Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 2.4.1.41 - polypeptide N-acetylgalactosaminyltransferase and Organism(s) Toxoplasma gondii and UniProt Accession Q6TBR4

for references in articles please use BRENDA:EC2.4.1.41
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.41 polypeptide N-acetylgalactosaminyltransferase
IUBMB Comments
Requires both Mn2+ and Ca2+. The glycosyl residue is transferred to threonine or serine hydroxy groups on the polypeptide core of submaxillary mucin, kappa-casein, apofetuin and some other acceptors of high molecular mass.
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Toxoplasma gondii
UNIPROT: Q6TBR4
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The taxonomic range for the selected organisms is: Toxoplasma gondii
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
galnt3, n-acetylgalactosaminyltransferase, galnt2, galnac-t3, galnac-t, galnt14, galnac-transferase, galnac transferase, galnac-t2, galnac-t1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase
-
acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-glycoprotein
-
-
-
-
GalNAc-transferase
-
-
-
-
glycoprotein acetylgalactosaminyltransferase
-
-
-
-
polypeptide-N-acetylgalactosamine transferase
-
-
-
-
ppGalNAc-T
-
-
-
-
ppGaNTase
-
-
-
-
protein-UDP acetylgalactosaminyltransferase
-
-
-
-
UDP-acetylgalactosamine-glycoprotein acetylgalactosaminyltransferase
-
-
-
-
UDP-acetylgalactosamine:peptide-N-galactosaminyltransferase
-
-
-
-
UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase
-
-
-
-
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase
-
-
-
-
UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-T3
-
UDP-N-acetylgalactosamine-glycoprotein N-acetylgalactosaminyltransferase
-
-
-
-
UDP-N-acetylgalactosamine-protein N-acetylgalactosaminyltransferase
-
-
-
-
UDP-N-acetylgalactosamine:kappa-casein polypeptide N-acetylgalactosaminyltransferase
-
-
-
-
UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase
-
-
-
-
UDP-N-acetylgalactosamine:protein N-acetylgalactosaminyl transferase
-
-
-
-
uridine diphosphoacetylgalactosamine-glycoprotein acetylgalactosaminyltransferase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hexosyl group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase
Requires both Mn2+ and Ca2+. The glycosyl residue is transferred to threonine or serine hydroxy groups on the polypeptide core of submaxillary mucin, kappa-casein, apofetuin and some other acceptors of high molecular mass.
CAS REGISTRY NUMBER
COMMENTARY hide
9075-15-4
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
UDP-N-acetyl-D-galactosamine + GTTPSPVPTTS-(O-GalNAc)T-SAP
UDP + ?
show the reaction diagram
-
-
-
?
UDP-N-acetyl-D-galactosamine + GTTPSPVPTTSTTSAP
UDP + ?
show the reaction diagram
0.3% of the activity with GTTPSPVPTTS-(O-GalNAc)T-TSAP
-
-
?
UDP-N-acetyl-D-galactosamine + P-(O-GalNAc)T-TDSTTPAPTTK
UDP + ?
show the reaction diagram
0.3% of the activity with GTTPSPVPTTS-(O-GalNAc)T-TSAP
-
-
?
UDP-N-acetyl-D-galactosamine + polypeptide
UDP + N-acetyl-D-galactosaminyl-polypeptide
show the reaction diagram
-
-
-
?
UDP-N-acetyl-D-galactosamine + PTTDS-(O-GalNAc)T-TPAPTTK
UDP + ?
show the reaction diagram
59.6% of the activity with GTTPSPVPTTS-(O-GalNAc)T-TSAP
-
-
?
UDP-N-acetyl-D-galactosamine + PTTDSTTPAPTTK
UDP + ?
show the reaction diagram
0.3% of the activity with GTTPSPVPTTS-(O-GalNAc)T-TSAP
-
-
?
UDP-N-acetyl-D-galactosamine + VESDRSTTTTQAP
UDP + ?
show the reaction diagram
0.3% of the activity with GTTPSPVPTTS-(O-GalNAc)T-TSAP
-
-
?
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0721
GTTPSPVPTTS-(O-GalNAc)T-SAP
pH 7.0, 37°C
0.182
PTTDS-(O-GalNAc)T-TPAPTTK
pH 7.0, 37°C
0.044
UDP-N-acetyl-D-galactosamine
pH 7.0, 37°C
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
contains a 680-amino acid C-terminal lumenal domain, and a 49-amino acid N-terminal cytoplasmic domain
Manually annotated by BRENDA team
type II membrane protein, 22-amino acid transmembrane sequence
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
Q6TBR4_TOXGO
329
0
37222
TrEMBL
other Location (Reliability: 3)
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant enzyme
recombinant from Drosophila melanogaster S2 cells
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
stable functional expression in Drosophila melanogaster S2 cells
stable transfected into Drosophila melanogaster S2 cells
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wojczyk, B.S.; Stwora-Wojczyk, M.M.; Hagen, F.K.; Striepen, B.; Hang, H.C.; Bertozzi, C.R.; Roos, D.S.; Spitalnik, S.L.
cDNA cloning and expression of UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase T1 from Toxoplasma gondii
Mol. Biochem. Parasitol.
131
93-107
2003
Toxoplasma gondii (Q8MM26), Toxoplasma gondii
Manually annotated by BRENDA team
Stwora-Wojczyk, M.M.; Dzierszinski, F.; Roos, D.S.; Spitalnik, S.L.; Wojczyk, B.S.
Functional characterization of a novel Toxoplasma gondii glycosyltransferase: UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-T3
Arch. Biochem. Biophys.
426
231-240
2004
Mus musculus, Rattus norvegicus, Toxoplasma gondii (Q6YBY0), Toxoplasma gondii
Manually annotated by BRENDA team
Stwora-Wojczyk, M.M.; Kissinger, J.C.; Spitalnik, S.L.; Wojczyk, B.S.
O-glycosylation in Toxoplasma gondii: identification and analysis of a family of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases
Int. J. Parasitol.
34
309-322
2004
Toxoplasma gondii (Q6TBR3), Toxoplasma gondii (Q6TBR4), Toxoplasma gondii (Q6YBY0), Toxoplasma gondii (Q6YK77), Toxoplasma gondii
Manually annotated by BRENDA team