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Information on EC 2.4.1.83 - dolichyl-phosphate beta-D-mannosyltransferase
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2.4.1.83 dolichyl-phosphate beta-D-mannosyltransferaseIUBMB Comments
Acts only on long-chain polyprenyl phosphates and alpha-dihydropolyprenyl phosphates that are larger than C35.
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Word Map
- 2.4.1.83
-
n-linked
-
n-glycosylation
- glycosylphosphatidylinositol
-
lipid-linked
- reesei
-
dolichol-phosphate-mannose
-
asparagine-linked
- amphomycin
-
dolichol-linked
-
glc3man9glcnac2-pp-dol
-
mannoproteins
-
c-mannosylation
- medicine
- drug development
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
dol-p-man synthase, dpm synthase, dolichol phosphate mannose synthase, mannosylphosphoryldolichol synthase, mpd synthase, d-p-m, dolichyl-phosphate mannosyltransferase, mannosylphospho dolichol synthase, dolichylphosphate mannose synthase, mannosylphosphodolichol synthase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
AglD
Dol-P-Man synthase
Dol-P-Man-synthase
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-
-
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Dol-P-Mansynthase
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-
-
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Dol-PMan synthase
dolichol phosphate mannose synthase
dolichol phosphoryl mannose synthase
dolichyl mannosyl phosphate synthase
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dolichyl phosphate mannosyltransferase
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dolichyl-phosphate mannose synthase
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dolichyl-phospho-mannose synthase
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dolichylphosphate mannose synthase
DPM
DPM synthase
DPMS
GDP-Man:DolP mannosyltransferase
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GDP-mannose-dolichol phosphate mannosyltransferase
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GDPMan:DolP mannosyltransferase
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GDPmannose-dolichylmonophosphate mannosyltransferase
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GDPmannose:dolichyl-phosphate mannosyltransferase
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mannosylphosphodolichol synthase
mannosylphosphoryldolichol synthase
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-
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mannosyltransferase, guanosine diphosphomannose-dolichol phosphate
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MPD synthase
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PF0058
PfDPMS
dolichol phosphate mannose synthase
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DPMS
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mannosylphosphodolichol synthase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
GDP-alpha-D-mannose + dolichyl phosphate = GDP + dolichyl beta-D-mannosyl phosphate
sequential mechanism
-
GDP-alpha-D-mannose + dolichyl phosphate = GDP + dolichyl beta-D-mannosyl phosphate
catalytic mechanism of PfDPMS, overview. Catalytic mechanism of the transfer reaction, nucleophilic attack by the Dol-P phosphate oxygen on the mannosyl C1 carbon yields GDP and Dol-P-Man. Asp91 and Gln93 coordinate the GDP-Man diphosphate groups via the metal ion, while the key side chains for positioning the Dol-P phosphate group for mannosyl transfer are Ser135 and Arg117. The Dol-P phosphate group is pre-activated for nucleophilic attack, and not dependent on a catalytic base for activation
GDP-alpha-D-mannose + dolichyl phosphate = GDP + dolichyl beta-D-mannosyl phosphate
catalytic mechanism of PfDPMS, overview. Catalytic mechanism of the transfer reaction, nucleophilic attack by the Dol-P phosphate oxygen on the mannosyl C1 carbon yields GDP and Dol-P-Man. Asp91 and Gln93 coordinate the GDP-Man diphosphate groups via the metal ion, while the key side chains for positioning the Dol-P phosphate group for mannosyl transfer are Ser135 and Arg117. The Dol-P phosphate group is pre-activated for nucleophilic attack, and not dependent on a catalytic base for activation
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GDP-alpha-D-mannose + dolichyl phosphate = GDP + dolichyl beta-D-mannosyl phosphate
catalytic mechanism of PfDPMS, overview. Catalytic mechanism of the transfer reaction, nucleophilic attack by the Dol-P phosphate oxygen on the mannosyl C1 carbon yields GDP and Dol-P-Man. Asp91 and Gln93 coordinate the GDP-Man diphosphate groups via the metal ion, while the key side chains for positioning the Dol-P phosphate group for mannosyl transfer are Ser135 and Arg117. The Dol-P phosphate group is pre-activated for nucleophilic attack, and not dependent on a catalytic base for activation
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GDP-alpha-D-mannose + dolichyl phosphate = GDP + dolichyl beta-D-mannosyl phosphate
catalytic mechanism of PfDPMS, overview. Catalytic mechanism of the transfer reaction, nucleophilic attack by the Dol-P phosphate oxygen on the mannosyl C1 carbon yields GDP and Dol-P-Man. Asp91 and Gln93 coordinate the GDP-Man diphosphate groups via the metal ion, while the key side chains for positioning the Dol-P phosphate group for mannosyl transfer are Ser135 and Arg117. The Dol-P phosphate group is pre-activated for nucleophilic attack, and not dependent on a catalytic base for activation
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GDP-alpha-D-mannose + dolichyl phosphate = GDP + dolichyl beta-D-mannosyl phosphate
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hexosyl group transfer
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
GDP-mannose:dolichyl-phosphate beta-D-mannosyltransferase
Acts only on long-chain polyprenyl phosphates and alpha-dihydropolyprenyl phosphates that are larger than C35.
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CAS REGISTRY NUMBER
COMMENTARY
62213-44-9
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(6Z,10E,14E,18E,22E)-3,7,15,19,23,27-hexamethyl-11-[(naphthalen-1-ylamino)methyl]octacosa-6,10,14,18,22,26-hexaen-1-yl dihydrogen phosphate + dolichyl phosphate
?
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?
(6Z,10Z,14Z,18Z,22E,26E)-3,7,11,15,19,23,27-heptamethyl-30-(naphthalen-1-ylamino)triaconta-6,10,14,18,22,26-hexaen-1-yl dihydrogen phosphate + dolichyl phosphate
?
-
-
-
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?
(6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-3,7,11,15,19,23,27,31,35,39-decamethyl-42-(naphthalen-1-ylamino)dotetraconta-6,10,14,18,22,26,30,34,38-nonaen-1-yl dihydrogen phosphate + dolichyl phosphate
?
-
-
-
-
?
GDP-alpha-D-mannose + farnesyl phosphate
GDP + farnesyl beta-D-mannosyl phosphate
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less efficient than dolichol phosphate
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-
?
GDP-mannose + C110-dolichyl phosphate
GDP + C110-dolichyl D-mannosyl phosphate
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-
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?
GDP-mannose + C120-dolichyl phosphate
GDP + C120-dolichyl D-mannosyl phosphate
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-
-
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?
GDP-mannose + C55-undecaprenyl phosphate
GDP + C55-undecaprenyl D-mannosyl phosphate
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-
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?
GDP-mannose + C85-dolichyl phosphate
GDP + C85-dolichyl D-mannosyl phosphate
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-
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?
GDPmannose + (S)-3-methyloctadecanyl phosphate
GDP + (S)-3-methyloctadecanyl D-mannosyl phosphate
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-
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?
GDPmannose + C100 alpha-dihydropolyprenyl phosphate
GDP + C100 alpha-dihydropolyprenyl D-mannosyl phosphate
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-
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?
GDPmannose + C55 alpha-dihydropolyprenyl phosphate
GDP + C55 alpha-dihydropolyprenyl D-mannosyl phosphate
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-
-
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?
GDPmannose + C55-polyisoprenol
GDP + D-mannosyl-C55-polyisopropenol
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?
GDPmannose + C80 alpha-dihydropolyprenyl phosphate
GDP + C80 alpha-dihydropolyprenyl D-mannosyl phosphate
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?
GDPmannose + cetyl phosphate
GDP + cetyl D-mannosyl phosphate
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less efficient than dolichol phosphate
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?
GDPmannose + phytanyl phosphate
GDP + phytanyl D-mannosyl phosphate
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at 60-70% of the activity with dolichyl phosphate
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?
GDP-alpha-D-mannose + dolichyl phosphate
GDP + dolichyl beta-D-mannosyl phosphate
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?
GDP-alpha-D-mannose + dolichyl phosphate
GDP + dolichyl beta-D-mannosyl phosphate
GDP-alpha-D-mannose binding structure analysis, overview
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?
GDP-alpha-D-mannose + dolichyl phosphate
GDP + dolichyl beta-D-mannosyl phosphate
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-
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?
GDP-alpha-D-mannose + dolichyl phosphate
GDP + dolichyl beta-D-mannosyl phosphate
GDP-alpha-D-mannose binding structure analysis, overview
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?
GDP-alpha-D-mannose + dolichyl phosphate
GDP + dolichyl beta-D-mannosyl phosphate
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-
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?
GDP-alpha-D-mannose + dolichyl phosphate
GDP + dolichyl beta-D-mannosyl phosphate
GDP-alpha-D-mannose binding structure analysis, overview
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?
GDP-alpha-D-mannose + dolichyl phosphate
GDP + dolichyl beta-D-mannosyl phosphate
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?
GDP-alpha-D-mannose + dolichyl phosphate
GDP + dolichyl beta-D-mannosyl phosphate
GDP-alpha-D-mannose binding structure analysis, overview
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?
GDP-mannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
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?
GDP-mannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
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?
GDP-mannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
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?
GDP-mannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
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cAMP-dependent protein kinase is essential for upregulating the Dol-P-Man synthase activity and consequently the Glc3Man9GlcNAc-PP-Dol biosymthesis and protein N-glycosylation in cAMP-responsive cells
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?
GDP-mannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
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?
GDP-mannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
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?
GDP-mannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
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the enzyme transfers mannose from the water soluble cytoplasmic donor GDP-Man, to the membrane bound, extremely hydrophobic, and long-chain polyisoprenoid acceptor, dolichyl-phosphate
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-
?
GDP-mannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
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or synthetic analogs of dolichyl phosphate
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?
GDP-mannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
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?
GDP-mannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
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?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
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?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
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?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
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-
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?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
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-
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?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
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r
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
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essential enzyme in glycoprotein biosynthesis
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?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
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?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
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?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
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?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
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?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
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-
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?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
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-
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?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
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-
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?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
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-
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?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
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-
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?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
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-
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?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
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-
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?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
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cAMP-mediated protein phosphorylation of microsomal membranes increases mannosylphosphodolichol synthase activity
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?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
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?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
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-
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?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
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-
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?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
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?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
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-
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?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
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-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
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-
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?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
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-
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?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
the enzyme is involved in glycoconjugate biosynthesis
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?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
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synthesis of dolichol-phosphate mannose, a key mannosyl donor for the biosynthesis of N-linked oligosaccharides as well as for O-linked oligosaccharides on yeast glycoproteins
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?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
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?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
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r
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
-
-
?
additional information
?
-
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two binding proteins, DPMS2 and DPMS3 serve as membrane anchors for DPMS1 or provide catalytic assistance. Recombinant DPMS1 alone does not catalyze dolichyl D-mannosyl phosphate synthesis
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?
additional information
?
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activities of fluorescent labeled dolichyl-phosphate derivatives
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?
additional information
?
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branching of lipid phosphates is essential for substrates of the enzyme, transfer of mannose occurs even if only branching at C3 is present
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?
additional information
?
-
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increased availability of GDP-mannose corrects glycosylation defects in the endoplasmic reticulum, such as dolichyl D-mannosyl phosphate formation in dolichyl-phosphate beta-D-mannosyltransferase mutants of Saccharomyces cerevisiae
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-
?
additional information
?
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glycosylphosphatidylinositol anchor biosynthesis
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-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
increased availability of GDP-mannose corrects glycosylation defects in the endoplasmic reticulum, such as dolichyl D-mannosyl phosphate formation in dolichyl-phosphate beta-D-mannosyltransferase mutants of Saccharomyces cerevisiae
-
-
?
GDP-alpha-D-mannose + dolichyl phosphate
GDP + dolichyl beta-D-mannosyl phosphate
-
-
-
?
GDP-alpha-D-mannose + dolichyl phosphate
GDP + dolichyl beta-D-mannosyl phosphate
-
-
-
?
GDP-alpha-D-mannose + dolichyl phosphate
GDP + dolichyl beta-D-mannosyl phosphate
-
-
-
?
GDP-alpha-D-mannose + dolichyl phosphate
GDP + dolichyl beta-D-mannosyl phosphate
-
-
-
?
GDP-mannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
cAMP-dependent protein kinase is essential for upregulating the Dol-P-Man synthase activity and consequently the Glc3Man9GlcNAc-PP-Dol biosymthesis and protein N-glycosylation in cAMP-responsive cells
-
-
?
GDP-mannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
the enzyme transfers mannose from the water soluble cytoplasmic donor GDP-Man, to the membrane bound, extremely hydrophobic, and long-chain polyisoprenoid acceptor, dolichyl-phosphate
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
essential enzyme in glycoprotein biosynthesis
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
cAMP-mediated protein phosphorylation of microsomal membranes increases mannosylphosphodolichol synthase activity
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
the enzyme is involved in glycoconjugate biosynthesis
-
-
?
GDPmannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
-
synthesis of dolichol-phosphate mannose, a key mannosyl donor for the biosynthesis of N-linked oligosaccharides as well as for O-linked oligosaccharides on yeast glycoproteins
-
-
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Co2+
Mg2+
Mn2+
Mg2+
-
divalent cation required for dolichol phosphate mannose: 2.5-7.5 mM Mg2+ or 2-3 mM Mn2+. Mg2+ is a better activator than Mn2+ in the reverse reaction
Mg2+
-
Mg2+ and Mn2+ up to a concentration of 5 mM result in the same activation
Mn2+
-
divalent cation required for synthesis of dolichyl D-mannosyl phosphate: 2.5-7.5 mM Mg2+ or 2-3 mM Mn2+. Mg2+ is a better activator than Mn2+ in the reverse reaction
Mn2+
can substitute for Mg2+, binding structure analysis, overview
Mn2+
-
Mg2+ and Mn2+ up to a concentration of 5 mM result in the same activation
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
[(5Z)-4-oxo-5-(phenylmethylidene)-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
-
42% residual DPMS activity in the presence of 1 mM
[(5Z)-5-[(2-hydroxyphenyl)methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
-
23% residual DPMS activity in the presence of 1 mM. Does not affect dolichyl D-mannosyl phosphate production in the cell-free system, but potently inhibits formation of mannosylated glycosylphosphatidylinositol intermediates
[(5Z)-5-[(3-hydroxyphenyl)methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
-
90% residual DPMS activity in the presence of 1 mM
[(5Z)-5-[(4-chlorophenyl)methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
-
86% residual DPMS activity in the presence of 1 mM
[(5Z)-5-[(4-cyanophenyl)methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
-
73% residual DPMS activity in the presence of 1 mM
[(5Z)-5-[(4-ethynylphenyl)methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
-
94% residual DPMS activity in the presence of 1 mM
[(5Z)-5-[(4-hydroxyphenyl)methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
-
70% residual DPMS activity in the presence of 1 mM. Abolishes the formation of dolichyl D-mannosyl phosphate almost completely, and significantly reduces the formation of downstream glycosylphosphatidylinositol intermediates
[(5Z)-5-[[3,4-bis(benzyloxy)phenyl]methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
-
20% residual DPMS activity in the presence of 1 mM. Abolishes the formation of dolichyl D-mannosyl phosphate almost completely, and significantly reduces the formation of downstream glycosylphosphatidylinositol intermediates
[(5Z)-5-[[3-(benzyloxy)phenyl]methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
-
23% residual DPMS activity in the presence of 1 mM
[(5Z)-5-[[4-(benzyloxy)phenyl]methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
-
10% residual DPMS activity in the presence of 1 mM. Does not affect dolichyl D-mannosyl phosphate production in the cell-free system, but potently inhibits formation of mannosylated glycosylphosphatidylinositol intermediates
additional information
-
GDP, GTP, IDP or GMP provide protection against inactivation by thiol reagents
-
additional information
-
DPMS inhibitors prevent the biosynthesis of glycosylphosphatidylinositol anchors, and possess trypanocidal activity against live trypanosomes
-
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
8-bromo-cAMP
-
capillary endothelial cells treated with the cAMP enhancer 8-bromo-cAMP show a 20% and 30% higher activity after 24h and 32h, respectively
Phospholipid
-
no absolute requirement for phospholipid, the phospholipid is required for interaction of the enzyme with the long chain polyisoprenol substrate dolichyl phosphate
phosphatidylcholine
-
increases activity 1.3fold at the optimal concentration
phosphatidylethanolamine
-
increases activity 2.3fold at the optimal concentration
phosphatidylinositol
-
increases activity 2.3fold at the optimal concentration
additional information
-
cAMP-dependent protein kinase is essential for upregulating the Dol-P-Man synthase activity and consequently the Glc3Man9GlcNAc-PP-Dol biosynthesis and protein N-glycosylation in cAMP-responsive cells
-
additional information
-
optimally active in a phospholipid matrix that contains some component phospholipids that prefer non-bilayer structural organization in isolation
-
additional information
-
the activity of dolichyl-phosphate beta-D-mannosyltransferase is subject to activation by a cAMP-dependent protein kinase in vitro
-
additional information
-
the enzyme is activated by cAMP-dependent protein kinase
-
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Anemia, Hypochromic
DOLICHOL PHOSPHATE MANNOSE SYNTHASE1 mediates the biogenesis of isoprenyl-linked glycans and influences development, stress response, and ammonium hypersensitivity in Arabidopsis.
Congenital Disorders of Glycosylation
Deficiency of Dol-P-Man synthase subunit DPM3 bridges the congenital disorders of glycosylation with the dystroglycanopathies.
Congenital Disorders of Glycosylation
Dilated cardiomyopathy and limb-girdle muscular dystrophy-dystroglycanopathy due to novel pathogenic variants in the DPM3 gene.
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Deficiency of Dol-P-Man synthase subunit DPM3 bridges the congenital disorders of glycosylation with the dystroglycanopathies.
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Dilated cardiomyopathy and limb-girdle muscular dystrophy-dystroglycanopathy due to novel pathogenic variants in the DPM3 gene.
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Dolichol phosphate mannose synthase (DPM1) mutations define congenital disorder of glycosylation Ie (CDG-Ie)
Exostoses
[Primary study on glycan structure in pathopoiesis mechanism of recurrent respiratory papillomatosis]
Hypersensitivity
DOLICHOL PHOSPHATE MANNOSE SYNTHASE1 mediates the biogenesis of isoprenyl-linked glycans and influences development, stress response, and ammonium hypersensitivity in Arabidopsis.
Infections
A newly cloned pig dolichyl-phosphate mannosyl-transferase for preventing the transmission of porcine endogenous retrovirus to human cells.
Trypanosomiasis, African
First small molecular inhibitors of T. brucei dolicholphosphate mannose synthase (DPMS), a validated drug target in African sleeping sickness.
Walker-Warburg Syndrome
Dilated cardiomyopathy and limb-girdle muscular dystrophy-dystroglycanopathy due to novel pathogenic variants in the DPM3 gene.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY