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Information on EC 2.4.1.398 - beta-galactofuranoside beta-1,5-galactofuranosyltransferase
for references in articles please use BRENDA:EC2.4.1.398
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EC Tree 2 Transferases
2.4 Glycosyltransferases
2.4.1 Hexosyltransferases
2.4.1.398 beta-galactofuranoside beta-1,5-galactofuranosyltransferase
IUBMB Comments
Requires Mn2+. The enzyme, characterized from the flilamentous fungi Aspergillus nidulans and Aspergillus fumigatus, participates in the synthesis of fungal-type galactomannan and O-mannose-type galactomannan, which are embedded in the fungal cell walls. While the reaction shown here describes the transfer of one galactofuransyl residue, the enzyme can add up to 5 more galactofuranosyl residues.
The expected taxonomic range for this enzyme is: Aspergillus
Reaction Schemes
show+
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+
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a beta-D-galactofuranoside
=
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a beta-D-Galf-(1->5)-beta-D-galactofuranoside
Synonyms
AN8677, beta-galactofuranoside beta-(1->5)-galactofuranosyltransferase, beta1,5-galactofuranosyltransferase, Galf-transferase, gfsA, GfsB, GfsC, O-glycan beta-1,5-galactofuranosyltransferase, UDP-alpha-D-galactofuranose:beta-D-galactofuranoside beta1,5-galactofuranosyltransferase, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
AN8677
beta-galactofuranoside beta-(1->5)-galactofuranosyltransferase
beta1,5-galactofuranosyltransferase
gfsA
GfsB
GfsC
O-glycan beta-1,5-galactofuranosyltransferase
-
-
-
-
UDP-alpha-D-galactofuranose:beta-D-galactofuranoside beta1,5-galactofuranosyltransferase
gfsA
-
-
-
-
UDP-alpha-D-galactofuranose:beta-D-galactofuranoside beta1,5-galactofuranosyltransferase
-
-
UDP-alpha-D-galactofuranose:beta-D-galactofuranoside beta1,5-galactofuranosyltransferase
Aspergillus fumigatus A1151
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
UDP-alpha-D-galactofuranose + a beta-D-galactofuranoside = UDP + a beta-D-Galf-(1->5)-beta-D-galactofuranoside
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
UDP-alpha-D-galactofuranose:beta-D-galactofuranoside beta-1,5-galactofuranosyltransferase (configuration-inverting)
Requires Mn2+. The enzyme, characterized from the flilamentous fungi Aspergillus nidulans and Aspergillus fumigatus, participates in the synthesis of fungal-type galactomannan and O-mannose-type galactomannan, which are embedded in the fungal cell walls. While the reaction shown here describes the transfer of one galactofuransyl residue, the enzyme can add up to 5 more galactofuranosyl residues.
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
UDP-alpha-D-galactofuranose + 4-methylumbelliferyl beta-D-galactofuranoside
UDP + 4-methylumbelliferyl beta-D-Galf-(1->5)-beta-D-galactofuranoside
UDP-alpha-D-galactofuranose + 4-nitrophenyl beta-D-galactofuranoside
UDP + 4-methylumbelliferyl beta-D-Galf-(1->5)-beta-D-galactofuranoside
UDP-alpha-D-galactofuranose + 4-nitrophenyl beta-D-galactofuranoside
UDP + 4-nitrophenyl beta-D-Galf-(1->5)-beta-D-galactofuranoside
UDP-alpha-D-galactofuranose + a beta-D-galactofuranoside
UDP + a beta-D-Galf-(1->5)-beta-D-galactofuranoside
UDP-alpha-D-galactofuranose + 4-methylumbelliferyl beta-D-galactofuranoside
UDP + 4-methylumbelliferyl beta-D-Galf-(1->5)-beta-D-galactofuranoside
-
Substrates: -
Products: -
Products: -
?
UDP-alpha-D-galactofuranose + 4-methylumbelliferyl beta-D-galactofuranoside
UDP + 4-methylumbelliferyl beta-D-Galf-(1->5)-beta-D-galactofuranoside
Aspergillus fumigatus A1151
-
Substrates: -
Products: -
Products: -
?
UDP-alpha-D-galactofuranose + 4-nitrophenyl beta-D-galactofuranoside
UDP + 4-methylumbelliferyl beta-D-Galf-(1->5)-beta-D-galactofuranoside
-
Substrates: -
Products: -
Products: -
?
UDP-alpha-D-galactofuranose + 4-nitrophenyl beta-D-galactofuranoside
UDP + 4-methylumbelliferyl beta-D-Galf-(1->5)-beta-D-galactofuranoside
Aspergillus fumigatus A1151
-
Substrates: -
Products: -
Products: -
?
UDP-alpha-D-galactofuranose + 4-nitrophenyl beta-D-galactofuranoside
UDP + 4-nitrophenyl beta-D-Galf-(1->5)-beta-D-galactofuranoside
-
Substrates: -
Products: -
Products: -
?
UDP-alpha-D-galactofuranose + 4-nitrophenyl beta-D-galactofuranoside
UDP + 4-nitrophenyl beta-D-Galf-(1->5)-beta-D-galactofuranoside
Aspergillus fumigatus A1151
-
Substrates: -
Products: -
Products: -
?
UDP-alpha-D-galactofuranose + a beta-D-galactofuranoside
UDP + a beta-D-Galf-(1->5)-beta-D-galactofuranoside
-
Substrates: -
Products: -
Products: -
?
UDP-alpha-D-galactofuranose + a beta-D-galactofuranoside
UDP + a beta-D-Galf-(1->5)-beta-D-galactofuranoside
Aspergillus fumigatus A1151
-
Substrates: -
Products: -
Products: -
?
UDP-alpha-D-galactofuranose + a beta-D-galactofuranoside
UDP + a beta-D-Galf-(1->5)-beta-D-galactofuranoside
Aspergillus fumigatus A1160
-
Substrates: -
Products: -
Products: -
?
UDP-alpha-D-galactofuranose + a beta-D-galactofuranoside
UDP + a beta-D-Galf-(1->5)-beta-D-galactofuranoside
-
Substrates: -
Products: -
Products: -
?
UDP-alpha-D-galactofuranose + a beta-D-galactofuranoside
UDP + a beta-D-Galf-(1->5)-beta-D-galactofuranoside
Aspergillus nidulans AKU89-AnwscA
-
Substrates: -
Products: -
Products: -
?
UDP-alpha-D-galactofuranose + a beta-D-galactofuranoside
UDP + a beta-D-Galf-(1->5)-beta-D-galactofuranoside
-
Substrates: -
Products: -
Products: -
?
UDP-alpha-D-galactofuranose + WscA-HA protein
?
-
Substrates: -
Products: -
Products: -
?
UDP-alpha-D-galactofuranose + WscA-HA protein
?
Aspergillus fumigatus A1151
-
Substrates: -
Products: -
Products: -
?
UDP-alpha-D-galactofuranose + WscA-HA protein
?
Aspergillus fumigatus A1160
-
Substrates: -
Products: -
Products: -
?
UDP-alpha-D-galactofuranose + WscA-HA protein
?
-
Substrates: -
Products: -
Products: -
?
UDP-alpha-D-galactofuranose + WscA-HA protein
?
Aspergillus nidulans AKU89-AnwscA
-
Substrates: -
Products: -
Products: -
?
additional information
?
-
-
Substrates: no activity with UDP-alpha-D-galactopyranose, GDP-alpha-D-mannopyranose, 4-nitrophenyl beta-D-galactopyranoside or 4-nitrophenyl alpha-D-mannopyranoside
Products: -
Products: -
-
additional information
?
-
-
Substrates: isoforms GfsA, GfsB, and GfsC can synthesize beta-(1->5)-galactofuranosyl oligomers at up to lengths of 7, 3, and 5 galactofuranoses, respectively
Products: -
Products: -
-
additional information
?
-
Aspergillus fumigatus A1151
-
Substrates: no activity with UDP-alpha-D-galactopyranose, GDP-alpha-D-mannopyranose, 4-nitrophenyl beta-D-galactopyranoside or 4-nitrophenyl alpha-D-mannopyranoside
Products: -
Products: -
-
additional information
?
-
Aspergillus fumigatus A1151
-
Substrates: isoforms GfsA, GfsB, and GfsC can synthesize beta-(1->5)-galactofuranosyl oligomers at up to lengths of 7, 3, and 5 galactofuranoses, respectively
Products: -
Products: -
-
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
UDP-alpha-D-galactofuranose + a beta-D-galactofuranoside
UDP + a beta-D-Galf-(1->5)-beta-D-galactofuranoside
UDP-alpha-D-galactofuranose + a beta-D-galactofuranoside
UDP + a beta-D-Galf-(1->5)-beta-D-galactofuranoside
-
Substrates: -
Products: -
Products: -
?
UDP-alpha-D-galactofuranose + a beta-D-galactofuranoside
UDP + a beta-D-Galf-(1->5)-beta-D-galactofuranoside
Aspergillus fumigatus A1151
-
Substrates: -
Products: -
Products: -
?
UDP-alpha-D-galactofuranose + a beta-D-galactofuranoside
UDP + a beta-D-Galf-(1->5)-beta-D-galactofuranoside
Aspergillus fumigatus A1160
-
Substrates: -
Products: -
Products: -
?
UDP-alpha-D-galactofuranose + a beta-D-galactofuranoside
UDP + a beta-D-Galf-(1->5)-beta-D-galactofuranoside
-
Substrates: -
Products: -
Products: -
?
UDP-alpha-D-galactofuranose + a beta-D-galactofuranoside
UDP + a beta-D-Galf-(1->5)-beta-D-galactofuranoside
Aspergillus nidulans AKU89-AnwscA
-
Substrates: -
Products: -
Products: -
?
UDP-alpha-D-galactofuranose + a beta-D-galactofuranoside
UDP + a beta-D-Galf-(1->5)-beta-D-galactofuranoside
-
Substrates: -
Products: -
Products: -
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Mn2+
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
Highest Expressing Human Cell Lines
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
metabolism
physiological function
malfunction
-
enzyme-deficient cells exhibit an abnormal morphology characterized by poor hyphal extension, hyphal curvature, and limited formation of conidia
malfunction
-
enzyme-deficient cells exhibit an abnormal morphology characterized by poor hyphal extension, hyphal curvature, and limited formation of conidia
malfunction
Aspergillus fumigatus A1160
-
enzyme-deficient cells exhibit an abnormal morphology characterized by poor hyphal extension, hyphal curvature, and limited formation of conidia
-
malfunction
Aspergillus fumigatus A1151
-
enzyme-deficient cells exhibit an abnormal morphology characterized by poor hyphal extension, hyphal curvature, and limited formation of conidia
-
malfunction
Aspergillus nidulans AKU89-AnwscA
-
enzyme-deficient cells exhibit an abnormal morphology characterized by poor hyphal extension, hyphal curvature, and limited formation of conidia
-
metabolism
-
the enzyme is required for the galactofuranosylation of N- and O-glycans
metabolism
-
the enzyme is responsible for the biosynthesis of beta1,5-galactofuranose in the galactofuran side chain of fungal-type galactomannan
metabolism
-
the enzyme is involved in biosynthesis of galactofuranose antigen of O-glycan in the Golgi
metabolism
-
the enzyme is involved in biosynthesis of galactofuranose antigen of O-glycan in the Golgi
metabolism
-
isoforms GfsA and GfsC synthesize all beta-(1->5)-galactofuranosyl residues of fungal-type and O-mannose-type galactomannans, and isoform GfsB exhibits limited function in Aspergillus fumigatus
metabolism
Aspergillus fumigatus A1160
-
the enzyme is involved in biosynthesis of galactofuranose antigen of O-glycan in the Golgi
-
metabolism
Aspergillus fumigatus A1151
-
the enzyme is responsible for the biosynthesis of beta1,5-galactofuranose in the galactofuran side chain of fungal-type galactomannan
-
metabolism
Aspergillus fumigatus A1151
-
the enzyme is involved in biosynthesis of galactofuranose antigen of O-glycan in the Golgi
-
metabolism
Aspergillus fumigatus A1151
-
isoforms GfsA and GfsC synthesize all beta-(1->5)-galactofuranosyl residues of fungal-type and O-mannose-type galactomannans, and isoform GfsB exhibits limited function in Aspergillus fumigatus
-
metabolism
Aspergillus nidulans AKU89-AnwscA
-
the enzyme is involved in biosynthesis of galactofuranose antigen of O-glycan in the Golgi
-
physiological function
-
the enzyme is involved in biosynthesis of galactofuranose antigen of O-glycan
physiological function
-
the enzyme has a significant role during hyphal development, during conidiation, and in the conidia
physiological function
-
the enzyme has a significant role during hyphal development, during conidiation, and in the conidia
physiological function
Aspergillus fumigatus A1160
-
the enzyme has a significant role during hyphal development, during conidiation, and in the conidia
-
physiological function
Aspergillus fumigatus A1151
-
the enzyme is involved in biosynthesis of galactofuranose antigen of O-glycan
-
physiological function
Aspergillus fumigatus A1151
-
the enzyme has a significant role during hyphal development, during conidiation, and in the conidia
-
physiological function
Aspergillus nidulans AKU89-AnwscA
-
the enzyme has a significant role during hyphal development, during conidiation, and in the conidia
-
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
glycoprotein
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
His60 Ni resin column chromatography and Q Sepharose column chromatography
-
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Arentshorst, M.; de Lange, D.; Park, J.; Lagendijk, E.; Alazi, E.; van den Hondel, C.; Ram, A.
Functional analysis of three putative galactofuranosyltransferases with redundant functions in galactofuranosylation in Aspergillus niger
Arch. Microbiol.
202
197-203
2020
Aspergillus niger
brenda
Katafuchi, Y.; Li, Q.; Tanaka, Y.; Shinozuka, S.; Kawamitsu, Y.; Izumi, M.; Ekino, K.; Mizuki, K.; Takegawa, K.; Shibata, N.; Goto, M.; Nomura, Y.; Ohta, K.; Oka, T.
GfsA is a beta1,5-galactofuranosyltransferase involved in the biosynthesis of the galactofuran side chain of fungal-type galactomannan in Aspergillus fumigatus
Glycobiology
27
568-581
2017
Aspergillus fumigatus, Aspergillus fumigatus A1151
brenda
Komachi, Y.; Hatakeyama, S.; Motomatsu, H.; Futagami, T.; Kizjakina, K.; Sobrado, P.; Ekino, K.; Takegawa, K.; Goto, M.; Nomura, Y.; Oka, T.
gfsA encodes a novel galactofuranosyltransferase involved in biosynthesis of galactofuranose antigen of O-glycan in Aspergillus nidulans and Aspergillus fumigatus
Mol. Microbiol.
90
1054-1073
2013
Aspergillus fumigatus, Aspergillus nidulans, Aspergillus fumigatus A1160, Aspergillus fumigatus A1151, Aspergillus nidulans AKU89-AnwscA
brenda
Chihara, Y.; Tanaka, Y.; Izumi, M.; Hagiwara, D.; Watanabe, A.; Takegawa, K.; Kamei, K.; Shibata, N.; Ohta, K.; Oka, T.
Biosynthesis of beta(1->5)-galactofuranosyl chains of fungal-type and o-mannose-type galactomannans within the invasive pathogen Aspergillus fumigatus
mSphere
5
e00770-19
2020
Aspergillus fumigatus, Aspergillus fumigatus A1151
brenda
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