Involved in the production of milk oligosaccharides in the lacto-N-triose (LNT) series. Cf. EC 2.4.1.150 (N-acetyllactosaminide β-1,6-N-acetylglucosaminyltransferase; cIGnT) and EC 2.4.1.148 (acetylgalactosaminyl-O-glycosyl-glycoprotein β-1,6-N-acetylglucosaminyltransferase).
The enzyme appears in viruses and cellular organisms
Involved in the production of milk oligosaccharides in the lacto-N-triose (LNT) series. Cf. EC 2.4.1.150 (N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase; cIGnT) and EC 2.4.1.148 (acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase).
Substrates: enzyme additionally catalyzes the conversion of the polylactosamine acceptor beta-GlcNAc-(1->3')-LacNAc into beta-GlcNAc-(1->3')-beta-GlcNAc-(1->6')-LacNAc (dIGnT activity), but it cannot transfer GlcNAc to beta-LacNAc-(1-3')-LacNAc (cIGnT activity) and is able to convert mucin core 1 and core 3 analogs Products: -
the enzyme is able to synthesize branch points in branched lactosaminoglycans. Branching occurs only during the elongation process at the nonreducing end and follows a well-defined order. N-Acetylglucosamine is first transferred to position 3 of a terminal galactose followed immediately by the addition of a second N-acetylglucosamine to position 6, only then the 1->3 and the 1->6 branches are further elongated by galactose residues
enzyme plays a critical role in O-glycan synthesis in mucins, able to synthesize all known mucin beta 6 N-acetylglucosaminides. It mediates core 2 and core 4 O-glycan branching in mucin-type biosynthesis and has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans
Purification and cDNA cloning of UDP-GlcNAc:GlcNAcbeta1-3Galbeta1-4Glc(NAc)-R [GlcNAc to Gal] beta1,6N-acetylglucosaminyltransferase from rat small intestine: A major carrier of dIGnT activity in rat small intestine
Biosynthesis of blood group I antigens. Identification of a UDP-GlcNAc GlcNAcbeta1-3Gal(-R)beta1-6(GlcNAc to Gal) N-acetylglucosaminyltransferase in hog gastric mucosa
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