Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
UDP-alpha-GalNAc + polypeptide
GalNAc-alpha-polypeptide + UDP
-
major mucin-type O-glycan in embryonic tracheal system along the apical region and luman of the tracheal tubes O-glycan, detectable by lectins Jacalin, soybean agglutinin and Vicia villosa agglutinin
-
?
UDP-N-acetyl-alpha-D-galactosamine + EA2 peptide
?
-
-
-
?
UDP-N-acetyl-D-galactosamine + GalNAc-glycosylated peptide
UDP + N-acetyl-D-galactosaminyl-GalNAc-glucosylated peptide
acceptor: MUC5AC-13 glycopeptide
-
-
?
UDP-N-acetyl-D-galactosamine + polypeptide
UDP + N-acetyl-D-galactosaminyl-polypeptide
UDP-GalNAc + GAGA(X)3T(X)3AGAGK
GAGA(X)3(GalNAc)T(X)3AGAGK + UDP
-
-
-
?
UDP-GalNAc + GAGA(X)5T(X)5AGAGK
GAGA(X)5(GalNAc)T(X)5AGAGK + UDP
UDP-GalNAc + GAGA(X)nT(X)nAGAGK
GAGA(X)n(GalNAc)T(X)nAGAGK + UDP
library of unmodified peptides, with randomized residue at position X and n=3 or n=5
-
-
?
UDP-N-acetyl-D-galactosamine + GKPRPYSPRPTSHPRPIRV
UDP + ?
i.e. drosocin, low activity, enzyme form PGANT8
-
-
?
UDP-N-acetyl-D-galactosamine + GTTPSPVPTTSTTSAP
UDP + ?
UDP-N-acetyl-D-galactosamine + mucin MUC4AC-13
UDP + ?
enzyme form PGANT2
-
-
?
UDP-N-acetyl-D-galactosamine + mucin MUC5AC-3
UDP + ?
UDP-N-acetyl-D-galactosamine + mucin MUC5AC-3/13
UDP + ?
UDP-N-acetyl-D-galactosamine + mucin MUC5AX-13
UDP + ?
UDP-N-acetyl-D-galactosamine + PDTRPAPGSTAPPAC
UDP + ?
UDP-N-acetyl-D-galactosamine + polypeptide
UDP + N-acetyl-D-galactosaminyl-polypeptide
mucin-type O-linked glycosylation of serine or threonine residues
-
-
?
UDP-N-acetyl-D-galactosamine + PSTPPTPSPSTPPTPSPS
UDP + ?
UDP-N-acetyl-D-galactosamine + PTTDSTTPAPTTK
UDP + ?
UDP-N-acetyl-D-galactosamine + SPTTSTPISSTPQPTS
UDP + ?
additional information
?
-
UDP-N-acetyl-D-galactosamine + polypeptide
UDP + N-acetyl-D-galactosaminyl-polypeptide
acceptors: substantial activity only with EA2 peptide, less active with IgAh peptide
-
-
?
UDP-N-acetyl-D-galactosamine + polypeptide
UDP + N-acetyl-D-galactosaminyl-polypeptide
transfer of GalNAc to a serine or threonine residue on the acceptor protein
-
-
?
UDP-N-acetyl-D-galactosamine + polypeptide
UDP + N-acetyl-D-galactosaminyl-polypeptide
mucin-type O-linked glycosylation of serine or threonine residues
-
-
?
UDP-GalNAc + GAGA(X)5T(X)5AGAGK
GAGA(X)5(GalNAc)T(X)5AGAGK + UDP
transferase activity relatively insensitive to the nature of amino acids 4 and 5 residues away from site of glycosylation, high correlation between peptide preferences of PGANT5 and mammalian orthologue ppGalNAc T1 with r(square) = 0.67, the hydrophobic residue proline is preferred at the -1, +1, and +3 positions, the hydrophobic residues valine and tyrosin are moderately preferred at the -1 and +3 positions, the hydrophobic residue methionine is disfavoured at the -1 position, low hydrophilic preference at the -1 position, strong glutamate/aspartate preference at the +1 position, higher preference of glutamate at +1 and +2 positions than mammalian orthologue ppGalNAc T1
-
-
?
UDP-GalNAc + GAGA(X)5T(X)5AGAGK
GAGA(X)5(GalNAc)T(X)5AGAGK + UDP
transferase activity relatively insensitive to the nature of amino acids 4 and 5 residues away from site of glycosylation, very high correlation between peptide preferences of PGANT2 and mammalian orthologue ppGalNAc T2 with r(square) = 0.92
-
-
?
UDP-N-acetyl-D-galactosamine + GTTPSPVPTTSTTSAP
UDP + ?
i.e. MUC5AC
-
-
?
UDP-N-acetyl-D-galactosamine + GTTPSPVPTTSTTSAP
UDP + ?
i.e. MUC5AC, enzyme form PGANT4
-
-
?
UDP-N-acetyl-D-galactosamine + GTTPSPVPTTSTTSAP
UDP + ?
i.e. MUC5AC, low activity enzyme form PGANT6
-
-
?
UDP-N-acetyl-D-galactosamine + GTTPSPVPTTSTTSAP
UDP + ?
i.e. MUC5AC, low activity, enzyme form PGANT8
-
-
?
UDP-N-acetyl-D-galactosamine + GTTPSPVPTTSTTSAP
UDP + ?
i.e. MUC5AC, very low activity, enzyme form PGANT3
-
-
?
UDP-N-acetyl-D-galactosamine + mucin MUC5AC-3
UDP + ?
enzyme form PGANT2
-
-
?
UDP-N-acetyl-D-galactosamine + mucin MUC5AC-3
UDP + ?
enzyme form PGANT4
-
-
?
UDP-N-acetyl-D-galactosamine + mucin MUC5AC-3
UDP + ?
enzyme form PGANT6
-
-
?
UDP-N-acetyl-D-galactosamine + mucin MUC5AC-3
UDP + ?
enzyme form PGANT7
-
-
?
UDP-N-acetyl-D-galactosamine + mucin MUC5AC-3
UDP + ?
enzyme form PGANT8
-
-
?
UDP-N-acetyl-D-galactosamine + mucin MUC5AC-3
UDP + ?
high activity, enzyme form PGANT5
-
-
?
UDP-N-acetyl-D-galactosamine + mucin MUC5AC-3
UDP + ?
PGANT1
-
-
?
UDP-N-acetyl-D-galactosamine + mucin MUC5AC-3
UDP + ?
very low activity, enzyme form PGANT3
-
-
?
UDP-N-acetyl-D-galactosamine + mucin MUC5AC-3/13
UDP + ?
enzyme form PGANT8
-
-
?
UDP-N-acetyl-D-galactosamine + mucin MUC5AC-3/13
UDP + ?
high activity, enzyme form PGANT4
-
-
?
UDP-N-acetyl-D-galactosamine + mucin MUC5AC-3/13
UDP + ?
high activity, enzyme form PGANT5
-
-
?
UDP-N-acetyl-D-galactosamine + mucin MUC5AC-3/13
UDP + ?
high activity, enzyme form PGANT7
-
-
?
UDP-N-acetyl-D-galactosamine + mucin MUC5AC-3/13
UDP + ?
low activity, enzyme form PGANT2
-
-
?
UDP-N-acetyl-D-galactosamine + mucin MUC5AC-3/13
UDP + ?
preferred substrate, enzyme form PGANT4
-
-
?
UDP-N-acetyl-D-galactosamine + mucin MUC5AX-13
UDP + ?
enzyme form PGANT4
-
-
?
UDP-N-acetyl-D-galactosamine + mucin MUC5AX-13
UDP + ?
enzyme form PGANT6
-
-
?
UDP-N-acetyl-D-galactosamine + mucin MUC5AX-13
UDP + ?
enzyme form PGANT8
-
-
?
UDP-N-acetyl-D-galactosamine + mucin MUC5AX-13
UDP + ?
high activity, enzyme form PGANT5
-
-
?
UDP-N-acetyl-D-galactosamine + mucin MUC5AX-13
UDP + ?
low activity, enzyme form PGANT7
-
-
?
UDP-N-acetyl-D-galactosamine + PDTRPAPGSTAPPAC
UDP + ?
i.e. MUC1b
-
-
?
UDP-N-acetyl-D-galactosamine + PDTRPAPGSTAPPAC
UDP + ?
i.e. MUC1b, enzyme form PGANT4
-
-
?
UDP-N-acetyl-D-galactosamine + PDTRPAPGSTAPPAC
UDP + ?
i.e. MUC1b, low activity, enzyme form PGANT2
-
-
?
UDP-N-acetyl-D-galactosamine + PDTRPAPGSTAPPAC
UDP + ?
i.e. MUC1b, low activity, enzyme form PGANT6
-
-
?
UDP-N-acetyl-D-galactosamine + PDTRPAPGSTAPPAC
UDP + ?
i.e. MUC1b, low activity, enzyme form PGANT8
-
-
?
UDP-N-acetyl-D-galactosamine + PSTPPTPSPSTPPTPSPS
UDP + ?
i.e. IgAh
-
-
?
UDP-N-acetyl-D-galactosamine + PSTPPTPSPSTPPTPSPS
UDP + ?
i.e. IgAh, low activity, enzyme form PGANT2
-
-
?
UDP-N-acetyl-D-galactosamine + PSTPPTPSPSTPPTPSPS
UDP + ?
i.e. IgAh, low activity, enzyme form PGANT8
-
-
?
UDP-N-acetyl-D-galactosamine + PSTPPTPSPSTPPTPSPS
UDP + ?
i.e. IgAh, very low activity, enzyme form PGANT3
-
-
?
UDP-N-acetyl-D-galactosamine + PTTDSTTPAPTTK
UDP + ?
enzyme form PGANT2
-
-
?
UDP-N-acetyl-D-galactosamine + PTTDSTTPAPTTK
UDP + ?
enzyme form PGANT3
-
-
?
UDP-N-acetyl-D-galactosamine + PTTDSTTPAPTTK
UDP + ?
i.e. EA2, enzyme form PGANT4
-
-
?
UDP-N-acetyl-D-galactosamine + PTTDSTTPAPTTK
UDP + ?
i.e. EA2, enzyme form PGANT6
-
-
?
UDP-N-acetyl-D-galactosamine + PTTDSTTPAPTTK
UDP + ?
i.e. EA2, enzyme form PGANT8
-
-
?
UDP-N-acetyl-D-galactosamine + PTTDSTTPAPTTK
UDP + ?
i.e. EA2, glycosylation at threonines 7, 11, and 12, enzyme form PGANT1
-
-
?
UDP-N-acetyl-D-galactosamine + PTTDSTTPAPTTK
UDP + ?
i.e. EA2, high activity, glycosylation at threonines 7, 11, and 12, enzyme form PGANT1
-
-
?
UDP-N-acetyl-D-galactosamine + SPTTSTPISSTPQPTS
UDP + ?
i.e. rMUC-2, enzyme form PGANT2
-
-
?
UDP-N-acetyl-D-galactosamine + SPTTSTPISSTPQPTS
UDP + ?
i.e. rMUC-2, enzyme form PGANT4
-
-
?
UDP-N-acetyl-D-galactosamine + SPTTSTPISSTPQPTS
UDP + ?
i.e. rMUC-2, high activity
-
-
?
UDP-N-acetyl-D-galactosamine + SPTTSTPISSTPQPTS
UDP + ?
i.e. rMUC-2, low activity. enzyme form PGANT6
-
-
?
additional information
?
-
519-amino acid putative catalytic region
-
-
?
additional information
?
-
-
519-amino acid putative catalytic region
-
-
?
additional information
?
-
involved in development, necessary for viability
-
-
?
additional information
?
-
-
involved in development, necessary for viability
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Ten Hagen, K.G.; Tran, D.T.
A UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase is essential for viability in Drosophila melanogaster
J. Biol. Chem.
277
22616-22622
2002
Drosophila melanogaster (Q8MVS5), Drosophila melanogaster
brenda
Ten Hagen, K.G.; Tran, D.T.; Gerken, T.A.; Stein, D.S.; Zhang, Z.
Functional characterization and expression analysis of members of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family from Drosophila melanogaster
J. Biol. Chem.
278
35039-35048
2003
Drosophila melanogaster, Drosophila melanogaster (Q6WV16), Drosophila melanogaster (Q6WV17), Drosophila melanogaster (Q6WV19), Drosophila melanogaster (Q6WV20), Drosophila melanogaster (Q8IA42), Drosophila melanogaster (Q8MV48), Drosophila melanogaster (Q9Y117)
brenda
Gerken, T.A.; Hagen, K.G.; Jamison, O.
Conservation of peptide acceptor preferences between Drosophila and mammalian polypeptide-GalNAc transferase orthologue pairs
Glycobiology
18
861-870
2008
Bos taurus (Q07537), Homo sapiens (Q10471), Drosophila melanogaster (Q6WV17), Drosophila melanogaster (Q6WV19)
brenda
Tian, E.; ten Hagen, K.G.
A UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase is required for epithelial tube formation
J. Biol. Chem.
282
606-614
2007
Drosophila melanogaster (Q8MVS5)
brenda