Disease on EC 2.4.1.90 - N-acetyllactosamine synthase

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DISEASE
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Adenocarcinoma
Aberrant promoter methylation of beta-1,4 galactosyltransferase 1 as potential cancer-specific biomarker of colorectal tumors.
Galactosylation of N-linked oligosaccharides by human beta-1,4-galactosyltransferases I, II, III, IV, V, and VI expressed in Sf-9 cells.
Adenoma
Aberrant promoter methylation of beta-1,4 galactosyltransferase 1 as potential cancer-specific biomarker of colorectal tumors.
Arthritis, Rheumatoid
beta1,4-Galactosyltransferase-I contributes to the inflammatory processes in synovial tissue of patients with rheumatoid arthritis.
Astrocytoma
Over-expression of beta-1,4-galactosyltransferase I, II, and V in human astrocytoma.
Over-expression of beta-1,4-galactosyltransferase V increases the growth of astrocytoma cell line.
Autoimmune Diseases
Human Retrotransposon Insertion Polymorphisms Are Associated with Health and Disease via Gene Regulatory Phenotypes.
Breast Neoplasms
Molecular cloning of a human cDNA encoding beta-1,4-galactosyltransferase with 37% identity to mammalian UDP-Gal:GlcNAc beta-1,4-galactosyltransferase.
Carcinogenesis
beta4GalT-II increases cisplatin-induced apoptosis in HeLa cells depending on its Golgi localization.
Carcinoma
Expression of galactosyltransferase in prostatic tumors.
Increase in beta-1,4-galactosyltransferase activity during PC12 cell differentiation induced by forskolin and 2-chloroadenosine.
Increased B4GALT1 expression associates with adverse outcome in patients with non-metastatic clear cell renal cell carcinoma.
Carcinoma, Ehrlich Tumor
Ehrlich ascites tumor cell UDP-Gal:N-acetyl-D-glucosamine beta(1,4)-galactosyltransferase. Purification, characterization, and topography of the acceptor-binding site.
Carcinoma, Embryonal
Cell surface and Golgi pools of beta-1,4-galactosyltransferase are differentially regulated during embryonal carcinoma cell differentiation.
Characterization of a murine beta 1-4 galactosyltransferase expressed in COS-1 cells.
Dominant negative mutation in cell surface beta 1,4-galactosyltransferase inhibits cell-cell and cell-matrix interactions.
Effects of overexpression of beta 1,4-galactosyltransferase on glycoprotein biosynthesis in F9 embryonal carcinoma cells.
Evidence for a molecular distinction between Golgi and cell surface forms of beta 1,4-galactosyltransferase.
Carcinoma, Renal Cell
Increased B4GALT1 expression associates with adverse outcome in patients with non-metastatic clear cell renal cell carcinoma.
Colonic Neoplasms
Characterization of monoclonal antibodies to serum galactosyltransferase.
Colorectal Neoplasms
Aberrant promoter methylation of beta-1,4 galactosyltransferase 1 as potential cancer-specific biomarker of colorectal tumors.
Tumor beta-1,4-galactosyltransferase IV overexpression is closely associated with colorectal cancer metastasis and poor prognosis.
Connective Tissue Diseases
Determination of beta4-galactosyltransferase-7 activity using high-performance liquid chromatography-electrospray ionization tandem mass spectrometry.
Crohn Disease
Human Retrotransposon Insertion Polymorphisms Are Associated with Health and Disease via Gene Regulatory Phenotypes.
Cystadenoma
A combined blood based gene expression and plasma protein abundance signature for diagnosis of epithelial ovarian cancer--a study of the OVCAD consortium.
Ehlers-Danlos Syndrome
Cloning and expression of a proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I. A seventh member of the human beta4-galactosyltransferase gene family.
Endometriosis
Differentially expressed gene profiles in the serum before and after the ultrasound-guided ethanol sclerotherapy in patients with ovarian endometriomas.
Gastrointestinal Neoplasms
Characterization of monoclonal antibodies to serum galactosyltransferase.
Glioblastoma
Over-expression of beta-1,4-galactosyltransferase I, II, and V in human astrocytoma.
Herpes Zoster
Aggregation of beta-1,4-galactosyltransferase on mouse sperm induces the acrosome reaction.
Binding of caput epididymal mouse sperm to the zona pellucida.
Cell surface beta-1,4-galactosyltransferase-I activates G protein-dependent exocytotic signaling.
Characterization of a novel ZP3-independent sperm-binding ligand that facilitates sperm adhesion to the egg coat.
Egg cortical granule N-acetylglucosaminidase is required for the mouse zona block to polyspermy.
Overexpressing sperm surface beta 1,4-galactosyltransferase in transgenic mice affects multiple aspects of sperm-egg interactions.
Plasma membrane association, purification, and partial characterization of mouse sperm beta 1,4-galactosyltransferase.
Porcine sperm surface beta1,4galactosyltransferase binds to the zona pellucida but is not necessary or sufficient to mediate sperm-zona pellucida binding.
Receptor function of mouse sperm surface galactosyltransferase during fertilization.
Sperm from a variety of mammalian species express beta1,4-galactosyltransferase on their surface.
Sperm from beta1,4-galactosyltransferase I-null mice exhibit precocious capacitation.
Sperm require beta-N-acetylglucosaminidase to penetrate through the egg zona pellucida.
Sperm-egg binding requires a multiplicity of receptor-ligand interactions: new insights into the nature of gamete receptors derived from reproductive tract secretions.
Spermatozoa from a marsupial, the brushtail possum, contain beta1,4-galactosyltransferase.
The receptor function of galactosyltransferase during mammalian fertilization.
Infections
Beta-(1 --> 4)-galactosyltransferase activity in native and engineered insect cells measured with time-resolved europium fluorescence.
Leukemia
B4GALT family mediates the multidrug resistance of human leukemia cells by regulating the hedgehog pathway and the expression of p-glycoprotein and multidrug resistance-associated protein 1.
B4GALT1 gene knockdown inhibits the hedgehog pathway and reverses multidrug resistance in the human leukemia K562/adriamycin-resistant cell line.
Liver Diseases
Characterization of monoclonal antibodies to serum galactosyltransferase.
Lung Neoplasms
Elevated beta1,4-galactosyltransferase I in highly metastatic human lung cancer cells. Identification of E1AF as important transcription activator.
Lupus Erythematosus, Systemic
Human Retrotransposon Insertion Polymorphisms Are Associated with Health and Disease via Gene Regulatory Phenotypes.
Mastocytoma
Galactosyltransfer in mouse mastocytoma: purification and properties of N-acetyllactosamine synthetase.
Melanoma
Functionally distinct laminin receptors mediate cell adhesion and spreading: the requirement for surface galactosyltransferase in cell spreading.
The level of cell surface beta1,4-galactosyltransferase I influences the invasive potential of murine melanoma cells.
Neoplasm Metastasis
?-1,4-Galactosyltransferase III suppresses ?1 integrin-mediated invasive phenotypes and negatively correlates with metastasis in colorectal cancer.
B4GALT1 expression predicts prognosis and adjuvant chemotherapy benefits in muscle-invasive bladder cancer patients.
Deoxygenated disaccharide analogs as specific inhibitors of beta1-4-galactosyltransferase 1 and selectin-mediated tumor metastasis.
Tumor beta-1,4-galactosyltransferase IV overexpression is closely associated with colorectal cancer metastasis and poor prognosis.
Neoplasms
?-1,4-Galactosyltransferase III Enhances Invasive Phenotypes Via ?1-Integrin and Predicts Poor Prognosis in Neuroblastoma.
A combined blood based gene expression and plasma protein abundance signature for diagnosis of epithelial ovarian cancer--a study of the OVCAD consortium.
Aberrant genes promoter methylation in neural crest-derived tumors.
Aberrant promoter methylation of beta-1,4 galactosyltransferase 1 as potential cancer-specific biomarker of colorectal tumors.
B4GALT1 expression predicts prognosis and adjuvant chemotherapy benefits in muscle-invasive bladder cancer patients.
B4GALT3 up-regulation by miR-27a contributes to the oncogenic activity in human cervical cancer cells.
Circular RNA circUBXN7 represses cell growth and invasion by sponging miR-1247-3p to enhance B4GALT3 expression in bladder cancer.
Convergent actions of I kappa B kinase beta and protein kinase C delta modulate mRNA stability through phosphorylation of 14-3-3 beta complexed with tristetraprolin.
Deoxygenated disaccharide analogs as specific inhibitors of beta1-4-galactosyltransferase 1 and selectin-mediated tumor metastasis.
Ehrlich ascites tumor cell UDP-Gal:N-acetyl-D-glucosamine beta(1,4)-galactosyltransferase. Purification, characterization, and topography of the acceptor-binding site.
Estrogen induced ?-1,4-galactosyltransferase 1 expression regulates proliferation of human breast cancer MCF-7 cells.
Expression of galactosyltransferase in prostatic tumors.
Increased B4GALT1 expression associates with adverse outcome in patients with non-metastatic clear cell renal cell carcinoma.
Multifaceted roles of 5'-regulatory region of the cancer associated gene B4GALT1 and its comparison with the gene family.
Tumor beta-1,4-galactosyltransferase IV overexpression is closely associated with colorectal cancer metastasis and poor prognosis.
Tumor necrosis factor-alpha up-regulates the expression of beta1,4-galactosyltransferase I in primary human endothelial cells by mRNA stabilization.
Prostatic Hyperplasia
Expression of galactosyltransferase in prostatic tumors.
Sarcoma, Avian
D-galactosyltransferase and its endogenous substrates in chick embryo fibroblasts transformed by Rous sarcoma virus.
Urinary Bladder Neoplasms
B4GALT1 expression predicts prognosis and adjuvant chemotherapy benefits in muscle-invasive bladder cancer patients.
Circular RNA circUBXN7 represses cell growth and invasion by sponging miR-1247-3p to enhance B4GALT3 expression in bladder cancer.
Uterine Cervical Neoplasms
B4GALT3 up-regulation by miR-27a contributes to the oncogenic activity in human cervical cancer cells.
Whooping Cough
Cell surface beta-1,4-galactosyltransferase-I activates G protein-dependent exocytotic signaling.
Epithelial-mesenchymal transformation in the embryonic heart is mediated through distinct pertussis toxin-sensitive and TGFbeta signal transduction mechanisms.