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Information on EC 2.4.1.65 - 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase and Organism(s) Gorilla gorilla gorilla and UniProt Accession Q8HYJ6

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IUBMB Comments
This enzyme is the product of the Lewis blood group gene. Normally acts on a glycoconjugate where R (see reaction) is a glycoprotein or glycolipid. Although it is a 4-fucosyltransferase, it has a persistent 3-fucosyltransferase activity towards the glucose residue in free lactose. This enzyme fucosylates on O-4 of an N-acetylglucosamine that carries a galactosyl group on O-3, unlike EC 2.4.1.152, 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase, which fucosylates on O-3 of an N-acetylglucosamine that carries a galactosyl group on O-4. Enzymes catalysing the 4-alpha-fucosylation of the GlcNAc in beta-D-Gal-(1->3)-beta-GlcNAc sequences (with some activity also as 3-alpha-fucosyltransferases) are present in plants, where the function in vivo is the modification of N-glycans. In addition, the fucTa gene of Helicobacter strain UA948 encodes a fucosyltransferase with both 3-alpha- and 4-alpha-fucosyltransferase activities.
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Gorilla gorilla gorilla
UNIPROT: Q8HYJ6
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Word Map
The taxonomic range for the selected organisms is: Gorilla gorilla gorilla
The enzyme appears in selected viruses and cellular organisms
Synonyms
fuc-t, fuc-tiii, alpha-1,3-fucosyltransferase, fucosyltransferase iv, fuct-iii, fuct-vi, fuct v, fuct iii, fucosyltransferase vi, ft-iv, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
(Lea)-dependent alpha-3/4-fucosyltransferase
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alpha(1,3/1,4) fucosyltransferase III
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alpha(1,3/4) fucosyltransferase
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alpha-(1->4)-L-fucosyltransferase
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alpha-4-L-fucosyltransferase
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alpha4-fucosyltransferase
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alpha4-FucT
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beta-acetylglucosaminylsaccharide fucosyltransferase
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blood group Lewis alpha-4-fucosyltransferase
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blood-group substance Lea-dependent fucosyltransferase
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Fuc-TIII
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fucosyltransferase, guanosine diphosphofucose-beta-acetylglucosaminylsaccharide 4-alpha-L-
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fucosyltransferase, guanosine diphosphofucose-glycoprotein 4-alpha-
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FucT-II
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FucTIII
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FUT3
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guanosine diphosphofucose-glycoprotein 4-alpha-L-fucosyltransferase
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Lewis alpha-3/4-fucosyltransferase
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Lewis alpha1-3/4 fucosyltransferase
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Lewis blood group alpha1-3/4 fucosyltransferase
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Lewis(Le) blood group gene-dependent alpha-3/4-L-fucosyltransferase
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SFT3
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hexosyl group transfer
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SYSTEMATIC NAME
IUBMB Comments
GDP-beta-L-fucose:beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase
This enzyme is the product of the Lewis blood group gene. Normally acts on a glycoconjugate where R (see reaction) is a glycoprotein or glycolipid. Although it is a 4-fucosyltransferase, it has a persistent 3-fucosyltransferase activity towards the glucose residue in free lactose. This enzyme fucosylates on O-4 of an N-acetylglucosamine that carries a galactosyl group on O-3, unlike EC 2.4.1.152, 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase, which fucosylates on O-3 of an N-acetylglucosamine that carries a galactosyl group on O-4. Enzymes catalysing the 4-alpha-fucosylation of the GlcNAc in beta-D-Gal-(1->3)-beta-GlcNAc sequences (with some activity also as 3-alpha-fucosyltransferases) are present in plants, where the function in vivo is the modification of N-glycans. In addition, the fucTa gene of Helicobacter strain UA948 encodes a fucosyltransferase with both 3-alpha- and 4-alpha-fucosyltransferase activities.
CAS REGISTRY NUMBER
COMMENTARY hide
37277-69-3
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
FUT6_GORGO
359
0
41688
Swiss-Prot
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