Disease on EC 2.4.1.65 - 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
3-galactosyl-n-acetylglucosaminide 4-alpha-l-fucosyltransferase deficiency
Synthesis of {alpha}(1,3) fucosyltransferases IV- and VII-dependent eosinophil selectin ligand and recruitment to the skin.
Adenocarcinoma
Death receptor 5 is activated by fucosylation in colon cancer cells.
Adenoma
Altered mRNA expression of glycosyltransferases in human colorectal carcinomas and liver metastases.
Breast Neoplasms
Fucosylation enhances the efficacy of adoptively transferred antigen-specific cytotoxic T lymphocytes.
Fucosyltransferase IV (FUT4) as an effective biomarker for the diagnosis of breast cancer.
Gene expression of fucosyl- and sialyl-transferases which synthesize sialyl Lewisx, the carbohydrate ligands for E-selectin, in human breast cancer.
MicroRNA-106b targets FUT6 to promote cell migration, invasion, and proliferation in human breast cancer.
miR-200b inhibits proliferation and metastasis of breast cancer by targeting fucosyltransferase IV and ?1,3-fucosylated glycans.
Role of fucosyltransferase IV in epithelial-mesenchymal transition in breast cancer cells.
Specific detection of sialyl Lewis X determinant carried on the mucin GlcNAcbeta1-->6GalNAcalpha core structure as a tumor-associated antigen.
[Study on relationship of fucosyltransferase gene types in breast cancer with metastasis and prognosis]
Carcinoma
alpha-2,3-Sialyltransferase type 3N and alpha-1,3-fucosyltransferase type VII are related to sialyl Lewis(x) synthesis and patient survival from lung carcinoma.
Altered mRNA expression of glycosyltransferases in human colorectal carcinomas and liver metastases.
Altered mRNA expression of glycosyltransferases in human gastric carcinomas.
C2-O-sLeX glycoproteins are E-selectin ligands that regulate invasion of human colon and hepatic carcinoma cells.
Different expression levels of alpha3/4 fucosyltransferases and Lewis determinants in ovarian carcinoma tissues and cell lines.
Differential fucosyltransferase IV expression in squamous carcinoma cells is regulated by promoter methylation.
Fucosyltransferase III and sialyl-Le(x) expression correlate in cultured colon carcinoma cells but not in colon carcinoma tissue.
Metastatic potential of human CX-1 colon adenocarcinoma cells is dependent on the expression of sialosyl Le(a) antigen.
Neutrophil interactions with sialyl lewis X on human nonsmall cell lung carcinoma cells regulate invasive behavior.
Promoter analysis of the human alpha1,3/4-fucosyltransferase gene (FUT III).
Role of sialosyl Lewis(a) in adhesion of colon cancer cells--the antisense RNA approach.
Sialosyl-Le(x) expression defines invasive and metastatic properties of bladder carcinoma.
Up-regulation of a set of glycosyltransferase genes in human colorectal cancer.
Carcinoma, Hepatocellular
Transcriptional regulation of the fucosyltransferase VI gene in hepatocellular carcinoma cells.
Carcinoma, Squamous Cell
Differential fucosyltransferase IV expression in squamous carcinoma cells is regulated by promoter methylation.
Fucosyltransferase IV enhances expression of MMP-12 stimulated by EGF via the ERK1/2, p38 and NF-?B pathways in A431 cells.
Colonic Neoplasms
Altered mRNA expression of specific molecular species of fucosyl- and sialyl-transferases in human colorectal cancer tissues.
The biosynthesis of the selectin-ligand sialyl Lewis x in colorectal cancer tissues is regulated by fucosyltransferase VI and can be inhibited by an RNA interference-based approach.
Colorectal Neoplasms
Alpha1,3 fucosyltransferase VII plays a role in colorectal carcinoma metastases by promoting the carbohydration of glycoprotein CD24.
Altered mRNA expression of specific molecular species of fucosyl- and sialyl-transferases in human colorectal cancer tissues.
Evidence that the aberrant alpha 1-->2fucosyltransferase found in colorectal carcinoma may be encoded by Fuc-TIII (Le) gene.
Relationship Between Increased Fucosylation and Metastatic Potential in Colorectal Cancer.
The biosynthesis of the selectin-ligand sialyl Lewis x in colorectal cancer tissues is regulated by fucosyltransferase VI and can be inhibited by an RNA interference-based approach.
Up-regulation of a set of glycosyltransferase genes in human colorectal cancer.
Coronary Disease
Fucosyltransferase 3 polymorphism and atherothrombotic disease in the Framingham Offspring Study.
Eosinophilia
Synthesis of {alpha}(1,3) fucosyltransferases IV- and VII-dependent eosinophil selectin ligand and recruitment to the skin.
Infections
Expression of a human alpha-1,3/4-fucosyltransferase in the pit cell lineage of FVB/N mouse stomach results in production of Leb-containing glycoconjugates: a potential transgenic mouse model for studying Helicobacter pylori infection.
Use of flow cytometry to monitor infection and recombinant human alpha-1,3/4 fucosyltransferase production in baculovirus infected Sf9 cell cultures.
Viral vector-mediated delivery of competing glycosyltransferases modifies epitope expression cell specifically.
Inflammatory Bowel Diseases
[Association of inflammatory bowel disease with the polymorphisms and haplotypes of fucosyltransferase 3 gene].
Leukemia
Expression of alpha-(1,3)-fucosyltransferases which synthesize sialyl Le(x) and sialyl Le(a), the carbohydrate ligands for E- and P-selectins,in human malignant cell lines.
Fucosylation enhances the efficacy of adoptively transferred antigen-specific cytotoxic T lymphocytes.
Transcriptional regulation of expression of carbohydrate ligands for cell adhesion molecules in the selectin family.
Leukemia, Erythroblastic, Acute
Expression of GDP-L-Fuc: Gal(beta 1-4)GlcNAc-R (Fuc to GlcNAc) alpha-1,3-fucosyltransferase and its relationship to glycoprotein structure in a human erythroleukemia cell line, HEL.
Leukemia, T-Cell
Human T-cell leukemia virus-1 encoded Tax protein transactivates alpha 1-->3 fucosyltransferase Fuc-T VII, which synthesizes sialyl Lewis X, a selectin ligand expressed on adult T-cell leukemia cells.
Transcriptional regulation of expression of carbohydrate ligands for cell adhesion molecules in the selectin family.
Leukemia-Lymphoma, Adult T-Cell
Human T-cell leukemia virus-1 encoded Tax protein transactivates alpha 1-->3 fucosyltransferase Fuc-T VII, which synthesizes sialyl Lewis X, a selectin ligand expressed on adult T-cell leukemia cells.
Suppression of sialyl Lewis X expression and E-selectin-mediated cell adhesion in cultured human lymphoid cells by transfection of antisense cDNA of an alpha1-->3 fucosyltransferase (Fuc-T VII).
Liver Neoplasms
The Expression of Human alpha(1,3) Fucosyltransferase in Human Liver Cancer by in situ Hybridization.
Lung Neoplasms
Expression of alpha-1,3-fucosyltransferase type IV and VII genes is related to poor prognosis in lung cancer.
Neutrophil interactions with sialyl lewis X on human nonsmall cell lung carcinoma cells regulate invasive behavior.
Melanoma
A sialyl-Le(x)-negative melanoma cell line binds to E-selectin but not to P-selectin.
Fucosylation enhances the efficacy of adoptively transferred antigen-specific cytotoxic T lymphocytes.
Ginsenoside Rg3-induced EGFR/MAPK pathway deactivation inhibits melanoma cell proliferation by decreasing FUT4/LeY expression.
Neoplasm Metastasis
Alpha1,3 fucosyltransferase VII plays a role in colorectal carcinoma metastases by promoting the carbohydration of glycoprotein CD24.
Fucosyltransferase IV (FUT4) as an effective biomarker for the diagnosis of breast cancer.
Human fucosyltransferase 6 enables prostate cancer metastasis to bone.
Metastatic potential of human CX-1 colon adenocarcinoma cells is dependent on the expression of sialosyl Le(a) antigen.
miR-200b inhibits proliferation and metastasis of breast cancer by targeting fucosyltransferase IV and ?1,3-fucosylated glycans.
Role of fucosyltransferase IV in epithelial-mesenchymal transition in breast cancer cells.
Tumor-associated macrophages promote Ezrin phosphorylation-mediated epithelial-mesenchymal transition in lung adenocarcinoma through FUT4/LeY up-regulation.
[Study on relationship of fucosyltransferase gene types in breast cancer with metastasis and prognosis]
Neoplasms
alpha-2,3-Sialyltransferase type 3N and alpha-1,3-fucosyltransferase type VII are related to sialyl Lewis(x) synthesis and patient survival from lung carcinoma.
Altered mRNA expression of glycosyltransferases in human colorectal carcinomas and liver metastases.
Altered mRNA expression of specific molecular species of fucosyl- and sialyl-transferases in human colorectal cancer tissues.
Cyclophosphamide-induced apoptosis in A431 cells is inhibited by fucosyltransferase IV.
Differential fucosyltransferase IV expression in squamous carcinoma cells is regulated by promoter methylation.
Expression of alpha-(1,3)-fucosyltransferases which synthesize sialyl Le(x) and sialyl Le(a), the carbohydrate ligands for E- and P-selectins,in human malignant cell lines.
Fucosyltransferase IV enhances expression of MMP-12 stimulated by EGF via the ERK1/2, p38 and NF-?B pathways in A431 cells.
FUT4 is involved in PD-1-related immunosuppression and leads to worse survival in patients with operable lung adenocarcinoma.
Gene expression of fucosyl- and sialyl-transferases which synthesize sialyl Lewisx, the carbohydrate ligands for E-selectin, in human breast cancer.
Ginsenoside Rg3 inhibits epithelial-mesenchymal transition (EMT) and invasion of lung cancer by down-regulating FUT4.
Ginsenoside Rg3 suppresses FUT4 expression through inhibiting NF-?B/p65 signaling pathway to promote melanoma cell death.
Neutrophil interactions with sialyl lewis X on human nonsmall cell lung carcinoma cells regulate invasive behavior.
Overexpression of fucosyltransferase IV in A431 cell line increases cell proliferation.
Platelet-endothelial interactions in inflamed mesenteric venules.
Role of fucosyltransferase IV in epithelial-mesenchymal transition in breast cancer cells.
Sialosyl-Le(x) expression defines invasive and metastatic properties of bladder carcinoma.
The biosynthesis of the selectin-ligand sialyl Lewis x in colorectal cancer tissues is regulated by fucosyltransferase VI and can be inhibited by an RNA interference-based approach.
Tumor-associated macrophages promote Ezrin phosphorylation-mediated epithelial-mesenchymal transition in lung adenocarcinoma through FUT4/LeY up-regulation.
Osteosarcoma
Identification of Key Genes and miRNAs in Osteosarcoma Patients with Chemoresistance by Bioinformatics Analysis.
Pancreatic Diseases
The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice.
Pancreatic Neoplasms
Potential Biomarkers in Lewis Negative Patients With Pancreatic Cancer.
Polycystic Kidney Diseases
Family-based analysis identified CD2 as a susceptibility gene for primary open angle glaucoma in Chinese Han population.
Prostatic Neoplasms
Human fucosyltransferase 6 enables prostate cancer metastasis to bone.
Tuberculosis
Fucosyltransferase IV and VII-directed selectin ligand function determines long-term survival in experimental tuberculosis.