Information on EC 2.4.1.385 - sterol 27-beta-glucosyltransferase

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EC Tree
     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.385 sterol 27-beta-glucosyltransferase
IUBMB Comments
The enzyme, isolated from the plant Withania somnifera (ashwagandha), transfers D-glucose to a beta-hydroxyl group present at the C-27 position in sterols/withanolides, provided the substrate possesses a 17alpha-OH group. Natural substrates are 17alpha-hydroxywithaferin A, 27beta-hydroxywithanone, and 5alpha,6beta,17alpha,27beta-tetrahydroxywithanolide. The enzyme's activity with withanolide A and withanolide U, which lack a 17alpha-hydroxyl group, suggests it may also be able to glucosylate the C-20 beta-OH position, although this has not been verified yet. The enzyme does not glucosylate sterols at the C-3 position.
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The enzyme appears in viruses and cellular organisms
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-alpha-D-glucose + a 27-hydroxysteroid = UDP + a sterol 27-beta-D-glucoside
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