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Information on EC 2.4.1.79 - globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase

for references in articles please use BRENDA:EC2.4.1.79

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IUBMB Comments

Globoside is a neutral glycosphingolipid in human erythrocytes and has blood-group-P-antigen activity . The enzyme requires a divalent cation for activity, with Mn2+ required for maximal activity . UDP-GalNAc is the only sugar donor that is used efficiently by the enzyme: UDP-Gal and UDP-GlcNAc result in very low enzyme activity . Lactosylceramide, globoside and gangliosides GM3 and GD3 are not substrates . For explanation of the superscripted ’3′ in the systematic name, see GL-5.3.4.

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

Synonyms
globoside synthetase, udp-n-acetylgalactosamine:globotriaosylceramide beta-3-n-acetylgalactosaminyltransferase, udp-n-acetylgalactosamine:globotriaosylceramide 3-beta-n-acetylgalactosaminyltransferase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-N-acetyl-alpha-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
MetaCyc
globo-series glycosphingolipids biosynthesis
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