Kitajima, Y.; Hiraki, M.; Satoh, S.; Tanaka, M.; Nakafusa, Y.; Tokunaga, O.; Miyazaki, K.
Quantitative double-fluorescence immunohistochemistry (qDFIHC), a novel technology to assess protein expression: a pilot study analyzing 5-FU sensitive markers thymidylate synthase, dihydropyrimidine dehydrogenase and orotate phosphoribosyl transferases in gastric cancer tissue specimens
Cancer Lett.
258
45-54
2007
Homo sapiens
Manually annotated by BRENDA team
Sakurai, Y.; Kamoshida, S.; Furuta, S.; Sunagawa, R.; Inaba, K.; Isogaki, J.; Komori, Y.; Uyama, I.; Tsutsumi, Y.
Levels and expressions of orotate phosphoribosyltransferase in gastric carcinoma and normal gastric mucosa tissues
Gastric Cancer
10
234-240
2007
Homo sapiens
Manually annotated by BRENDA team
Miyake, K.; Imura, S.; Yoshizumi, T.; Ikemoto, T.; Morine, Y.; Shimada, M.
Role of thymidine phosphorylase and orotate phosphoribosyltransferase mRNA expression and its ratio to dihydropyrimidine dehydrogenase in the prognosis and clinicopathological features of patients with pancreatic cancer
Int. J. Clin. Oncol.
12
111-119
2007
Homo sapiens
Manually annotated by BRENDA team
Wang, X.; Ma, C.; Wang, X.; Xu, P.
Orotate phosphoribosyltransferase from Corynebacterium ammoniagenes lacking a conserved lysine
J. Bacteriol.
189
9030-9036
2007
Corynebacterium ammoniagenes
Manually annotated by BRENDA team
Nio, Y.; Toga, T.; Maruyama, R.; Fukushima, M.
Expression of orotate phosphoribosyl transferase in human pancreatic cancer: implication for the efficacy of uracil and tegafur-based adjuvant chemotherapy
Oncol. Rep.
18
59-64
2007
Homo sapiens
Manually annotated by BRENDA team
Zhang, Y.; Luo, M.; Schramm, V.L.
Transition states of Plasmodium falciparum and human orotate phosphoribosyltransferases
J. Am. Chem. Soc.
131
4685-4694
2009
Homo sapiens, Plasmodium falciparum
Manually annotated by BRENDA team
Sanada, Y.; Yoshida, K.; Hihara, J.; Okada, M.
Expression of orotate phosphoribosyltransferase in colorectal carcinoma: an immunohistochemical analysis in several components of neoplastic lesions
Oncol. Rep.
20
1005-1011
2008
Homo sapiens
Manually annotated by BRENDA team
Tsutani, Y.; Yoshida, K.; Sanada, Y.; Wada, Y.; Konishi, K.; Fukushima, M.; Okada, M.
Decreased orotate phosphoribosyltransferase activity produces 5-fluorouracil resistance in a human gastric cancer cell line
Oncol. Rep.
20
1545-1551
2008
Homo sapiens
Manually annotated by BRENDA team
Tanaka, T.; Kawashima, H.; Matsumura, K.; Yamashita-Hosono, T.; Yoshimura, R.; Kuratsukuri, K.; Harimoto, K.; Nakatani, T.
Overexpression of orotate phosphoribosyl transferase in hormone-refractory prostate cancer
Oncol. Rep.
21
33-37
2009
Homo sapiens
Manually annotated by BRENDA team
Liu, C.; Xu, R.; Gao, Z.; Xu, J.; Hou, H.; Li, L.; She, Z.; Li, L.; Su, X.; Liu, P.; Dong, Y.
Structure of orotate phosphoribosyltransferase from the caries pathogen Streptococcus mutans
Acta Crystallogr. Sect. F
66
498-502
2010
Streptococcus mutans (Q8DTV2), Streptococcus mutans
Manually annotated by BRENDA team
Takashima, Y.; Mizohata, E.; Tokuoka, K.; Krungkrai, S.; Kusakari, Y.; Konishi, S.; Satoh, A.; Matsumura, H.; Krungkrai, J.; Horii, T.; Inoue, T.
Crystallization and preliminary X-ray diffraction analysis of orotate phosphoribosyltransferase from the human malaria parasite Plasmodium falciparum
Acta Crystallogr. Sect. F
68
244-246
2012
Plasmodium falciparum
Manually annotated by BRENDA team
Zhang, Y.; Schramm, V.
Ground-state destabilization in orotate phosphoribosyltransferases by binding isotope effects
Biochemistry
50
4813-4818
2011
Homo sapiens, Plasmodium falciparum
Manually annotated by BRENDA team
Hansen, M.; Harris, R.; Barr, E.; Cheng, H.; Girvin, M.; Grubmeyer, C.
Backbone 1H, 13C, 15N NMR assignments of yeast OMP synthase in unliganded form and in complex with orotidine 5'-monophosphate
Biomol. NMR Assign.
8
103-108
2014
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Breda, A.; MacHado, P.; Rosado, L.; Souto, A.; Santos, D.; Basso, L.
Pyrimidin-2(1H)-ones based inhibitors of Mycobacterium tuberculosis orotate phosphoribosyltransferase
Eur. J. Med. Chem.
54
113-122
2012
Mycobacterium tuberculosis
Manually annotated by BRENDA team
Zhang, Y.; Deng, H.; Schramm, V.
Leaving group activation and pyrophosphate ionic state at the catalytic site of plasmodium falciparum orotate phosphoribosyltransferase
J. Am. Chem. Soc.
132
17023-17031
2010
Plasmodium falciparum
Manually annotated by BRENDA team
Zhang, Y.; Schramm, V.
Pyrophosphate interactions at the transition states of plasmodium falciparum and human orotate phosphoribosyltransferases
J. Am. Chem. Soc.
132
8787-8794
2010
Homo sapiens, Plasmodium falciparum
Manually annotated by BRENDA team
Breda, A.; Rosado, L.; Lorenzini, D.; Basso, L.; Santos, D.
Molecular, kinetic and thermodynamic characterization of Mycobacterium tuberculosis orotate phosphoribosyltransferase
Mol. Biosyst.
8
572-586
2012
Mycobacterium tuberculosis (P9WHK9), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WHK9)
Manually annotated by BRENDA team
Kumar, S.; Krishnamoorthy, K.; Mudeppa, D.G.; Rathod, P.K.
Structure of Plasmodium falciparum orotate phosphoribosyltransferase with autologous inhibitory protein-protein interactions
Acta Crystallogr. Sect. F
71
600-608
2015
Plasmodium falciparum (Q8N0R1), Plasmodium falciparum
Manually annotated by BRENDA team
Qi, Z.; Liu, M.; Dong, Y.; Yang, J.; Zhang, H.; Zheng, X.; Zhang, Z.
Orotate phosphoribosyl transferase MoPyr5 is involved in uridine 5-phosphate synthesis and pathogenesis of Magnaporthe oryzae
Appl. Microbiol. Biotechnol.
100
3655-3666
2016
Pyricularia oryzae (G4MT58), Pyricularia oryzae, Pyricularia oryzae ATCC MYA-4617 (G4MT58)
Manually annotated by BRENDA team
Imprasittichail, W.; Roytrakul, S.; Krungkrai, S.R.; Krungkrail, J.
A unique insertion of low complexity amino acid sequence underlies protein-protein interaction in human malaria parasite orotate phosphoribosyltransferase and orotidine 5-monophosphate decarboxylase
Asian Pac. J. Trop. Med.
7
184-192
2014
Plasmodium falciparum (Q8N0R1), Plasmodium falciparum
Manually annotated by BRENDA team
Hozumi, Y.; Tanaka, T.; Nakano, T.; Matsui, H.; Nasu, T.; Koike, S.; Kakehata, S.; Ito, T.; Goto, K.
Orotate phosphoribosyltransferase localizes to the Golgi complex and its expression levels affect the sensitivity to anti-cancer drug 5-fluorouracil
Biomed. Res.
36
403-409
2015
Homo sapiens
Manually annotated by BRENDA team
Subrahmanyeswara Rao, N.; Deshpande, P.
An organism-independent unified model for activity of orotate phosphoribosyltransferases for orotidine monophosphate synthesis
Chem. Eng. Sci.
128
109-118
2015
Saccharomyces cerevisiae, Mycobacterium tuberculosis, Plasmodium falciparum, Salmonella enterica subsp. enterica serovar Typhimurium
-
Manually annotated by BRENDA team
Surekha, K.; Prabhu, D.; Richard, M.; Nachiappan, M.; Biswal, J.; Jeyakanthan, J.
Investigation of vital pathogenic target orotate phosphoribosyltransferases (OPRTase) from Thermus thermophilus HB8: Phylogenetic and molecular modeling approach
Gene
583
102-111
2016
Thermus thermophilus (Q5SHI8), Thermus thermophilus HB8 / ATCC 27634 / DSM 579 (Q5SHI8)
Manually annotated by BRENDA team
Zhang, Y.; Evans, G.B.; Clinch, K.; Crump, D.R.; Harris, L.D.; Froehlich, R.F.; Tyler, P.C.; Hazleton, K.Z.; Cassera, M.B.; Schramm, V.L.
Transition state analogues of Plasmodium falciparum and human orotate phosphoribosyltransferases
J. Biol. Chem.
288
34746-34754
2013
Homo sapiens, Plasmodium falciparum
Manually annotated by BRENDA team
Paojinda, P.; Imprasittichai, W.; Krungkrai, S.R.; Palacpac, N.M.Q.; Horii, T.; Krungkrai, J.
Bifunctional activity of fused Plasmodium falciparum orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase
Parasitol. Int.
67
79-84
2018
Plasmodium falciparum (Q8N0R1), Plasmodium falciparum
Manually annotated by BRENDA team
Akahoshi, K.; Ban, D.; Kuboki, R.; Oba, A.; Ono, H.; Mitsunori, Y.; Kudo, A.; Tanaka, S.; Tanabe, M.
Orotate phosphoribosyltransferase as a predictor of benefit from S-1 adjuvant chemotherapy for cholangiocarcinoma patients
J. Gastroenterol. Hepatol.
34
1108-1115
2019
Homo sapiens
Manually annotated by BRENDA team
Okuda, K.; Tatematsu, T.; Yano, M.; Nakamae, K.; Yamada, T.; Kasugai, T.; Nishida, T.; Sano, M.; Moriyama, S.; Haneda, H.; Kawano, O.; Sakane, T.; Oda, R.; Watanabe, T.; Nakanishi, R.
The relationship between the expression of thymidylate synthase, dihydropyrimidine dehydrogenase, orotate phosphoribosyltransferase, excision repair cross-complementation group 1 and class III beta-tubulin, and the therapeutic effect of S-1 or carboplatin plus paclitaxel in nonx1esmallx1ecell lung cancer
Mol. Clin. Oncol.
9
21-29
2018
Homo sapiens
Manually annotated by BRENDA team
Hamamoto, Y.; Takeoka, S.; Mouri, A.; Fukusumi, M.; Wakuda, K.; Ibe, T.; Honma, C.; Arimoto, Y.; Yamada, K.; Wagatsuma, M.; Tashiro, A.; Kamoshida, S.; Kamimura, M.
Orotate phosphoribosyltransferase is overexpressed in malignant pleural mesothelioma Dramatically responds one case in high OPRT expression
Rare Dis.
4
e1165909
2016
Homo sapiens
Manually annotated by BRENDA team
Donini, S.; Ferraris, D.M.; Miggiano, R.; Massarotti, A.; Rizzi, M.
Structural investigations on orotate phosphoribosyltransferase from Mycobacterium tuberculosis, a key enzyme of the de novo pyrimidine biosynthesis
Sci. Rep.
7
1180
2017
Mycobacterium tuberculosis (P9WHK9), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WHK9)
Manually annotated by BRENDA team