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Information on EC 2.4.1.68 - glycoprotein 6-alpha-L-fucosyltransferase

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EC Tree
     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.68 glycoprotein 6-alpha-L-fucosyltransferase
IUBMB Comments
This enzyme catalyses a reaction similar to that of EC 2.4.1.214, glycoprotein 3-alpha-L-fucosyltransferase, but transfers the L-fucosyl group from GDP-beta-L-fucose to form an alpha1,6-linkage rather than an alpha1,3-linkage.
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Word Map
  • 2.4.1.68
  • fucosylation
  • oligosaccharide
  • n-glycans
  • glcnac
  • antibody-dependent
  • innermost
  • asparagine-linked
  • alpha1,6-fucosylation
  • triantennary
  • fcgammariiia
  • non-fucosylated
  • glycomics
  • emphysema-like
  • alpha1,3-fucosyltransferase
  • core-fucosylated
  • alpha1,2
  • medicine
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
6FucT, alpha(1,6)FT, alpha(1,6)fucosyltransferase, alpha-1,6-fucosyltransferase, alpha-6-fucosyltransferase, alpha1,6-fucosyltransferase, alpha1,6-FucT, alpha1,6FucT, alpha1-6,fucosyltransferase, alpha1-6FucT, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
GDP-beta-L-fucose + N4-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = GDP + N4-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein]
show the reaction diagram
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