Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Reference on EC 2.4.1.65 - 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase and Organism(s) Homo sapiens and UniProt Accession P21217

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wong, C.H.; Dumas, D.P.; Ichikawa, Y.; Koseki, K.; Danishefsky, S.J.; Weston, B.W.; Lowe, J.B.
Specificity, inhibition, and synthetic utility of a recombinant human alpha-1,3-fucosyltransferase
J. Am. Chem. Soc.
114
7321-7322
1992
Homo sapiens
-
Manually annotated by BRENDA team
Prieels, J.P.; Monnom, D.; Dolmans, M.; Beyer, T.A.; Hill, R.L.
Co-purification of the Lewis blood group N-acetylglucosaminide alpha 1-4 fucosyltransferase and an N-acetylglucosaminide alpha 1-3 fucosyltransferase from human milk
J. Biol. Chem.
256
10456-10463
1981
Homo sapiens
Manually annotated by BRENDA team
Palma, A.S.; Vila-Verde, C.; Pires, A.S.; Fevereiro, P.S.; Costa, J.
A novel plant alpha4-fucosyltransferase (Vaccinium myrtillus L.) synthesises the Lewisa adhesion determinant
FEBS Lett.
499
235-238
2001
Homo sapiens, Vaccinium myrtillus
Manually annotated by BRENDA team
Sousa, V.L.; Costa, M.T.; Palma, A.S.; Enguita, F.; Costa, J.
Localization, purification and specificity of the full-length membrane-bound form of human recombinant alpha 1,3/4-fucosyltransferase from BHK-21B cells
Biochem. J.
357
803-810
2001
Homo sapiens
Manually annotated by BRENDA team
Legault, D.J.; Kelly, R.J.; Natsuka, Y.; Lowe, J.B.
Human alpha(1,3/1,4)-fucosyltransferases discriminate between different oligosaccharide acceptor substrates through a discrete peptide fragment
J. Biol. Chem.
270
20987-20996
1995
Homo sapiens
Manually annotated by BRENDA team
Holmes, E.H.; Yen, T.Y.; Thomas, S.; Joshi, R.; Nguyen, A.; Long, T.; Gallet, F.; Maftah, A.; Julien, R.; Macher, B.A.
Human alpha1,3/4 fucosyltransferases. Characterization of highly conserved cysteine residues and N-linked glycosylation sites
J. Biol. Chem.
275
24237-24245
2000
Homo sapiens
Manually annotated by BRENDA team
Dupuy, F.; Germot, A.; Marenda, M.; Oriol, R.; Blancher, A.; Julien, R.; Maftah, A.
alpha1,4-Fucosyltransferase activity: a significant function in the primate lineage has appeared twice independently
Mol. Biol. Evol.
19
815-824
2002
Homo sapiens, Macaca mulatta
Manually annotated by BRENDA team
Morais, V.A.; Serpa, J.; Palma, A.S.; Costa, T.; Maranga, L.; Costa, J.
Expression and characterization of recombinant human alpha-3/4-fucosyltransferase III from Spodoptera frugiperda (Sf9) and Trichoplusia ni (Tn) cells using the baculovirus expression system
Biochem. J.
353
719-725
2001
Homo sapiens
Manually annotated by BRENDA team
Weston, B.W.; Nair, R.P.; Larsen, R.D.; Lowe, J.B.
Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specificities
J. Biol. Chem.
267
4152-4160
1992
Homo sapiens
Manually annotated by BRENDA team
Vo, L.; Lee, S.; Marcinko, M.C.; Holmes, E.H.; Macher, B.A.
Human alpha1,3/4-fucosyltransferases II. A single amino acid at the COOH terminus of FucT III and V alters their kinetic properties
J. Biol. Chem.
273
25250-25255
1998
Homo sapiens
Manually annotated by BRENDA team
Dupuy, F.; Petit, J.M.; Mollicone, R.; Oriol, R.; Julien, R.; Maftah, A.
A single amino acid in the hypervariable stem domain of vertebrate alpha1,3/1,4-fucosyltransferases determines the type 1/type 2 transfer. Characterization of acceptor substrate specificity of the Lewis enzyme by site-directed mutagenesis
J. Biol. Chem.
274
12257-12262
1999
Homo sapiens
Manually annotated by BRENDA team
Chandrasekaran, E.V.; Chawda, R.; Rhodes, J.M.; Xia, J.; Piskorz, C.; Matta, K.L.
Human lung adenocarcinoma alpha1,3/4-L-fucosyltransferase displays two molecular forms, high substrate affinity for clustered sialyl LacNAc type 1 units as well as mucin core 2 sialyl LacNAc type 2 unit and novel alpha1,2-L-fucosylating activity
Glycobiology
11
353-363
2001
Homo sapiens
Manually annotated by BRENDA team
Costa, J.; Grabenhorst, E.; Nimtz, M.; Conradt, H.S.
Stable expression of the Golgi form and secretory variants of human fucosyltransferase III from BHK-21 cells. Purification and characterization of an engineered truncated form from the culture medium
J. Biol. Chem.
272
11613-11621
1997
Homo sapiens
Manually annotated by BRENDA team
Kukowska-Latallo, J.F.; Larsen, R.D.; Nair, R.P.; Lowe, J.B.
A cloned human cDNA determines expression of mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase
Genes Dev.
4
1288-1303
1990
Homo sapiens (P21217)
Manually annotated by BRENDA team
Cameron, H.S.; Szczepaniak, D.; Weston, B.W.
Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms
J. Biol. Chem.
270
20112-20122
1995
Homo sapiens (P21217)
Manually annotated by BRENDA team
Elmgren, A.; Rydberg, L.; Larson, G.
Genotypic heterogeneity among Lewis negative individuals
Biochem. Biophys. Res. Commun.
196
515-520
1993
Homo sapiens (P21217)
Manually annotated by BRENDA team
Nishihara, S.; Yazawa, S.; Iwasaki, H.; Nakazato, M.; Kudo, T.; Ando, T.; Narimatsu, H.
alpha(1,3/1,4)fucosyltransferase (FucT-III) gene is inactivated by a single amino acid substitution in Lewis histo-blood type negative individuals
Biochem. Biophys. Res. Commun.
196
624-631
1993
Homo sapiens (P21217), Homo sapiens
Manually annotated by BRENDA team
Koda, Y.; Kimura, H.; Mekada, E.
Analysis of Lewis fucosyltransferase genes from the human gastric mucosa of Lewis-positive and -negative individuals
Blood
82
2915-2919
1993
Homo sapiens (P21217)
Manually annotated by BRENDA team
Mollicone, R.; Reguigne, I.; kelly, R.J.; Fletcher, A.; Watt, J.; Chatfield, S.; Aziz, A.; Cameron, H.S.; Weston, B.W.; Lowe, J.B.; Oriol, R.
Molecular basis for Lewis alpha(1,3/1,4)-fucosyltransferase gene deficiency (FUT3) found in Lewis-negative Indonesian pedigrees
J. Biol. Chem.
269
20987-20994
1994
Homo sapiens (P21217)
Manually annotated by BRENDA team
Nishihara, S.; Narimatsu, H.; Iwasaki, H.; Yazawa, S.; Akamatsu, S.; Ando, T.; Sena, T.; Narimatsu, I.
Molecular genetic analysis of the human Lewis histo-blood group system
J. Biol. Chem.
269
29271-29278
1994
Homo sapiens (P21217), Homo sapiens
Manually annotated by BRENDA team
Elmgren, A.; Boerjeson, C.; Svensson, L.; Rydberg, L.; Larson, G.
DNA sequencing and screening for point mutations in the human Lewis FUT gene enables molecular genotyping of the human Lewis blood group system
Vox Sang.
70
97-103
1996
Homo sapiens (P21217)
Manually annotated by BRENDA team
Elmgren, A.; Mollicone, R.; Costache, M.; Boerjeson, C.; Oriol, R.; Harrington, J.; Larson, G.
Significance of individual point mutations, T202C and C314T in the human Lewis FTA3' gene for expression of Lewis antigens by human alpha1,3/1,4'-fucosyltransferase, Fuc-TIII
J. Biol. Chem.
272
21994-21998
1997
Homo sapiens (P21217), Homo sapiens
Manually annotated by BRENDA team
Pang, H.; Liu, Y.; Koda, Y.; Soejima, M.; Jia, J.; Schlaphoff, T.; du Toit, E.D.; Kimura, H.
Five novel missense mutations of the Lewis gene FUT3' in African Xhosa and Caucasian populations in South Africa
Hum. Genet.
102
675-680
1998
Homo sapiens (P21217)
Manually annotated by BRENDA team
Koszdin, K.L.; Bowen, B.R.
The cloning and expression of a human alpha-1,3 fucosyltransferase capable of forming the E-selectin ligand
Biochem. Biophys. Res. Commun.
187
152-157
1992
Homo sapiens (P51993), Homo sapiens
Manually annotated by BRENDA team
Galan, M.C.; Venot, A.P.; Boons, G.J.
Glycosyltransferase activity can be modulated by small conformational changes of acceptor substrates
Biochemistry
42
8522-8529
2003
Homo sapiens
Manually annotated by BRENDA team
Niu, X.; Fan, X.; Sun, J.; Ting, P.; Narula, S.; Lundell, D.
Inhibition of fucosyltransferase VII by gallic acid and its derivatives
Arch. Biochem. Biophys.
425
51-57
2004
Homo sapiens (Q11130)
Manually annotated by BRENDA team
Stoykova, L.I.; Liu, A.; Scanlin, T.F.; Glick, M.C.
alpha1,3 Fucosyltransferases in cystic fibrosis airway epithelial cells
Biochimie
85
363-367
2003
Homo sapiens
Manually annotated by BRENDA team
Palma, A.S.; Morais, V.A.; Coelho, A.V.; Costa, J.
Effect of the manganese ion on human alpha3/4 fucosyltransferase III activity
BioMetals
17
35-43
2004
Homo sapiens
Manually annotated by BRENDA team
Norris, A.J.; Whitelegge, J.P.; Strouse, M.J.; Faull, K.F.; Toyokuni, T.
Inhibition kinetics of carba- and C-fucosyl analogues of GDP-fucose against fucosyltransferase V: implication for the reaction mechanism
Bioorg. Med. Chem. Lett.
14
571-573
2004
Homo sapiens
Manually annotated by BRENDA team
Chandrasekaran, E.V.; Chawda, R.; Rhodes, J.M.; Locke, R.D.; Piskorz, C.F.; Matta, K.L.
The binding characteristics and utilization of Aleuria aurantia, Lens culinaris and few other lectins in the elucidation of fucosyltransferase activities resembling cloned FT VI and apparently unique to colon cancer cells
Carbohydr. Res.
338
887-901
2003
Homo sapiens (P51993), Homo sapiens (Q11128)
Manually annotated by BRENDA team
Abe, H.; Ohba, M.; Shimma, Y.I.; Jigami, Y.
Yeast cells harboring human alpha-1,3-fucosyltransferase at the cell surface engineered using Pir, a cell wall-anchored protein
FEMS Yeast Res.
4
417-425
2004
Homo sapiens
Manually annotated by BRENDA team
Dupuy, F.; Germot, A.; Julien, R.; Maftah, A.
Structure/function study of Lewis alpha3- and alpha3/4-fucosyltransferases: the alpha1,4 fucosylation requires an aromatic residue in the acceptor-binding domain
Glycobiology
14
347-356
2004
Homo sapiens (P21217), Homo sapiens (P51993), Homo sapiens (Q11128), Hylobates lar (Q8HYJ3), Pongo pygmaeus (Q8HYJ4), Pongo pygmaeus (Q8HYJ5), Gorilla gorilla (Q8HYJ6), Gorilla gorilla (Q8HYJ7)
Manually annotated by BRENDA team
Morais, V.A.; Costa, J.
Stable expression of recombinant human alpha3/4 fucosyltransferase III in Spodoptera frugiperda Sf9 cells
J. Biotechnol.
106
69-75
2003
Homo sapiens
Manually annotated by BRENDA team
Guo, P.; Zhang, Y.; Zhang, X.Y.; Chen, H.L.; Wang, H.; Narimatsu, H.
Analysis of lewis antigens on cell surface and alpha1,3 fucosyltransferase subtypes in H7721 human hepatocarcinoma cells
J. Exp. Clin. Cancer Res.
22
135-139
2003
Homo sapiens
Manually annotated by BRENDA team
Bengtson, P.; Lundblad, A.; Larson, G.; Pahlsson, P.
Polymorphonuclear leukocytes from individuals carrying the G329A mutation in the alpha 1,3-fucosyltransferase VII gene (FUT7) roll on E- and P-selectins
J. Immunol.
169
3940-3946
2002
Homo sapiens
Manually annotated by BRENDA team
Dabrowska, A.; Baczynska, D.; Widerak, K.; Laskowska, A.; Ugorski, M.
Promoter analysis of the human alpha1,3/4-fucosyltransferase gene (FUT III)
Biochim. Biophys. Acta
1731
66-73
2005
Homo sapiens
Manually annotated by BRENDA team
Escrevente, C.; Machado, E.; Brito, C.; Reis, C.A.; Stoeck, A.; Runz, S.; Marme, A.; Altevogt, P.; Costa, J.
Different expression levels of alpha3/4 fucosyltransferases and Lewis determinants in ovarian carcinoma tissues and cell lines
Int. J. Oncol.
29
557-566
2006
Homo sapiens
Manually annotated by BRENDA team
Khaled, A.; Piotrowska, O.; Dominiak, K.; Auge, C.
Exploring specificity of glycosyltransferases: synthesis of new sugar nucleotide related molecules as putative donor substrates
Carbohydr. Res.
343
167-178
2008
Homo sapiens
Manually annotated by BRENDA team
Shetterly, S.; Jost, F.; Watson, S.R.; Knegtel, R.; Macher, B.A.; Holmes, E.H.
Site-specific fucosylation of sialylated polylactosamines by alpha1,3/4-fucosyltransferases-V and -VI is defined by amino acids near the N terminus of the catalytic domain
J. Biol. Chem.
282
24882-24892
2007
Homo sapiens
Manually annotated by BRENDA team
Lin, C.H.; Lin, C.W.; Khoo, K.H.
Proteomic identification of specific glycosyltransferases functionally implicated for the biosynthesis of a targeted glyco-epitope
Proteomics
8
475-483
2008
Homo sapiens (P21217), Homo sapiens (P51993)
Manually annotated by BRENDA team
Tefsen, B.; van Stijn, C.M.; van den Broek, M.; Kalay, H.; Knol, J.C.; Jimenez, C.R.; van Die, I.
Chemoenzymatic synthesis of multivalent neoglycoconjugates carrying the helminth glycan antigen LDNF
Carbohydr. Res.
344
1501-1507
2009
Homo sapiens
Manually annotated by BRENDA team
Fagerberg, D.; Angstroem, J.; Halim, A.; Hultberg, A.; Rakhimova, L.; Hammarstroem, L.; Boren, T.; Teneberg, S.
Novel Leb-like Helicobacter pylori-binding glycosphingolipid created by the expression of human alpha-1,3/4-fucosyltransferase in FVB/N mouse stomach
Glycobiology
19
182-191
2009
Homo sapiens
Manually annotated by BRENDA team
Carvalho, A.; Harduin-Lepers, A.; Magalhaes, A.; Machado, E.; Mendes, N.; Costa, L.; Matthiesen, R.; Almeida, R.; Costa, J.; Reis, C.
Differential expression of alpha-2,3-sialyltransferases and alpha-1,3/4-fucosyltransferases regulates the levels of sialyl Lewis a and sialyl Lewis x in gastrointestinal carcinoma cells
Int. J. Biochem. Cell Biol.
42
80-89
2010
Homo sapiens
Manually annotated by BRENDA team
Mollicone, R.; Moore, S.E.; Bovin, N.; Garcia-Rosasco, M.; Candelier, J.J.; Martinez-Duncker, I.; Oriol, R.
Activity, splice variants, conserved peptide motifs, and phylogeny of two new alpha1,3-fucosyltransferase families (FUT10 and FUT11)
J. Biol. Chem.
284
4723-4738
2009
Homo sapiens (Q495W5), Homo sapiens (Q6P4F1)
Manually annotated by BRENDA team
Barthel, S.; Wiese, G.; Cho, J.; Opperman, M.; Hays, D.; Siddiqui, J.; Pienta, K.; Furie, B.; Dimitroff, C.
Alpha 1,3 fucosyltransferases are master regulators of prostate cancer cell trafficking
Proc. Natl. Acad. Sci. USA
106
19491-19496
2009
Homo sapiens
Manually annotated by BRENDA team
Guo, Q.; Guo, B.; Wang, Y.; Wu, J.; Jiang, W.; Zhao, S.; Qiao, S.; Wu, Y.
Functional analysis of alpha1,3/4-fucosyltransferase VI in human hepatocellular carcinoma cells
Biochem. Biophys. Res. Commun.
417
311-317
2012
Homo sapiens
Manually annotated by BRENDA team
Seelhorst, K.; Piernitzki, T.; Lunau, N.; Meier, C.; Hahn, U.
Synthesis and analysis of potential alpha1,3-fucosyltransferase inhibitors
Bioorg. Med. Chem.
22
6430-6437
2014
Helicobacter pylori, Homo sapiens
Manually annotated by BRENDA team
Lunau, N.; Seelhorst, K.; Kahl, S.; Tscherch, K.; Stacke, C.; Rohn, S.; Thiem, J.; Hahn, U.; Meier, C.
Fluorescently labeled substrates for monitoring alpha1,3-fucosyltransferase IX activity
Chemistry
19
17379-17390
2013
Helicobacter pylori, Homo sapiens
Manually annotated by BRENDA team
Brazil, J.C.; Liu, R.; Sumagin, R.; Kolegraff, K.N.; Nusrat, A.; Cummings, R.D.; Parkos, C.A.; Louis, N.A.
alpha3/4 Fucosyltransferase 3-dependent synthesis of Sialyl Lewis A on CD44 variant containing exon 6 mediates polymorphonuclear leukocyte detachment from intestinal epithelium during transepithelial migration
J. Immunol.
191
4804-4817
2013
Homo sapiens
Manually annotated by BRENDA team
Huang, V.W.; Lee, C.L.; Lee, Y.L.; Lam, K.K.; Ko, J.K.; Yeung, W.S.; Ho, P.C.; Chiu, P.C.
Sperm fucosyltransferase-5 mediates spermatozoa-oviductal epithelial cell interaction to protect human spermatozoa from oxidative damage
Mol. Hum. Reprod.
21
516-526
2015
Homo sapiens
Manually annotated by BRENDA team